nitrofurantoin / Generic mfg. 
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  • ||||||||||  ketorolac / Generic mfg., sirolimus / Generic mfg., paclitaxel / Generic mfg.
    Review, Journal:  Drug-delivering devices in the urinary tract: A systematic review. (Pubmed Central) -  Jun 10, 2021   
    A total of eight studies investigated the release of anti-inflammatory agents by DES (ketorolac, indomethacin, EW-7197)...Despite the inconclusive outcomes of the three randomised controlled trials, drug-coated/eluting devices constitute a promising field in urology for the prevention of complications associated with conventional stents including pain and encrustation. Pre-clinical in vitro and in vivo studies have shown their ability to mitigate inflammation, inhibit re-stenosis and improve pain as indicated by declined use of anti-inflammatory drugs.Abbreviations: DES: drug-eluting stents; DCB: drug-coated balloons; DCS: drug-coated stents; HF: halofungione; MCP-1: monocyte chemoattractant protein 1; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PTCA: percutaneous transluminal coronary angioplasty; RANTES: regulated on activation, normal T-cell expressed and secreted; RCT: randomised controlled trial; USSQ, Ureteric Stent Symptoms Questionaire.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Clinical, Journal:  Using external data to assess the external validity of a randomised controlled trial. (Pubmed Central) -  Jun 1, 2021   
    While differences were observed between included and excluded patients, the excluded group did not represent a more 'complicated' population. The present study shows the importance of collecting data on patients excluded from randomized controlled trials.
  • ||||||||||  Clinical, Journal:  Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania. (Pubmed Central) -  Jun 1, 2021   
    This is the first comprehensive study that evaluates antibiotic resistance in UTIs in children, and their association with urinary tract abnormalities in Romania. As a result of this research, the protocol for initial empiric treatment of infants with febrile or complicated UTI should be modified considering a detailed and ongoing monitoring of local sensitivity of uropathogens to antimicrobial agents.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Journal:  Investigation of the bacterial cell envelope nanomechanical properties after long-term exposure to nitrofurans. (Pubmed Central) -  May 29, 2021   
    In this study, two representatives of 5-nitrofuran antibiotics (nitrofurantoin and furaltadone) were investigated in terms of their long-term influence on the cell envelopes of newly isolated environmental bacterial strains (Sphingobacterium caeni FTD2, Achromobacter xylosoxidans NFZ2 and Pseudomonas hibiscicola FZD2)...Changes in the permeability of bacterial membrane, fatty acids' composition and bacterial cell surface hydrophobicity were determined. Despite visible bacterial adaptation to nitrofurans, prolonged presence of pharmaceuticals in the environment has led to significant alterations in the cells' structures which was particularly visible in P. hibiscicola.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Journal:  Acute lung toxicity by nitrofurantoin. (Pubmed Central) -  May 15, 2021   
    CT of the chest revealed bilateral pleural effusion and extensive pulmonary interstitial prominence, suggesting pulmonary fibrosis. According to the Naranjo Adverse Drug Reaction Probability Scale score of 6, it was determined that nitrofurantoin was the probable cause, and immediate cessation of the medication showed a marked clinical improvement and resolution after 10 days.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    Review, Journal:  Autoimmune hepatitis-is histology conclusive? (Pubmed Central) -  May 15, 2021   
    Wilson´s disease is also an important differential diagnosis especially in young adults. A liver biopsy is mandatory to confirm the diagnosis of autoimmune hepatitis but histopathology alone is not conclusive.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
    Journal:  Management of Urinary Tract Infections in Direct to Consumer Telemedicine. (Pubmed Central) -  May 11, 2021   
    DTC telemedicine offers convenient, low-cost care that is generally appropriate. Efforts should be made to ensure high-risk patients get proper follow-up.
  • ||||||||||  norfloxacin / Generic mfg., nitrofurantoin / Generic mfg.
    [VIRTUAL] Cryptic Antibiotic Resistance in Escherichia coli (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_3725;    
    This study reveals a diversity of cryptic genes conferring an antibiotic resistance phenotype when present in high copy number, while also showing fundamental differences between E. coli strains. Thus, our assay can identify potential novel resistance genes and antibiotics that are prone to induce cryptic antibiotic resistance in E. coli.
  • ||||||||||  ciprofloxacin oral / Generic mfg., tetracycline / Generic mfg., nitrofurantoin / Generic mfg.
    [VIRTUAL] Sublethal Antibiotic Concentrations as Drivers of the Evolution of Antibiotic Resistance in Escherichia coli (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_3350;    
    Thus, for the clinically relevant antibiotics (mecillinam, tetracycline, fosfomycin, nitrofurantoin and ciprofloxacin), and with drug concentrations up to thousand-fold below the minimal inhibitory concentration of susceptible bacteria, we show rapid enrichment of highly resistant bacteria in the Escherichia coli strain MG1655. These results, combined with characterization of the mutants evolved from sublethal antibiotic exposure, provide us with fundamental knowledge regarding the potential impact low drug levels have in maintaining and generating clinically relevant resistances.
  • ||||||||||  ampicillin / Generic mfg.
    [VIRTUAL] BIXX () -  May 9, 2021 - Abstract #WMF2021WMF_1599;    
    Abnormal crystals of urine were observed in children below 4 years of age. Antibiotics Gentamicin, Carbenicillinfound effective against UTI and can be recommended as first line of treatment.
  • ||||||||||  ampicillin / Generic mfg., meropenem / Generic mfg.
    [VIRTUAL] Prevalence and Seasonal Disparity of Meropenem Resistant E. coli in Sewage Water in Islamabad, Pakistan (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_452;    
    All environmental meropenem resistant E. coli were MDR and mostly belonged to commensals phylogenetics group (clad I/II) which indirectly represents the community carriage and potential hazard for public health. Co-occurrence of carbapenemases with ESBLs and PMQRs in E. coli in environment calls for extensive surveillance and prompt action to control clinically important resistant bacteria in environment before they become part of ecosystem.
  • ||||||||||  ampicillin / Generic mfg.
    [VIRTUAL] Characterization of Antimicrobial Resistance and Bacterial Sequence Types in Patients with Urinary Tract Infection Caused by Klebsiella pneumoniae (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_437;    
    Eighteen isolates (39%) were resistant to ≥1 antimicrobial agent other than ampicillin (AMP)...pneumoniae isolates demonstrated frequent resistance (≥ 20%) to two antimicrobial agents commonly used in the empiric treatment of uncomplicated UTI - nitrofurantoin and trimethoprim-sulfamethoxazole...Alarmingly, ST35, frequently reported to be a hypervirulent carbapenem-resistant strain, was found in our collection. Understanding the resistance of K. pneumoniae to common therapies by utilizing molecular epidemiological techniques has the potential to improve clinical management of UTIs.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery (clinicaltrials.gov) -  Apr 23, 2021   
    P=N/A,  N=142, Recruiting, 
    Our findings provide important and updated information about the baseline antimicrobial-resistant data for food safety and a risk assessment of S. Enteritidis from broiler chickens in Shandong Province and will be helpful for future surveillance activities to ensure the safety of the chicken supply. Trial completion date: Jul 2022 --> Dec 2022 | Trial primary completion date: Jul 2021 --> Dec 2021
  • ||||||||||  linezolid oral / Generic mfg.
    Enrollment change, Trial termination:  PRESTO:Osteo: Patients Response to Early Switch To Oral:Osteomyelitis Study (clinicaltrials.gov) -  Apr 6, 2021   
    P1,  N=11, Terminated, 
    Trial completion date: Jul 2022 --> Dec 2022 | Trial primary completion date: Jul 2021 --> Dec 2021 N=456 --> 11 | Recruiting --> Terminated; Not enough patient enrollment and lack of staffing
  • ||||||||||  hydrochlorothiazide / Generic mfg.
    [VIRTUAL] A SUSPECTED CASE OF BENAZEPRIL-HYDROCHLOROTHIAZIDE INDUCING AUTOIMMUNE HEPATITIS (DDW Virtual) -  Mar 15, 2021 - Abstract #DDW2021DDW_3678;    
    There is one case report of benazepril-hydrochlorothiazide causing fatal sub-fulminant hepatitis however no literature exists on this combination drug causing DIAIH. Further studies are warranted to illuminate the distinctions between DIAIH, AIH and DILI in this context.
  • ||||||||||  nitrofurantoin / Generic mfg.
    [VIRTUAL] A Surprising Pulmonary Nodule: Hyalinizing Granulomas () -  Mar 14, 2021 - Abstract #ATS2021ATS_4622;    
    She had a history of UTIs for which she took nitrofurantoin rarely in the past...We present a case of hyalinizing granulomas in a patient with chronic cough and exposure to metal foundries. Exposures for these patients is rarely reported and the pathophysiology of these nodules is poorly understood; however they are most often reported in patients with mediastinal fibrosis, chronic infections such as tuberculosis or histoplasmosis, or autoimmune disorders1.
  • ||||||||||  Darzalex IV (daratumumab) / J&J
    [VIRTUAL] A Case of Respiratory Failure in a Patient Receiving Multiple Immune-Modulatory Agents () -  Mar 14, 2021 - Abstract #ATS2021ATS_2670;    
    She was being treated for Multiple Myeloma with Atezolizumab and Daratumumab over the last 3 years and using chronic nitrofurantoin for recurrent UTIs over the last year...Treatment with trimethoprim-sulfamethoxazole and higher doses of steroids was initiated...Pneumocystis has long been associated with HIV and other immunosuppressed conditions; however, there have been increasing cases associated with immune-modulatory agents. Overall, our case illustrates the importance of a broad differential and the utility of diagnostic bronchoscopy and imaging to avoid misdiagnosis in a patient receiving immune-modulatory therapies who presents with respiratory failure.
  • ||||||||||  nitrofurantoin / Generic mfg.
    [VIRTUAL] An Old Foe: Nitrofurantoin Induced Acute Pulmonary Toxicity () -  Mar 14, 2021 - Abstract #ATS2021ATS_2130;    
    Nitrofurantoin should not be reused due to high rates of recurrence. This case reflects the need for vigilance for uncommon adverse effects of commonly used medications and their appropriate management.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Journal:  Nitrofurantoin for urinary tract infections in men: it is possible (Pubmed Central) -  Dec 19, 2020   
    However, this is undesirable because of side effects, more microbiome disturbance and resistance development. Therefore, nitrofurantoin is a valuable treatment option for a urinary tract infection in men, provided that systemic symptoms are absent.