- |||||||||| nifedipine immediate release / Generic mfg., labetalol / Generic mfg.
Retrospective data, Journal, Adverse events: Is there a relationship between visit-to-visit blood pressure variability and adverse perinatal outcomes? (Pubmed Central) - Mar 9, 2025
The difference in BP variability between antihypertensives may reflect varying effectiveness or factors influencing antihypertensive choice. Prospective research is needed to investigate any potential link between antihypertensive medications, BP variability and perinatal outcome.
- |||||||||| Cardene (nicardipine) / Chiesi
Trial completion date, Trial primary completion date, Adverse events: Hypotensive Anesthesia for Orthognathic Surgery (clinicaltrials.gov) - Jan 31, 2025
P4, N=90, Not yet recruiting,
Rates of side effects were similar between groups, but there was a statistically significant difference in medication discontinuation rates. Trial completion date: Jul 2025 --> Dec 2025 | Trial primary completion date: Jul 2025 --> Dec 2025
- |||||||||| nitroprusside / Generic mfg., labetalol / Generic mfg.
Review, Journal: Malignant hypertension: current challenges, prevention strategies, and future perspectives. (Pubmed Central) - Jan 12, 2025
The International Society of Hypertension 2020 and European Society of Cardiology/European Society of Hypertension 2018 recommendations suggest using labetalol and nicardipine as the first-line choice, with urapidil and nitroprusside serving as alternative medications. Elevated risk of MHT has been linked to many socio-demographic and genetic factors.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Kineret (anakinra) / SOBI
Trial completion date, Trial primary completion date: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (clinicaltrials.gov) - Dec 18, 2024
P=N/A, N=1600, Recruiting,
Active, not recruiting --> Completed Trial completion date: Jul 2026 --> Jul 2027 | Trial primary completion date: Sep 2024 --> Jul 2026
- |||||||||| Cardene (nicardipine) / Chiesi
Trial completion date, Trial primary completion date, Adverse events: Hypotensive Anesthesia for Orthognathic Surgery (clinicaltrials.gov) - Dec 5, 2024
P4, N=90, Not yet recruiting,
The results obtained herein warrant the exploration of these new inhibitors in preclinical disease models. Trial completion date: Mar 2025 --> Jul 2025 | Trial primary completion date: Mar 2025 --> Jul 2025
- |||||||||| TNKASE (tenecteplase) / Roche, Boehringer Ingelheim
A Case of Focal Neurologic Deficits, Seizure, and Lateralized EEG Findings After ECT (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_1444;
Post-ECT seizures and complications are an uncommon occurrence, with only few reports in the literature, and our case is unique with left LPDs and LRDA being seen on the EEG following the procedure. This case adds further information to the limited knowledge and reporting of post-ECT complications.
- |||||||||| labetalol / Generic mfg.
Journal: Unexpected delivery: cryptic pregnancy. (Pubmed Central) - Nov 14, 2024
She was diagnosed with pre-eclampsia and commenced treatment with labetalol...This case also highlights the need for primary care and emergency physicians to be aware of the phenomenon of cryptic pregnancy. It also provides a cautionary reminder of having a high index of clinical suspicion to establish the diagnosis due to the paucity of cases in the literature.
- |||||||||| Rituxan (rituximab) / Roche
Differentiating Lupus Nephritis from Pre-eclampsia-A Diagnostic Dilemma () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_35;
She became pregnant in 2020 and irbesartan was switched to labetalol to manage underlying hypertension...Reduced levels of placental growth factor later in pregnancy have predicted onset of pre-eclampsia in one study. This would need further clinical validation.
- |||||||||| Study of the Availability of Antihypertensive Therapy During Pregnancy During Wartime in Ukraine () - Nov 4, 2024 - Abstract #ISPOREU2024ISPOR_EU_1026;
There are no 5 proven effective antihypertensive substances on the pharmaceutical market of Ukraine, therefore there is a need to make them available for therapy. There is a need to ensure, with the help of budget funds, rational therapy of arterial hypertension during pregnancy, because it is known that during the war, all medicines are bought by pregnant women with their own money.
- |||||||||| Journal: African-Colombian woman with preeclampsia and high-risk APOL1 genotype: A case report. (Pubmed Central) - Nov 4, 2024
This case reflects the importance of considering genetic predisposition in the context of preeclampsia. A stratified approach to preeclampsia management that acknowledges genetic factors harbors the potential to significantly diminish the maternal morbidity and mortality entwined with this condition.
- |||||||||| labetalol / Generic mfg.
Journal, Metabolomic study: A rapid diagnostic technique based on metabolomics to differentiate between preeclampsia (PE) and chronic kidney disease (CKD) using maternal urine. (Pubmed Central) - Nov 4, 2024
A total of 15 small molecules were tentatively identified as biomarkers to differentiate these two diseases, including potential internally exposed drugs and their metabolites like labetalol and SN-38, metabolites of exogenous substances like 3-phenylpropyl glucosinolate, and endogenous substances related to metabolism such as isoglobotriaose and chitobiose...Subsequent clinical symptoms and manifestations further supported the diagnosis of preeclampsia, and one of patient's pregnancy was ultimately terminated due to severe preeclampsia. Results of this study contribute to a better understanding of the pathogenesis and clinical diagnosis of preeclampsia, offering insights that could potentially improve future diagnostic and management approaches.
- |||||||||| labetalol / Generic mfg.
Journal: Reversible postoperative vision loss (POVL): A tale of four patients. (Pubmed Central) - Oct 21, 2024
Her blood pressure was high and reached up to 200 mmHg after induction of anesthesia, which was controlled with deep anesthesia and a labetalol infusion in the perioperative period...Follow-up MRIs in the outpatient clinic for all four patients normalized in due time. Extremes of hypertension and/or hypotension in the perioperative period can cause PRES, which may lead to reversible POVL.
- |||||||||| labetalol / Generic mfg.
Journal: Leveraging adrenergic receptor blockade for enhanced nonalcoholic fatty liver disease treatment via a biomimetic nanoplatform. (Pubmed Central) - Sep 29, 2024
Herein, a biomimetic nanoplatform with ROS-responsive and ROS-scavenging properties was developed for the codelivery of retinoic acid (RA) and the adrenoceptor antagonist labetalol (LA)...We demonstrated the excellent ability of the biomimetic nanoplatform to ameliorate liver inflammation, fibrosis and steatosis. Our work highlights the tremendous potential of a sympathetic nerve-focused strategy for the management of NAFLD and provides a promising nanoplatform for the treatment of NAFLD.
- |||||||||| nifedipine immediate release / Generic mfg., hydralazine hydrochloride / Generic mfg., labetalol / Generic mfg.
Review, Journal: Diagnosis and Treatment of Eclampsia. (Pubmed Central) - Sep 27, 2024
The timing and mode of delivery depend on obstetric indications, the severity of eclampsia, the gestational age of the fetus, and the overall clinical status of the patient. Neuraxial anesthesia is the anesthesia of choice for conscious, seizure-free, and with stable vital signs women undergoing cesarean section.
- |||||||||| Visken (pindolol) / Novartis
Journal: Magnetic particle spray mass spectrometry for the determination (Pubmed Central) - Sep 25, 2024
The method is aligned with green chemistry principles, requiring minimal sample, solvent, and sorbent amounts. MPS-MS successfully integrates sample preparation and ambient ionization mass spectrometry and holds great potential for application with other sorbents, samples, and analytes.
- |||||||||| A Case of Reninoma in a 42-Year-Old Patient with Recurrent Strokes (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3870;
He was discharged on Hydralazine 75 mg twice a day, Quinapril 20 mg twice a day, and Labetalol 300 mg nightly.Repeat testing 3 months later in clinic showed an AM renin level of 46 ng/mL/h, AM aldosterone level of 71.2 ng/dL, serum creatinine of 0.87 mg/dL, sodium of 139, and potassium of 3.4...His blood pressure remained uncontrolled averaging 150s systolic over 90s diastolic during his office visits and his regimen was uptitrated to Lisinopril 40 mg daily, Spironolactone 75 mg daily, Hydralazine 75 mg thrice daily, and Carvedilol 12.5 mg twice a day...The mean age at diagnosis was 27 years with a mean duration of HTN of 47 months. Our case highlights the importance of keeping reninoma on the differential of causes of secondary HTN.
- |||||||||| Bilateral Nephrectomy as a Salvage Therapy for Resistant Hypertension in ESKD (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3868;
Post-surgery, Lisinopril was stopped, labetalol was discontinued after one month, and the doses of other antihypertensive medications were gradually reduced. The prevalence of bilateral nephrectomy as a treatment option ranges from 0 to 7% in various countries.[1] Bilateral nephrectomy leads to reduction in the levels of renin, angiotensin and aldosterone, which subsequently lowers the BP in resistant hypertension.[2][1]doi: 10.1016/j.ijscr.2022.107566[2]doi: 10.7759/cureus.9031
- |||||||||| labetalol / Generic mfg.
A Rare Case of Atraumatic Page Kidney in a Patient with ESRD (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3863;
Our case is unique as it is one of the first cases of Page kidney occurring in the setting of anticoagulation use in ESRD. Page kidney should be considered a possibility for malignant hypertension in the setting of anticoagulation use in ESRD.
- |||||||||| Henletor (torsemide) / Orchid
A Curious Case of Salt-Sensitive Hypertension (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3858;
After years of ineffective anti-HTN therapy missing the mechanism of SS-HTN, serial PAC/PRA measurements with 24H, prompted an unconventional diuretic combination to achieve HTN control and reduce pill burden. This case highlights: 1) the utility of serial PAC/PRA with 24H to diagnose SS-HTN; 2) the efficacy of non-thiazide distal diuretics to treat SS-HTN; and 3) an evolving role for genetic testing to further our understanding of SS-HTN.
- |||||||||| Cardene (nicardipine) / Chiesi
Trial initiation date, Adverse events: Hypotensive Anesthesia for Orthognathic Surgery (clinicaltrials.gov) - Sep 3, 2024
P4, N=90, Not yet recruiting,
EOSP patients given with LMWH combined with magnesium sulfate and labetalol can effectively reduce the patient's blood pressure and urinary protein level; improve coagulation function, oxidative stress, and vascular endothelial function indices; reduce the adverse pregnancy outcomes; and improve the safety of treatment. Initiation date: Aug 2024 --> Nov 2024
- |||||||||| labetalol / Generic mfg.
A Rare Case of Drug-Induced Autoimmune-Like Hepatitis Associated With Labetalol Use (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5209;
Increased physician awareness of the potential for labetalol-induced liver injury could ensure timely recognition and improve patient outcomes. Figure: Liver function tests trend showing a significant improvement after discontinuation of labetalol use.
- |||||||||| labetalol / Generic mfg.
Labetalol and the Liver: A Rare Postpartum Encounter With Drug-Induced Liver Injury (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1788;
Subsequently she was admitted to inpatient with hepatology consultation and started on N-Acetylcysteine...Due to the inflammatory infiltrate present on histology she was started on Solu-Medrol 250 mg for 3 days eventually transitioning to oral steroids...Subsequently was discharged with outpatient hepatology follow-up and 3 months of oral prednisone with normalization in liver tests and total bilirubin AST: 15, ALT: 18, Tbili: 1...Negative autoimmune serologies further supported this diagnosis. Figure: A: Acute hepatitis featuring apoptotic bodies B: Hepatocyte drop out, consistent with severe acute hepatitis C: Periportal inflammation with eosinophils, neutrophils and paucity of plasma cells suggesting classic DILI D: Increased magnification of periportal inflammation with eosinophils, neutrophils and paucity of plasma cells suggesting classic DILI
- |||||||||| atenolol / Generic mfg.
Retrospective data, Journal: Does atenolol use during pregnancy cause small for gestational age neonates? A meta-analysis. (Pubmed Central) - Aug 8, 2024
Figure: A: Acute hepatitis featuring apoptotic bodies B: Hepatocyte drop out, consistent with severe acute hepatitis C: Periportal inflammation with eosinophils, neutrophils and paucity of plasma cells suggesting classic DILI D: Increased magnification of periportal inflammation with eosinophils, neutrophils and paucity of plasma cells suggesting classic DILI Our results suggested an elevated risk of small for gestational age associated with atenolol use in comparison to other beta blockers, specifically labetalol, propranolol, bisoprolol, and metoprolol.
- |||||||||| esmolol / Generic mfg., labetalol / Generic mfg.
Anesthetic Considerations for Removal of Carotid Body Tumor (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4471;
Maintained on 1.0 MAC with esmolol and labetalol for BP and HR control. Patient successfully extubated and transferred to floor before being discharged the next day.
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