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- | nefopam / Generic mfg.
Journal: Enantiomeric separation of nefopam and cathinone derivatives using a supramolecular deep eutectic solvent as a chiral selector in capillary electrophoresis. (Pubmed Central) - Jul 4, 2024
In the case of 4-MMC and MDMC, a higher percentage of the CS, equal to 0.075% and 0.10% v/v, respectively, was required to achieve baseline separation (Rs
- | nefopam / Generic mfg.
Preclinical, Journal: The synergistic anti-nociceptive effects of nefopam and gabapentinoids in inflammatory, osteoarthritis, and neuropathic pain mouse models. (Pubmed Central) - Jul 1, 2024
Moreover, the combination of nefopam-pregabalin/gabapentin alleviated carrageenan-induced inflammation and edema, and also prevented gabapentinoids-related sedation or ataxia by lowering their effective doses. Collectively, the co-administration of nefopam and gabapentinoids showed synergistic analgesic effects and may result in improved therapeutic benefits for treating pain.
- | nefopam / Generic mfg.
Journal, Surgery: Comparison of Nefopam-Based Patient-Controlled Analgesia with Opioid-Based Patient-Controlled Analgesia for Postoperative Pain Management in Immediate Breast Reconstruction Surgery: A Randomized Controlled Trial. (Pubmed Central) - Jun 27, 2024
However, there were no significant differences in opioid-related complications among the three groups. PCA with nefopam, whether alone or in combination with opioids, offers non-inferior analgesic efficacy compared to PCA with fentanyl alone in patients undergoing immediate BRS.
- || nefopam / Generic mfg.
Clinical, Journal: Impact of Intraoperative Nefopam on Postoperative Pain, Opioid Use, and Recovery Quality with Parietal Pain Block in Single-Port Robotic Cholecystectomy: A Prospective Randomized Controlled Trial. (Pubmed Central) - Jun 27, 2024
Nefopam reduces RUQ pain and opioid use post-single-port RALC with a parietal pain block without markedly boosting RSB's effect on umbilicus or shoulder pain. It may also better manage postoperative nausea and vomiting, underscoring its role in analgesia strategies for this surgery.
- | nefopam / Generic mfg.
New P2 trial: analgesic effect of orally administrated nefopam (EUDRACT) - May 30, 2024
P2, N=40, Ongoing, Sponsor: Hospices Civils de Lyon
- | nefopam / Generic mfg.
Journal: Evaluating the Efficacy of Methocarbamol and Nefopam in Orthopedic Surgical Pain. (Pubmed Central) - May 6, 2024
Conclusion The present study showed a higher efficacy of methocarbamol in post-operative pain reduction in comparison to nefopam. No serious side effects were observed with both drugs.
- || Retrospective data, Review, Journal, Surgery: Prevention of postoperative nausea and vomiting after orthognathic surgery: a scoping review. (Pubmed Central) - Apr 1, 2024
For the non-pharmacological methods, throat packs are not recommended for routine use because of their poor effect and serious complications. More prospective RCTs are required to confirm whether gastric aspiration can prevent PONV effectively for patients undergoing orthognathic surgery.
- | nefopam / Generic mfg.
Journal: Antinociceptive effects of nefopam activating descending serotonergic modulation via 5-HT2 receptors in the nucleus raphe magnus. (Pubmed Central) - Jan 9, 2024
This study revealed supraspinal mechanisms of nefopam-produced analgesia mediated by 5-HT2 receptors in the NRM recruiting the descending serotonergic fibres to increase the release of 5-HT into the spinal dorsal horn. These observations support a potential role for nefopam in multimodal analgesia based on its distinct mechanisms of action that are not shared by the other analgesics.
- | nefopam / Generic mfg.
Journal, Surgery: Effect of Nefopam on Dysesthesia, Postoperative Pain, and Satisfaction in Patients with Lumbar Spinal Stenosis Undergoing Spine Surgery: A Double-Blind, Randomized Study. (Pubmed Central) - Dec 9, 2023
These observations support a potential role for nefopam in multimodal analgesia based on its distinct mechanisms of action that are not shared by the other analgesics. Satisfaction scores for postoperative pain management were significantly higher in the nefopam group (3.7
- | nefopam / Generic mfg., bupropion / Generic mfg.
Journal: Simultaneous quantification of 55 psychotropic drugs and metabolites in human plasma with a fast UPLC-MS/MS method. (Pubmed Central) - Dec 7, 2023
Satisfaction scores for postoperative pain management were significantly higher in the nefopam group (3.7 We developed and validated one of the most sensitive and complete UPLC-MS/MS methods in psychopharmacology, allowing the simultaneous determination of 55 psychotropic drugs in only 5.7
- | nefopam / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal, Surgery: Changes in hospital consumption of opioid and non-opioid analgesics after colorectal endometriosis surgery. (Pubmed Central) - Nov 28, 2023
A history of abdominal surgery (OR?=?0.37 (0.16-0.78, p?=?0.011) and having surgery in 2020 rather than in 2019 (OR?=?0.10 (0.04-0.24, p?<?10)) and in 2021 than in 2019 (OR?=?0.08 (0.03-0.20, p?<?10)) were the only variables independently associated with the risk of opioid use. We found that neither clinical characteristics nor intraoperative findings had an impact on opioid consumption in this setting, and that it was possible to rapidly modify in-hospital analgesic consumption modalities by significantly reducing opioid consumption in favor of NSAIDS or nefopam.
- | morphine sulphate / Generic mfg., nefopam / Generic mfg.
Journal: The effect of the addition of nefopam to intraoperative ketoprofen and acetaminophen on postoperative morphine requirements after laparoscopic cholecystectomy: a randomized controlled trial. (Pubmed Central) - Nov 21, 2023
We found that neither clinical characteristics nor intraoperative findings had an impact on opioid consumption in this setting, and that it was possible to rapidly modify in-hospital analgesic consumption modalities by significantly reducing opioid consumption in favor of NSAIDS or nefopam. Adding nefopam to ketoprofen and acetaminophen before the end of laparoscopic cholecystectomy provides a reduction in morphine consumption with superior analgesia in PACU.
- | nefopam / Generic mfg.
Biomarker, Journal, IO biomarker: Expression signature of ten small nuclear RNAs serves as novel biomarker for prognosis prediction of acute myeloid leukemia. (Pubmed Central) - Oct 29, 2023
Furthermore, we screened six compounds (chicago sky blue 6 B, 5230742, clorsulon, nefopam, nicardipine, and streptomycin) that may serve as targeted therapeutic drugs for AML using connectivity maps...Immune infiltration analysis also revealed significant differences in the abundance of multiple immune cells in the bone marrow of the two groups of AML patients groups. In conclusion, our results revealed a novel prognostic expression signature of AML consisting of ten snRNAs, and we conducted a preliminary exploration of its potential biological functions and tumor immunity.
- || Dopram (doxapram) / Kissei, pethidine / Samaritan Pharma
Retrospective data, Review, Journal: Pharmacologic interventions for the therapy of postanesthetic shivering in adults: a systematic review and network meta-analysis. (Pubmed Central) - Jul 17, 2023
Furthermore, both lack data on side effects. Further studies are needed to clarify the efficacy of dexmedetomidine to treat postanesthetic shivering.
- | nefopam / Generic mfg.
Journal: Nefopam for pain control in Duchenne muscular dystrophy. (Pubmed Central) - Jul 15, 2023
Further studies are needed to clarify the efficacy of dexmedetomidine to treat postanesthetic shivering. No abstract available
- | nefopam / Generic mfg.
Trial completion, Surgery: Nefopam for Post Video-Assisted Thoracoscopic Lobectomy (clinicaltrials.gov) - Jun 29, 2023
P4, N=72, Completed, Sponsor: Mahidol University
No abstract available Recruiting --> Completed
- | morphine sulphate / Generic mfg., nefopam / Generic mfg., paracetamol / Generic mfg.
Trial completion: Nonopioid Analgesics and Cholecystectomy (clinicaltrials.gov) - May 6, 2023
P3, N=90, Completed, Sponsor: American University of Beirut Medical Center
Recruiting --> Completed Recruiting --> Completed
- | Retrospective data, Journal: Improving pain control during transarterial chemoembolization for hepatocellular carcinoma performed under local anesthesia with multimodal analgesia. (Pubmed Central) - Mar 9, 2023
Recruiting --> Completed Reinforcing the analgesic protocol by combining non-opioid and opioid molecules reduces perioperative pain in patients undergoing cTACE for HCC.
- || Vesicare (solifenacin) / Astellas, Dynastat (parecoxib) / Pfizer
Retrospective data, Review, Journal, HEOR: Comparative effectiveness of interventions for managing urological postoperative catheter-related bladder discomfort: a systematic review and network meta-analysis. (Pubmed Central) - Mar 9, 2023
Reinforcing the analgesic protocol by combining non-opioid and opioid molecules reduces perioperative pain in patients undergoing cTACE for HCC. Nefopam reduced the incidence of CRBD and prevented severe events, but limited by the small number of studies for each intervention and heterogeneous patients.
- | Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
New P3 trial: Role of Nefopam in Rituximab Transfusion Reaction (clinicaltrials.gov) - Dec 13, 2022
P3, N=100, Not yet recruiting, Sponsor: Ministry Of Health / Nineveh Health Directorate
- ||| nefopam / Generic mfg.
Clinical: C’est comme pour l’acupan…il n’est prescrit quasi que per os, mais c’est hors AMM ! La sécu nous tape sur les doigts quand on le fait passer en remboursé alors que c’est ecrit « à boire » sur l’ordo… du coup faut pas le préciser sinon les patients payent 🤦🏻♀️ (Twitter) - Dec 1, 2022
- ||||||| Metapain (nefopam/paracetamol) / Aptys Pharma
Trial completion: Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction (clinicaltrials.gov) - Nov 14, 2022
P3, N=321, Completed, Sponsor: Unither Pharmaceuticals, France
Nefopam reduced the incidence of CRBD and prevented severe events, but limited by the small number of studies for each intervention and heterogeneous patients. Active, not recruiting --> Completed
- || nefopam / Generic mfg.
Clinical, Journal: Single-dose intravenous nefopam on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of prostate: a randomized, double-blind placebo-controlled trial. (Pubmed Central) - Nov 3, 2022
Active, not recruiting --> Completed Single-dose nefopam significantly reduced the incidence and severity of CRBD in patients undergoing TURP with urinary catheter traction at 6 h after the procedure and before the end of catheter traction without increasing the adverse effects.
- || nefopam / Generic mfg.
Clinical, Journal: Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial. (Pubmed Central) - Nov 2, 2022
Single-dose nefopam significantly reduced the incidence and severity of CRBD in patients undergoing TURP with urinary catheter traction at 6 h after the procedure and before the end of catheter traction without increasing the adverse effects. A single, intraoperative infusion of 20 mg of nefopam did not significantly reduce postoperative (24 hours) morphine consumption in patients undergoing anterior cervical spine surgery.
- ||||| Metapain (nefopam/paracetamol) / Aptys Pharma
Enrollment closed: Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction (clinicaltrials.gov) - Oct 13, 2022
P3, N=321, Active, not recruiting, Sponsor: Unither Pharmaceuticals, France
A single, intraoperative infusion of 20 mg of nefopam did not significantly reduce postoperative (24 hours) morphine consumption in patients undergoing anterior cervical spine surgery. Recruiting --> Active, not recruiting
- | nefopam / Generic mfg.
Journal: Assessment of surface water quality and mercury levels from Artisanal and small-scale gold mining (ASGM) along Acupan River, Benguet, Philippines. (Pubmed Central) - Oct 4, 2022
The higher amounts of inorganic Hg in human hairs could be attributed to the discrete yet prevalent use of amalgamation. The findings of this study emphasize the need for better regulations of the small-scale mining activities and for stricter implementation of the total ban on the use of Hg in ore processing to ensure better water quality of Acupan River as well as the health and safety of the communities surrounding the river.
- | nefopam / Generic mfg.
Journal, Video: Effect of Continuous Infusion of Intravenous Nefopam on Postoperative Opioid Consumption After Video-assisted Thoracic Surgery: A Double-blind Randomized Controlled Trial. (Pubmed Central) - Sep 28, 2022
Perioperative nefopam infusion using a dual-channel elastomeric infusion pump has a significant opioid-sparing effect in patients undergoing VATS for lung resection. Therefore, it could be a feasible option for multimodal analgesia in these patients.
- | nefopam / Generic mfg.
Trial completion date, Surgery: Nefopam for Post Video-Assisted Thoracoscopic Lobectomy (clinicaltrials.gov) - Sep 26, 2022
P4, N=92, Recruiting, Sponsor: Mahidol University
Therefore, it could be a feasible option for multimodal analgesia in these patients. Trial completion date: Oct 2022 --> Mar 2023
- || nefopam / Generic mfg.
Clinical, Journal, Video: The Lack of Analgesic Efficacy of Nefopam after Video-Assisted Thoracoscopic Surgery for Lung Cancer: A Randomized, Single-Blinded, Controlled Trial. (Pubmed Central) - Aug 27, 2022
Pain intensity during the 72 h postoperatively and the incidence of chronic pain 3 months after surgery did not differ between the groups. Intraoperative nefopam did not decrease acute postoperative opioid consumption or pain intensity, nor did it reduce the incidence of chronic pain after VATS.
- | nefopam / Generic mfg.
Journal: Nefopam prescribing preferences in French hospitals: results of a survey. (Pubmed Central) - Jun 22, 2022
Prescribers consider oral nefopam efficient and safe for patients. Regulatory actions regarding the oral nefopam prescription authorization and duration of such prescription are needed.
- |||| Metapain (nefopam/paracetamol) / Aptys Pharma
Trial completion date, Trial primary completion date: Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction (clinicaltrials.gov) - Jun 1, 2022
P3, N=321, Recruiting, Sponsor: Unither Pharmaceuticals, France
Regulatory actions regarding the oral nefopam prescription authorization and duration of such prescription are needed. Trial completion date: Jul 2022 --> Oct 2022 | Trial primary completion date: May 2022 --> Oct 2022
- | nefopam / Generic mfg.
Preclinical, Journal: Improvement of Pain Management by Nefopam in a Rat Adjuvant-Induced Arthritis Model. (Pubmed Central) - May 14, 2022
Nefopam provided a slight reduction in the level of pain at the arthritis onset without reducing arthritis severity and bone loss in the rat AIA model. However, it should be administrated orally for a shorter period to avoid inflammation reduction in the long run.
- | nefopam / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date, Video, Surgery: Effects of Continuous Infusion of Intravenous Nefopam on Postoperative Pain and Opioid Consumption After VATS (clinicaltrials.gov) - May 6, 2022
P=N/A, N=90, Completed, Sponsor: Seoul National University Hospital
However, it should be administrated orally for a shorter period to avoid inflammation reduction in the long run. Trial completion date: May 2021 --> Nov 2021 | Trial primary completion date: Feb 2021 --> Aug 2021 | Not yet recruiting --> Completed
- | morphine sulphate / Generic mfg., nefopam / Generic mfg.
Journal: Does Nefopam Provide Analgesic Effect and Reduce Morphine Consumption after Primary Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial. (Pubmed Central) - Apr 26, 2022
However, there was a notable reduction in morphine use 48 hours postop. Nefopam is a useful agent for contemporary pain control after TKA.
- || Metapain (nefopam/paracetamol) / Aptys Pharma
Trial completion: ARL/20/277: Pharmacokinetic Study of a Fixed Dose Combination Nefopam Hydrochloride (30 mg) / Paracetamol (500 mg) (clinicaltrials.gov) - Mar 24, 2022
P1, N=31, Completed, Sponsor: Unither Pharmaceuticals, France
Nefopam is a useful agent for contemporary pain control after TKA. Not yet recruiting --> Completed
- | nefopam / Generic mfg.
Journal: Analgesic Effect of Intravenous Nefopam for Postoperative Pain in Minimally Invasive Spine Surgery: A Randomized Prospective Study. (Pubmed Central) - Mar 11, 2022
Nefopam did not significantly reduce opioid consumption or postoperative pain score. Adding nefopam as part of multimodal analgesia did not show beneficial effects for enhancing recovery after spine surgery.
- nefopam / Generic mfg., tramadol hydrochloride / Generic mfg.
Comparison of the postoperative analgesic effects of nefopam and tramadol in females undergoing caesarean section: A randomized clinical trial ([VIRTUAL]) - Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1194;
The anesthesia technique was standardized with a spinal anesthetic using hyperbaric bupivacaine 10mg (0, 5%) with fentanyl 25 mcg and 0,1 mg of preservative free morphine... In conclusion, this study suggests that nefopam produces better postoperative analgesia compared with tramadol in females undergoing c-section.
- | nefopam / Generic mfg.
Journal: Thirty years of nefopam abuse in France (Pubmed Central) - Nov 25, 2021
In conclusion, this study suggests that nefopam produces better postoperative analgesia compared with tramadol in females undergoing c-section. In France, the prescription of nefopam outside of its marketing authorization is regrettable, because it contributes to the development of abuse and drug dependence.
- || Metapain (nefopam/paracetamol) / Aptys Pharma
New P1 trial: ARL/20/277: Pharmacokinetic Study of a Fixed Dose Combination Nefopam Hydrochloride (30 mg) / Paracetamol (500 mg) (clinicaltrials.gov) - Nov 21, 2021
P1, N=32, Not yet recruiting, Sponsor: Unither Pharmaceuticals, France
- || nefopam / Generic mfg.
Clinical, Journal: Outpatient surgery of the first ray of the foot: post-operative pain monitoring at home. (Pubmed Central) - Oct 27, 2021
Pain management after outpatient first ray surgery using the injectable Nefopam protocol was satisfactory in the majority of cases, with a high degree of patient satisfaction. This protocol is routinely offered to our patients who must undergo first ray surgery.
- || nefopam / Generic mfg., tramadol hydrochloride / Generic mfg.
Récemment a l’Aphp on m.a prescrit. Tramadol et acupan (Twitter) - Oct 21, 2021
- || nefopam / Generic mfg.
L’acupan et son sucre … effet antalgique douteux , effets indésirables avérés . Et ça continue encore et encore … (Twitter) - Oct 21, 2021
- || nefopam / Generic mfg., tramadol hydrochloride / Generic mfg.
Ah mais je n’aime pas le tramadol et j’essaye de ne pas en prescrire et mon équipe non plus. Mais les événements recents nous ont appris que les infos techniques reprises directement sont assez dangereuses. Et on a rien sur l’acupan (oui je hais l’acupan, ce medoc sans etude)? (Twitter) - Oct 21, 2021
- |||| Metapain (nefopam/paracetamol) / Aptys Pharma
Trial completion date, Trial primary completion date: Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction (clinicaltrials.gov) - Sep 27, 2021
P3, N=321, Recruiting, Sponsor: Unither Pharmaceuticals, France
This protocol is routinely offered to our patients who must undergo first ray surgery. Trial completion date: Jul 2021 --> Jul 2022 | Trial primary completion date: Jul 2021 --> May 2022
- | nefopam / Generic mfg.
Journal: Physicochemical stability of nefopam and nefopam/droperidol solutions in polypropylene syringes for intensive care units. (Pubmed Central) - Aug 11, 2021
Nefopam solutions at 2.5 mg/mL and the mixture of nefopam 2.5 mg/mL with droperidol 52 µg/mL diluted in NaCl 0.9% were stable over a period of 48 hours at room temperature. These stability data provide additional knowledge to assist intensive care services in daily practice.
- | Journal: Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain? (Pubmed Central) - Jun 30, 2021
The use of opioids even for acute pain of short duration has been questioned. The ideal analgesic has yet to be developed, but effective pain control pharmacological regimens for acute pain are available.
- || Ryzolt (abuse resistant formulation) / Endo
Clinical, Journal: Multimodal oral analgesia strategy after ambulatory arthroscopic shoulder surgery: case series using adaptive therapeutic approaches by sequential analysis. (Pubmed Central) - Jun 23, 2021
The ideal analgesic has yet to be developed, but effective pain control pharmacological regimens for acute pain are available. The present study shows that a combination of IR and ER oxycodone over a short period of time (<48 hours) is associated with a better QoR at home after ambulatory shoulder surgery.
- | morphine sulphate / Generic mfg., nefopam / Generic mfg., paracetamol / Generic mfg.
Enrollment open: The Effect of Intraoperative Nefopam, Ketoprofen and Paracetamol Combination vs Ketoprofen and Paracetamol Combination on Postoperative Morphine Requirements After Laparoscopic Cholecystectomy: A Randomized, Controlled Trial (clinicaltrials.gov) - Jun 9, 2021
P3, N=90, Recruiting, Sponsor: American University of Beirut Medical Center
The present study shows that a combination of IR and ER oxycodone over a short period of time (<48 hours) is associated with a better QoR at home after ambulatory shoulder surgery. Not yet recruiting --> Recruiting
- | gabapentin / Generic mfg., nefopam / Generic mfg.
Trial completion, Enrollment change, Surgery: The Efficacy of Postoperative Analgesia of Gabapentin Plus Nefopam in the Spinal Surgery (clinicaltrials.gov) - Jun 7, 2021
P=N/A, N=60, Completed, Sponsor: Gia Dinh People Hospital
Not yet recruiting --> Recruiting Recruiting --> Completed | N=30 --> 60
- || fentanyl citrate / Generic mfg., nefopam / Generic mfg.
Clinical, Journal, Head-to-Head: Effect of Nefopam-Based Patient-Controlled Analgesia with and without Fentanyl on Postoperative Pain Intensity in Patients Following Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Non-Inferiority Trial. (Pubmed Central) - May 15, 2021
Postoperative adverse effects were not significantly different between the two groups (p = 1.000) and other outcomes were also not significantly different between the two groups (p ≥ 0.225). PCA using nefopam alone has a non-inferior and effective analgesic efficacy and produces a lower incidence of postoperative adverse effects compared to a combination of fentanyl and nefopam after laparoscopic cholecystectomy.