 |
47 Diseases |  |
10 Trials |
|
10 Trials |  |
1303 News |  |
| «12...4567891011121314...1516» |
- | Aduhelm (aducanumab) / Eisai, Biogen
Journal: Aducanumab (Aduhelm) for Alzheimer's disease. (Pubmed Central) - Sep 29, 2021
No abstract available
- galantamine hydrobromide / Generic mfg.
[VIRTUAL] Autonomic Modulation Mitigates Perivascular and Perirenal Adipose Inflammation and Consequent Cardiorenal Involvement in Prediabetes (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_278;
Moxonidine and galantamine were administered orally at daily doses of 2.4 mg/Kg and 4 mg/Kg for the last two weeks of feeding to reduce and facilitate sympathetic and parasympathetic discharge, respectively... Pharmacological interventions to reverse sympathetic predominance could be of therapeutic value treating perivascular and perirenal adipose inflammation that cause early cardiorenal manifestations of prediabetes.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg., citicoline / Generic mfg.
Retrospective data, Journal: A Retrospective Study on the Benefits of Combined Citicoline, Memantine, and Acetylcholinesterase Inhibitor Treatments in Older Patients Affected with Alzheimer's Disease. (Pubmed Central) - Sep 17, 2021
Pharmacological interventions to reverse sympathetic predominance could be of therapeutic value treating perivascular and perirenal adipose inflammation that cause early cardiorenal manifestations of prediabetes. In older patients with AD, a triple therapy with citicoline, memantine, and AChEI was more effective than memantine and AChEI without citicoline in maintaining the MMSE total score after 12 months.
- || galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Clinical, Journal: Gender Disparities in Anti-dementia Medication Use among Older Adults: Health Equity Considerations and Management of Alzheimer's Disease and Related Dementias. (Pubmed Central) - Sep 14, 2021
Healthcare providers should be aware of gender disparities in receiving anti-dementia medications among patients with ADRD, and the need to plan programs of care to support both women and men. Future approaches to finding barriers of prescribing, receiving and, adhering to anti-dementia medications by gender should include differences in longevity, biology, cognition, social roles, and environment.
- galantamine hydrobromide / Generic mfg.
SAHRANG: Subarachnoid Hemorrhage Recovery and Galantamine- A pilot multicenter randomized placebo controlled trial () - Sep 10, 2021 - Abstract #NCS2021NCS_15;
- | galantamine hydrobromide / Generic mfg.
Journal: Potential Nutraceutical Properties of Leaves from Several Commonly Cultivated Plants. (Pubmed Central) - Sep 8, 2021
In silico molecular modeling of these polyphenols demonstrated their improved AChE and BuChE binding affinities compared to the current FDA-approved dual ChEI, galantamine. Collectively, all the plant extracts contained nutraceutical agents as antioxidants and ChEIs and, therefore, their chronic consumption may prove beneficial to combat the pathological deficits that accrue in Alzheimer disease.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Journal: Transdermal drug delivery systems and their potential on Alzheimer's disease management. (Pubmed Central) - Sep 5, 2021
Collectively, all the plant extracts contained nutraceutical agents as antioxidants and ChEIs and, therefore, their chronic consumption may prove beneficial to combat the pathological deficits that accrue in Alzheimer disease. In summary, the transdermal administration of Alzheimer's drugs is an interesting and promising topic, which should be further elaborated.
- | galantamine hydrobromide / Generic mfg.
Journal: Synthesis, biological evaluation, theoretical investigations, docking study and ADME parameters of some 1,4-bisphenylhydrazone derivatives as potent antioxidant agents and acetylcholinesterase inhibitors. (Pubmed Central) - Sep 4, 2021
The obtained results indicate that compound 2 is the best acetylcholinesterase inhibitor with a low IC value comparable to that of the galantamine...As a result, a strong interaction between this compound and the active site of AChE enzyme was revealed. Finally, ADME properties of the synthesized compounds were also studied and showed good drug-like properties.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Chemical composition, in vitro antioxidant, anticholinesterase, and antidiabetic potential of essential oil of Elaeagnus umbellata Thunb. (Pubmed Central) - Sep 4, 2021
Essential oil extracted from the fruits of E. umbellata exhibited reasonable antioxidant, anticholinesterase, and antidiabetic potentials that could be used as alternative medicine in treating diabetes and neurodegenerative disorders. However, further studies are needed to isolate responsible compounds and evaluate the observed potential in animal models.
- || galantamine hydrobromide / Generic mfg.
Review, Journal: Galantamine as a Treatment Option for Nicotine Addiction. (Pubmed Central) - Sep 3, 2021
There are not many studies to illustrate the effectiveness of galantamine for smoking cessation. This article explores the possibility of potential use of galantamine in alleviating the symptoms of nicotine withdrawal.
- | galantamine hydrobromide / Generic mfg.
Journal: Chemical constituents, antioxidant, anticholinesterase and antiproliferative effects of Algerian Pistacia atlantica Desf. extracts. (Pubmed Central) - Sep 2, 2021
This article explores the possibility of potential use of galantamine in alleviating the symptoms of nicotine withdrawal. This study demonstrated good antioxidant, anticholinesterase and antiproliferative activities of P. atlantica extracts, which opens up new possibilities for pharmaceutical and food industries.
- | galantamine hydrobromide / Generic mfg.
Journal: Analysis of Carotenoids in Haloarchaea Species from Atacama Saline Lakes by High Resolution UHPLC-Q-Orbitrap-Mass Spectrometry: Antioxidant Potential and Biological Effect on Cell Viability. (Pubmed Central) - Aug 28, 2021
AChE inhibition IC was 2.96 ± 0.08 μg/mL and BuChE inhibition IC was 2.39 ± 0.09 μg/mL for the most active strain, Halorubrum tebenquichense Te Se-85, respectively, which is more active in BuCHe than that of the standard galantamine. Docking calculation showed that carotenoids can exert their inhibitory activity fitting into the enzyme pocket by their halves, in the presence of cholinesterase dimers.
- | galantamine hydrobromide / Generic mfg.
Trial completion, Enrollment change: COGICRehab: Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment (clinicaltrials.gov) - Aug 27, 2021
P2, N=47, Completed, Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Docking calculation showed that carotenoids can exert their inhibitory activity fitting into the enzyme pocket by their halves, in the presence of cholinesterase dimers. Recruiting --> Completed | N=30 --> 47
- | galantamine hydrobromide / Generic mfg.
Journal: A Galantamine-Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells. (Pubmed Central) - Aug 19, 2021
Allosteric stimulation of α7 nAChRs is suggested as a possible mechanism of the cytoprotectivity of 4b. These and previous findings characterize 4b as a prospective non-toxic multi-target agent against neurodegenerative disorders with inhibitory activity on acetylcholinesterase, antioxidant, and cytoprotective properties.
- | galantamine hydrobromide / Generic mfg.
Journal: Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease. (Pubmed Central) - Aug 18, 2021
In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.
- | galantamine hydrobromide / Generic mfg.
Journal: Multi-target approach for Alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4-N-phenylaminoquinoline derivative reveal promising potentials. (Pubmed Central) - Aug 13, 2021
More recently, a novel series of 4-N-phenylaminoquinolines was synthesized and evaluated against AChE and BuChE in which one of the compounds displayed appreciable inhibition compared to the standard compound, galantamine...It was proposed that the studied compound could serve as a dual inhibitor for AChE and BuChE, therefore, would potentially be a promising moiety in a multi-target approach for the treatment of Alzheimer's disorder. Communicated by Ramaswamy H. Sarma.
- || donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Review, Journal: Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase. (Pubmed Central) - Aug 13, 2021
In this review we summarize the studies reporting phytocompounds and extracts from medicinal plants that show AChE inhibitory activities and could be of potential benefit in AD. Future research directions are suggested and recommendations made to expand the use of medicinal plants and their formulations to prevent, mitigate and treat AD.
- | galantamine hydrobromide / Generic mfg.
Journal: Integrating Narcissus-derived galanthamine production into traditional upland farming systems. (Pubmed Central) - Aug 11, 2021
Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited...There was no difference in overall galanthamine yield if N. pseudonarcissus was cut biennially (1.64 vs. 1.75 kg galanthamine/ha for annual combined vs biennial cuts respectively; s.e.d = 0.117 kg galanthamine/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine.
- | galantamine hydrobromide / Generic mfg.
Journal: Aporphinoid alkaloids derivatives as selective cholinesterases inhibitors: biological evaluation and docking study. (Pubmed Central) - Aug 8, 2021
In addition, these alkaloids demonstrated better inhibition of BChE than reference drug galantamine...Molecular modelling studies were performed in order to illustrate key interactions between most active compounds and the enzymes and to explain their selectivity. These studies reveal that the benzodioxole moiety exhibits strong interactions due to hydrogen bonds that form with the Glu201 (AChE) and Tyr440 (BChE) residues, which is reflected in the IC 50 values.
- risperidone / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
[VIRTUAL] Pharmacological treatment of neuropsychiatric symptoms of dementia: a network meta- analysis () - Aug 7, 2021 - Abstract #CTAD2021CTAD_190;
Evidence from our meta-analysis shows that risperidone was more efficacious than placebo with relatively good acceptability. Collectively, our analysis should provide a helpful perspective to assist in treatment decisions.
- galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Understanding Treatment Goals for Patients and Caregivers with Alzheimer’s Disease Along the Continuum of the Disease Consideration in Clinical Trial Design () - Aug 7, 2021 - Abstract #CTAD2021CTAD_182;
There is a discrepancy between the primary outcomes recommended by regulators and what is a relevant outcome to AD patients and caregivers. When considering the design of an AD clinical trial, patient-relevant outcomes, specifically Quality of Life should be given more relevance in response to AD patients and caregivers’ needs and demands.
- || donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
Review, Journal: Multi-Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets. (Pubmed Central) - Aug 6, 2021
On the other hand, memantine is the only non-competitive NMDAR antagonist approved in AD treatment...This review focus on the significance of privileged scaffolds in the generation of the multi-target lead compound for treating AD, investigating the idea and challenges of multi-target drug design. Furthermore, the most auspicious elementary units for designing as well as synthesizing hybrid drugs are demonstrated as pharmacological probes in the rational design of new potential AD therapeutics.
- | galantamine hydrobromide / Generic mfg.
Journal: LC-ESI-QTOF-MS/MS Analysis, Cytotoxic, Antiviral, Antioxidant, and Enzyme Inhibitory Properties of Four Extracts of Geranium pyrenaicum Burm. f.: A Good Gift from the Natural Treasure. (Pubmed Central) - Aug 6, 2021
It can be concluded that the presence of certain bioactive antiviral molecules may be related to the high anti HSV-1 activity of the methanolic extract. This work has generated vital scientific data on this medicinal plant, which is a prospective candidate for the creation of innovative phyto-pharmaceuticals.
- || galantamine hydrobromide / Generic mfg.
PK/PD data, Journal: Comparative evaluation of fish oil and butter oil in modulating delivery of galantamine hydrobromide to brain via intranasal route: pharmacokinetic and oxidative stress studies. (Pubmed Central) - Aug 4, 2021
The study concluded the potential benefits of co-administering FO- and BO-enriched microemulsion is not only enhancing the permeation of drugs across BBB but also improving efficacy against lipopolysaccharide-induced oxidative stress. Graphical abstract.
- [VIRTUAL] The involvement of inflammation in the effect of the administration of donepezil, galantamine, memantine and/or fluoxetine in an animal model of depression and dementia () - Aug 2, 2021 - Abstract #AAIC2021AAIC_2229;
Graphical abstract. The results obtained in the present study indicate that there is a pathophysiological interaction between diseases, and that the association of medications in the future may be a possible therapeutic strategy to reduce the inflammation, especially in association with fluoxetine.
- Nuplazid (pimavanserin) / Acadia Pharma
[VIRTUAL] Impact of concomitant acetylcholinesterase inhibitor use on the pharmacokinetic profile of pimavanserin in patients with dementia-related psychosis: modeling data from the phase 3 HARMONY study () - Aug 2, 2021 - Abstract #AAIC2021AAIC_1875;
Differences in exposure measures (C max and AUC) between groups were negligible (<10%). These results suggest that concomitant AChEI use does not have a clinically relevant impact on the PK profile of pimavanserin.
- Kinaction (masitinib) / AB Science
Masitinib in mild to moderate Alzheimer’s disease: Results from study AB09004 (Convention Ctr - Four Seasons Ballroom 1) - Aug 2, 2021 - Abstract #AAIC2021AAIC_1821;
Eligible patients that had a clinical diagnosis of AD with baseline mini-mental state examination (MMSE) score ≥12–≤25, and had received a stable dose of cholinesterase inhibitor (donepezil, rivastigmine or galantamine) and/or memantine for ≥6 months, were treated for 24 weeks. Masitinib (4.5mg/kg/day), a tyrosine kinase inhibitor targeting mast cell and microglia activity, may provide a new treatment option for mild to moderate AD.
- donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
[VIRTUAL] Populacional epidemiological study of dementia in the city of Londrina - Paraná - Brazil () - Aug 2, 2021 - Abstract #AAIC2021AAIC_1441;
Masitinib (4.5mg/kg/day), a tyrosine kinase inhibitor targeting mast cell and microglia activity, may provide a new treatment option for mild to moderate AD. It has been concluded that additional studies are needed to prove the potential risk factors for dementias, so that an early approach and prevention of this disease can be invested in, improving care even more.
- donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
[VIRTUAL] Dementia care in diverse older adults in the Deep South and the rest of the US () - Aug 2, 2021 - Abstract #AAIC2021AAIC_1094;
ADRD specialist and drug utilization is relatively low in both DS and non-DS, with no significant R/E differences. Research should continue to examine factors that may drive medical care decisions of older adults with ADRD in US regions with different socio-economic and medical resource contexts.
- donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., memantine / Generic mfg.
[VIRTUAL] Care Processes Related to Clinical Detection of Alzheimer’s Disease in the US Veterans Affairs Healthcare System () - Aug 2, 2021 - Abstract #AAIC2021AAIC_947;
Prior to the first ICD coding, 53.1% received codes for non-specific dementia and 29.4% for mild cognitive impairment (MCI), with the first code appearing an average of 3 years before the first AD code. In the year before the first AD code, 51.1% visited specialists, 25.7% received neuropsychological assessments, 31.3% had brain imaging (but only 1.3% had a fluorodeoxyglucose-PET scan), 30.2% received prescriptions for dementia medication, 45.8% received community-based services, and 15.0% were admitted to institutional long-term care.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Brain-derived acetylcholine maintains peak bone mass in adult female mice. (Pubmed Central) - Jul 30, 2021
Increasing brain ACh levels through the use of the blood brain barrier (BBB)-permeable acetylcholinesterase inhibitor (AChEI) galantamine increased trabecular bone mass in adult female mice, whereas a peripheral increase in ACh levels induced by the BBB-impermeable AChEI pyridostigmine caused trabecular bone loss...Lastly, ChT heterozygosity and galantamine treatment triggered bone changes in female mice only, thus revealing the existence of a gender-specific skeletal response to brain ACh level. In conclusion, this study supports the stimulatory effect of central ACh on bone mass accrual, shows that it also promotes peak bone mass maintenance in adult mice, and suggests that central ACh regulates bone mass via different mechanisms in growing versus sexually mature mice.
- || galantamine hydrobromide / Generic mfg.
PK/PD data, Preclinical, Journal: Galantamine nanoparticles outperform oral galantamine in an Alzheimer's rat model: pharmacokinetics and pharmacodynamics. (Pubmed Central) - Jul 30, 2021
G-NP potentiated galantamine brain delivery and delayed its elimination. G-NP hold promising therapeutic potentials and brain targeting, outperforming conventional galantamine therapy.
- | donepezil / Generic mfg., galantamine hydrobromide / Generic mfg.
Journal: Biphenylalkoxyamine Derivatives-Histamine H Receptor Ligands with Butyrylcholinesterase Inhibitory Activity. (Pubmed Central) - Jul 30, 2021
Furthermore, in vivo studies using the Passive Avoidance Task showed that compound 19 (E153) effectively alleviated memory deficits caused by scopolamine. Taken together, these findings suggest that compound 19 can be a lead structure for developing new anti-AD agents.
- | galantamine hydrobromide / Generic mfg.
Journal: Co-Immobilized Capillary Enzyme Reactor Based on Beta-Secretase1 and Acetylcholinesterase: A Model for Dual-Ligand Screening. (Pubmed Central) - Jul 27, 2021
To validate the system, galantamine and a β-secretase inhibitor were employed as standard inhibitors, which confirmed that the developed screening assay was able to identify reference ligands and to provide quantitative parameters...The innovative huAChE+BACE1-ICER/MS dual enzymatic system reported herein proved to be a reliable tool to identify and to characterize hit ligands for AChE and BACE1 in an enzymatic competitive environment. This innovative system assay involved lower costs; measured the product from enzymatic hydrolysis directly by MS; enabled immediate recovery of the enzymatic activity; showed specificity, selectivity, and sensitivity; and mimicked the cellular process.
- || galantamine hydrobromide / Generic mfg.
Galantamine please. I hear it's the hipster choice. (Twitter) - Jul 26, 2021
- || donepezil / Generic mfg., galantamine hydrobromide / Generic mfg.
Review, Journal: The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. (Pubmed Central) - Jul 22, 2021
The purpose of this review is to provide an overview of what has been published over the last decade on the effectiveness of AChEIs in AD, analysing the most relevant issues under the clinical and methodological profiles and the consequent possible welfare effects for the whole world. Furthermore, novel drugs and possible therapeutic approaches are also discussed.
- galantamine hydrobromide / Generic mfg.
[VIRTUAL] DEXTRAN SODIUM SULPHATE-INDUCED GASTROINTESTINAL INJURY FURTHER AGGRAVATES THE IMPACT OF GALANTAMINE ON THE GASTRIC MYOELECTRIC ACTIVITY IN EXPERIMENTAL PIGS (Poster Exhibition) - Jul 20, 2021 - Abstract #UEGW2021UEGW_4127;
It can be a plausible explanation of galantamine-associated dyspepsia in humans. DSS caused further profound decrease of EGG power.
- galantamine hydrobromide / Generic mfg.
[VIRTUAL] DEXTRAN SODIUM SULPHATE-INDUCED GASTROINTESTINAL INJURY FURTHER AGGRAVATES THE IMPACT OF GALANTAMINE ON THE GASTRIC MYOELECTRIC ACTIVITY IN EXPERIMENTAL PIGS (Poster Exhibition) - Jul 20, 2021 - Abstract #UEGW2021UEGW_1947;
It can be a plausible explanation of galantamine-associated dyspepsia in humans. DSS caused further profound decrease of EGG power.
- galantamine hydrobromide / Generic mfg.
[VIRTUAL] DEXTRAN SODIUM SULPHATE-INDUCED GASTROINTESTINAL INJURY FURTHER AGGRAVATES THE IMPACT OF GALANTAMINE ON THE GASTRIC MYOELECTRIC ACTIVITY IN EXPERIMENTAL PIGS (Poster Exhibition) - Jul 20, 2021 - Abstract #UEGW2021UEGW_116;
It can be a plausible explanation of galantamine-associated dyspepsia in humans. DSS caused further profound decrease of EGG power.
- | galantamine hydrobromide / Generic mfg.
Journal: Profiles of Secondary Metabolites (Phenolic Acids, Carotenoids, Anthocyanins, and Galantamine) and Primary Metabolites (Carbohydrates, Amino Acids, and Organic Acids) during Flower Development in Lycoris radiata. (Pubmed Central) - Jul 15, 2021
Furthermore, quantitation data of the 51 hydrophilic compounds were subjected to partial least-squares discriminant analyses (PLS-DA) to assess significant differences in the metabolites of L. radiata flowers from stages 1 to 4. Therefore, this study will serve as the foundation for a biochemical approach to understand both primary and secondary metabolism in L. radiata flower development.
- | galantamine hydrobromide / Generic mfg.
Journal: Pharmacological influencing of cholinergic anti-inflammatory pathway in infectious diseases and inflammatory pathologies. (Pubmed Central) - Jul 14, 2021
This review is focused on cholinergic anti-inflammatory pathway regulation by drugs. Compounds that inhibit cholinesterases like huperzine, rivastigmine, galantamine and distinguishing between types of inhibitors and impact on cholinergic anti-inflammatory pathway is discussed and survey of actual literature is provided.
- | donepezil / Generic mfg., galantamine hydrobromide / Generic mfg.
Journal: Natural products and their derivatives as multifunctional ligands against Alzheimer's disease. (Pubmed Central) - Jul 11, 2021
Therefore, natural products and their derivatives with proven efficacy could be used in the management of the neurodegenerative disorders. This review focuses on the natural product based multitarget directed ligands like tacrine-coumarin, tacrine-huperzine A, harmine-isoxazoline, berberine-thiophenyl, galantamine-indole, pyridoxine-resveratrol, donepezil-curcumin and their mode of action.
- | galantamine hydrobromide / Generic mfg., propranolol / Generic mfg.
Preclinical, Journal: Identification of two arylimides as cholinesterase inhibitors and testing of propranolol addition on impaired rat memory. (Pubmed Central) - Jul 11, 2021
in vivo evaluation of memory performance enhancement was performed in an animal model of cognitive disturbance with each of these compounds and propranolol individually as well as each compound combined with propranolol. Memory improvement was observed in each case, but without a significant additive effect with the combinations.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Genistein and Galantamine Combinations Decrease β-Amyloid Peptide -Induced Genotoxicity and Cell Death in SH-SY5Y Cell Line: an In Vitro and In Silico Approach for Mimic of Alzheimer's Disease. (Pubmed Central) - Jul 11, 2021
In silico analysis, suggest that genistein modulates positively the expression of AChE, BChE, and NMDA. In this context, a combination of two or more drugs could inspire an attractive therapeutic strategy.
- |||| Clinical: And this: "We have been here before: the dementia drugs donepezil, galantamine, rivastigmine, and memantine were defunded in France in 2018 after over a decade of use because there was no evidence of clinically meaningful benefit" (Twitter) - Jul 10, 2021
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine by low-dose galantamine in rats. (Pubmed Central) - Jul 9, 2021
The results suggest that cognitive-enhancing effects of nicotine may be potentiated or uncovered by an extremely small dose of galantamine, well below its typical therapeutic range in humans. Furthermore, these findings provide a general proof-of-principle for a nAChR agonist and PAM combination strategy for cognitive enhancement.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect. (Pubmed Central) - Jul 8, 2021
Also, GSH level and SOD activity were significantly enhanced in CX-NP2 treated group compared to the control group. CX-NP2 did not induce a statistically significant oxidative stress or neuroinflammation in rat brains after 30-day treatment, they rather elicited neuroprotective potentials.HighlightsIntranasal GH/chitosan complex nanoparticles (CX-NP2) show promising potential as a brain targeting carrier.Compared to GH nasal solution, nasal CX-NP2 formulation did not exert oxidative stress nor neuroinflammation when administered for 30 days.
- | galantamine hydrobromide / Generic mfg.
Journal: Transcriptomic and Genetic Associations between Alzheimer's Disease, Parkinson's Disease, and Cancer. (Pubmed Central) - Jul 4, 2021
Significant genetic correlations were found between PD and melanoma and prostate cancers. Several drugs indicated for the treatment of neurodegenerative disorders and cancer, such as galantamine, selegiline, exemestane, and estradiol, were identified as potential modulators of the comorbidities observed between neurodegeneration and cancer.
- | galantamine hydrobromide / Generic mfg.
Journal: Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs. (Pubmed Central) - Jul 4, 2021
DSS caused further profound decrease of EGG power. That may indicate that underlying inflammatory, ischaemic or NSAIDs-induced condition of the intestine in humans can have aggravated the effect of galantamine on gastric myoelectric activity.
- | galantamine hydrobromide / Generic mfg.
Journal: The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ Oligomers in Primary Cortical Neurons. (Pubmed Central) - Jul 4, 2021
Interestingly, the monoterpene limonene showed a specific activity against acetylcholinesterase with an IC almost comparable to that of galantamine, used as positive control...This, in turn, prevented cell death in primary cortical neurons, showing an interesting neuroprotective profile against Aβ-induced toxicity. Collectively, the present results showed that the antioxidant properties of the main component of the genus Citrus, limonene, may be useful to prevent neuronal suffering induced by Aβ oligomers preventing the hyperactivity of K3.4.