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111 Diseases |  |
73 Trials |
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- | memantine / Generic mfg.
Journal: Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy. (Pubmed Central) - May 7, 2022
We conducted an online survey of all American Society for Radiation Oncology-registered radiation oncologists (ROs), excluding trainees, regarding their practice patterns and attitudes toward employing memantine and hippocampal avoidance whole brain radiation therapy (HA-WBRT)...Our survey suggests that the majority of respondents offer approaches for neurocognitive preservation during WBRT for their patients. Further efforts are needed to broaden education and reduce barriers among ROs to improve implementation of neurocognitive-sparing techniques in patients undergoing WBRT.
- ||| ketamine / Generic mfg., memantine / Generic mfg., piracetam / Generic mfg.
Retrospective data, Review, Journal, Adverse events: Pharmacological interventions to diminish cognitive side-effects of electroconvulsive therapy: a systematic review and meta-analysis. (Pubmed Central) - May 6, 2022
These findings provide a guide for rational choices of potential pharmacological intervention research targets to decrease the burden of cognitive side-effects of ECT. Future research should be more uniform in design and attempt to clarify pathophysiological mechanisms of cognitive side-effects of ECT.
- | memantine / Generic mfg.
Preclinical, Journal, IO biomarker: Win55,212-2 Improves Neural Injury induced by HIV-1 Glycoprotein 120 in Rats by Exciting CB2R. (Pubmed Central) - May 6, 2022
And the effects aroused by Win55,212-2 could be reversed by the CB2R antagonist AM630. These data suggest that the activation of the CB2R is neuroprotective against GP120-induced neurotoxicity, and CB2R agonist might play a potential therapeutic role in HAND.
- | memantine / Generic mfg.
Journal: Insoluble Salt of Memantine with a Unique Fluorescence Phenomenon. (Pubmed Central) - May 6, 2022
Therefore, memantine and pamoic acid have a synergistic effect on the fluorescence performance and can be expected to be used for real-time monitoring in continuous and controlled release drug delivery systems. In addition, the polymorphic solid crystals also exhibit reversible mechanochromic luminescence under the fumigation of acetonitrile vapor, which has a guiding role in the fluorescence design and synthesis of Pam substances and is expected to be used for information security, visual inspection of organic substances, etc.
- | memantine / Generic mfg.
Journal: Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization. (Pubmed Central) - May 6, 2022
However, the combined pharmacological treatment promoted the aggregation of tau. Our data suggests that the synaptic:extrasynaptic balance of NR2B function regulates AD-tau pathogenesis, and that the inhibition of CK2, and concomitant prevention of NR2B mislocalization, may be a useful therapeutic tool for AD patients.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Observational data, Journal: Analysis of treatment pattern of anti-dementia medications in newly diagnosed Alzheimer's dementia using OMOP CDM. (Pubmed Central) - May 6, 2022
A 12-month persistence analysis showed values of approximately 50% for donepezil and memantine and approximately 40% for rivastigmine and galantamine. There were differences in the prescribing pattern and persistence among anti-dementia medications from database using the Observational Medical Outcome Partnership Common Data Model on the Federated E-health Big Data for Evidence Renovation Network platform in Korea.
- memantine / Generic mfg.
When Being Antagonistic Is a Good Thing: Using Memantine as Salvage Therapy for Catatonia From NMDA-Receptor Encephalitis () - May 5, 2022 - Abstract #APA2022APA_1128;
Memantine was later uptitrated to 5 mg twice a day - while lorazepam was weaned down - with continued improvement in catatonic symptoms...First, catatonia has a medical etiology in up to 46% of cases (Stern 2018), and this rate increases with age and level of care (Oldham 2018)...In turn, many clinicians are hesitant to prescribe memantine for such cases, with scant evidence to refute this. This is a unique case that demonstrates memantine’s utility and safety profile in cases of NMDA-R encephalitis-induced catatonia through a patient who was falsely assumed to have a primary psychiatric illness due to demographic factors.
- memantine / Generic mfg.
Use of Memantine for Autism Spectrum Disorder in an Adult Female, a Case Report () - May 5, 2022 - Abstract #APA2022APA_1116;
Similar to our case, the prospective trial documented improvement in measures of autism severity, anxiety and ADHD symptoms with no serious adverse events reported (4). In conclusion more research is needed to fully elucidate the efficacy and safety of Memantine in treating ASD in the adult population.
- memantine / Generic mfg.
Prediction of Long-Term Medication Outcome in Patients With Alzheimer’s Diseases Base on EEG Brain Connectivity () - May 5, 2022 - Abstract #APA2022APA_1015;
This study suggests the potential of EEG connectivity as a biomarker to predict long-term medical treatment by AchE inhibitor and NMDA antagonist in AD. This research was supported by Brain Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science and ICT(NRF-2017M3C7A1049051) and Eisai Korea.
- lorazepam / Generic mfg., memantine / Generic mfg.
To Exercise the Right to Exorcise? A Non-Canonical Case of Catatonia () - May 5, 2022 - Abstract #APA2022APA_696;
He improved after a lorazepam trial and was transferred for consideration of ECT...Memantine was subsequently initiated and BFCRS scores dropped to 10... Psychiatrists should be cognizant of the need for informed consent around religious practices and special consideration should be given to any proposed intervention for a patient who cannot provide consent.
- escitalopram / Generic mfg.
Escitalopram-Induced SIADH in a Geriatric Patient: A Case Report and Literature Review () - May 5, 2022 - Abstract #APA2022APA_462;
Her home medications were donepezil, memantine, atorvastatin, and aspirin. Providers should be aware of this rare side effect of escitalopram in future treatment considerations.
- | memantine / Generic mfg.
Trial completion date, Trial primary completion date: Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors (clinicaltrials.gov) - May 4, 2022
P2, N=50, Recruiting, Sponsor: St. Jude Children's Research Hospital
Providers should be aware of this rare side effect of escitalopram in future treatment considerations. Trial completion date: Mar 2023 --> Sep 2023 | Trial primary completion date: Mar 2022 --> Sep 2022
- | dizocilpine (MK801) / Merck (MSD)
Journal: Effects of Excessive Activation of N-methyl-D-aspartic Acid Receptors in Neonatal Cardiac Mitochondrial Dysfunction Induced by Intrauterine Hypoxia. (Pubmed Central) - May 3, 2022
These facts suggest that memantine could provide a novel and promising treatment for clinical use in intrauterine hypoxia during pregnancy to protect the cardiac mitochondrial function in the offspring. To our best knowledge, our research is the first study that shows intrauterine hypoxia can excessively activate cardiac NMDARs and thus cause mitochondrial dysfunction.
- || Retrospective data, Review, Journal: Pharmacological Treatments for Psychotic Symptoms in Dementia: A Systematic Review with Pairwise and Network Meta-Analysis. (Pubmed Central) - Apr 30, 2022
Besides, donepezil, memantine and mirtazapine were more efficacious than sertraline (SMDs ranged from -0.47 to -0.36)...Donepezil, memantine and aripiprazole are probably the appropriate options to consider when a pharmacological treatment is indicated. Given the limitations of the meta-analytic approach and the low methodological quality of the majority of studies, our results should be cautiously interpreted.
- | memantine / Generic mfg.
Journal: Computational Modeling of Therapy with the NMDA Antagonist in Neurodegenerative Disease: Information Theory in the Mechanism of Action of Memantine. (Pubmed Central) - Apr 30, 2022
(4) information theory results of simulation studies show that the NMDA antagonist, memantine, causes neuroprotective benefits in patients with AD. Our simulation study opens up remarkable new scenarios in which a medical product, drug, or device, can be developed and tested for efficacy based on parameters of information theory.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Retrospective data, Journal: Patterns of dementia treatment in older adults with Parkinson's disease using nationwide medical claims data. (Pubmed Central) - Apr 30, 2022
In Korea, dementia was observed to occur relatively soon after the diagnosis of PD. Anti-dementia medication was prescribed to approximately 66% of PD + D patients, with the majority receiving donepezil as monotherapy.
- || galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Retrospective data, Review, Journal: Comparative safety and efficacy of cognitive enhancers for Alzheimer's dementia: a systematic review with individual patient data network meta-analysis. (Pubmed Central) - Apr 28, 2022
The MDs of all cognitive enhancer regimens except for single-agent oral rivastigmine, galantamine and memantine, against placebo were clinically important for cognition (MD larger than 1.40 MMSE points), but results were quite imprecise. However, two-thirds of the published RCTs were associated with high risk of bias for incomplete outcome data, and IPD were only available for 15% of the included RCTs.
- memantine / Generic mfg.
A single-arm feasibility trial of memantine to prevent chemotherapy-related cognitive decline in patients with early breast cancer. (Available On Demand; 353) - Apr 28, 2022 - Abstract #ASCO2022ASCO_915;
P2
Our findings suggest that memantine is a safe and feasible intervention for chemotherapy-related cognitive decline and may ameliorate cognitive loss. Randomized controlled trials are needed to determine its preliminary efficacy.
- | memantine / Generic mfg.
Journal: Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A. (Pubmed Central) - Apr 26, 2022
AD patients' brains show reduced GluN3A expression. We propose that chronic "degenerative excitotoxicity" leads to sporadic AD, while GluN3A represents a primary pathogenic factor, an early biomarker, and an amyloid-independent therapeutic target.
- | memantine / Generic mfg.
Journal: Memantine-Derived Schiff Bases as Transdermal Prodrug Candidates. (Pubmed Central) - Apr 23, 2022
In addition, hydrolysis of 3 with the release of pyridoxal, a daily cofactor in human metabolism, was observed. The results suggested that 3 is the most promising compound and that formation of the pyridoxal Schiff base with Me might be an effective strategy to obtain a prodrug candidate with increased lipophilicity, which would be able to passively cross biological barriers during transdermal delivery and might have applications in the treatment of Alzheimer's disease and other neurological disorders.
- || sertraline / Generic mfg., memantine / Generic mfg., mirtazapine / Generic mfg.
Retrospective data, Review, Journal, HEOR: Cost-effectiveness of pharmacological therapies for people with Alzheimer's disease and other dementias: a systematic review and meta-analysis. (Pubmed Central) - Apr 22, 2022
AChEIs and memantine are cost-effective with improvements in dementia-related symptoms and trends of cost-savings. More empirical evidence with non-industrial sponsorships and rigorous design in different settings is warranted.
- | memantine / Generic mfg.
Preclinical, Journal: Memantine Disrupts Motor Coordination through Anxiety-like Behavior in CD1 Mice. (Pubmed Central) - Apr 22, 2022
These data provide further insights into the potential deleterious effects of memantine which may result from the lack of adaptation to novel, stressful conditions. This effect of memantine may affect the results of tests used to assess motor performance and should be considered during clinical trials of memantine in patients.
- | memantine / Generic mfg., escitalopram / Generic mfg.
Journal: Default mode network connectivity and treatment response in geriatric depression. (Pubmed Central) - Apr 21, 2022
P4
This effect of memantine may affect the results of tests used to assess motor performance and should be considered during clinical trials of memantine in patients. Increased within-network connectivity of core DMN nodes was more strongly correlated with depressive symptom improvement with ESC/MEM than with ESC/PBO, supporting an improved engagement of brain circuitry implicated in the amelioration of depressive symptoms with combined ESC/MEM treatment in older adults with depression and subjective memory complaints.
- || Review, Journal: Perioperative Breast Analgesia: a Systematic Review of the Evidence for Perioperative Analgesic Medications. (Pubmed Central) - Apr 19, 2022
Some agents may also decrease the incidence of chronic postoperative pain, including flurbiprofen, gabapentin, venlafaxine, and memantine. While many individual agents are well studied, optimal combinations of analgesic medications remain unclear.
- | Journal: Sex Differences in Demographic and Pharmacological Factors in Alzheimer Patients With Dementia and Cognitive Impairments. (Pubmed Central) - Apr 19, 2022
African American females were associated with ADD and more likely to be treated with buspirone and presented with a history of ETOH. This finding suggests the need for a pharmacological treatment approach encompassing sex-sensitive strategies for MCI-AD and ADD patients.
- |||||| Aduhelm (aducanumab) / Eisai, Biogen, memantine / Generic mfg.
FDA event: Between 1995 and 2021, 878 drugs across all therapeutic areas have been approved by the US Food and Drug Administration (FDA); only six of these drugs are indicated for Alzheimer’s Disease (four cholinesterase inhibitors [ChEIs], memantine, and aducanumab) https://t.co/DQlIwO889s (Twitter) - Apr 19, 2022
- || carbidopa/levodopa / Generic mfg., memantine / Generic mfg.
Retrospective data, Review, Journal: Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. (Pubmed Central) - Apr 15, 2022
Our systematic review did not reveal any effective treatment. Further investigations are needed to find therapy for NAION.
- || memantine / Generic mfg.
PK/PD data, Journal: Comparative clinical study of the pharmacokinetics and bioequivalence of the combined drug Mioreol and the combined use of mono-drugs containing donepezil and memantine (Pubmed Central) - Apr 15, 2022
Further investigations are needed to find therapy for NAION. The results of the study allow us to recommend Mioreol for further clinical study and wide practical application.
- | dizocilpine (MK801) / Merck (MSD)
Preclinical, Journal: Opposing effects of NMDA receptor antagonists on early life stress-induced aggression in mice. (Pubmed Central) - Apr 14, 2022
These findings indicate that MK-801, memantine, and ketamine have distinct and opposing effects on early life stress-induced aggression, suggesting these drugs may be mechanistically distinct. This study identifies memantine as a promising pharmacological treatment for aggressive behavior associated with early life stress and demonstrates the need for greater care when using glutamate receptor antagonists to treat aggression.
- | bryostatin 1 (NSC 339555) / Synaptogenix
Journal: Bryostatin Placebo-Controlled Trials Indicate Cognitive Restoration Above Baseline for Advanced Alzheimer's Disease in the Absence of Memantine1. (Pubmed Central) - Apr 14, 2022
This study identifies memantine as a promising pharmacological treatment for aggressive behavior associated with early life stress and demonstrates the need for greater care when using glutamate receptor antagonists to treat aggression. Pre-specified exploratory analyses for the individual trials and the pooled trials confirmed significant bryostatin-induced improvement over baseline (treatment p < 0.001, placebo NS).
- | memantine / Generic mfg.
Journal: Drug delivery of memantine with carbon dots for Alzheimer's disease: blood-brain barrier penetration and inhibition of tau aggregation. (Pubmed Central) - Apr 14, 2022
The kinetics and magnitude of tau aggregation were measured in the presence of CDs, which demonstrates that both B-CDs-MH and B-CDs alone are the most effective inhibitors of tau aggregation with IC values of 1.5 ± 0.3 and 1.6 ± 1.5 μg/mL, respectively. Taken together, our findings hold therapeutic significance to enhance the efficient delivery of MH to target AD pathology in the brain for improved efficacy.
- | levetiracetam / Generic mfg., memantine / Generic mfg., minocycline / Generic mfg.
Preclinical, Journal: Preclinical evaluation of drug treatment options for sleep-related epileptiform spiking in Alzheimer's disease. (Pubmed Central) - Apr 14, 2022
Levetiracetam appears promising for treating sleep-related epileptiform spiking in AD while lamotrigine should be used with caution. Donepezil at low doses appeared neutral but the memantine effects warrant further studies.
- || Aduhelm (aducanumab) / Eisai, Biogen
Biomarker, Review, Journal, IO biomarker: Role of Pharmacogenomics in Individualizing Treatment for Alzheimer's Disease. (Pubmed Central) - Apr 13, 2022
Introducing a limited genetic panel consisting of APOE4, CYP2D6*10, and BChE*K would optimize acetylcholinesterase inhibitor therapy, facilitate immunotherapy risk assessment, and inform an amyloid-related imaging abnormality surveillance schedule. In view of the genetic heterogeneity of Alzheimer's disease identified in genome-wide association studies, pharmacogenetics is expected to play an increasing role in mechanism-specific treatment strategies and personalized medicine.
- | memantine / Generic mfg.
Journal: The Computer Simulation of Therapy with the NMDA Antagonist in Excitotoxic Neurodegeneration in an Alzheimer's Disease-like Pathology. (Pubmed Central) - Apr 13, 2022
However, its very modest effect provides motivation for further research into new drugs in AD. We are the first to present a mathematical model of the NMDA receptor that allows the simulation of excitotoxicity and virtual memantine therapy.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Journal: The listed, delisted, and sustainability of therapeutic medicines for dementia patients: the study is specific to South Korea. (Pubmed Central) - Apr 12, 2022
We could not decide on galantamine because it is one of the other groups. We made a straightforward decision-maker of delisted, listed, or sustainable criteria based on mortality and datum line.
- || memantine / Generic mfg.
Retrospective data, Review, Journal: The efficacy and tolerability of memantine for depressive symptoms in major mental diseases: A systematic review and updated meta-analysis of double-blind randomized controlled trials. (Pubmed Central) - Apr 12, 2022
The present meta-analysis indicates that memantine effectively alleviates depressive symptoms in patients with mood disorders with a small effect size. Furthermore, memantine is well-tolerated and acceptable.
- | memantine / Generic mfg.
Biomarker, Trial completion date, Trial primary completion date: Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease (clinicaltrials.gov) - Apr 12, 2022
P4, N=88, Recruiting, Sponsor: University of California, San Diego
Furthermore, memantine is well-tolerated and acceptable. Trial completion date: Aug 2023 --> Jun 2024 | Trial primary completion date: Aug 2023 --> Jun 2024
- | oxaliplatin / Generic mfg., memantine / Generic mfg.
Journal, IO biomarker: Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection. (Pubmed Central) - Apr 9, 2022
Moreover, the terminal deoxynucleotidyl Transferase-mediated dUTP nick end labeling (TUNEL) apoptosis assay revealed that Memantine protected oxaliplatin-induced apoptosis through mitigating the ratio of Bax/Bcl-2 and Caspase-3 cleavage. We concluded Memantine ameliorated the neurotoxicity of oxaliplatin in a mitochondrial-dependent pathway.
- | memantine / Generic mfg.
Journal: Memantine induced encephalopathy in chronic kidney disease: a case report. (Pubmed Central) - Apr 9, 2022
We concluded Memantine ameliorated the neurotoxicity of oxaliplatin in a mitochondrial-dependent pathway. No abstract available
- | memantine / Generic mfg.
Trial completion: Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer (clinicaltrials.gov) - Apr 8, 2022
P2, N=56, Completed, Sponsor: UNC Lineberger Comprehensive Cancer Center
No abstract available Active, not recruiting --> Completed
- | memantine / Generic mfg.
Journal: Pharmacotherapeutic combinations for the treatment of Alzheimer's disease. (Pubmed Central) - Apr 7, 2022
The combination of symptomatic therapies with approved anti-dementia medicines (one ChEI and memantine) has been found to be functionally effective for a moderately severe disease stage. Furthermore, combination strategies involving p-DMTs, symptomatic therapies, and neuro-regeneration may be useful in the future.
- | memantine / Generic mfg.
Trial completion: MAGD: Memantine for Agitation in Dementia (clinicaltrials.gov) - Apr 6, 2022
P4, N=153, Completed, Sponsor: East Kent Hospitals University NHS Foundation Trust
Furthermore, combination strategies involving p-DMTs, symptomatic therapies, and neuro-regeneration may be useful in the future. Recruiting --> Completed
- || galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Clinical, Journal: Global trends in symptomatic medication use against dementia in 66 countries/regions from 2008 to 2018. (Pubmed Central) - Apr 2, 2022
There was an increasing trend in use of symptomatic medications against dementia globally, but the use remained low in LMICs. Interventions may be needed to support the medication use in some countries.
- | memantine / Generic mfg.
Journal: European Stroke Organisation (ESO) and European Academy Neurology (EAN) Joint Guidelines on Post Stroke Cognitive Impairment. (Pubmed Central) - Apr 2, 2022
These guidelines highlight fundamental areas where robust evidence is lacking. Further, definitive randomised controlled trials are needed, and we suggest priority areas for future research.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Journal: Nutraceuticals and their Derived Nano-formulations for the Prevention and Treatment of Alzheimer's disease. (Pubmed Central) - Apr 1, 2022
Thus, in this review, we have discussed the etiology of AD, focused on the pharmacotherapeutics of nutraceuticals with preclinical and clinical evidence, discussed pharmaceutical limitation and regulatory aspects of nutraceuticals to ensure safety and efficacy. We further explored the latitude of various nanoformulation of nutraceuticals as a novel approach to overcome the existing pharmaceutical limitation and for effective delivery into the brain.
- || bryostatin 1 (NSC 339555) / Synaptogenix
Enrollment closed: Bryostatin Treatment of Moderately Severe Alzheimer's Disease (clinicaltrials.gov) - Mar 29, 2022
P2, N=100, Active, not recruiting, Sponsor: Neurotrope Bioscience, Inc.
We further explored the latitude of various nanoformulation of nutraceuticals as a novel approach to overcome the existing pharmaceutical limitation and for effective delivery into the brain. Recruiting --> Active, not recruiting
- | memantine / Generic mfg.
Journal: Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study. (Pubmed Central) - Mar 25, 2022
Memantine alone did not induce repolarization delay, indicating lack of risk for inducing torsade de pointes. Thus, these in vivo experimental findings may provide basic information to better understand the clinically observed adverse events of memantine.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Journal: Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model. (Pubmed Central) - Mar 24, 2022
It was possible to identify the most effective drug for the real-world treatment of cognitive impairment in dementia at an individual patient level. Routine care patients whose prescribed medications were the best fit according to the model had better cognitive performance after 2 years.
- || memantine / Generic mfg.
Clinical, Review, Journal: Effectiveness of medication for opioid use disorders in transition-age youth: A systematic review. (Pubmed Central) - Mar 23, 2022
The literature guiding youth MOUD is limited, and more research should evaluate the effectiveness of options other than buprenorphine, optimal treatment duration, and the benefit of adjunctive behavioral interventions. Subgroup analyses of extant randomized clinical trials could help to extend knowledge of MOUD effectiveness in this age cohort.
- || methylphenidate tablet / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Review, Journal: Pharmacological Management of Apathy in Dementia. (Pubmed Central) - Mar 23, 2022
Regarding FTD- and DLB-related apathy, initial studies with agomelatine and rivastigmine showed benefits, respectively...With regards to mixed populations, memantine, galantamine and gingko biloba showed effects on apathy in the AD plus VaD populations and nimodipine in the VaD plus mixed dementia populations...There should also be a consensus on using scales with high test/retest and interrater reliabilities to limit the inconsistencies between clinical trials. In conclusion, there are currently no US FDA-approved drugs that target apathy in dementia, so there is an ongoing need for the development of such drugs.