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- || Retrospective data, Review, Journal: Effect of long-term pharmacological treatments on Alzheimer disease: A systematic review and network meta-analysis. (Pubmed Central) - Sep 23, 2024
In this network meta-analysis of studies of patients with AD and a follow-up period of at least 1 year, EGb 120?mg demonstrated cognitive benefits, while placebo posed the least harm for AD. More RCTs are required to address the uncertainty surrounding the efficacy of medication.
- | galantamine hydrobromide / Generic mfg.
Journal: Systems pharmacology-based drug discovery from Amaryllidaceae alkaloids and investigation of mechanisms of action in treatment of Alzheimer's disease. (Pubmed Central) - Sep 23, 2024
More RCTs are required to address the uncertainty surrounding the efficacy of medication. This study explained the mechanisms of Amaryllidaceae alkaloids in preventing and treating Alzheimer's disease and established a novel strategy to discover new drugs from biological chemical sources.
- | galantamine hydrobromide / Generic mfg.
Journal: Phytochemical analysis, evaluation of the antioxidant and anti alzheimer activities of Algerian Seseli Trotuosum. (Pubmed Central) - Sep 20, 2024
This study explained the mechanisms of Amaryllidaceae alkaloids in preventing and treating Alzheimer's disease and established a novel strategy to discover new drugs from biological chemical sources. Compared with galantamine, DCME had a significantly greater inhibitory effect on BChE (CI50 = 9.14
- | Aduhelm (aducanumab) / Neurimmune, Eisai, Leqembi (lecanemab-irmb) / Biogen, Eisai, Kisunla (donanemab-azbt) / Eli Lilly
Journal: Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective. (Pubmed Central) - Sep 20, 2024
Another medication that can temporarily alleviate dementia symptoms is memantine, which blocks the N-methyl-D-aspartate (NMDA) receptor...For some Alzheimer's pa-tients, the FDA-approved monoclonal antibody, aducanumab, is an option; for others, phase 3 clinical studies are underway for drugs, like lecanemab and donanemab, which have demonstrat-ed potential in eliminating amyloid protein. However, additional study is required to identify and address these limitations in order to reduce the likelihood of side effects and maximize the thera-peutic efficacy.
- | cyclopamine / University of Macau
Journal: A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes. (Pubmed Central) - Sep 15, 2024
A notable example is the >150 Amaryllidaceae alkaloids (AmAs), including galantamine, an FDA-approved treatment for Alzheimer's disease...A similar trend is found in the production of steroidal alkaloids (e.g., cyclopamine) in corn lily...Taken together, our work sheds light on the developmental and enzymatic logic of diverse alkaloid biosynthesis in daffodils. More broadly, it suggests a paradigm for biosynthesis regulation in monocot geophytes, where plants are protected from herbivory through active charging of newly formed cells with eukaryotic toxins that persist as above-ground tissue develops.
- | galantamine hydrobromide / Generic mfg.
Journal: Galantamine suppresses ?-synuclein aggregation by inducing autophagy via the activation of ?7 nicotinic acetylcholine receptors. (Pubmed Central) - Aug 24, 2024
In an in vivo synucleinopathy mouse model, the propagation of ?-syn aggregation in the cerebral cortex was inhibited by galantamine administration for 90 days. These results suggest that ?7-nAChR is expected to be a novel therapeutic target, and galantamine is a potential agent for synucleinopathies.
- | Aduhelm (aducanumab) / Neurimmune, Eisai, Leqembi (lecanemab-irmb) / Biogen, Eisai
Journal: Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders. (Pubmed Central) - Aug 23, 2024
deposition, tau phosphorylation, oxidative stress, and neuroinflammation. In the present article, we evaluate the therapeutic potential of different PDE5 inhibitors to outline their multifaceted impact in the NCDs.
- || Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Review, Journal: Mechanisms of mitophagy and oxidative stress in cerebral ischemia-reperfusion, vascular dementia, and Alzheimer's disease. (Pubmed Central) - Aug 22, 2024
Despite the availability of the U.S. Food and Drug Administration (FDA)-approved clinical first-line drugs for AD, including memantine, donepezil hydrochloride, and galantamine, these agents do not fundamentally block the pathological process of AD. In this paper, we undertake a review of the mechanisms of mitophagy and oxidative stress in neurological disorders, a summary of the clinical trials conducted in recent years, and a proposal for a new strategy for targeted treatment of neurological disorders based on both mitophagy and oxidative stress.
- | galantamine hydrobromide / Generic mfg.
Journal: Investigation of bio-active Amaryllidaceae alkaloidal small molecules as putative SARS-CoV-2 main protease and host TMPRSS2 inhibitors: interpretation by in-silico simulation study. (Pubmed Central) - Aug 17, 2024
All atomistic long range 100?ns MD simulation studies of each top ranked complex in triplicates also illustrated strong binding affinity of three compounds towards M and TMPRSS2. Identified compounds might be recommended as prospective anti-viral agents for future drug development selectively targeting the SARS-CoV-2 M or blocking host TMPRSS2 receptor, subjected to pre-clinical and clinical assessment for a better understanding of in-vitro molecular interaction and in-vivo validation.Communicated by Ramaswamy H. Sarma.
- | cefixime / Generic mfg., galantamine hydrobromide / Generic mfg.
Journal: Pharmacological evaluation and binding behavior of 4,4'-diamino-2,2'-stilbene disulfonic acid with metal ions using spectroscopic techniques. (Pubmed Central) - Aug 16, 2024
Identified compounds might be recommended as prospective anti-viral agents for future drug development selectively targeting the SARS-CoV-2 M or blocking host TMPRSS2 receptor, subjected to pre-clinical and clinical assessment for a better understanding of in-vitro molecular interaction and in-vivo validation.Communicated by Ramaswamy H. Sarma. The DSD were shown to be more effective than the conventional medication galantamine in inhibiting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with an IC50 value of 12.18 and 20.87
- | Kisunla (donanemab-azbt) / Eli Lilly
Journal: Donanemab (Kisunla) for Alzheimer's disease. (Pubmed Central) - Aug 13, 2024
The DSD were shown to be more effective than the conventional medication galantamine in inhibiting acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with an IC50 value of 12.18 and 20.87 No abstract available
- | galantamine hydrobromide / Generic mfg.
Journal: Benzyloxychalcone Hybrids as Prospective Acetylcholinesterase Inhibitors against Alzheimer's Disease: Rational Design, Synthesis, In Silico ADMET Prediction, QSAR, Molecular Docking, DFT, and Molecular Dynamic Simulation Studies. (Pubmed Central) - Aug 5, 2024
The synthesized compounds outperformed galantamine, which is used as a positive control against acetylcholinesterase...We used the molecular electrostatic surface potential (MESP) with high-quality data and visualization to find the most active site in these molecules. Reactivity descriptors, including the condensed Fukui function, chemical hardness (?), dual descriptors, chemical potential (?), and electrophilicity (?), were calculated for the chalcone derivatives.
- || galantamine hydrobromide / Generic mfg.
Review, Journal: Exploring the therapeutic potential of steroidal alkaloids in managing Alzheimer's disease. (Pubmed Central) - Jul 28, 2024
Some examples of alkaloid derivatives currently used to treat AD symptoms include galantamine, huperzine A, and other alkaloids...The purpose of this review article is to provide an overview of the mechanism, toxicity and neuroprotective benefits of steroidal alkaloids and to discuss future possibilities to improve the application of steroidal alkaloids as anti-AD agents. The therapeutic value and limitations of the steroidal alkaloid are investigated to provide new perspectives for future clinical development studies.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: O-demethyl galantamine alters protein expression in cerebellum of 5xFAD mice. (Pubmed Central) - Jul 26, 2024
Reregulation of these proteins through Ras signaling and retrograde endocannabinoid signaling pathways, which were found to be enriched, might contribute to reversing AD-induced molecular changes. We suggest that, since it targets specifically the cerebellum, ODG may be further evaluated for combination therapies for AD.
- || Qelbree (viloxazine) / Supernus Pharma, Knight Therap
Review, Journal: Current nonstimulant medications for adults with attention-deficit/hyperactivity disorder. (Pubmed Central) - Jul 26, 2024
While according to clinical guidelines, atomoxetine may serve as the only second-line option in adults with ADHD, several other nonstimulant compounds may be effectively used in order to personalize treatment based on comorbid conditions and ADHD features. Nevertheless, further research is needed to identify and test more personalized treatment strategies for adults with ADHD.
- | galantamine hydrobromide / Generic mfg.
Journal: Brain targeting efficacy of novel drug delivery system in the treatment of Alzheimer's disease. (Pubmed Central) - Jul 16, 2024
This study concludes that compared with the original drug solution, the nano drug delivery system has significant brain targeting for nasal administration, and intravenous injection also has brain targeting. In the olfactory bulb, olfactory tract, brain, and cerebellum, the brain targeting index at the olfactory bulb is the highest, and the targeting is the best.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Evaluating the Efficacy of Chronic Galantamine on Sustained Attention and Cholinergic Neurotransmission in A Pre-Clinical Model of Traumatic Brain Injury. (Pubmed Central) - Jul 12, 2024
In both experiments, there were no differences in cortical lesion volume across treatment groups (p's > 0.05). In summary, albeit the higher dose of GAL increased ACh release, it did not improve measures of sustained attention or histopathological markers, thereby partially supporting the hypothesis and providing the impetus for further investigations into alternative cholinergic pharmacotherapies such as nAChR positive allosteric modulators.
- | galantamine hydrobromide / Generic mfg., methadone / Generic mfg.
Journal: Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. (Pubmed Central) - Jul 5, 2024
As part of a larger randomized controlled trial, these participants were randomly assigned to receive (or not) computer-based training for cognitive behavioral therapy (CBT4CBT), and galantamine (or placebo)...These results extend previous findings regarding changes in caudate and cerebellar GMV as a function of cocaine use and provide the first evidence of a change in brain structure as a function of engagement in digital CBT for addiction. These data suggest a novel potential mechanism underlying how CBT4CBT and CBT more broadly may exert therapeutic effects on substance-use-related behaviors through brain regions implicated in semantic knowledge.
- | Journal: Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and Their Mitigation Using Theranostic Agents. (Pubmed Central) - Jul 2, 2024
We discuss various proteins associated with NDDs and their implications in NDD. In addition, we document
- | galantamine hydrobromide / Generic mfg.
Journal: Scalable drop-casting construction of light-addressable photoelectrochemical biosensor on laser-induced graphene electrode arrays for high-throughput drug screening. (Pubmed Central) - Jun 30, 2024
In addition, we document The resulting biosensor exhibits good sensitivity toward an AChE inhibitor, i.e., galantamine hydrobromide (GH), with a calibration range of 10-300
- || Cognex (tacrine) / Shionogi
Review, Journal: Innovative Therapeutic Strategies in Alzheimer's Disease: A Synergistic Approach to Neurodegenerative Disorders. (Pubmed Central) - Jun 27, 2024
This necessity has led to the incorporation advanced technologies like artificial intelligence and machine learning into the drug discovery process for neurodegenerative diseases. These technologies help identify therapeutic targets and optimize lead compounds, offering a more effective approach to addressing the challenges of AD and similar conditions.
- galantamine hydrobromide / Generic mfg.
Crocetin inhibits A? aggregation in vitro and reduces ROS production and A? mediate cellular toxicity in neuronal SHSY5Y cells (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_3858;
Our results show that crocetin was shown to inhibit aggregation of A?1-40 up to>60%.Compared to Galantamine. Overall, these findings suggest that Crocetin may be a promising candidate for the management of AD
- galantamine hydrobromide / Generic mfg.
Exploring the neuroprotective effects of fenchone against ICV-STZ-induced Sporadic Alzheimer's disease in rats: Investigating neuroinflammation, oxidative stress and mitochondrial dysfunction as potential mechanisms. (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_3830;
To assess the neuroprotective potential of fenchone (20, 40, and 80 mg/kg) and galantamine (2 mg/kg) were given orally in ICV-STZ-induced wistar rats for 21 days... This study demonstrates the neuroprotective effects of fenchone in the ICV-STZ rat model, alleviating oxidative stress, apoptotic damage, reversing mitochondrial dysfunction, acetylcholinesterase activity, and neuroinflammation in brain.
- donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
Cholinesterase inhibitors for patients with dementia: Patterns of prescribing and disparities in treatment (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_3130;
This study demonstrates the neuroprotective effects of fenchone in the ICV-STZ rat model, alleviating oxidative stress, apoptotic damage, reversing mitochondrial dysfunction, acetylcholinesterase activity, and neuroinflammation in brain. We analyzed electronic health record and claims data for patients diagnosed with AD, DLB, or VD between October 2015 and August 2022 from a large healthcare system in the U.S. Claims for ChEI prescriptions (donepezil, galantamine, rivastigmine) were identified in the
- galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Therapeutic potential of beta-carotene on intracisternal injection of glucose oxidase-induced senile dementia in diabetic rats (Virtual) - Jun 19, 2024 - Abstract #AAIC2024AAIC_2265;
Besides, only a few medications were approved for the symptomatic relief of SD i.e., donepezil, galantamine, rivastigmine, and memantine. The present results revealed that BC possesses the ameliorative potential against GOD-induced neurotoxicity and SD due to its anti-oxidative, anti-cholinesterase, reduction of IR, prevention of microglial activation, and enhancement of the glucose update actions.
- galantamine hydrobromide / Generic mfg., minocycline / Generic mfg.
Ethyl acetate fruit fraction of tetrapleura tetraptera modulates cholinergic anti-inflammatory pathways: an invivo and insilico study (Virtual) - Jun 19, 2024 - Abstract #AAIC2024AAIC_2230;
In the experimental study, I/R without treatment showed a significant increase in IL-6, AChE, and the number of activated microglia. However, a significant decrease in IL-6, AChE, and the number of reactive microglia was observed in I/R +EAFFTT (100 and 200 mg/kg), and I/R +MNC (50 mg/kg) -treated groups Conclusion : Tetrapleura tetraptera fruit phenolics docked well with IBA1, IL-6 and AChE, thereby modulating their expression, as EAFFTT is a potential neurotherapeutic agent against stroke-induced neuroinflammation
- galantamine hydrobromide / Generic mfg.
Assessment of the potential neuroprotective effect of PhKv toxin, isolated from Phoneutria nigriventer venom, in vesicular acetylcholine transporter-deficient mice (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_661;
Ongoing research explores the molecular aspects of PhKv's action on acetylcholinesterase. Our study suggests PhKv's therapeutic relevance in addressing cognitive deficits associated with acetylcholine dysregulation.
- | donepezil / Generic mfg.
Preclinical, Journal: Tailored Melatonin- and Donepezil-Based Hybrids Targeting Pathognomonic Changes in Alzheimer's Disease: An In Vitro and In Vivo Investigation. (Pubmed Central) - Jun 19, 2024
Donepezil (DNPZ) and/or galantamine (GAL) were used as reference drugs, aiming to establish any pharmacological superiority of the multifaceted approach in battling hallmark features of neurodegeneration. Our promising results give first insights into emerging disease-modifying strategies to combine multiple synergistic activities in a single molecule.
- | galantamine hydrobromide / Generic mfg., acarbose / Generic mfg.
Preclinical, Journal: Exploring beetroot (Beta vulgaris L.) for diabetes mellitus and Alzheimer's disease dual therapy: in vitro and computational studies. (Pubmed Central) - Jun 18, 2024
Our promising results give first insights into emerging disease-modifying strategies to combine multiple synergistic activities in a single molecule. Flavonoid-rich extracts of B. vulgaris fruit (IC50 = 73.062
- | galantamine hydrobromide / Generic mfg., acarbose / Generic mfg.
Journal: Valorization of various nut residues grown in Turkiye: Antioxidant, anticholinesterase, antidiabetic, and cytotoxic activities. (Pubmed Central) - Jun 14, 2024
Furthermore, the extracts may have the potential to induce cytotoxic effects, varying from moderate to mild, on both cancerous (IC50?=?454.55-617.28??g/mL) and healthy cells (IC50?=?438.60-490.20??g/mL). The results of this research showed that shell residues of nut hold promise for a variety of industrial applications spanning the food, pharmaceutical, and cosmetic sectors.
- || Aduhelm (aducanumab) / Neurimmune, Eisai, Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai, donanemab (LY3002813) / Eli Lilly
Review, Journal: Alzheimer's disease and its treatment-yesterday, today, and tomorrow. (Pubmed Central) - Jun 13, 2024
monoclonal antibodies (MABs), namely, aducanumab, lecanemab and donanemab...A comparison of the benefits and disadvantages of the different classes of drugs forms the basis for determining new directions for research and alternative drug targets that are undergoing pre-clinical and clinical assessments. In addition, we discuss and stress the importance of the treatment of the co-morbidities, including hypertension, diabetes, obesity and depression that are known to increase the risk of developing AD.
- | galantamine hydrobromide / Generic mfg.
Journal: Synthesis, computational docking and molecular dynamics studies of a new class of spiroquinoxalinopyrrolidine embedded chromanone hybrids as potent anti-cholinesterase agents. (Pubmed Central) - Jun 13, 2024
In addition, we discuss and stress the importance of the treatment of the co-morbidities, including hypertension, diabetes, obesity and depression that are known to increase the risk of developing AD. Although docking scores for the synthesized derivatives were higher than those of the standard drug, MD MMPBSA results showed better binding of synthesized derivatives (-93.5
- || Review, Journal: Emerging pharmacotherapy for the treatment of cannabis use disorder. (Pubmed Central) - Jun 7, 2024
Considering sample size, follow-up, and effect size, further studies using objective tools are necessary. The future of CUD treatment is promising.
- | Cognex (tacrine) / Shionogi
Journal: A computational approach to identify phytochemicals as potential inhibitor of acetylcholinesterase: Molecular docking, ADME profiling and molecular dynamics simulations. (Pubmed Central) - Jun 4, 2024
The investigation suggested 3 ligands as a potent inhibitor of AChE which are [3-(1-methylpiperidin-2-yl)phenyl] N,N-diethylcarbamate, 4-Amino-2-styrylquinoline and bisdemethoxycurcumin. Furthermore, investigation, including in-vitro and in-vivo studies, is needed to validate the efficacy, safety profiles, and therapeutic potential of these compounds for AD treatment.
- | donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: The involvement of neuroinflammation in an animal model of dementia and depression. (Pubmed Central) - Jun 3, 2024
In addition, fluoxetine + donepezil reversed the reduction of IL-10 levels in the hippocampus. The results indicate a pathophysiological interaction between AD and depression, and the association of medications in the future may be a possible therapeutic strategy to reduce inflammation, especially the fluoxetine-associated treatments.
- || galantamine hydrobromide / Generic mfg.
Review, Journal: Neuropsychopharmacological Induction of (Lucid) Dreams: A Narrative Review. (Pubmed Central) - May 25, 2024
However, the main limitation of this technique is the complexity of these neurotransmitter systems, which challenges interpreting results in a simple way. We conclude that, despite these promising substances, more research is necessary to find a reliable way to pharmacologically induce LD.
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal, FDG PET: Evaluation of the Therapeutical Effect of Matricaria Chamomilla Extract vs. Galantamine on Animal Model Memory and Behavior Using 18F-FDG PET/MRI. (Pubmed Central) - May 24, 2024
Behavioral assessments evidenced a less anxious status and a better locomotor activity manifested by the MCE-treated group compared to the Gal-treated group. These findings prove evident metabolic ameliorative qualities of MCE over Gal classic treatment, suggesting that the extract could be a potent neuropharmacological agent against amnesia.
- | galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
Journal: Trends of use and characterisation of anti-dementia drugs users: a large multinational-network population-based study. (Pubmed Central) - May 24, 2024
Treatment of dementia remains highly heterogeneous. Further consensus in the pharmacological management of patients living with dementia is urgently needed.
- | galantamine hydrobromide / Generic mfg.
Journal: Quest for antibacterial alkaloids from Rauhia multiflora through bioassay complementary-guided fractionation. (Pubmed Central) - May 20, 2024
The tentative structure of one of the galantamine-type skeletons is proposed here for the first time. Altogether, these results support the use of Rauhia genus to inhibit bacterial growth.
- | galantamine hydrobromide / Generic mfg.
Journal: Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. (Pubmed Central) - May 11, 2024
Altogether, these results support the use of Rauhia genus to inhibit bacterial growth. Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0
- | galantamine hydrobromide / Generic mfg.
Preclinical, Journal: Hypoglycemic, anti-inflammatory, and neuroprotective potentials of crude methanolic extract from Acacia nilotica L. - results of an in (Pubmed Central) - May 10, 2024
This inhibitory potential was lower as compared to the standard drug Galantamine that exhibited 82.43 and 89.50% inhibition at the same concentration, respectively...The percent inhibitory activity of 5-LOX and COX-2 ranged from 42.47% to 71.53% and 43.48% to 75.22%, respectively. Furthermore, in silico, in
- || galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
Review, Journal: Alkaloids as drug leads in Alzheimer's treatment: Mechanistic and therapeutic insights. (Pubmed Central) - May 9, 2024
A pharmaceutical option containing an alkaloid may potentially slow down the progression of AD while enhancing its symptoms. This review highlights the potential of alkaloids as valuable drug leads in treating AD, providing a comprehensive understanding of their mechanisms of action and therapeutic implications.
- | azasugar (AZ-3102) / Azafaros
Journal: Coumarin-azasugar-benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth. (Pubmed Central) - May 1, 2024
Nine of the compounds behaved as stronger BuChE inhibitors than galantamine, one of the few drugs in clinical use against Alzheimer's disease. The most potent BuChE inhibitor (IC50 = 74 nM) was found to exhibit dual activities, as it also showed high activity (GI50 = 5.6
- || Retrospective data, Review, Journal: Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review. (Pubmed Central) - Apr 23, 2024
ChEIs, memantine, and GV-971 all can slow the progression of AD but have different effects on respective assessments. Donepezil and GV-971 were relatively well tolerated.
- | donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
Retrospective data, Journal: Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer's Disease Initiating Cholinesterase Inhibitors. (Pubmed Central) - Apr 17, 2024
Several predisposing, enabling, and need factors were associated with the cumulative anticholinergic burden. The study findings suggest a critical need to minimize the cumulative anticholinergic burden to improve AD care.
- | donepezil / Generic mfg., galantamine hydrobromide / Generic mfg.
Journal: Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors. (Pubmed Central) - Mar 16, 2024
The study findings suggest a critical need to minimize the cumulative anticholinergic burden to improve AD care. Moreover, compound 7m had a higher inhibitory effect than galantamine and the effect was comparable to that of donepezil against both AChE (Ki
- | galantamine hydrobromide / Generic mfg.
Journal: Effect of high-frequency (5Hz) rTMS stimulating left DLPFC combined with galantamine on cognitive impairment after ischemic stroke and serum homocysteine and neuron-specific enolase. (Pubmed Central) - Mar 14, 2024
No randomized controlled trials of similar combination treatments have been reported. The better therapeutic effect may be related to the fact that galantamine combined with repetitive transcranial magnetism can activate the brain cholinergic system more extensively, promote brain neural remodeling through long-term potentiation and inhibit local neuroinflammatory responses in brain injury.
- Myrbetriq (mirabegron) / Astellas, Cognex (tacrine) / Shionogi
Long-term Dementia Risk with Use of Anticholinergic versus Beta-3-Agonist Pharmacotherapy for Overactive Bladder (302A) - Mar 12, 2024 - Abstract #AUA2024AUA_3326;
In men, ACM were not associated with a higher risk relative to BA. These findings may reflect differences in the disease processes presenting with OAB and dementia risk between men and women.
- Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai
Clinical and Humanistic Burden Associated with Alzheimer's Disease in the United States: An Analysis of Patient Characteristics, Treatment Patterns, and Quality of Life Using a Physician Notes Real-World Database () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_2274;
Analysis of this real-world database revealed that patients with AD are significantly impacted by their disease in terms of comorbidities, symptoms, and QoL burden, with QoL burdens that extend to their caregivers. Furthermore, these data suggest that AD diagnoses and treatment decisions may remain focused on clinical symptoms versus a biomarker-guided approach.
- Leqembi (lecanemab-irmb) / Biogen, BioArctic, Eisai
Estimate Broader Economic Impact of Lecanemab for Medicare Beneficiaries Alzheimer's Disease Patients: Budget Impact and Input-Output Models () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_2166;
Lecanemab, an AD treatment, minimally affects health plan budgets in the US. However, it holds substantial potential to impact the broader economy positively by improving employment, exports, and patient adherence through six annual doses.