- |||||||||| ceftriaxone / Generic mfg.
Clinical, Journal: The Dark Purple Side of Ceftriaxone: A Case Report on Leucocytoclastic Vasculitis. (Pubmed Central) - Apr 21, 2020
Several days after ceftriaxone and digoxin therapy initiation, worsening multiple non-blanching palpable purpuric lesions with bullae and papules, limited to the lower extremities, were noted...Ceftriaxone was discontinued and systemic corticosteroids were introduced, with a clear improvement in the cutaneous condition. Leucocytoclastic vasculitis is a rare but significant side effect related to the administration of ceftriaxone.The importance of skin biopsy in the differential diagnosis of skin eruptions.
- |||||||||| Henletor (torsemide) / Orchid, furosemide / Generic mfg.
Retrospective data, Journal: Meta-Analysis Comparing Torsemide Versus Furosemide in Patients With Heart Failure. (Pubmed Central) - Apr 17, 2020
However, there was no difference in all-cause mortality or medication side effects between the 2 groups. In conclusion, compared with furosemide, torsemide use was associated with significant more improvement in functional status and lower cardiac mortality; and numerically fewer hospitalizations in patients with heart failure.
- |||||||||| hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
Enrollment open: ProDUCT-HF: Protocol of Diuretics Use in Congestive Therapy in Heart Failure (clinicaltrials.gov) - Apr 17, 2020
P4, N=300, Recruiting,
In conclusion, compared with furosemide, torsemide use was associated with significant more improvement in functional status and lower cardiac mortality; and numerically fewer hospitalizations in patients with heart failure. Not yet recruiting --> Recruiting
- |||||||||| acetazolamide / Generic mfg., topiramate / Generic mfg.
Journal: Topiramate is more effective than acetazolamide at lowering intracranial pressure. (Pubmed Central) - Apr 15, 2020
Other drugs tested, including acetazolamide, did not significantly reduce intracranial pressure. Future clinical trials evaluating the efficacy and side effects of topiramate in idiopathic intracranial hypertension patients would be of interest.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic mfg., furosemide / Generic mfg.
Clinical, Journal: Prospective evaluation of immune haemolysis in liver transplantation. (Pubmed Central) - Apr 14, 2020
Auto- and alloantibodies against red blood cell antigens are frequent in LT, but the frequency of immune haemolysis was only 2·8%. The only risk factor for PLS was minor ABO mismatch.
- |||||||||| Lucassin (terlipressin) / Mallinckrodt
Retrospective data, Journal: Pharmacological treatment of hepatorenal syndrome: a network meta-analysis. (Pubmed Central) - Apr 14, 2020
Terlipressin plus albumin and dopamine plus furosemide plus albumin should be prioritized for decreasing Scr in HRS, and octreotide plus midodrine plus albumin was the most effective at increasing serum sodium. Terlipressin plus albumin showed a comprehensive effect in both decreasing Scr and increasing serum sodium.
- |||||||||| furosemide / Generic mfg., epinephrine / Generic mfg.
Clinical, Journal: Three-year experience with immediate extubation in pediatric patients after congenital cardiac surgery. (Pubmed Central) - Apr 12, 2020
Immediate and early extubation was significantly associated with several factors, including patient age and size, duration of CPB, use of certain anesthetic drugs, and the amount of blood loss and blood replacement. IE can be successfully accomplished in a majority of pediatric patients undergoing surgery for congenital heart disease, including in a minority of infants.
- |||||||||| furosemide / Generic mfg.
Biomarker, Clinical, Review, Journal: The Sick Adult Horse: Renal Clinical Pathologic Testing and Urinalysis. (Pubmed Central) - Apr 11, 2020
Clinicopathologic evaluation of renal function and renal disease in sick adult horses remains grounded in detection of azotemia, assessment of serum and urine electrolyte concentrations, and evaluation of urinalysis findings, including specific gravity, reagent strip analysis, and sediment examination. Because increases in serum or plasma urea nitrogen and creatinine concentrations are insensitive indicators of a decreased glomerular filtration rate, there is considerable interest in identifying novel biomarkers of renal function or injury in blood and urine, with serum symmetric dimethylarginine concentration being the most recent addition to the commercial market.
- |||||||||| Frumeron (indapamide) / Remedica, ibuprofen / Generic mfg.
Clinical, Journal, Adverse events: Nonsteroidal Anti-inflammatory Drugs Utilization Patterns and Risk of Adverse Events due to Drug-Drug Interactions among Elderly Patients: A Study from Jordan. (Pubmed Central) - Apr 11, 2020
In addition, Aspirin was the highest NSAIDs co-prescribed with ACEI (e.g., Enalapril), ARBs (e.g. Candesartan and Losartan), Diuretics (Furosemide, Indapamide, Hydrochlorothiazide, Amiloride, and Spironolactone), Warfarin and antiplatelets (Clopidogreal and Ticagrelor) followed by Diclofenac and other NSAIDs...Additionally the co-prescribing of NSAIDs especially Aspirin with other agents, which contributes to NSAIDs nephrotoxicity and gastrointestinal toxicity, were high. Strict measurements and action plans should be taken by prescribers to optimize the medical treatment in elderly through maximizing the benefits and decreasing the unwanted side effects.
- |||||||||| zoledronic acid / Generic mfg.
Journal: Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia. (Pubmed Central) - Apr 10, 2020
Strict measurements and action plans should be taken by prescribers to optimize the medical treatment in elderly through maximizing the benefits and decreasing the unwanted side effects. Our case shows how a single low dose of zoledronic acid was safe and effective in managing severe hypercalcemia unresponsive to conventional treatment while minimizing the risk of hypocalcemic rebounds.
- |||||||||| furosemide / Generic mfg.
Preclinical, Journal: Impaired glucose tolerance, glucagon and insulin responses in mice lacking the loop diuretic-sensitive Nkcc2a. (Pubmed Central) - Apr 10, 2020
The NaK2Cl cotransporter-2 (Nkcc2, Slc12a1) is abundantly expressed in the kidney and its inhibition with the loop-diuretics bumetanide and furosemide has been linked to transient or permanent hyperglycemia in mice and humans...Under basal conditions, Nkcc2amice have impaired glucose homeostasis characterized by increased blood glucose, intolerance to the sugar, delayed/blunted in vivoinsulin and glucagon responses to glucose and increased glycemic responses to the gluconeogenic substrate alanine. Further, we provide evidence of conserved quantitative secretory responses of Nkcc2aislets within a context of increased islet size related to hyperplastic/hypertrophic α- and β-cells, normal total islet Clcontent and reduced β-cell expression of the Clextruder Kcc2.
- |||||||||| furosemide / Generic mfg.
Journal: Diuretic Enhanced Ultrasonography in the Diagnosis of Pyeloureteral Obstruction. (Pubmed Central) - Apr 10, 2020
Logistic regression model demonstrated that significant factors for surgery were: AD 60 min after furosemide infection and ultrasonographic parenchymal sclerosis. Ultrasound measurement of the AD of renal pelvis 1 h after the injection of furosemide used as an additional investigation can help in predicting obstructive hydronephrosis.
- |||||||||| tranexamic acid / Generic mfg., University of Alabama, furosemide / Generic mfg.
Clinical, Journal: Breakthroughs in global critical care medicine 2019 (Pubmed Central) - Apr 9, 2020
And there are also negatives trials as following: individual mechanical ventilation, maximal recruitment open lung ventilation or early neuromuscular blockade for moderate-to-severe ARDS, N95 respirators preventing influenza, flexible family visit program against delirium or early sedation with dexmedetomidine to mechanically ventilated patients, intensive care unit (ICU) diary or nurse-led preventive psychological intervention against posttraumatic stress disorder (PTSD) in patients with mechanical ventilation, recombinant human soluble thrombomodulin (rhsTM) in patients with sepsis-associated coagulopathy, and so on. Further investigations should be focus on the phenotype analysis, by which individualized management fitting for specific pathophysiologic and immune characters for each patient could be clarified.
- |||||||||| furosemide / Generic mfg.
Journal: Furosemide reverses medullary tissue hypoxia in ovine septic acute kidney injury. (Pubmed Central) - Mar 29, 2020
In septic AKI, furosemide rapidly restored medullary PO to pre-septic levels. This effect was not accompanied by changes in medullary perfusion or renal oxygen delivery but was accompanied by a transient increase in fractional sodium excretion, implying decreased oxygen consumption as a mechanism.
- |||||||||| furosemide / Generic mfg., Alverix (amiloride hydrochloride) / Remedica
Preclinical, Journal: Effects of myricetin-3-O-α-rhamnoside (myricitrin) treatment on urinary parameters of Wistar rats. (Pubmed Central) - Mar 29, 2020
This effect was not accompanied by changes in medullary perfusion or renal oxygen delivery but was accompanied by a transient increase in fractional sodium excretion, implying decreased oxygen consumption as a mechanism. Taking together, although the results of this study point to the diuretic potential of myricitrin, the reduction in urinary Cl and excretion should be considered in future approaches, as well as for therapeutic applicability.
- |||||||||| Herceptin (trastuzumab) / Roche
What Is The Cause Of This Patient’s Hypertension? () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_405;
Health care providers and the public need to be aware of the potential adverse effects of excessive licorice intake. We report this case because detailed history taking is very important in arriving at the correct diagnosis.
- |||||||||| apixaban / Generic mfg.
Management of arterial thrombosis secondary to nephrotic syndrome in a patient on chronic apixaban () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_367;
He was treated with prednisone, furosemide and lisinopril, while apixaban was continued...Apixaban is non-inferior to warfarin for the treatment of thromboembolism in the general population. There is a need for further studies of direct oral anticoagulants to fully assess their effectiveness for prophylaxis against and treatment of thrombosis in patients with nephrotic syndrome.
- |||||||||| furosemide / Generic mfg.
Case Series of Oxytocin Induced Hyponatremia () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_328;
These cases emphasize the need to be aware of hyponatremia as a complication of oxytocin and need to limit the concomitant use of hypotonic fluids with oxytocin. Most cases resolve on their own with discontinuation of oxytocin, however as seen in case one concomitant liver disease can lead to prolonged oxytocin activity and need for active management of hyponatremia.
- |||||||||| furosemide / Generic mfg.
The TUMS Epidemic: A Case Looking into OTC Antacid Induced Hypercalcemia () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_78;
Work needs to be done to further discern the dose at which this can occur in most patients in order to avoid this condition. Further patient education needs to be given by all providers on the dangers on overuse of antacid.
- |||||||||| furosemide / Generic mfg.
NSAID-induced hyperkalemia despite normal renal function () - Mar 27, 2020 - Abstract #NKFCSM2020NKF_CSM_38;
The opioid crisis has led to the liberal use of NSAIDS for managing pain. This unique case demonstrates the risks associated with this therapeutic trend in patients even with an otherwise low chance of renal, cardiovascular, or electrolyte abnormalities.
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