nitrofurantoin / Generic mfg. 
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  • ||||||||||  The Face Says It All: A Rare Case of Central Venous Obstruction Mimicking Angioedema in a Patient with Permcath Dysfunction (Area A, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1671;    
    She had multiple listed allergies, including hives to nitrofurantoin and anaphylaxis to propoxyphene N-acetaminophen...She received Dexamethasone 10 mg IV and Diphenhydramine 25 mg IV with minimal improvement of her swelling...CT angiography of the neck/chest was performed the following day, but she experienced an anaphylactic reaction to the IV contrast and received IM Epinephrine x2, Diphenhydramine 50 mg IV, Methylprednisolone 125 mg IV, and Pepcid 20 mg IV with marked improvement of her anaphylaxis...However, her symptoms improved after the permacath was replaced, and the cause was determined to be from central vein obstruction. Her original permacath placed one month prior was noted to migrate distally, as seen in the images below, with the distal ports becoming significantly more splayed leading to mechanical obstruction.
  • ||||||||||  ampicillin / Generic mfg.
    Journal:  Prevalence and Resistance Patterns of Pediatric Urinary Tract Infections in Bahrain. (Pubmed Central) -  Feb 11, 2022   
    coli was most resistant to cefazolin (94%), followed by ampicillin (62.68%), whilst it was most sensitive to nitrofurantoin (98.96%) followed by amikacin (98.43%) (p<0.01)...pneumoniae showed the highest rate of resistance to ampicillin (95.24%) followed by cefazolin (83.33%), meanwhile having the highest sensitivity rate to amikacin (95.24%), followed by ciprofloxacin (90.48%)...mirabilis had the highest resistance to cefazolin (100%) followed by nitrofurantoin (87.50%), while having the highest sensitivity to piperacillin/tazobactam (100%)...Similarities between our study and previous studies around the world were found when comparing the antibiotics resistance patterns. Nevertheless, it is our recommendation that empirical antibiotic selection should be tailored to the local data collected from the region.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Journal:  Antibiotic Stewardship and Postoperative Infections in Urethroplasties. (Pubmed Central) -  Feb 10, 2022   
    This protocol, with clear definitions of UTI and wound infection, allowed determination of accurate infection rates in urethroplasties. Pre-operative UTI, even when properly treated, increases the risk of post-operative UTI.
  • ||||||||||  Journal:  Antibiogram and molecular characterization of multi-drug resistant microorganisms isolated from urinary tract infections. (Pubmed Central) -  Feb 8, 2022   
    While Pseudomonas aurignosa showed resistance to Amikacin, Ciprofloxacin, Gentamicin, Piperacillin tazobactam, Imipenem, and Polymyxin B. E. coli exhibited the highest sensitivity for Piperacillin tazobactam, Klebsiella pneumonia for Imipenem and Pseudomonas aurignosa for Ciprofloxacin. Further, the isolated DNA samples of these microorganisms were confirmed by gel electrophoresis and subjected to molecular characterization by performing trace file and phylogenetic tree analysis.
  • ||||||||||  nitrofurantoin / Generic mfg.
    Clinical, Journal:  Efficacy of vaccination with StroVac for recurrent urinary tract infections in women: a comparative single-centre study. (Pubmed Central) -  Feb 2, 2022   
    When using our complicated cystitis treatment algorithm regardless of uropathogen, our results outperformed real-life scenario provider choice and our prior published algorithm for uncomplicated cystitis, which can help guide empiric antimicrobial choice. StroVac is an effective and lasting non-antibiotic prophylaxis for rUTI, easy to administer with low rates of adverse events and should be offered to patients with rUTI.
  • ||||||||||  amoxicillin / Generic mfg.
    Clinical, Journal:  Rising resistance of urinary tract pathogens in children: a cause for concern. (Pubmed Central) -  Jan 28, 2022   
    Nitrofurantoin should be reserved for treating non-coliform/atypical UTIs or multi-drug resistant UTIs. There is an ongoing need for clinicians in all geographic regions to continue to monitor antibiotic resistance rates every few years.
  • ||||||||||  ciprofloxacin oral / Generic mfg., nitrofurantoin / Generic mfg.
    Role of functional groups in drug loading capacity of Zein nano-drug delivery systems (Room 20BCD Theater 5 (San Diego Convention Center)) -  Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_2502;    
    Correlation studies between the different modifications and the loading capacity showed a correlation between the deamination degrees and the amount of drug-loaded.The analysis of the antimicrobial properties showed that the functional groups introduced played an important role in the synergistic effect between the nanoparticles and the antibiotics, improving their antimicrobic properties. Moreover, the cytotoxicity of the synthesized nanoparticles was investigated with CCD18-Co fibroblasts, showing that the nanoparticles were non-toxic at the concentration needed for antimicrobial treatments.
  • ||||||||||  colistin sulphate / Generic mfg., nitrofurantoin / Generic mfg.
    Clinical, Journal:  A Study on Multidrug-Resistant Escherichia coli Clinical Isolates from Different Hospitals in Greater Cairo. (Pubmed Central) -  Jan 27, 2022   
    We reported that three isolates carried the mcr-1 gene encoding colistin resistance from three different hospitals. Upon performing sequencing and phylogenetic analysis on the three positive mcr-1 isolates (MT890587, MT890588, and MT890589), the three isolates showed 100% identity with themselves, with some strains from Egypt and Japan, and 99.9% identity with an isolate from China.
  • ||||||||||  cefuroxime / Generic mfg.
    Review, Journal:  How to avoid drug resistance during treatment and prevention of urinary tract infections. (Pubmed Central) -  Jan 26, 2022   
    The first-line treatment in patients with acute simple cystitis include nitrofurantoin, trimethoprim-sulfamethoxazole, or fosfomycin...During pregnancy recommended treatment includes administration of cephalosporins (e.g. cefuroxime) or nitrofurantoin...Until now only one product - oral immunostimulant OM-89 - has been sufficiently investigated. Wider implementation of immunoprophylaxis in the future may reduce possible side effects of inappropriate antibiotic consumption.
  • ||||||||||  Urinary Tract Infections in immunocompromised patients with diabetes and correlation with renal dysfunction - a single centre experience (Poster Area (Virtual)) -  Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_900;    
    The most typically grown organisms were E.coli, E.faecalis, and K.pneumoniae, in that order.Amikacin, piperacillin/tazobactam, cefoperazone/sulbactam, and carbapenems were all effective against Gram-negative isolates, while nitrofurantoin, linezolid, and vancomycin were effective against Gram-positive cocci. Antibiotic resistance is a typical occurrence in our lab.For empirical treatment, we cannot rely on commonly used oral antibiotics and specific groups such as fluoroquinolones, cephalosporins (excluding those containing sulbactam), and ampicillin.
  • ||||||||||  rivaroxaban / Generic mfg., metformin / Generic mfg., nitrofurantoin / Generic mfg.
    POLYPHARMACY AND POTENTIALLY INAPPROPRIATE MEDICATION USE IN PATIENTS WITH CKD MANAGED IN CANADIAN PRIMARY CARE (Poster Area (Virtual)) -  Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_880;    
    Polypharmacy and use of PIMs are highly prevalent among patients with CKD managed in primary care. These findings highlight opportunities for interventions aimed at improving prescribing practices in the management of CKD.This abstract was also submitted for ASN Kidney Week 2021.
  • ||||||||||  ampicillin / Generic mfg., cefuroxime / Generic mfg.
    Journal:  Prevalence and antibiotic resistance of Escherichia coli O157:H7 in beef at a commercial slaughterhouse in Moro, Kwara State, Nigeria. (Pubmed Central) -  Jan 13, 2022   
    The samples were enriched in modified tryptone broth containing novobiocine, and plated onto Sorbitol-MacConkey agar (Oxoid SR0172E) supplemented with 0.05 mg l cefixime and 2.5 mg l potassium tellurite (Oxoid) (CT-SMAC)...Commercially available Gram-negative multi-discs (Oxoid) comprising nitrofurantoin (30 µg), ampicillin (5 µg), ceftazidime (30 µg), gentamicin (10 µg), ciprofloxacin (5 µg), augmentin (30 µg), ofloxacin (5 µg) and cefuroxime (30 µg) were tested...The pathogen reveals a high frequency of multidrug resistance, suggesting that consumers and handlers of such meat are at risk of contracting antibiotic-resistant E. coli O157:H7-associated foodborne disease. Routine monitoring of antibiotic resistance is critical to uncovering novel therapeutic strategies that will help inform clinical practice guidelines.
  • ||||||||||  ampicillin / Generic mfg.
    Retrospective data, Journal:  Caracterización molecular de enterobacterias multirresistentes en dos departamentos de la selva peruana (Pubmed Central) -  Jan 11, 2022   
    As for the antimicrobial susceptibility profile, we detected resistance levels of 72.6% for ampicillin, 82.3% for cephalothin, and 88.7% for nitrofurantoin.Conclusiones. El porcentaje de cepas de enterobacterias multirresistentes productoras de BLEE en ambos departamentos fue del 57,4 % y el gen bla CTX-M fue el más frecuente.
  • ||||||||||  ampicillin / Generic mfg., cefuroxime / Generic mfg., amoxicillin / Generic mfg.
    Clinical, Journal:  Potential influence of food value chain level of regulation on prevalence and patterns of antimicrobial resistance: case of tilapia (Oreochromis niloticus). (Pubmed Central) -  Dec 29, 2021   
    In order to mitigate the risk of transmitting antimicrobial resistant bacteria to consumers along the fish value chain, good manufacturing practices coupled with identification and management of possible sources of contamination are recommended for fish and potentially other foods distributed along the less regulated value chains. Importance In order to mitigate the risk of transmitting antimicrobial resistant bacteria to consumers along the fish value chain, good manufacturing practices coupled with identification and management of possible sources of contamination are recommended for fish and potentially other foods distributed along the less regulated value chains.
  • ||||||||||  ampicillin / Generic mfg., amoxicillin / Generic mfg.
    Clinical, Journal:  Risk of Antibiotic Treatment Failure in Premenopausal Women with Uncomplicated Urinary Tract Infection. (Pubmed Central) -  Dec 25, 2021   
    The risk of treatment failure differed by antibiotic agent, with higher risk associated with TMP/SMX versus nitrofurantoin, and lower or similar risk associated with broad- versus narrow-spectrum β-lactams. Given serious safety warnings for fluoroquinolones, these results suggest that nitrofurantoin may be preferable as the first-line agent for outpatient treatment of uncomplicated UTI.
  • ||||||||||  amikacin sulfate / Generic mfg., clindamycin phosphate / Generic mfg., nitrofurantoin / Generic mfg.
    Clinical, Journal:  Antimicrobial resistance and antibiotic consumption in a third level pediatric hospital in Mexico City. (Pubmed Central) -  Dec 16, 2021   
    Histopathological examination showed necrosis of intertubular connective tissue and tubule, sloughing of epithelial cells in hepatopancreatic tubule, haemocytic infiltration, massive vacuolation and loss of hepatopancreatic tubule structure. The antibiotic resistance profile showed by our study highlights the need of an appropriate antibiotic control use in the Hospital setting.
  • ||||||||||  ampicillin / Generic mfg.
    Preclinical, Journal, Heterogeneity:  Uropathogenic Escherichia coli shows antibiotic tolerance and growth heterogeneity in an in-vitro model of intracellular infection. (Pubmed Central) -  Dec 16, 2021   
    Intracellularly, kill curves showed biphasic kinetics for both fluoroquinolones, suggesting the presence of drug-tolerant subpopulations. Flow cytometry analysis of TIMERbac fluorescence revealed a marked heterogeneity in intracellular growth of individual bacteria, suggesting that the presence of subpopulations reaching a state of metabolic dormancy was the main reason for increased antibiotic tolerance of intracellular UPEC.