- |||||||||| furosemide / Generic mfg.
Journal: Unravelling Guest Dynamics in Crystalline Molecular Organics Using 2H Solid-State NMR and Molecular Dynamics Simulation. (Pubmed Central) - Jun 27, 2024
2H solid-state NMR and atomistic molecular dynamics (MD) simulations are used to understand the disorder of guest solvent molecules in two cocrystal solvates of the pharmaceutical furosemide...Time-independent component analysis of the MD trajectories provides additional insights, particularly for motions that are invisible to NMR. This allows a coherent picture of the dynamics of molecules restricted in molecular-sized cavities to be determined.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Biomarker, Retrospective data, Journal: Safety and Efficacy of Dapagliflozin in Patients with Heart Failure with Reduced Ejection Fraction: Multicentre Retrospective Study on Echocardiographic Parameters and Biomarkers of Heart Congestion. (Pubmed Central) - Jun 27, 2024
By multivariable Cox regression, after adjustment for age, sex, the presence of diabetes/prediabetes, and HF duration, higher baseline Hb concentrations (HR 1.347, 95% CI 1.038-1.746, p = 0.025), and eGFR levels (HR 1.016, 95% CI 1.000-1.033, p = 0.46). In a real-life HFrEF population, dapagliflozin therapy is safe and well-tolerated, improves echocardiographic parameters and biomarkers of congestion, and can also facilitate the titration of drugs with a prognostic impact.
- |||||||||| Henletor (torsemide) / Orchid
Journal: Impact of baseline kidney dysfunction on oral diuretic efficacy following hospitalization for heart failure (Pubmed Central) - Jun 26, 2024
In a real-life HFrEF population, dapagliflozin therapy is safe and well-tolerated, improves echocardiographic parameters and biomarkers of congestion, and can also facilitate the titration of drugs with a prognostic impact. Among patients discharged after hospitalization for HF, there was no significant difference in clinical and patient-reported outcomes between torsemide and furosemide, irrespective of renal function.
- |||||||||| Clotinab (abciximab) / ISU Abxis, Integrilin (eptifibatide) / Takeda, NovoLog (insulin aspart) / Novo Nordisk
Keeping Coronary Stents Patent in Patients (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3263;
(ASA, Clopidogrel (Plavix), Eptifibatide (Integrelin), Abciximab (Reopro), prasugrel (Effient), ticagrelor (Brilinta) Intra operatively, the patient develops hypotension, ST elevation and T wave inversion on EKG.16. What are the therapeutic options available in this scenario?
- |||||||||| Oh My God! This Is the Worst Headache of My Life; I Can (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3145;
What are the therapeutic options available in this scenario? She also has a history of well-controlled hypertension treated with losartan...Desflurane, sevoflurane or isoflurane?...Would you add remifentanil and dexmedetomidine to your TIVA technique?The patient
- |||||||||| Catastrophic Airway Emergency and Bleeding in Endotracheal Tube After Pulmonary Angioplasty in the Cardiac Catheterization Laboratory! What Is Next? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2563;
Case Description:A 14-year-old girl, who has a previous medical history of DiGeorge syndrome, Tetralogy of Fallot, and MAPCAs, repaired by Unifocalization, right ventricle to pulmonary artery (RV-PA) Conduit, and VSD repair in 2009, presented for elective left pulmonary artery (LPA) rehabilitation and pulmonary vasodilator testing in the interventional cardiac catheterization lab.Her history of cardiac repairs and interventions included; Unifocalization and RV-PA conduit (2009), Left BT shunt to left pulmonary artery (LPA), right pulmonary artery (RPA) angioplasty, RV-PA replacement (2011), Unifocalization LUPA, RV-PA conduit replacement (2021), VSD patch (2022), and multiple catheterization-based interventions for RPA / RPV stenosis.Her medications included home oxygen, sildenafil and furosemide...Qp:Qs 1.5After uneventful induction with IV midazolam, fentanyl, propofol and rocuronium, and endotracheal intubation the anesthesia maintenance was conducted by 1% Sevoflurane and boluses of rocuronium...Was there further patient optimization in preparation for the procedure? What could be done better next time?
- |||||||||| furosemide / Generic mfg.
Perioperative Management of the Patient With End-stage Liver Disease (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2555;
She does have evidence of mild ascites that has been well-controlled with furosemide...What medications would you use for management of postoperative pain?18. Can this patient receive regional anesthesia?
- |||||||||| Optimal Perioperative Management of Carotid Endarterectomy (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2547;
What target pressures are reassuring of adequate cerebral perfusion? 15.What are the advantages and disadvantages of Transcranial Doppler (TCD) as a monitoring modality for patients under carotid endarterectomy?16.Is there a role for near-infrared spectroscopy (NIRS) in carotid endarterectomy in perioperative stroke prevention?17.Is there a role for a
- |||||||||| furosemide / Generic mfg.
Perioperative Management of the Patient With End-stage Liver Disease (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2231;
She does have evidence of mild ascites that has been well-controlled with furosemide...What medications would you use for management of postoperative pain?18. Can this patient receive regional anesthesia?
- |||||||||| Lantus (insulin glargine) / Sanofi, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
LVAD Patient Presenting for Urgent Laparoscopic Surgery: What Do I Do? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1854;
If the patient's mental status is normal after awakening, would you extubate? If the patient does not awaken, how would you proceed?
- |||||||||| Oh My God! This Is the Worst Headache of My Life; I Can (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1441;
If the patient does not awaken, how would you proceed? She also has a history of well-controlled hypertension treated with losartan...Desflurane, sevoflurane or isoflurane?...Would you add remifentanil and dexmedetomidine to your TIVA technique?The patient
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Impella Standby and Pharmacologic Support During Mitral Clip Procedure in an Unstable Cardiac Patient (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1429;
Preoperative medications included: Sacubitril-valsartan (Entresto), Metoprolol, Empagliflozin, Furosemide, Protonix, Sertraline and Digoxin...He then received 150 mg of IV amiodarone load followed by continuous infusion and was taken to the hybrid Cath Lab to undergo a TEE followed by cardioversion and mitral clip application...Anesthesia was induced with etomidate, fentanyl, rocuronium and esmolol...Inotropic support was provided pharmacologically with milrinone and norepinephrine infusions...How can the Impella flow adjustments facilitate mitral clipping. 10-How would you manage new onset hypotension in PACU after extubation.$$graphic_{0ABD30CA-3234-47A0-BF39-C8A2B62426BB}$$$$graphic_{4A201CBB-4F60-48BB-8303-A453EB511991}$$$$graphic_{9098DA9F-016F-4F1F-8A03-547F0E5ED0EB}$$$$graphic_{5A825C96-1CED-4442-9DFB-AA998C5488EE}$$$$graphic_{DE57C476-94EB-4AE3-AE8C-715C50C45F61}$$
- |||||||||| High Risk Transvenous Lead Extractions (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1217;
10-How would you manage new onset hypotension in PACU after extubation.$$graphic_{0ABD30CA-3234-47A0-BF39-C8A2B62426BB}$$$$graphic_{4A201CBB-4F60-48BB-8303-A453EB511991}$$$$graphic_{9098DA9F-016F-4F1F-8A03-547F0E5ED0EB}$$$$graphic_{5A825C96-1CED-4442-9DFB-AA998C5488EE}$$$$graphic_{DE57C476-94EB-4AE3-AE8C-715C50C45F61}$$ Her outpatient medications are metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is
- |||||||||| Catastrophic Airway Emergency and Bleeding in Endotracheal Tube After Pulmonary Angioplasty in the Cardiac Catheterization Laboratory! What Is Next? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1068;
Case Description:A 14-year-old girl, who has a previous medical history of DiGeorge syndrome, Tetralogy of Fallot, and MAPCAs, repaired by Unifocalization, right ventricle to pulmonary artery (RV-PA) Conduit, and VSD repair in 2009, presented for elective left pulmonary artery (LPA) rehabilitation and pulmonary vasodilator testing in the interventional cardiac catheterization lab.Her history of cardiac repairs and interventions included; Unifocalization and RV-PA conduit (2009), Left BT shunt to left pulmonary artery (LPA), right pulmonary artery (RPA) angioplasty, RV-PA replacement (2011), Unifocalization LUPA, RV-PA conduit replacement (2021), VSD patch (2022), and multiple catheterization-based interventions for RPA / RPV stenosis.Her medications included home oxygen, sildenafil and furosemide...Qp:Qs 1.5After uneventful induction with IV midazolam, fentanyl, propofol and rocuronium, and endotracheal intubation the anesthesia maintenance was conducted by 1% Sevoflurane and boluses of rocuronium...Was there further patient optimization in preparation for the procedure? What could be done better next time?
- |||||||||| High Risk Transvenous Lead Extractions (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_679;
If the patient does not awaken, how would you proceed? Her outpatient medications are metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is
- |||||||||| Optimal Perioperative Management of Carotid Endarterectomy (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_671;
What target pressures are reassuring of adequate cerebral perfusion? 15.What are the advantages and disadvantages of Transcranial Doppler (TCD) as a monitoring modality for patients under carotid endarterectomy?16.Is there a role for near-infrared spectroscopy (NIRS) in carotid endarterectomy in perioperative stroke prevention?17.Is there a role for a
- |||||||||| Clotinab (abciximab) / ISU Abxis, Integrilin (eptifibatide) / Takeda, NovoLog (insulin aspart) / Novo Nordisk
Keeping Coronary Stents Patent in Patients (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_481;
(ASA, Clopidogrel (Plavix), Eptifibatide (Integrelin), Abciximab (Reopro), prasugrel (Effient), ticagrelor (Brilinta) Intra operatively, the patient develops hypotension, ST elevation and T wave inversion on EKG.16. What are the therapeutic options available in this scenario?
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Impella Standby and Pharmacologic Support During Mitral Clip Procedure in an Unstable Cardiac Patient (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_471;
Preoperative medications included: Sacubitril-valsartan (Entresto), Metoprolol, Empagliflozin, Furosemide, Protonix, Sertraline and Digoxin...He then received 150 mg of IV amiodarone load followed by continuous infusion and was taken to the hybrid Cath Lab to undergo a TEE followed by cardioversion and mitral clip application...Anesthesia was induced with etomidate, fentanyl, rocuronium and esmolol...Inotropic support was provided pharmacologically with milrinone and norepinephrine infusions...How can the Impella flow adjustments facilitate mitral clipping. 10-How would you manage new onset hypotension in PACU after extubation.
- |||||||||| Henletor (torsemide) / Orchid
What's New in Diuretics? (Room 6D/E, Convention Center) - Jun 19, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_118;
Particular emphasis is given to the potential benefits of acetazolamide and hypertonic saline, as well as the relative benefits of chlorthalidone vs. hydrochlorothiazide and torsemide vs. furosemide. Learning Objective(s):
- |||||||||| furosemide / Generic mfg.
Journal: "Decreased percent change in (Pubmed Central) - Jun 16, 2024
Therefore, the appropriate selection of values for key parameters in the synthesis of HPMC films containing drug-loaded NLCs is important in the effective development of films for medical applications. No abstract available
- |||||||||| furosemide / Generic mfg., spironolactone / Generic mfg.
Journal: Diuretic effects of Hecogenin and Hecogenin acetate via aldosterone synthase inhibition. (Pubmed Central) - Jun 14, 2024
This enhanced diuretic activity of HA can be attributed to its stronger impact on aldosterone synthase inhibition. These findings offer valuable insights into the diuretic effects of both HEC and HA along with their underlying molecular mechanisms.
- |||||||||| amlodipine/benazepril / Generic mfg., furosemide / Generic mfg., spironolactone / Generic mfg.
Journal: Case report: A case of bradycardia triggered by diarrhea. (Pubmed Central) - Jun 14, 2024
Clinicians should be alert to patients with hyperkalemia and maintain a high index of suspicion for BRASH syndrome. Timely diagnosis and comprehensive intervention are critical for better outcomes in managing patients with BRASH.
- |||||||||| Bystolic (nebivolol) / Menarini, AbbVie
Biomarker, Journal: (NDMA) METFORMIN AND (NTTP) SITAGLIPTIN INDUCED CUTANEOUS MELANOMAS: LINKS TO NITROSOGENESIS, NITROSO-PHOTOCARCINOGENESIS, ONCOPHARMACOGENESIS AND THE METABOLIC REPROGRAMMING. (Pubmed Central) - May 29, 2024
Similarly to cutaneous melanomas occurring (and published in the scientific literature) after combined intake (or monomedication) of/ between ranitidine, valsartan, olmesartan, candesartan, telmisartan, irbesartan, losartan, enalapril, lisinopril, perindopril, hydrochlorothiazide, nifedipine, amlodipine, propafenone, bisoprolol, nebivolol, melitracen and a number of others, we inform about another rare but not unexpected clinical observation: occurrence of cutaneous melanomas after taking another class of drugs- oral antidiabetic ones...The data shared in patients one and two in the presented scientific work are confirmatory in relation to the potential pathogenetic action of nitrosamine contaminated drugs such as 1) bisoprolol/ nebivolol/ candesartan/ hydrochlorothiazide and amlodipine, as well as 2) furosemide in the direction of cutaneous melanoma...Apart from the "cancer-generating benefit", of course, which is already widely known. And let us not forget that: "A lie stops being a lie and becomes a truth the moment it is officially refuted".
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Observational data, Retrospective data, Journal: Progress of patients hospitalized with acute heart failure treated with empagliflozin. (Pubmed Central) - May 29, 2024
Introduction of empagliflozin before discharge from hospital in patients admitted with HF made it possible to reduce the dose of diuretics during admission. The frequency of complications was as expected, and treatment was largely maintained.
- |||||||||| furosemide / Generic mfg.
Journal: Transport activity regulates mitochondrial bioenergetics and biogenesis in renal tubules. (Pubmed Central) - May 28, 2024
Chronic inhibition of transport activity by 2-week furosemide treatment or deletion of with-no-lysine kinase 4 (Wnk4) decreases maximal mitochondrial capacity...Transport activity tightly regulates mitochondrial bioenergetics and biogenesis to meet the energy demand in renal tubules. The system allows future investigation into whether and how mitochondria contribute to tubular remodeling adapted to changes in transport activity.
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