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- || hydrochlorothiazide / Generic mfg.
Clinical, Journal: Combining Loop and Thiazide Diuretics (Pubmed Central) - Jun 27, 2024
P4
Adding HCTZ to intravenous furosemide seems to be effective strategy for improving diuretic response in AHF without treatment effect modification according to baseline LVEF. (Combining Loop with Thiazide Diuretics for Decompensated Heart
- | hydrochlorothiazide / Generic mfg.
Journal: Protective Role of Rosmarinic Acid in Experimental Urolithiasis: Understanding Its Impact on Renal Parameters. (Pubmed Central) - Jun 27, 2024
There was an increase in diuresis in the normotensive (NTRs) and hypertensive rats (SHRs) treated with hydrochlorothiazide (HCTZ) and exposed to EG/AC, while RA restored urine volume in NTRs...Docking analysis showed that RA exhibited good binding affinity with matrix metalloproteinase-9, phosphoethanolamine cytidylyltransferase, and human glycolate oxidase enzymes. The data disclosed herein underscore the importance of further research to understand the underlying mechanisms better and validate the potential of RA for clinical use.
- | hydrochlorothiazide / Generic mfg.
Journal: Thiazide diuretics in chronic kidney disease: Is there still a role? (Pubmed Central) - Jun 26, 2024
The data disclosed herein underscore the importance of further research to understand the underlying mechanisms better and validate the potential of RA for clinical use. No abstract available
- Busting Craniotomy Myths and Dogmas: Analgesia and Hyperosmolar Agents (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3155;
No abstract available The patient
- Busting Craniotomy Myths and Dogmas: Analgesia and Hyperosmolar Agents (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2223;
The patient The patient
- hydrochlorothiazide / Generic mfg., warfarin / Generic mfg.
Acute Pulmonary Embolism: Responding to Complexity (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2131;
Thepatient has a history of hypertension that was well controlled on hydrochlorothiazide and smoking (pack year index: 20). Five years ago, the patient underwent a left total hip arthroplasty complicated by the development of a deep vein thrombosis for which he received a 6-months course of warfarin.The patient
- hydrochlorothiazide / Generic mfg., warfarin / Generic mfg.
Acute Pulmonary Embolism: Responding to Complexity (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_116;
Thepatient has a history of hypertension that was well controlled on hydrochlorothiazide and smoking (pack year index: 20). Five years ago, the patient underwent a left total hip arthroplasty complicated by the development of a deep vein thrombosis for which he received a 6-months course of warfarin.The patient
- | Tryvio (aprocitentan) / J&J
Journal: Aprocitentan (Tryvio) for hypertension. (Pubmed Central) - Jun 21, 2024
Five years ago, the patient underwent a left total hip arthroplasty complicated by the development of a deep vein thrombosis for which he received a 6-months course of warfarin.The patient No abstract available
- | Journal: Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs. (Pubmed Central) - Jun 19, 2024
Seven RSGs (TCF7L2, SLC27A4, PCSK5, NOL6, CHCHD4, EIF3B, and SCO1) may be associated with the ORS gene signatures in osteosarcoma. Repaglinide, tacrolimus, sirolimus, cyclosporine, hydrochlorothiazide and the small molecule VU-0365117-1 are potential therapeutic drugs for osteosarcoma.
- chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
Which One: Chlorthalidone vs. Hydrochlorothiazide? (Room 6D/E, Convention Center) - Jun 19, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_122;
- Henletor (torsemide) / Orchid
What's New in Diuretics? (Room 6D/E, Convention Center) - Jun 19, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_118;
Particular emphasis is given to the potential benefits of acetazolamide and hypertonic saline, as well as the relative benefits of chlorthalidone vs. hydrochlorothiazide and torsemide vs. furosemide. Learning Objective(s):
- | hydrochlorothiazide / Generic mfg., nifedipine immediate release / Generic mfg., labetalol / Generic mfg.
Journal: Chronic Hypertension During Pregnancy: Prevalence and Treatment in the United States, 2008-2021. (Pubmed Central) - Jun 17, 2024
Labetalol replaced methyldopa as the most commonly used antihypertensive during pregnancy. However, only about 60% of individuals with chronic hypertension in pregnancy were treated with antihypertensive medications.
- | hydrochlorothiazide / Generic mfg.
Preclinical, Journal, IO biomarker: Effects of acupuncture on fecal short-chain fatty acids and TLR4/MyD88/NF-?B signaling pathway in spontaneously hypertensive rats (Pubmed Central) - Jun 13, 2024
Acupuncture at bilateral "Renying" (ST 9) and "Zusanli" (ST 36) can effectively play an anti-hypertensive role in SHR. Its mechanism may be related to regulating fecal SCFAs level and inhibiting the TLR4/MyD88/NF-?B signaling pathway.
- | Journal: Comparison of Permitted Daily Exposure (PDE) Values for Active Pharmaceutical Ingredients (APIs) - Evidence of Robust Approach. (Pubmed Central) - Jun 10, 2024
We conclude that the investigated PDE methods and calculations are robust and scientifically defensible. Additionally, we provide further recommendations to harmonise PDE calculation approaches across the pharmaceutical industry.
- | Journal: Resolution of overlapping spectra using chemometric manipulations of UV-spectrophotometric data for the determination of Atenolol, Losartan, and Hydrochlorothiazide in pharmaceutical dosage form. (Pubmed Central) - Jun 9, 2024
The proposed methods were simple, accurate, precise and were applied efficiently for the quantitation of the three components in laboratory-prepared mixtures, and in dosage form showing good recovery values. In addition, the obtained results were compared statistically with each other using ANOVA test showing non-significant difference between them.
- | Ruiqin (henagliflozin) / Jiangsu Hengrui Pharma
Journal: Evaluation of Drug-Drug Interaction Between Henagliflozin and Hydrochlorothiazide in Healthy Chinese Volunteers. (Pubmed Central) - Jun 3, 2024
P1
Given these results, coadministration of HCTZ should not require any adaptation of henagliflozin dosing. ClinicalTrials.gov NCT06083116.
- ||| Prolia (denosumab) / Amgen
Journal, Adverse events: Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database. (Pubmed Central) - Jun 2, 2024
For hydrochlorothiazide, hyphosphatemia was often moderate, associated with other electrolytic disturbances and occurred during a long-term treatment. Awareness of healthcare professionals is essential to detect as soon as possible hypophosphatemia and its complications related to these drugs.
- | furosemide / Generic mfg., amiloride hydrochloride / Generic mfg.
Journal: Amiloride versus furosemide for the treatment of edema in patients with nephrotic syndrome: A pilot study (AMILOR). (Pubmed Central) - Jun 1, 2024
P3
The AMILOR study is the first randomized controlled pilot study suggesting a similar antiedematous effect as furosemide. Further studies are required to better define the role of amiloride in NS (EudraCT 2019-002607-18).
- | hydrochlorothiazide / Generic mfg.
Journal: Sympathetic overactivity and nocturnal diuresis in obstructive sleep apnea alter the response to hypertension therapy. (Pubmed Central) - Jun 1, 2024
P4
Drugs that block sympathetic nerve function are not among the 4 most commonly recommended classes of antihypertensives but diuretics are. Sympatholytic therapy was superior to diuretic treatment for hypertension associated with sleep apnea.
- | hydrochlorothiazide / Generic mfg.
Journal: The association between hydrochlorothiazide use and non-melanoma skin cancer in kidney transplant recipients. (Pubmed Central) - May 30, 2024
However, no significant association was observed between HCTZ exposure and squamous cell carcinoma. These findings suggest a benefit of increased frequency of dermatologist inspection in kidney transplant recipients receiving HCTZ especially in increased ultraviolet exposure area.
- | chlorthalidone / Generic mfg., indapamide / Generic mfg., hydrochlorothiazide / Generic mfg.
Journal: Thiazide Diuretic Utilization Within the VA. (Pubmed Central) - May 30, 2024
However, there was a significant trend toward increased chlorthalidone prescribing from 2016 to 2021. Application of these data may guide further research to increase guideline-recommended therapy.
- | Bystolic (nebivolol) / Menarini, AbbVie
Biomarker, Journal: (NDMA) METFORMIN AND (NTTP) SITAGLIPTIN INDUCED CUTANEOUS MELANOMAS: LINKS TO NITROSOGENESIS, NITROSO-PHOTOCARCINOGENESIS, ONCOPHARMACOGENESIS AND THE METABOLIC REPROGRAMMING. (Pubmed Central) - May 29, 2024
Similarly to cutaneous melanomas occurring (and published in the scientific literature) after combined intake (or monomedication) of/ between ranitidine, valsartan, olmesartan, candesartan, telmisartan, irbesartan, losartan, enalapril, lisinopril, perindopril, hydrochlorothiazide, nifedipine, amlodipine, propafenone, bisoprolol, nebivolol, melitracen and a number of others, we inform about another rare but not unexpected clinical observation: occurrence of cutaneous melanomas after taking another class of drugs- oral antidiabetic ones...The data shared in patients one and two in the presented scientific work are confirmatory in relation to the potential pathogenetic action of nitrosamine contaminated drugs such as 1) bisoprolol/ nebivolol/ candesartan/ hydrochlorothiazide and amlodipine, as well as 2) furosemide in the direction of cutaneous melanoma...Apart from the "cancer-generating benefit", of course, which is already widely known. And let us not forget that: "A lie stops being a lie and becomes a truth the moment it is officially refuted".
- | CoAprovel (irbesartan hydrochlorothiazide) / Sanofi, Prezista (darunavir) / J&J
Journal: Comparing the adsorption of micropollutants on activated carbon from anaerobically stored, organics-depleted, and nitrified urine. (Pubmed Central) - May 27, 2024
In addition, we showed that the relative pharmaceutical removal in all solutions was independent of the initial pharmaceutical concentration unless the background organics matrix changed considerably. We conclude that removal of micropollutants in GAC columns from organics-depleted urine can be performed without clogging, but with the drawback of a higher carbon usage compared to removal from nitrified urine.
- | hydrochlorothiazide / Generic mfg.
Journal: A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion - Simulating Powder Dissolution. (Pubmed Central) - May 23, 2024
Moreover, the study indicated that not all surfaces on a drug particle contribute to dissolution. Therefore, relying on the experimentally-determined specific surface area for predicting drug dissolution is not advisable.
- | Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Preclinical, Journal: Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rats. (Pubmed Central) - May 23, 2024
These findings suggest that NCC upregulation counteracts EMPA-mediated inhibition of PT NHE3 in male normotensive rats, maintaining their baseline BP. Moreover, the reduction of NHE3 activity without further upregulation of major apical sodium transporters beyond the PT may contribute to the BP-lowering effect of SGLT2i in experimental models and patients with hypertension.
- | metformin / Generic mfg., hydrochlorothiazide / Generic mfg.
Preclinical, Journal: Defective natriuresis contributes to hyperkalemia in db/db mice during potassium supplementation. (Pubmed Central) - May 23, 2024
Moreover, the reduction of NHE3 activity without further upregulation of major apical sodium transporters beyond the PT may contribute to the BP-lowering effect of SGLT2i in experimental models and patients with hypertension. Collectively, the impaired K+-induced natriuresis in diabetic mice under high-K+ intake may be primarily attributed to impaired NCC-mediated renal K+ excretion, despite the role of NHE3.
- | torkinib (PP242) / Takeda, UCSF Medical Center
Preclinical, Journal: Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity. (Pubmed Central) - May 23, 2024
Evidence also indicated that PP242 also prevents the loss of K+ associated with the inhibition of NCC. These findings suggest that PP242 may represent an improved therapeutic approach for antihypertensive intervention, potentially controlling blood pressure and mitigating kidney injury in salt-sensitive human subjects.
- | chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
Enrollment change: DCP: Diuretic Comparison Project (clinicaltrials.gov) - May 22, 2024
P3, N=20723, Completed, Sponsor: VA Office of Research and Development
These findings suggest that PP242 may represent an improved therapeutic approach for antihypertensive intervention, potentially controlling blood pressure and mitigating kidney injury in salt-sensitive human subjects. N=13523 --> 20723
- ||| hydrochlorothiazide / Generic mfg.
Trial completion date: An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ (clinicaltrials.gov) - May 22, 2024
P=N/A, N=20000, Recruiting, Sponsor: Boryung Pharmaceutical Co., Ltd
N=13523 --> 20723 Trial completion date: Oct 2026 --> Jun 2026
- || Review, Journal: Drugs for hypertension. (Pubmed Central) - May 21, 2024
Trial completion date: Oct 2026 --> Jun 2026 No abstract available
- | hydrochlorothiazide / Generic mfg., captopril / Generic mfg.
Journal: Differing contributions of the gut microbiota to the blood pressure lowering effects induced by first-line antihypertensive drugs. (Pubmed Central) - May 21, 2024
No abstract available First-line antihypertensive drugs induced different modifications of gut integrity and gut dysbiosis in SHR, which result in no contribution of microbiota in the BP lowering effects of hydrochlorothiazide, whereas the vasculo-protective effect induced by amlodipine involves gut microbiota reshaping and gut-immune system communication.
- | Veltassa (patiromer) / CSL Behring, Jesduvroq (daprodustat) / GSK, Kyowa Kirin, Kerendia (finerenone) / Bayer
Journal: Nephrology: What You May Have Missed in 2023. (Pubmed Central) - May 20, 2024
Another study found that once-daily hydrochlorothiazide did not prevent kidney stone recurrence. Finally, an antibiotic stewardship intervention safely reduced antibiotic prescribing for suspected urinary tract infection in frail older adults.
- rivaroxaban / Generic mfg., amiodarone / Generic mfg.
Drug-drug interaction in a patient with concomitant use of strong CYP3A4 and P-gp inhibitor amiodarone and direct oral anticoagulant rivaroxaban (Exhibition Hall) - May 17, 2024 - Abstract #ISTH2024ISTH_829;
CT angiography has not shown signs of AV malformation or aneurism. Laboratory diagnostics has revealed rivaroxaban concentration of 928 ng/mL (peak therapeutic range 184-383 ng/mL).
- || chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
Clinical, Journal: Chlorthalidone vs Hydrochlorothiazide for Hypertension Treatment After Myocardial Infarction or Stroke: A Secondary Analysis of a Randomized Clinical Trial. (Pubmed Central) - May 15, 2024
P3
Results of this secondary analysis of the DCP trial suggest that CTD may be associated with reduced major adverse CV events and noncancer deaths in patients with prior MI or stroke compared with HCTZ. ClinicalTrials.gov Identifier: NCT02185417.
- | hydrochlorothiazide / Generic mfg.
Journal: A randomized, placebo-controlled, trial to assess the photosensitizing, phototoxic and carcinogenic potential of hydrochlorothiazide in healthy volunteers. (Pubmed Central) - May 8, 2024
P1
HCT did not increase photosensitivity for UVA or UVB in healthy volunteers compared with placebo, and was not associated with phototoxic or carcinogenic reactions. In vitro, HCT was also not associated with phototoxicity or carcinogenesis (NCT04654312).
- || chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
Clinical, Journal: Chlorthalidone vs Hydrochlorothiazide for Hypertension-CV Events: Did the Design Influence the Outcome? (Pubmed Central) - May 8, 2024
Chlorthalidone vs Hydrochlorothiazide for Hypertension-CV Events: Did the Design Influence the Outcome? J Assoc Physicians India 2023;71(10):93-93.
- | hydrochlorothiazide / Generic mfg.
Journal: Novel Leptin-Cardiac TRH pathway responsible for the cardiac alterations in the Hyperleptinemic obesity. (Pubmed Central) - Apr 28, 2024
J Assoc Physicians India 2023;71(10):93-93. As pressure could explain these results, we treated obese mice with diuretic (hydrochlorothiazide 20
- || acetazolamide / Generic mfg., hydrochlorothiazide / Generic mfg.
Review, Journal: Acetazolamide and Hydrochlorothiazide in Patients With Acute Decompensated Heart Failure: Insights From Recent Trials. (Pubmed Central) - Apr 22, 2024
27 mmol/L) and those with good renal function (GFR > 50). Conversely, though the upfront use of thiazide diuretic added to intravenous furosemide improved diuretic response in acute decompensated heart failure, it causes an increased risk of worsening renal function and lack of clear evidence of reducing hospital length of stay.
- | hydrochlorothiazide / Generic mfg.
Journal: Combined eutexia and amorphization for simultaneous enhancement of dissolution rate of triamterene and hydrochlorothiazide: Preparation of orodispersible tablets. (Pubmed Central) - Apr 22, 2024
Compression of the optimum formulation into ODT underwent fast disintegration and liberated acceptable amounts of both drugs. The study introduced simple co-processing with traditional excipients for development of ODT of triamterene and hydrochlorothiazide.
- | hydrochlorothiazide / Generic mfg., bisoprolol / Generic mfg.
Biomarker, Journal: DRUG RELATED NITROSOGENESIS, PHOTOCARCINOGENESIS AND ONCOPHARMACOGENESIS OF NODULAR MELANOMA: A CASE RELATED ANALYSIS CONCERNING THE POLYCONTAMINATION OF THE POLYMEDICATION WITH VALSARTAN/HYDROCHLOROTHIAZIDE AND BISOPROLOL. (Pubmed Central) - Apr 17, 2024
Nitrosogenesis' of Cancer as concept in the medical literature has been known for decades, but in relation to other forms of human cancer. Exogenously mediated drug-mediated nitrosogenesis is a logically conditioned and newly defined concept whose significance with respect to the clinical manifestation of skin cancer is only beginning to grow.
- | hydrochlorothiazide / Generic mfg.
Preclinical, Journal: Potential medical impact of unrecognized in (Pubmed Central) - Apr 15, 2024
We demonstrate the medical importance of detecting hemolysis for patients who have pseudoeukalemia. This is relevant because the HI cannot be obtained when electrolytes are tested using whole blood samples, and a normal potassium may lead to inappropriate patient management.
- | hydrochlorothiazide / Generic mfg.
Journal: Thiazides for kidney stone recurrence prevention. (Pubmed Central) - Apr 12, 2024
Given the limited efficacy and possible adverse effects, we advocate for a restrictive use of thiazides for kidney stone recurrence prevention. Clearly, there remains a high unmet medical need for effective, targeted therapies to prevent recurrence of kidney stones.
- | hydrochlorothiazide / Generic mfg.
Journal: Revolutionizing Three-Dimensional Printing: Enhancing Quality Assurance and Point-of-Care Integration through Instrumentation. (Pubmed Central) - Mar 28, 2024
Four formulations using hydrochlorothiazide as the active pharmaceutical ingredient and several excipients were used...In addition, due to the incorporation of a sensor, it was possible to conclude, for the first time, that there is a link between changes in essential printing parameters like printing speed or formulations and variations in printing pressure and printlet quality attributes such as the energy require to obtain a single dosage unit, weight or diameter. This breakthrough holds a lot of potential for assuring the quality of 3D printing dosage forms and paving the way for their future incorporation into point-of-care settings.
- | valsartan / Generic mfg.
Preclinical, Journal: In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug. (Pubmed Central) - Mar 28, 2024
This breakthrough holds a lot of potential for assuring the quality of 3D printing dosage forms and paving the way for their future incorporation into point-of-care settings. The purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products with hydrochlorothiazide (HCTZ, BCS class III) (Co-Diovan
- Atypical hypokalemic periodic paralysis secondary to Conn syndrome () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_817;
Atypical features include hyperreflexia and asymmetric weakness. Symptom improvement after K repletion is the key feature.
- hydrochlorothiazide / Generic mfg., desmopressin / Generic mfg.
A Tale of Two Sodiums: Concurrent Primary Polydipsia and Nephrogenic Diabetes Insipidus () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_566;
This normally leads to hypernatremia. However, given enough free water intake, such as the amounts that can be seen in PP, the kidney's ability to excrete water can be overwhelmed, leading to an excess of free water and hyponatremia.
- hydrochlorothiazide / Generic mfg.
Effect of oral phosphorus on hyperabsorptive hypercalciuria in a heterozygous SLC34A3 carrier: A Case Report () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_490;
In our case, there was an improvement in both calcitriol levels and hypercalciuria despite the absence of hypophosphatemia. Further research is needed to define the role of phosphorus supplementation in SLC34A3 heterozygotes with hyperabsorptive hypercalciuria.
- | hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
Journal: A Comprehensive Strategy for Stepwise Design of a Lab PROTOTYPE for the Removal of Emerging Contaminants in Water Using Cyclodextrin Polymers as Adsorbent Material. (Pubmed Central) - Mar 17, 2024
The maximum monolayer adsorption capacity (qmax) obtained by the Langmuir isotherm revealed a saturation of the ?-CDs-EPI polymer surface 1.45 times higher for furosemide (qmax = 1.282 mg/g) than hydrochlorothiazide (qmax = 0.844 mg/g). Based on these results, the sizing design and building of a lab-scale model were carried out, which in turn will be used later to evaluate its performance working in continuous flow in a real scenario.
- | hydrochlorothiazide / Generic mfg.
Journal: Hydrochlorothiazide and increased risk of atypical fibroxanthoma and pleomorphic dermal sarcoma. (Pubmed Central) - Mar 14, 2024
This result suggests that HCTZ may be a risk factor for AFX/PDS. Additionally, diabetes mellitus or its comorbidities may be associated with an increased risk for AFX/PDS.
- hydrochlorothiazide / Generic mfg.
Determination of photocatalytic degradation rate of hydrochlorothiazide | Poster Board #413 (In-person; Poster Board #413; Hall C (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_5254;
The control sample did not degrade at all in the same time period, indicating that the UV light was responsible for degradation of the drug. A rate constant is being determined and research continues to determine both the toxicity of the degraded solution, and possible degradants.