furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg., telmisartan / Generic mfg.
    [VIRTUAL] EFFECT ON BLOOD PRESSURE OF UNCOMPENSATED 130 MM SODIUM DIALYSATE IN CAPD PATIENT WITH RESISTANT HYPERTENSION (Mini-Orals Hall) -  Mar 19, 2021 - Abstract #ERAEDTA2021ERA_EDTA_1535;    
    At baseline, Ambulatory BP monitoring (ABPM) showed 24h-BP (152/81 mmHg), diurnal BP (151/83 mmHg) and nocturnal BP (153/75 mmHg), with inversion of circadian rhythm in systolic BP (systolic night/day ratio: 1.02), despite the use of three anti-hypertensive (doxazosin 4mg, amlodipine 10 mg, telmisartan 80 mg) and diuretic (furosemide 250 mg) at adequate doses. Six-months PD treatment with uncompensated glucose-based PD solution containing 130 mM sodium in all daily dwells has allowed to reduce systolic BP (-16 mmHg) in a CAPD patient affected by resistant hypertension, with no change in ultrafiltration and residual diuresis.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] DISTAL RENAL TUBULAR ACIDOSIS IN PATIENTS WITH AUTOIMMUNE DISEASES (Mini-Orals Hall) -  Mar 19, 2021 - Abstract #ERAEDTA2021ERA_EDTA_1246;    
    DRTA can evolve without symptoms and systemic acidosis, this form being defined as incomplete DRTA, that necessitates the use of a urinary acidification test like the Furosemide and Fludrocortisone test for establishing the diagnosis... Incomplete DRTA was found in 4 out of 21 patients with autoimmune diseases, one with Sjogren syndrome and nephrocalcinosis, two with pANCA and cryoglobulinemic vasculitis with decreased eGFR and severe tubular atrophy and interstitial fibrosis and one young female with SLE
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Coordinated downregulation of KCC2 and GABA receptor contributes to inhibitory dysfunction during seizure induction. (Pubmed Central) -  Mar 17, 2021   
    Further, pre-treatment with furosemide, a KCC2 inhibitor, during CTZ stimulation followed by washout significantly prevented convulsant stimulation-induced membrane KCC2 downregulation and significantly attenuated GABAR downregulation concomitant with recovery of suppressed KCC2-independent GABAergic mIPSC amplitude. Our results suggest that the coordinated downregulation of KCC2 and GABAR during seizure induction exerts a strong functional impact on GABAR, highlighting an important regulatory mechanism in epilepsy.
  • ||||||||||  Germanin (suramin) / Optimum Therap
    Enrollment open, Trial completion date:  Study of Suramin in Subjects With Furosemide-Resistant AKI (clinicaltrials.gov) -  Mar 16, 2021   
    P2,  N=58, Recruiting, 
    Our results suggest that the coordinated downregulation of KCC2 and GABAR during seizure induction exerts a strong functional impact on GABAR, highlighting an important regulatory mechanism in epilepsy. Not yet recruiting --> Recruiting | Trial completion date: May 2022 --> Aug 2022
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] The Pill and the Pea () -  Mar 14, 2021 - Abstract #ATS2021ATS_4043;    
    These cases are successfully resolved 90% of the time with use of various devices including shark tooth, alligator, or rat-tooth forceps, or baskets.1,2 Pill aspiration is a distinct entity often difficult to diagnose on imaging due to radiolucency and can be associated with airway injury.2,3 Retrieval is the mainstay of management, but can be complicated by airway anatomy and limitations of equipment. Our case demonstrates that use of multiple instruments and directly breaking down the object prior to retrieval may be necessary.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] Cocaine-Induced Bronchospasm Presenting as Severe COPD Exacerbation () -  Mar 14, 2021 - Abstract #ATS2021ATS_3108;    
    He was given nebulizer treatments, methylprednisolone, antibiotics, and furosemide...It is thought that bronchi exposed to inhaled cocaine have abnormal smooth muscle contraction, causing bronchoconstriction in patients with COPD and leading to a syndrome mimicking exacerbation [3]. Thus, it is important to recognize this phenomenon in order to further characterize risk factors and develop treatments.
  • ||||||||||  tenofovir disoproxil fumarate / Generic mfg., furosemide / Generic mfg.
    [VIRTUAL] Fanconi Syndrome with Multi-Organ Failure Secondary to Tenofovir Use in Chronic Hepatitis B () -  Mar 14, 2021 - Abstract #ATS2021ATS_2745;    
    The constellation of mixed gap metabolic acidosis, pancytopenia, and multiorgan dysfunction observed in this patient should be recognized as a severe manifestation of this phenomenon. This case highlights the importance of thorough medication review and supports the use of CRRT as a treatment strategy for severe metabolic disturbances in Fanconi syndrome.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] A Case of an Occupational Exposure to Hydrogen Sulfide Gas () -  Mar 14, 2021 - Abstract #ATS2021ATS_418;    
    He was treated with furosemide for diuresis since the ground glass opacities were thought to represent a component of pulmonary edema from cardiomyopathy...Among cases of non-fatal hydrogen sulfide exposures documented in the literature, most are low level environmental exposures rather than large occupational exposures. Although the patient improved rapidly during the hospital stay, it is especially important to monitor for the long-term effects of the exposure including bronchiolitis obliterans and cardiomyopathy.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    [VIRTUAL] Administration of COVID-19 Convalescent Plasma in a Metropolitan Health Care System () -  Mar 14, 2021 - Abstract #ATS2021ATS_214;    
    Sixty percent of our very sick study population survived to hospital discharge and there were only two transient infusion reactions. While larger studies with a control group are necessary to more clearly evaluate the benefit of CCP in COVID-19, our study lays the foundation for the rapid implementation of a Convalescent Plasma Program for possible future pandemics as a bridge to vaccine and therapeutic trials.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Potentially inappropriate prescriptions of anticholinergic medications in patients with closed-angle glaucoma. (Pubmed Central) -  Mar 11, 2021   
    Treatment with spironolactone is more effective reducing BP and albuminuria in patients with resistant hypertension compared with furosemide and it is associated with a slower progression of CKD in the long term follow up. Most patients were prescribed multiple antiglaucoma medications, reflecting a large number of potentially inappropriate prescriptions, with anticholinergic drugs, related to the increased intraocular pressure.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Evaluation of the Diuretic Activity of Aqueous and 80% Methanol Extracts of Croton macrostachyus(Euphorbiaceae) Leaves in Saline-Loaded Rats. (Pubmed Central) -  Mar 11, 2021   
    The animals were treated with vehicle (distilled water), standard (furosemide 10 mg/kg), and three doses (100, 200, and 400 mg/kg) of aqueous and 80% methanol leaf extracts after loading of normal saline (15 mL/kg)...In terms of effect on electrolysis, 400 mg/kg aqueous extract produced significant natriuresis, and a kaliuresis effect was observed for both extracts at higher doses and 200 mg/kg aqueous extract. The findings collectively indicated that both aqueous and 80% methanol extract showed significant diuretic activity, thereby justifying the plant's traditional use as a diuretic agent.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  COVID-19 in a Patient with Liver Cirrhosis. (Pubmed Central) -  Mar 10, 2021   
    He was also using furosemide and spironolactone to control ascites and propranolol for primary prophylaxis of esophageal varices...The patient received dexamethasone 6 mg/day and broad-spectrum antibiotic therapy (he was started on cefepime but switched to meropenem)...Success has been achieved with the use of medications in studies of broad-spectrum antibiotics and the rapid detection of complications caused by the virus. Further studies in SARS-CoV-2 patients with chronic liver disease are needed.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  PIMS-a new pediatric challenge (Pubmed Central) -  Mar 10, 2021   
    Other viral and bacterial infections were excluded as the cause of the symptoms.The patient received IVIG, ASS, furosemide and methylprednisolone and the antibiotic treatment was continued...A PICU background is crucial to treat possibly occurring symptoms and complications. High-dose steroids are used therapeutically alongside supportive therapies.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Laurinterol from Laurencia johnstonii eliminates Naegleria fowleri triggering PCD by inhibition of ATPases. (Pubmed Central) -  Mar 9, 2021   
    Moreover, since ATP levels were highly affected and laurinterol has been previously reported as an inhibitor of the Na/K-ATPase sodium-potassium ion pump, comparison with known inhibitors of ATPases were carried out. Our results points out that laurinterol was able to inhibit ENA ATPase pump at concentrations 100 times lower than furosemide.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Comparison between Branded and Generic Furosemide 40 mg Tablets Using Thermal Gravimetric Analysis and Fourier Transform Infrared Spectroscopy. (Pubmed Central) -  Mar 9, 2021   
    Drug release of FSD was slightly different between both products following incubation in different pH media (1.2, 3.0, and 6.5; 120 min), however, this was in accordance with USP dissolution requirements as < 80% of drug release was obtained within the first 30 min from each product. This study is a useful example for the independent investigations using thermal and spectroscopic analysis to confirm potential hidden variations between generic and branded products that could not be obtained by the bioequivalence studies.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Review, Journal:  Preeclampsia and low sodium (PALS): A case and systematic review. (Pubmed Central) -  Mar 6, 2021   
    Her hyponatremia was initially managed with furosemide and water restriction...Initially, hyponatremia may be treated with medical management. In addition to established obstetric or preeclamptic indications, delivery may be considered if severe hyponatremia no longer responds to conservative measures.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Furosemide administration results in a transient alteration in calcium balance in mature horses. (Pubmed Central) -  Mar 5, 2021   
    These findings corroborate previous studies on furosemide and calcium balance and provide evidence for a possible mechanism to recover net calcium losses after furosemide administration. Since calcium balance returns to baseline in 3 days and previous results have examined frequent, long-term use, furosemide may not negatively impact bone mineral content even if used over long periods.
  • ||||||||||  piroxicam / Generic mfg., furosemide / Generic mfg., promethazine / Generic mfg.
    Journal:  Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs. (Pubmed Central) -  Mar 5, 2021   
    In this work, multilayer gold-silver bimetallic nanorods (Au@Ag@AuNRs) have been prepared and used as platforms for SERS detection of specific drugs (namely promethazine, piroxicam, furosemide and diclofenac). The analysis of SERS spectra provided accurate information on the molecular location upon binding and gave some insight into molecule-surface interactions and selectivity in drug detection through SERS.