- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal, Adverse events: Adverse effects from counterfeit and mislabeled medicine containing tapentadol and carisoprodol. (Pubmed Central) - Aug 8, 2024
When self-administration with counterfeit or mislabeled medicine is suspected, comprehensive laboratory analysis should be preferred over immunoassay screening to avoid false negative results. Carisoprodol, which was formerly a popular muscle relaxant drug in many countries, has reappeared on illegal drug markets, and may cause an itching, purple-colored rash, even after a single dose.
- |||||||||| BATTLING THE BLOCKADE: A CASE OF MULTIFACTORIAL SHOCK IN POLYSUBSTANCE OVERDOSE (Convention Center Exhibit Hall: Rapid Fire Area 2D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_4820;
Early recognition of shock etiology can facilitate in choosing appropriate management and possibly reduce mortality. In the setting of CCB and BB overdose, ILE may improve patient outcomes by acting as a reservoir for these lipophilic medications and stabilize cardiac function.
- |||||||||| Journal: Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants. (Pubmed Central) - Jun 16, 2024
In the tramadol-SMR-triggered cohort, the adjusted HRs were 1.51 (1.01-2.26) for baclofen and 1.48 (1.03-2.11) for cyclobenzaprine...In conclusion, the relative injury rate associated with different SMRs used concurrently with the three most dispensed opioids appears to vary depending on the specific opioid and the order of combination initiation. If confirmed by future studies, clinicians should consider the varying injury rates when prescribing SMRs to individuals using hydrocodone, oxycodone, and tramadol.
- |||||||||| carisoprodol / Generic mfg.
Impact of Mandated Use of the Texas Prescription Monitoring Program on Carisoprodol Dispensing in Texas () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_428;
There is no sufficient evidence for the associations between the Texas PMP mandate and changes in carisoprodol prescribing and dispensing. Future research is warranted to continuously monitor the trend in carisoprodol dispensing and explore factors that may hinder the adoption of the PMP mandate by prescribers and dispensers in Texas.
- |||||||||| Journal: Examination of multiple drug arrests reported to the Maine Diversion Alert Program. (Pubmed Central) - May 19, 2022
The misuse of opioids, both alone and in conjunction with another drug, deserves continued surveillance. In addition, common prescription drugs with less appreciated misuse potential, especially carisoprodol, amitriptyline, and quetiapine, require greater attention for their ability to enhance the effects of other drugs.
- |||||||||| carisoprodol / Generic mfg.
Clinical, Journal: Secondary effects of an opioid-focused academic detailing program on non-opioid controlled substance prescribing in primary care. (Pubmed Central) - Mar 16, 2022
Outcomes were mean monthly prescriptions for benzodiazepines (BZD), non-BZD sedative-hypnotics, and carisoprodol, per clinician...Our findings may suggest the need for incorporation of targeted education on appropriate BZD prescribing into opioid-focused AD programs as a featured component. These findings warrant further consideration and investigation before large-scale implementation of opioid-focused educational outreach programs.
- |||||||||| risperidone / Generic mfg., trazodone ER / Generic mfg., duloxetine / Generic mfg.
Preclinical, Journal: Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat. (Pubmed Central) - Feb 23, 2022
The current study used that model to assess the impact on respiration of non-benzodiazepine sedative psychotropic drugs representative of different drug classes (clozapine, quetiapine, risperidone, zolpidem, trazodone, carisoprodol, cyclobenzaprine, mirtazapine, topiramate, paroxetine, duloxetine, ramelteon, and suvorexant) administered alone and with oxycodone...This study identified drug-drug interaction effects depressing respiration in an animal model when quetiapine or paroxetine were co-administered with oxycodone. Clinical pharmacodynamic drug interaction studies are being conducted with these drugs to assess translatability of these findings.
- |||||||||| carisoprodol / Generic mfg.
Clinical, PK/PD data, Journal: Single and Multiple Dose PK-PD Characterization for Carisoprodol. Part I: Pharmacokinetics, Metabolites, and 2C19 Phenotype Influence. Double-Blind, Placebo-Controlled Clinical Trial in Healthy Volunteers. (Pubmed Central) - Feb 16, 2022
After 14 days of treatment (350 mg/8 h) the results for carisoprodol were (mean ± SD) Cmax: 2504 ± 730 ng/mL, AUC: 7451 ± 3615 h·ng/mL, and T: 2 ± 0.7 h. For meprobamate (a steady state was reached), the parameters were Cmax: 5758 ± 1255 ng/mL and 79,699 ± 17,978 h·ng/mL y 8.7 ± 1.4 h. The study allowed for the full characterization of the pharmacokinetic profile of carisoprodol and meprobamate. Accumulation of meprobamate but not of carisoprodol was evident after 14 days of treatment.
- |||||||||| Somadril comp (carisoprodol + paracetamol + caffeine) / MinaPharm
Preclinical, Journal: Toxicity of Somadril Compound on Fetal Ileum Tissues of Albino Rats. (Pubmed Central) - Nov 5, 2021
Accumulation of meprobamate but not of carisoprodol was evident after 14 days of treatment. This study showed that several histopathological and histochemical deformities in the fetal ileum tissues were caused by the administration of carisoprodol.
- |||||||||| carisoprodol / Generic mfg., amphetamine/dextroamphetamine immediate release tablet / Generic mfg.
[VIRTUAL] Carisoprodol Overdose Clinical Implications And Review Of The Literature () - Oct 17, 2020 - Abstract #ASA2020ASA_805;
We present a 38-year-old woman who was admitted to the intensive care unit after taking approximately fifty 350-milligram tablets of carisoprodol (Somadril), an unknown amount of amphetamine/dextrampheatmine (Adderall), and alprazolam (Xanax). Carisoprodol overdose is characterized by excessive sedation, unresponsiveness to stimuli, severe ataxia, amnesia, agitation, myoclonus, CNS depression, respiratory failure, seizures, and coma.
- |||||||||| carisoprodol / Generic mfg.
Journal: Overlapping prescriptions of opioids, benzodiazepines, and carisoprodol: "Holy Trinity" prescribing in the state of Florida. (Pubmed Central) - Jun 28, 2020
Carisoprodol overdose is characterized by excessive sedation, unresponsiveness to stimuli, severe ataxia, amnesia, agitation, myoclonus, CNS depression, respiratory failure, seizures, and coma. These findings raise important questions as to how frequently prescribers are checking prescription drug monitoring programs, following US Centers for Disease Control and Prevention opioid prescribing guidelines, and/or handling the clinical challenges associated with pharmaceutical management of patients with complex, painful health conditions.
- |||||||||| carisoprodol / Generic mfg.
Analysis of an Opioid-Based Pharmacy Lock-In Program in a Medicaid Managed Care Population () - May 6, 2020 - Abstract #AMCP2020AMCP_343;
The considerable decrease in pharmacy utilization after lock-in exhibits programmatic success in reducing the number of claims for controlled substances, pharmacies used, and prescribing physicians through increased coordinated care at a single pharmacy. Sponsorship: Horizon NJ Health
- |||||||||| chloroquine phosphate / Generic Mfg., carisoprodol / Generic Mfg., Kolchin (colchicine) / Incepta
Journal: Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists. (Pubmed Central) - Oct 22, 2019
Experiments with TAS2R agonists' suggested the involvement of TAS2Rs 3, 4, 5, 9, 10, 14, 30, 39 and 40 in the inhibition of cytokine production. TAS2Rs may constitute new drug targets in inflammatory obstructive lung disease.
- |||||||||| Soma (carisoprodol) / Mylan
Journal: Analysis of Drugs in Oral Fluid Using LC-MS/MS. (Pubmed Central) - Jun 7, 2019
Because of the low volume of specimen available for analysis and the drug concentrations present (generally much lower than those in urine), efficient extraction methods and sensitive confirmation procedures are necessary for routine analysis of drugs in oral fluid. In this chapter, solid-phase extraction methods are described for a variety of drugs with liquid chromatography-tandem mass spectrometry detection.
- |||||||||| carisoprodol / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic (clinicaltrials.gov) - Sep 24, 2015
P=N/A, N=96, Completed,
Coupled with strategic community partnerships, successful PHM integration can assist in the financial survival of small health systems. Active, not recruiting --> Completed | N=500 --> 96 | Trial primary completion date: Dec 2015 --> Jan 2015
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