- |||||||||| furosemide / Generic mfg.
It’s lasix (Twitter) - Oct 13, 2022
- |||||||||| furosemide / Generic mfg., amiloride hydrochloride / Generic mfg., amiloride/hydrochlorothiazide / Generic mfg.
Experimental CKD Increases Per-Nephron Sodium Reabsorption and Impairs Acute Kaliuresis (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3748;
These alterations in Na + and K + handling may explain the tendency towards salt-sensitive hypertension and hyperkalemia in CKD. Table
- |||||||||| furosemide / Generic mfg.
Sodium Magnetic Resonance Imaging Shows Impairment of the Counter-Current Multiplication System in the Diabetic Model Mice Kidney (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3728;
Methods 23 Na-MRI was performed with a 9.4T vertical standard-bore super-conducting magnet using C57BL/6JJcl administrated of furosemide (10 mg/kg BW), BKS.Cg-Lepr db +/+ Lepr db /Jcl (db/db) mice and its corresponding control BKS.Cg-m+/m+/Jcl (m+/m+) mice...Conclusion 23 Na-MRI revealed reductions in the corticomedullary sodium gradients and impairment in the counter-current multiplication system in db/db mice at very early stages of diabetes mellitus. 23 Na-MRI may be useful for diagnosing diabetic kidney disease and elucidating the pathogenesis of sodium gradient impairments.
- |||||||||| furosemide / Generic mfg.
Differentiated Tubuloids to Model Human Distal Nephron (Patho) Physiology (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3725;
Luminal NKCC2 demonstrated furosemide-inhibitable Tl + (replacing K + ) uptake (n=3)...Treatment with Li + caused changes in line with diabetes insipidus, tubulointerstitial nephritis and tumors seen in vivo . Taken together, differentiated tubuloids enable modeling of the human distal nephron in health and disease.
- |||||||||| furosemide / Generic mfg.
Kidney Function Differs Between 4.5-Month Virgin and 12-Month Breeder Female Sprague Dawley Rats (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3710;
NKCC2 and NCC phosphorylation decreased between 4.5 and 12 mo, however, diuretic tests with thiazides and furosemide were not depressed in parallel, perhaps reflecting impact of tubular flow and/or renal energetics. Conclusion Kidney function is significantly different in adult (12 mo) vs young (4.5 mo) F rats suggesting that middle aged rats may be more appropriate for (patho)physiology studies.
- |||||||||| furosemide / Generic mfg.
Normal Renal Function in a Patient With Elevated Serum Creatinine (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3507;
Lasix and albumin were given and caused his JP drain output to increase significantly...The utility of measuring cystatin c is highlighted here– his eGFR using cystatin c was found to be 52 (compared to 14 using the creatinine equation)– showing a much more accurate indicator of renal function. Identifying pseudo-acute renal failure was imperative in this case to avoid unnecessary interventions such as dialysis.
- |||||||||| furosemide / Generic mfg.
Prerenal Azotemia Triggers the Hepatic Acute Response in a Novel, Clinically Defined Murine Model (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3481;
Interventions : 4 mg of furosemide IP (PRA) or vehicle (Veh) at time 0 hours and 3 hours in wild type (WT) and IL-6 -/- mice; at 6 hours, resuscitation was started with 1 mL IP saline x 4 over 36 hours...Conclusion These data demonstrate previously unknown systemic effects of PRA, demonstrating that significant consequences may occur with the sudden loss of GFR in the absence of tubular injury. Since it is widely thought that the systemic consequences of AKI are predominantly associated with tubular injury, these data change the paradigm by which the consequences of PRA should be be considered.
- |||||||||| Carcinoid Tumor Causing Cardiorenal Syndrome (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3478;
This case demonstrates a previously unreported combination of cardiorenal syndrome due to right heart failure caused by carcinoid heart disease. It also emphasizes the difficulty in management and the need for further studies regarding congestive nephropathy from right heart failure.
- |||||||||| furosemide / Generic mfg.
Olfactomedin 4 as a Loop of Henle-Specific AKI Biomarker That Predicts Furosemide Response (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3477;
OLFM4 colocalized to human LOH; higher uOLFM4 associated with furosemide resistance. OLFM4 may be a novel LOH-specific AKI biomarker that warrants further testing to determine whether it may enhance identification of pts likely to benefit from early kidney replacement therapy.
- |||||||||| losartan / Generic mfg., furosemide / Generic mfg., spironolactone / Generic mfg.
Parvovirus B19 and Collapsing Glomerulopathy in a Postpartum Female (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3120;
A previous case report of CG in a 36-year-old intrapartum female with acute PvB19 infection and little IF/TA on initial biopsy showed rapid progression to ESRD, though she carried two APOL1 risk alleles. Our patient’s preserved renal function and improved proteinuria on follow-up, despite risk factors of moderate IFTA on biopsy, may be related to a decreased genetic risk.
- |||||||||| furosemide / Generic mfg.
Nephrocalcinosis in Children: Clinical Outcomes According to Underlying Diseases (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3022;
Each of 143 (55.8 %) and 107 (41.7%) of patients had medication history of furosemide and vitamin D. Incidence of BPD, PDA and taking vitamin D were remarkably high in premature group comparing with full term group...On the other hand, full-term born children without the known risk factors were more likely to have genetic causes and to develop CKD. Therefore, our study suggests that although the children with NC present the favorable outcomes, regular follow-up and genetic analysis are necessary for the patients without the clinical risk factors.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Rapid Development of Severe Nephrolithiasis in Febrile Infection-Related Epilepsy Syndrome (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3021;
Oral hydrochlorothiazide was initiated resulting in decreased stone burden on abdominal CT scan...In our patient with possible underlying hypercalciuria, the pro-inflammatory state from FIRES may have triggered the rapid and massive kidney stone formation and bladder calcification. Further investigation is needed to delineate the association between nephrolithiasis and inflammatory conditions such as FIRES.
- |||||||||| furosemide / Generic mfg.
Acute Renal Papillary Necrosis With New-Onset Minimal Change Disease (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2992;
Upon hospitalization, she received albumin with furosemide overnight...Due to sudden onset of obstruction hydronephrosis did not develop. We speculate that the intravascular volume depletion from MCD triggered a hypoxic state resulting in RPN which is similar to the pathophysiology of severe dehydration induced RPN.
- |||||||||| prednisone / Generic mfg., furosemide / Generic mfg.
Severe Hypercalcemia due to Hypervitaminosis D (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2910;
The past medical history was significant for coronary heart disease, hypertension, CHF, COPD, rheumatoid arthritis (on prednisone), right femoral fracture and no history of CKD...He was started on IV fluids and calcitonin and furosemide...Hypercalcemia could be a contributory factor to AKI (caused by the radio-contrast) as well as to bone fracture by decreased bone turn over due to low PTH and cumulative steroid use. To conclude this case exemplifies how hypercalcemia can result from an usual cause and lead to multiple complications.
- |||||||||| tolvaptan / Generic mfg.
Nineteen Liters of Urine Output as a Consequence of Concomitant Use of Extracorporeal Membrane Oxygenation and Tolvaptan (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2878;
After high dose furosemide, he received 4 doses of TVP 30 mg/d and an additional 60 mg on the day of transfer...Desmopressin at 2 mcg/day was administered over 2 days and UOP decreased to 11, 9, 5.5 and 3L/day over the next 4 days...The washout period for tolvaptan should be 5 times the half-life of elimination (12h), which may be prolonged in case of passive hepatic congestion or use of CYP43A inducers. Concomitant use of tolvaptan and VA-ECMO should be avoided under penalty of causing massive polyuria and rapid overcorrection of hyponatremia.
- |||||||||| Beguiling but Harmful: IgA Nephropathy Manifests (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2379;
Our patient presented with nephrotic syndrome and rapidly progressive glomerulonephritis with multiple markers for poor prognosis like hypertension, proteinuria above 1 gm/day, and histologic predictors of disease progression such as chronic fibrotic disease, tubular atrophy and interstitial fibrosis on biopsy. Overall, the prognosis of IgAN may be difficult to predict but identifying these risk factors early may guide clinicians and patients.
- |||||||||| Tecentriq (atezolizumab) / Roche
Dual Paraneoplastic Syndrome in Small Cell Lung Cancer (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2325;
She was discharged on Urea therapy, which was later change to furosemide and sodium chloride tablets due to cost...Upon follow up, progression of her cancer was seen, prompting additional chemotherapy with carboplatin, etoposide, and atezolizumab...Cortisol level after low dose dexamethasone suppression test remained elevated at 66.6 mcg/dl...Cortisol and ADH have opposite effects on kidney sodium excretion. This may lead to masking of EAS by SIADH, leading to underdiagnosis.
- |||||||||| Syndrome of Inappropriate Antidiuresis (SIAD): A Clue to a Rare Diagnosis (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2323;
He continued treatment with salt tablets and furosemide with stabilization of his sodium at 130-136 mmol/L...It is usually diagnosed at an advanced stage and PSA can be disproportionately low compared to conventional adenocarcinoma of the prostate. This case illustrates the need for diligent investigation when patients present with hyponatremia and SIAD.
- |||||||||| furosemide / Generic mfg.
The Masked Parathyroid Adenoma in CKD: Is It Overlooked? (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2059;
Furosemide was held and hydration was recommended, PTH was 360 pg/mL, and repeated labs showed calcium of 10.7 mg/dL and phosphorus of 4.3 mg/dL with improvement in serum creatinine...These cases emphasize the importance of carefully interpreting mineral metabolism parameters in CKD populations where PHPT can be subclinical, normocalcemic, and masked by vitamin D deficiency. Normocalcemic PHPT cannot be easily differentiated from secondary hyperparathyroidism in CKD patients, requiring high clinical suspicion and imaging studies to establish the diagnosis.
- |||||||||| Focal Fungal Granulomatous Interstitial Nephritis on a Background of Class II Lupus Glomerulonephritis (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1892;
Discussion Candiduria is a common finding on routine evaluation of hospitalized patients with AKI and often represents colonization or a urinary tract infection. However, in the context of immunosuppression, those findings should raise suspicion for fungal GIN, as shown in this case, so that appropriate intervention can be promptly implemented.
- |||||||||| Reversal of ESKD After 4 Years of Peritoneal Dialysis (PD) With Improved Cardiorenal Pathophysiology (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1610;
After initial BP control, he was discharged on oral carvedilol, nifedipine, hydralazine, and furosemide and plan to start PD as outpatient...He was kept on low dose carvedilol and lisinopril for cardiorenal protection and furosemide...Discussion This is a rare case of reversal of ESKD after 4 years due to maintenance of euvolemia and BP control from significant lifestyle changes and daily PD, resulting in resolution of DD and likely improved renal perfusion and healing of remanent nephrons. It highlights the important cardiorenal interactions and need for aggressive BP/volume control to achieve best outcomes.
- |||||||||| furosemide / Generic mfg.
Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1101;
2 L lactated Ringer's, 4 grams (g) IV Ca gluconate, Lasix 80 mg IV, 40 mEq of potassium chloride IV, and 40 mEq oral were given...Generalizd weakness and hyporeflexia were resolved.He was discharged home 4 days later with baseline Cr and Mg 2.1 mg/dl Discussion Intermittent hemodialysis resulted in more rapid Mg removal in this patient with renal failure Figure1. CVVHD may be used as a adjunct therapy for prevention of rebound hypermagnesemia especially when prolonged GI release of ingested magnesium compounds is expected
- |||||||||| furosemide / Generic mfg.
Mixed Nephrotic/Nephritic Syndrome in a Pediatric Patient With SARS-CoV-2 Infection (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_913;
She was managed with antihypertensives, albumin infusions, and furosemide...SARS-CoV2 has also been reported to directly cause nephritis, although with more tubular than glomerular involvement. A renal biopsy is required for accurate diagnosis.
- |||||||||| furosemide / Generic mfg.
Furosemide (Twitter) - Oct 12, 2022
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