nitrofurantoin / Generic mfg. 
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  • ||||||||||  chloroquine phosphate / Generic mfg., nitrofurantoin / Generic mfg.
    Preclinical, Journal:  Towards development of new antimalarial compounds through in silico and in vitro assays. (Pubmed Central) -  Jun 17, 2024   
    Decreased susceptibility to last-resort carbapenems and the occurrence of various AMR genes during the second wave of the pandemic are of great concern. The molecules were tested against chloroquine-resistant W2 strain of Plasmodium falciparum (EC50 between 330.05 and 13.92?
  • ||||||||||  Journal, Real-world evidence, Real-world:  Medications and Acute Hemolysis in G6PD-Deficient Patients - A Real-World Study. (Pubmed Central) -  Jun 6, 2024   
    Within the 31,875 patients with no major hemolysis, nitrofurantoin has been prescribed safely to 1,366 G6PD-deficient males and females; hundreds/thousands of G6PD-deficient patients had been prescribed safely ciprofloxacin, glibenclamide, ofloxacin, phenazopyridine, sulfamethoxazole/cotrimoxazole, sulfasalazine, hydroxychloroquine, glimepiride, mesalazine, and sulfacetamide. In this real-world study, we are showing that a list of medications, suspected previously as carrying risks for hemolysis in G6PD-deficient patients, have been prescribed safely to G6PD-deficient patients, providing reassurance to patients, prescribers, and regulators.
  • ||||||||||  glibenclamide / Generic mfg., bupropion / Generic mfg., nitrofurantoin / Generic mfg.
    Journal:  Efflux transporters in drug disposition during pregnancy. (Pubmed Central) -  May 30, 2024   
    Qingcheng Mao and his team have made significant contributions to the investigation of the role of efflux transporters, especially P-glycoprotein and breast cancer resistance protein, in maternal-fetal exposure to many xenobiotics: nitrofurantoin, glyburide, buprenorphine, bupropion, tetrahydrocannabinol and their metabolites. Studies of individual compounds and the expression of transporters during gestation and pregnancy have improved the understanding of maternal-fetal pharmacokinetics.
  • ||||||||||  Journal:  Occurrence of Antimicrobial-Resistant Enterococcus spp. in Healthy Chickens Never Exposed to Antimicrobial Agents in Central Italy. (Pubmed Central) -  May 24, 2024   
    High percentages of susceptible strains were found with teicoplanin (100%), amoxicillin-clavulanic acid (97.96%), nitrofurantoin (94.90%), ampicillin (92.86%), chloramphenicol (90.82%), and linezolid (88.78%)...Genes were detected in 68 (69.38%) strains: 36 were shown to be resistant with the agar disk diffusion method, while 28 were intermediate, and 2 were susceptible. The present study showed that chickens never treated with antimicrobials potentially harbor enterococci having phenotypic and genotypic characters of antimicrobial resistance.
  • ||||||||||  Journal:  Antimicrobial resistance trends among Klebsiella pneumoniae associated with urinary tract infections in Crete, Greece, 2017-2022. (Pubmed Central) -  May 22, 2024   
    Resistance to ciprofloxacin, amoxicillin/clavulanic acid, tigecycline, and TMP/SMX significantly increased from 33.7%, 24%, 6%, and 33.1%, respectively, over the years 2017-2019, to 47.8%, 34.2%, 14.3% and 42.8%, respectively, over the period 2020-2022...The frequency of multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates were 32.6% and 7.7%, respectively. Continuous surveillance of local microbial prevalence and monitoring of antimicrobial resistance patterns provide critical information to guide the empiric therapy for UTIs and control the spread of MDR bacteria.
  • ||||||||||  Journal:  Emergence of NDM-producing Enterobacterales infections in companion animals from Argentina. (Pubmed Central) -  May 4, 2024   
    Even though different species and clones were observed, it is remarkable the finding of some major clones among K. pneumoniae and E. coli, as well as the circulation of NDM as the main carbapenemase. Surveillance in companion pets is needed to detect the spread of carbapenem-resistant Enterobacterales and to alert about the dissemination of these pathogens among pets and humans.
  • ||||||||||  ciprofloxacin oral / Generic mfg., nitrofurantoin / Generic mfg.
    Journal:  Antibiotic resistance begets more resistance: chromosomal resistance mutations mitigate fitness costs conferred by multi-resistant clinical plasmids. (Pubmed Central) -  May 2, 2024   
    Here, we introduced 13 multi-resistant clinical plasmids into a susceptible and three different resistant E. coli strains and found that most of these plasmids do confer fitness cost on susceptible cells, but these costs disappear in the resistant strains which often lead to fitness advantage for the resistant strains in the absence of antibiotic selection. Our results imply that already resistant bacteria are a more favorable reservoir for multi-resistant plasmids, promoting the ascendance of multi-resistant bacteria.
  • ||||||||||  Journal:  Diabetes-related lower limb wounds: Antibiotic susceptibility pattern and biofilm formation. (Pubmed Central) -  Apr 29, 2024   
    Several gram-negative bacteria are susceptible to piperacillin, meropenem, amikacin, gentamicin, imipenem, ciprofloxacin, and trimethoprim...To the best of our knowledge, Riyadh, Saudi Arabia is the first region where Serratia marcescens was the most common bacteria from DFU infections. Our research findings would deliver information on evidence-based alternative strategies to develop effective treatment approaches for DFU treatment.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    New P4 trial:  Bladder Botox UTI Antibiotic Prophylaxis (clinicaltrials.gov) -  Apr 28, 2024   
    P4,  N=100, Recruiting, 
  • ||||||||||  Review, Journal:  Human Leucocyte Antigen Genetics in Idiosyncratic Drug-Induced Liver Injury with Evidence Based on the Roussel Uclaf Causality Assessment Method. (Pubmed Central) -  Apr 26, 2024   
    Among the top-ranking drugs were amoxicillin-clavulanate (290 cases, HLA A*02:01 or HLA A*30:02), followed by flucloxacillin (255 cases, HLA B*57:01), trimethoprim-sulfamethoxazole (86 cases, HLA B*14:01 or HLA B*14:02), methimazole (40 cases, HLA C*03:02), carbamazepine (29 cases, HLA A*31:01), and nitrofurantoin (26 cases, HLA A*33:01). In conclusion, the HLA genetics in 900 idiosyncratic drug-induced liver injury cases with evidence based on the RUCAM are available for studying the mechanistic steps leading to the injury, including metabolic factors through cytochrome P450 isoforms and processes that activate the innate immune system to the adaptive immune system.
  • ||||||||||  sulphadiazine / Generic mfg., nitrofurantoin / Generic mfg.
    Journal:  Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection. (Pubmed Central) -  Apr 24, 2024   
    The second-choice antibioticsexamined do not have a more favorable resistanceprofile than the first-choice antibiotics. The two analytes for SERS quantitation are nitrofurantoin (NFT) and sulfadiazine (SDZ) whose residues can be traced down to 10-8 M. The highest enhancement factors (EFs) are competitive at 6.29
  • ||||||||||  ciprofloxacin oral / Generic mfg., amoxycillin/clavulanate / Generic mfg., nitrofurantoin / Generic mfg.
    Journal:  Mitigating antimicrobial resistance, an approach to stewardship in canine urinary tract infection. (Pubmed Central) -  Apr 22, 2024   
    Nitrofurantoin susceptible cases were kept in Group 3 and treated with a combination of nitrofurantoin and urinary acidifier ammonium chloride. Therapeutic outcome was evaluated and success rate was higher in Group 2 and 3 than Group 1 suggested that selection of antibiotics with the use of local or institutional antibiogram data is more considerate than acknowledged international guidelines in the existing situation.
  • ||||||||||  Journal:  Evaluation of the probiotic potential of yeast isolated from kombucha in New Zealand. (Pubmed Central) -  Mar 25, 2024   
    Notably, two of the fifteen strains (Pichia kudraivzevii GBY1 and Saccharomyces cerevisiae GBY2) exhibited desirable cell surface hydrophobicity (64.60-83.87%), auto-aggregation (>98%), co-aggregation, resistance to eight tested antibiotics (ampicillin, chloramphenicol, colistin sulphate, kanamycin, nalidixic acid, nitrofurantoin, streptomycin, and tetracycline), and high levels of antioxidant activities (>90%). Together, our data reveal the probiotic activities of two yeast strains GBY1 and GBY2 and their potential application in functional food production.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Observational data, Journal:  Drug-Gene Risk Stratification in Patients with Suspected Drug-Induced Interstitial Lung Disease. (Pubmed Central) -  Mar 21, 2024   
    P=N/A
    In 60%, the diagnosis of DI-ILD was likely, whereas in 37.5%, it was highly likely, based on CYP analyses. This study underlines the importance of considering both drug use and genetic make-up as a possible cause, or at least a contributing factor, in the development and/or progression of fibrotic lung diseases.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap, nitrofurantoin / Generic mfg.
    Journal:  Antibiotics for UTI Prevention After Intradetrusor OnabotulinumtoxinA Injections. (Pubmed Central) -  Mar 18, 2024   
    Prophylactic antibiotic choice and duration of treatment potentially affect UTI incidence after in-office, intradetrusor onabotulinumtoxinA injections. Nitrofurantoin and trimethoprim-sulfamethoxazole for 3 days have the lowest UTI incidence.