furosemide / Generic mfg. 
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 0 Diseases   77 Trials   77 Trials   6639 News 


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  • ||||||||||  acetazolamide / Generic mfg.
    Journal:  Tamm-Horsfall Protein/Uromodulin Deficiency Elicits Tubular Compensatory Responses Leading to Hypertension and Hyperuricemia. (Pubmed Central) -  Sep 11, 2019   
    By studying age-dependent changes of THP knockout (KO) mice, we show here that young KO mice had significant salt and water wasting but were partially responsive to furosemide, due to decreased luminal translocation of Na-K-Cl cotransporter 2 (NKCC2) in the TAL...These aged KO mice responded to metolazone and acetazolamide, known to target distal and proximal tubules, respectively...Finally, the aged THP KO mice had significant upregulation of Na-coupled urate transporters Slc5a8 and Slc22a12 as well as sodium-hydrogen exchanger 3 (NHE3) in the proximal tubule and elevated serum uric acid and allantoin. Collectively, our results suggest that THP deficiency can cause progressive disturbances in renal functions via initially NKCC2 dysfunction and later compensatory responses resulting in prolonged activation of the renin-angiotensin-aldosterone axis and hyperuricema.
  • ||||||||||  dobutamine / Generic mfg., furosemide / Generic mfg., epinephrine / Generic mfg.
    Enrollment change:  HEAL: Hemodynamics and Extravascular Lung Water in Acute Lung Injury (clinicaltrials.gov) -  Sep 10, 2019   
    P2,  N=33, Completed, 
    As a physiopathologically relevant neurodegeneration inducer, this new metabolite warrants further studies in the framework of public health and environment protection. N=72 --> 33
  • ||||||||||  lithium / generics
    Lithium intoxication in the pre-hospital care with stroke symptoms – Case report. () -  Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1432;    
    Clonazepam was administered because of tremor...The renal function was not affected and forced diuresis on high furosemide support was indicated...Conclusion We are presenting a case of lithium intoxication of elderly patient with bipolar affective disease and depressions who developed gastrointestinal and neurological symptoms which was in the pre-hospital care and also during the first neurological examination in the hospital misinterpreted as stroke symptoms. This case was resolved on intensive care unit and patient was dismissed 21 days after the admission with good neurological outcome.
  • ||||||||||  Omeprazole RBX (omeprazole) / Generic Mfg.
    Hemolytic anemia in probable relationship with periprosthetic leak. () -  Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1399;    
    Continued quarterly reviews in cardiology and vascular surgery. After stabilization of heart failure and right lower limb ischemia, she underwent closure of the prosthetic leak, improving her dyspnea and now follows annual revisions.
  • ||||||||||  Omeprazole RBX (omeprazole) / Generic Mfg.
    Acute adrenal insufficiency in the context of hyperkalemia. () -  Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1252;    
    Especially interesting case from the medical point of view in the emergency department, since the appearance of hyperkalemia and renal failure is a very common condition that usually corrects itself adequately with the specific treatment. In this case, potassium levels were again altered until the start of corticosteroid treatment, normalizing the analytical parameters in 2 hours.
  • ||||||||||  furosemide / generics
    ToRsemide compArisoN With furoSemide FOR Management of Heart Failure () -  Sep 9, 2019 - Abstract #HFSA2019HFSA_1316;    
    P3
    Enrollment started in the summer of 2018. For further details contact Shelby Morgan (Shelby.morgan@duke.edu), or visit study website at www.transformhfstudy.org ClinicalTrials.gov-identifier: NCT03296813.
  • ||||||||||  furosemide / generics
    Cardiac Autonomic Nerves Stimulation Improves Hemodynamics and Clinical Status in Advanced Heart Failure Patients () -  Sep 9, 2019 - Abstract #HFSA2019HFSA_452;    
    Patients received at least 80 mg/day of furosemide, had minimal change to existing heart failure medical management, received no new vasoactive therapies, and a majority of the patients (9/12) received no furosemide dose uptitration during CANS Therapy. Alongside concomitant medical therapy, CANS holds promise as a tool to improve in-hospital hemodynamics and relieve congestion.
  • ||||||||||  Furoscix (furosemide controlled release) / scPharma
    Subcutaneous Furosemide in the Treatment of Patients with Decompensated Heart Failure: Data from the Sub-Q Pilot Studies () -  Sep 9, 2019 - Abstract #HFSA2019HFSA_197;    
    sTreatment of selected HF patients with sc furosemide provided the anticipated effects on decongestion in both the inpatient and outpatient settings, although there were issues with the drug delivery system that limited feasibility. Ongoing developments of the delivery system for sc furosemide may make this a safe and feasible approach for treatment of congestion in the outpatient setting in selected patients.
  • ||||||||||  furosemide / generics
    Safety and Efficacy of an Auto-Titrating Diuretic Protocol: A Pilot () -  Sep 9, 2019 - Abstract #HFSA2019HFSA_132;    
    The YDP lead to safe and rapid loop diuretic titration in a population comprised largely of diuretic resistant HF patients. Randomized studies are needed better characterize the safety and efficacy of the YDP.
  • ||||||||||  furosemide / generics
    Give a Little, Get a Lot: The Power of IV Fluids in Heart Failure (Location: 204 C) -  Sep 9, 2019 - Abstract #HFSA2019HFSA_10;    
    Though an effective way to diurese patients, manual titration of IVF/diuretics was tedious, time consuming, and required significant manpower, including physicians and nurses for hourly patient clinical assessments and determination of FLL. This therapy was effective but would benefit from automation of the delivery system due to the workload burden on healthcare providers.
  • ||||||||||  furosemide / Generic mfg.
    Preclinical, Journal:  With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo. (Pubmed Central) -  Sep 7, 2019   
    Although the initial response to furosemide was similar in wnk4 mice and controls, the response was lower in the knockout mice when reabsorption along the distal convoluted tubule was inhibited...More supporting evidence that WNK4 may modulate NKCC2 emerges from a mouse model of WNK4-mediated familial hyperkalemic hypertension in which more phosphorylated NKCC2 is present than in controls. These data indicate that WNK4, in addition to modulating NCC, also modulates NKCC2, contributing to its physiological function in vivo.
  • ||||||||||  Henletor (torsemide) / Orchid
    Clinical, Journal:  Death: The Simple Clinical Trial Endpoint. (Pubmed Central) -  Aug 30, 2019   
    Our methods detail how a possible death is triggered from each of these components and the types of information we require to verify a triggered death. Our different trigger/verification elements collectively define the TRANSFORM-HF PCT's definition of a death event.
  • ||||||||||  Gilenya (fingolimod) / Novartis, Mitsubishi Tanabe
    Temporary left venticular dysfunction due to fingolimod treatment (Poster Exhibition) -  Aug 28, 2019 - Abstract #ECTRIMS2019ECTRIMS_707;    
    This case warned about us that patients should be examined by the cardiologist before starting Fingolimod therapy and followed by cardiac functions during this therapy, especially in the first six months. We think that we need to do more research in this area.
  • ||||||||||  furosemide / Generic mfg., nitroglycerin / Generic mfg.
    Trial completion date, Trial primary completion date:  N-FURIOUS: Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (clinicaltrials.gov) -  Aug 28, 2019   
    P2,  N=70, Recruiting, 
    We think that we need to do more research in this area. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Sep 2019 --> Sep 2020
  • ||||||||||  furosemide / generics
    Journal:  Essential role of Kir5.1 channels in renal salt handling and blood pressure control. (Pubmed Central) -  Aug 28, 2019   
    Supplementation of high-salt diet with increased potassium (2% KCl) prevented mortality in SSKcnj16-/- rats and prevented or mitigated hypertension in SSKcnj16-/- or control SS rats, respectively. Our results demonstrate that Kir5.1 channels are key regulators of renal salt handling in SS hypertension.
  • ||||||||||  ondansetron / generics, fluoxetine / generics, dronabinol oral / generics
    Efficacy of pharmacotherapy for OSA in adults: a systematic review and network meta-analysis (TP-13) -  Aug 26, 2019 - Abstract #ERS2019ERS_4395;    
    There is currently insufficient evidence to recommend any pharmacotherapy for OSA and no phase-III trials are available. Future studies are advised to account for the underlying mechanisms of the intervention, as current evidence suggests that pharmacotherapy may not be a stand-alone therapy in OSA.
  • ||||||||||  furosemide / generics
    Journal:  Dopaminergic-GABAergic interplay and alcohol binge drinking. (Pubmed Central) -  Aug 25, 2019   
    Whole-cell patch-clamp showed peak amplitudes of miniature inhibitory postsynaptic currents in NAc medium spiny neurons higher in DR compared to DR; Ro 15-4513 reduced the peak amplitude in the NAc of DR, but not in DR. We conclude that DR-dependent enhanced expression of α6 GABA subunit inhibits voluntary alcohol intake by increasing GABA inhibition in the NAc.
  • ||||||||||  aspirin / Generic Mfg.
    Impact of Chronic Obstructive Pulmonary Disease in Heart Failure With Preserved Ejection Fraction (Zone 2, Science and Technology Hall) -  Aug 21, 2019 - Abstract #AHA2019AHA_4947;    
    Aortic characteristic impedance was measured with a combination of arterial tonometry and phase-contrast MRI HFpEF patients with or without COPD exhibited a greater prevalence of female sex, obesity, furosemide, nitrate, beta-blocker and aspirin use. Individuals with co-morbid HFpEF and COPD exhibit a greater degree of systemic large artery stiffening, LV remodeling and LV fibrosis than those with either condition alone.
  • ||||||||||  furosemide / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing (clinicaltrials.gov) -  Aug 21, 2019   
    P4,  N=60, Active, not recruiting, 
    More research is needed to determine if higher DE and weight loss in AA reflects higher baseline volume overload. Recruiting --> Active, not recruiting | Trial completion date: Aug 2019 --> Aug 2020 | Trial primary completion date: Jun 2019 --> Jun 2020
  • ||||||||||  furosemide / generics
    Review, Journal:  Human albumin infusion for treating oedema in people with nephrotic syndrome. (Pubmed Central) -  Aug 20, 2019   
    We identified only one small study that was relevant to our review, therefore we are unable to draw any conclusions regarding the use of human albumin with or without diuretics in nephrotic syndrome. More RCTs are needed.