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Journal: Active prophages in coral-associated Halomonas capable of lateral transduction. (Pubmed Central) - May 13, 2024 By studying the prophages in coral-associated Halomonas meridiana, we found that two prophages, Phm1 and Phm3, are inducible by the DNA-damaging agent mitomycin C and that Phm3 is spontaneously activated under normal cultivation conditions...Further analysis of the Tara Ocean dataset revealed that Phm3 represents a new group of temperate phages that are widely distributed and transcriptionally active in the ocean. Therefore, the combination of lateral transduction mediated by temperate phages and OMV transmission offers a versatile strategy for host-phage co-evolution in marine ecosystems.
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Review, Journal, Surgery: Pharmacological prevention of fibrosis in dacryosurgery (Pubmed Central) - May 13, 2024 Based on this, the development of pharmacological methods for the prevention of fibrosis in dacryology is promising, among which the antitumor antibiotic Mitomycin C is the most studied...This has prompted researchers to look for and study alternative anti-fibrotic agents, such as antitumor drugs, glucocorticoids, hyaluronic acid, small molecule, biological, immunological and genetically engineered drugs, as well as nanoparticles. This review presents the current data on the efficacy and prospects of the use of these drugs in dacryology.
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Journal: Risk Factors for Recurrence in the Treatment of Recurrent Pterygium. (Pubmed Central) - May 7, 2024 The preoperative length of corneal involvement and number of previous pterygium surgeries were significantly correlated with recurrence. Male sex and nonuse of mitomycin C tended to correlate with recurrence.
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Determine the Precursor Frequency of Direct Alloreactive CD8+ T Cells Against a Single Allo-MHC Allele (Poster Hall, Exhibit Hall A, Level 2) - May 6, 2024 - Abstract #ATC2024ATC_1348; CTV-labeled CD8+ T cells from a donor triple negative for these MHC alleles were then co-cultured with mitomycin C-treated KCo2, KA1, KA2, and KA3 cells respectively for five days... Our in vitro MLR system yielded an estimated precursor frequency for CD8+ T cells responding to a single allo-MHC allele, ranging from 0.2% to 0.8%, across both human and mouse models.
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Journal: The dynamics of colicin E9 release from Escherichia coli in native conditions. (Pubmed Central) - May 6, 2024 In this study, using a mitomycin C sensitivity assay along with a live dead staining method of detection, we showed that the native pColE9-J plasmid which unusually carries an extended Col operon (ColE9) containing two lysis genes, did not confer a rapid decline in the culture turbidity following induction with mitomycin C. Interestingly a subset of the cells suffered perturbation of their outer membrane which was not observed from single lysis mutant (?celE or ?celI) cells. This observed heterogeneity in the ColE9 release leading to differential outer membrane perforation may bring a competitive advantage to these cells in a mixed population.
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Journal: Cytogenetic findings in Polish patients with suspected Fanconi anemia. (Pubmed Central) - Apr 26, 2024 Our results confirmed that the MMC sensitivity test distinguishes between individuals affected by FA, those with possible somatic mosaicism, and patients with bone marrow failure for other reasons, who were classified as non-FA in the first diagnostic step. However, a definitive differential diagnosis requires follow-up mutation testing and chromosome breakage analysis of skin fibroblasts.
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Journal: Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB. (Pubmed Central) - Apr 25, 2024 We show that Leu113 aids in coordinating the 3' end of the DNA substrate, and that a basic loop is important for substrate binding. This work provides insight into the function of a recently discovered bacterial exonuclease important for the repair of MMC-induced DNA adducts.
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PROMISING POTENTIAL FOR MITHRAMYCIN A, A NOVEL EPIGENETIC ANTINEOPLASTIC AGENT, IN CYTOREDUCTIVE SURGERY FOR PERITONEAL COLORECTAL CANCER (Room 207B) - Apr 21, 2024 - Abstract #SSAT2024SSAT_403; MMA was also found to promote senescence by tumor remodeling with increased expression of p53 in treated cells. This warrants additional study to assess its potency for clinical application for local perfusion during cytoreductive surgery to improve not only cytotoxicity but also local recurrence by increased tumor suppressor genes.Figure 1: Cell-Viability Assay after 48 hours of Treatment, IC50 visible.Figure 2: Cancer colonies seen in untreated cell group, compared to colonies seen 6-days after treatment with Mithramycin A (1.5
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Journal: Isolation and characterization of novel Staphylococcus aureus bacteriophage Hesat from dairy origin. (Pubmed Central) - Apr 19, 2024 This warrants additional study to assess its potency for clinical application for local perfusion during cytoreductive surgery to improve not only cytotoxicity but also local recurrence by increased tumor suppressor genes. Interestingly, its induction was obtained by exposing the bacterium to milk, while the conventional mitomycin C-based approach failed...
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Journal: Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome. (Pubmed Central) - Apr 5, 2024 Phages were mainly isolated after mitomycin C-induction, which does not resemble a natural stressor for C. difficile...We also detected phage-mediated lateral transduction of bacterial DNA, which is the first described case in C. difficile. This study significantly contributes to our knowledge of prophage activity in C. difficile and reveals novel aspects of C. difficile (phage) biology.
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Retrospective data, Review, Journal: AVASCULAR OVERHANGING BLEB REDUCTION WITH MODIFIED SUTURELESS TECHNIQUE. (Pubmed Central) - Apr 2, 2024 Nine years before, our patient had trabeculectomy using mitomycin C. After the surgery, the intraocular pressure was correct, without progression in the visual field, but on slit-lamp examination, a large avascular overhanging bleb was noted...In conclusion, this less invasive technique preserves better bleb function without ripping the surrounding ischemic tissue. The procedure is safe and easy to perform, with less surgical time and fast recovery.
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Journal: Reassessing Trabeculectomy: A Long-Term Study with Stringent Success Criteria. (Pubmed Central) - Mar 28, 2024 Background: The aim was to evaluate the long-term outcome and efficacy of primary trabeculectomy with adjunctive mitomycin c (MMC) for treating glaucoma...However, surgical revisions and/or further glaucoma surgeries might still be needed. The long-term success rate is lower in comparison to previous research, which may be explained by the stricter success criteria in our study.
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Journal: Sub-MIC Antibiotics Modulate Productions of Outer Membrane Vesicles in Tigecycline-Resistant Escherichia coli. (Pubmed Central) - Mar 27, 2024 The long-term success rate is lower in comparison to previous research, which may be explained by the stricter success criteria in our study. The results showed that sub-inhibitory (1/2 MIC or 1/4 MIC) concentrations of gentamicin, meropenem, ceftazidime, chloramphenicol, tigecycline, ciprofloxacin, polymycin, rifaximin and mitomycin C could significantly increase the secretion of OMVs (0.713
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Journal: Anthracycline-based hepatic arterial infusion chemotherapy achieved 17 (Pubmed Central) - Mar 25, 2024 Overall, a combination of PpIX-PDT and prodrug with 635?nm laser is promising for non-muscle invasive bladder cancer treatment. A 46-year-old woman with estrogen receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer who had multiple LMs and bone metastases underwent seven lines of systemic therapy (paclitaxel/bevacizumab for 38
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Preclinical, Journal: Qingguang'an-induced autophagy in TFs inhibits scar formation: A follow-up in (Pubmed Central) - Mar 14, 2024 Combined trabeculectomy was performed in 100 rabbits diagnosed with glaucoma, which were assigned to five groups, including the no surgery, surgery only, mitomycin C (MMC; positive control), Qingguang'an (experimental) and PBS (negative control) groups...Abundant autophagosomes were captured under TEM in this condition. Qingguang'an granules can inhibit scar formation in rabbits after GFS and restrain IOP increase by inducing autophagy in TFs.
- |||||||||| mitomycin / Generic mfg., clonazepam / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Designing Molecularly Imprinted Polymer-Modified Boron-Doped Diamond Electrodes for Highly Selective Electrochemical Drug Sensors. (Pubmed Central) - Mar 12, 2024 In this study, we selected the anticancer drug doxorubicin (DOX) as the template molecule...Other drugs, i.e., mitomycin C or clonazepam (CZP), also underwent a reduction reaction at a similar potential to that of DOX, when using the unmodified BDD, which rendered the accurate quantification of DOX in a mixture challenging...Selective DOX measurement using the MIP-BDD was also possible in human plasma, and the respective limits of detection of DOX in PBS and human plasma were 32.10 and 16.61 nM. The MIP-BDD was durable for use in six repeated measurements, and MIP-BDD may be applicable as an electrochemical sensor for application in therapeutic drug monitoring.
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