| hydrochlorothiazide / Generic mfg. |
ChiCTR-OCH-12002710: Pharmacogenetics study of hydrochlorothiazide and felodipine in Chinese hypertensive patients |
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| Completed | 4 | 1325 | | Hydrochlorothiazide ;Hydrochlorothiazide+Felodipine | Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, 863 project | Hypertension | | | | |
2008-000804-10: Valsartan 160 mg and hydrochlorothiazide 25 mg in subject suffering from arterial hypertension stage 1 or high normal with organ damage |
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| Ongoing | 4 | 20 | Europe | CORIXIL, CORIXIL | UNIVERSITA, DEGLI STUDI DI NAPOLI FEDERICO II | Arterial Hypertension with organ damage | | | | |
2008-005006-39: Study on the vascular effects of ACE-I + CA-antagonist (Enalapril + Lercanidipine) versus ACE-I + diuretic (Enalapril + hydrochlorothiazidE) combinations in hypertensive patients with metabolic syndrome not sufficiently controlled by ACE-I monotherapy |
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| Ongoing | 4 | 200 | Europe | Tablet | AZIENDA OSPEDALIERA PISANA | hypertensive patients of either sex aged 40-69 years | | | | |
2009-017464-17: Arterial Hypertension in patients with elevated aldosterone to renin ratio but negative confirmatory test for Primary Aldosteronism: comparison between anti-hypertensive efficacy of potassium canrenoate and hydrochlorothiazide |
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| Ongoing | 4 | 50 | Europe | Coated tablet, Tablet | AZIENDA OSPEDALIERA ISTITUTI OSPITALIERI DI VERONA | Arterial hypertension associated with elevated ARR | | | | |
2010-022232-37: Effects of a combination treatment with lercanidipine + enalapril vs. lercanidipine + hydrochlorothiazide on blood pressure and endothelial function in essential hypertensive patients |
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| Ongoing | 4 | 24 | Europe | Tablet | AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA | primary hypertension | | | | |
| Not yet recruiting | 4 | 100 | | felodipine 5mg; hydrochlorothiazide 25mg | Institute of Clinical Pharmacology, Central South University; Level of the institution：, Self-financing | Hypertension | | | | |
2017-002175-25: Effects on blood pressure and central sympathetic nerve traffic by SGLT2-inhibition with empagliflozin compared to hydrochlorothiazide in patients with type 2 diabetes mellitus |
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| Ongoing | 4 | 60 | Europe | Film-coated tablet, Tablet, Jardiance®, HCT-ratiopharm® 25 mg Tabletten | Profil Institut für Stoffwechselforschung GmbH, Boehringer Ingelheim Pharma GmbH & Co. KG | type 2 diabetes mellitus, type 2 diabetes mellitus, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
ChiCTR-IPR-17012046: First-Line Antihypertensive comparison for Tibetan mild-moderate hypertension (FLAT): study protocol for a randomized crossover controlled trial |
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| Not yet recruiting | 4 | 1593 | | omelsartan ;amlodipine ;hydrochlorothiazide | West China hospital, Sichuan university; West China hospital, Sichuan university, Funds from Science and technology department of Sichuan province | Hypertension | | | | |
ChiCTR-IPR-17013419: A randomized controlled trial of primary hypertension treated by diuretics combined with ARB compared to with CCB |
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| Not yet recruiting | 4 | 100 | | Erbesartan 150mg+ hydrochlorothiazide 12.5mg ;lercanidipine 10mg+ hydrochlorothiazide 12.5mg | Second Affiliated Hospital of Chongqing Medical University; Second Affiliated Hospital of Chongqing Medical University, Chongqing science and technology commission fund | primary hypertention | | | | |
ChiCTR-IPR-17013413: Research on chronic disease management by internet and application of diuretics in people with hypertension |
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| Not yet recruiting | 4 | 3750 | | hydrochlorothiazide ;Join hypertensive WeChat platform ;Join hypertensive WeChat platform | Second Affiliated Hospital of Chongqing Medical University; Second Affiliated Hospital of Chongqing Medical University, Chongqing science and technology commission fund | primary hypertention | | | | |
| Recruiting | 4 | 300 | Europe | Furosemide, Hydrochlorothiazide | University Hospital, Clermont-Ferrand, University Hospital, Grenoble, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, CH Puy en Velay, CH Moulins-Yzeure, CH Riom, Infirmerie Protestante de Lyon, CH Issoire, CH Annecy Genevois | Heart Failure, Acute Heart Failure, Chronic Heart Failure | 12/21 | 12/21 | | |
ChiCTR-IPR-17012048: First-line Antihypertensive Combinations comparison for Tibetan high-risk hypertension |
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| Not yet recruiting | 4 | 3417 | | omelsartan+amlodipine ;omelsartan+hydrochlorothiazide ;amlodipine+hydrochlorothiazide | Cardiovascular department of West China hospital; West China Hospital, Sichuan University, Funds from science and technology department of Sichuan province | Hypertension | | | | |
ACE, NCT05049616: Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension |
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| Active, not recruiting | 4 | 70 | US | ACE Inhibitors and Diuretics, NIFEdipine ER | The University of Texas Health Science Center, Houston | Hypertension in Pregnancy, Postpartum Preeclampsia | 06/22 | 10/23 | | |
ATLAS, NCT03109795: Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System |
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| Terminated | 4 | 30 | US | Clonidine Pill, Hydrochlorothiazide | University of Iowa | Anxiety, Hypertension | 06/23 | 06/23 | | |
ChiCTR2300067920: The efficacy of Chinese traditional single pill containing quadruple combination of blood pressure medicines versus valsartan/hydrochlorothiazide in patients with hypertension: a multicenter, open-label, non-inferiority, randomized controlled study |
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| Not yet recruiting | 4 | 1332 | | take compound reserpine and triamterene tablets ;take valsartan/hydrochlorothiazide | West China Hospital of Sichuan University; Huarun Shuanghe Limin Pharmaceutical (Ji'nan) Co., Ltd., Huarun Shuanghe Limin Pharmaceutical (Ji'nan) Co., Ltd. | Hypertension | | | | |
| Recruiting | 4 | 46 | US | Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide) | VA Office of Research and Development | Chronic Kidney Disease, Hypertension | 07/25 | 07/25 | | |
NCT05443932: Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients |
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| Not yet recruiting | 4 | 32 | Europe | Dapagliflozin, Hydrochlorothiazide | Medical University of Vienna | Urolithiasis, Hyperoxaluria | 12/24 | 12/25 | | |
| Completed | 3 | 416 | Europe | Placebo oral capsule, 12.5 mg hydrochlorothiazide, 25.0 mg hydrochlorothiazide, 50.0 mg hydrochlorothiazide | Insel Gruppe AG, University Hospital Bern | Nephrolithiasis | 12/21 | 04/22 | | |
NCT03298802: Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide |
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| Recruiting | 3 | 612 | US | Hydrochlorothiazide 50mg Tablet, HydroDIURIL, Microzide, Esidrix, Oretic, Placebo Tablet, sugar pill | The University of Texas Medical Branch, Galveston | Pre-Eclampsia, Gestational Hypertension, Superimposed Pre-Eclampsia, Hypertension, Pregnancy-Induced, Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia | 08/24 | 08/24 | | |
OPTION TREAT, NCT05920005: Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension |
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| Recruiting | 3 | 698 | RoW | candesartan cilexetil + chlorthalidone + amlodipine, Exforge HCT® (valsartan 160mg + hydrochlorothiazide 12.5mg + amlodipine 5mg) | Hospital Israelita Albert Einstein, Libbs Farmacêutica LTDA | Hypertension | 12/23 | 07/24 | | |
| Not yet recruiting | 3 | 300 | Europe | Hydrochlorothiazide 25 mg, Placebo | University Medical Center Groningen | ADPKD | 07/28 | 07/29 | | |
ChiCTR2000041306: II period clinical research of compound candesartan ester (candesartan ester 16 mg/hydrochlorothiazide 12.5 mg) in the treatment of Chinese patients with primary hypertension |
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| Completed | 2 | 276 | | Candesartan 16mg was taken ;Compound Candesartan ester (Can16/HCTZ12.5) ;Candesartan 8mg | Institute of Fuwai Cardiovascular Disease Hospital, Chinese Academy of Medical Sciences; Jiangsu Deyuan Pharmaceutical Co., Ltd., Fully self-financing | Hypertension | | | | |
2017-003864-10: Medication for excessive urine production in patients treated with tolvaptan Medicijnen tegen verhoogde urineproductie bij tolvaptan |
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| Ongoing | 2 | 12 | Europe | Hydrochlorothiazide, Metformin, HCT, Tablet | University Medical Center Groningen, University Medical Center Groningen | Autosomal dominant polycystic kidney disease Autosomaal dominante polycysteuze nierziekte, Polycystic kidney disease Familiaire cystenieren, Diseases [C] - Symptoms and general pathology [C23] | | | | |
2016-000500-29: A randomized Crossover TrIal to Compare recombinant human rhPTH(1-34) to the ASsociation alfacalcidol/hydrochlorothiazide in the treatment of Autosomal Dominant Hypocalcemia Essai croisé randomisé comparant la PTH (1-34) recombinante humaine à l'association alfacalcidol/hydrochlorothiazide dans le traitement de l'hypocalcémie autosomique dominante |
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| Not yet recruiting | 2 | 25 | Europe | FORSTEO-R, ESIDREX-R 25 mg, UN-ALPHA-R 0.25µg, Solution for injection, Tablet, Capsule, FORSTEO-R, ESIDREX-R 25 mg, UN-ALPHA-R 0.25µg | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | Autosomal dominant hypocalcemia (ADH) Hypocalcémie autosomique dominante (HAD), Autosomal dominant hypocalcemia (ADH) Hypocalcémie autosomique dominante (HAD), Diseases [C] - Hormonal diseases [C19] | | | | |
| Not yet recruiting | 2 | 99 | Europe | Indapamide 2.5 MG, Hydrochlorothiazide 50Mg, Chlorthalidone 25mg | Insel Gruppe AG, University Hospital Bern, University of Bern | Kidney Stone | 06/27 | 06/27 | | |
NCT03179163: Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans |
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| Terminated | 1/2 | 10 | US | Captopril Pill, National Drug Code (NDC) # 00781-8061-01, Enalapril Pill, NDC# 51672-4039-03, Hydrochlorothiazide, NDC# 00603-3857-32 | Penn State University, National Heart, Lung, and Blood Institute (NHLBI) | Hypertension,Essential | 08/22 | 12/22 | | |
| Completed | 1 | 24 | | taking the reference formulation first, then taking the test preparation ;taking the test preparation first, then taking the reference formulation | The first affiliated hospital, School of Medicine, Zhejiang University; None, Provided by Zhejiang Hisun Pharmaceutical Co. Ltd. | hypertension | | | | |
NCT06083116: Drug-Drug Interaction Study Between Henagliflozin Proline and Hydrochlorothiazide |
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| Completed | 1 | 12 | RoW | Hydrochlorothiazide、Henagliflozin Proline | Jiangsu HengRui Medicine Co., Ltd. | Diabetes in Adults | 10/19 | 10/19 | | |
ChiCTR2200062994: A randomized, open-label, two-sequence, two-agent, four-cycle, fully replicated crossover bioequivalence trial of a single oral dose of valsartan and hydrochlorothiazide tablets in healthy subjects |
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| Not yet recruiting | 1 | 112 | | R-T-R-T ;R-T-R-T ;T-R-T-R ;T-R-T-R | Huzhou Central Hospital; Zhejiang Ingle Pharmaceutical Co., Ltd., Zhejiang Ingle Pharmaceutical Co., Ltd. | Hypertension in all stages | | | | |
| Recruiting | 1 | 36 | US | Hydrochlorothiazide 12.5mg, HCTZ, Placebo | University of Kansas Medical Center | Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS | 12/24 | 12/24 | | |
| Recruiting | 1 | 78 | US | Clonidine, Hydrochlorothiazide, Placebo | University of Iowa | Hypertension, Systolic, Stiffness, Aortic | 06/25 | 12/25 | | |
| Recruiting | 1 | 60 | US | Hydrochlorothiazide 12.5Mg Tab, Hydrochlorothiazide, Clonidine Pill, Clonidine, Placebo | University of Kansas Medical Center | Blood Pressure, Diabetes, Obesity, Insulin Resistance, Diuretics Drug Reactions, Sympathetic Nerve Activity | 07/25 | 07/25 | | |
ChiCTR-IOR-15006718: Cost-effectiveness of nitrendipine plus hydrochlorothiazide or metoprolol in the treatment of hypertension |
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| Completed | N/A | 800 | | antihypertension regents | National center for cardiovascular diseases Fuwai hospital; Fuwai hospital, National Key R&D Program in the Twelfth Five-year Plan (No.2012BAJ18B04) | Hypertension | | | | |
ChiCTR-IOR-17014105: First-Line Antihypertensive comparison for Tibetan mild-moderate hypertension (FLAT): study protocol for a randomized crossover controlled trial |
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| Not yet recruiting | N/A | 531 | | three consecutively allocated 8-week treatment cycles with irbesartan, amlodipine and hydrochlorothiazide | West China Hospital, Sichuan University; Level of the institution：, Supportive technology funding from Sichuan provincial science and Technology Department | Hypertenison | | | | |
NCT04182854: Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management |
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| Recruiting | N/A | 46 | RoW | Furosemid hydrochlorothiazide | Capital Medical University | Diuretic Abuse | 02/20 | 07/21 | | |
ChiCTR-IOR-17014104: First-line Antihypertensive Combinations comparison for Tibetan high-risk hypertension (FACT): study protocol for an open label, paralleled, multi-center randomized controlled trial |
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| Not yet recruiting | N/A | 3417 | | irbesartan/amlodipine (maximum titrated to 300/10 mg) ;irbesartan/hydrochlorothiazide (maximum titrated to 300/25 mg) ;amlodipine/hydrochlorothiazide (maximum titrated to 10/25 mg) | West China Hospital, Sichuan University; Level of the institution：, Supportive technology funding from Sichuan provincial science and Technology Department | Hypertenison | | | | |
ChiCTR1900025446: Study for the safety and effectiveness of Wen-Yang Zhen-Shuai granule in treatment of chronic heart failure (Yang deficiency and water flooding syndrome) |
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| Not yet recruiting | N/A | 300 | | hydrochlorothiazide, enalaprilat, Metoprolol tartrate, Isosorbide mononitrate tablets ;Wen-Yang Zhen-Shuai granules + hydrochlorothiazide, enalaprilat, Metoprolol tartrate, Isosorbide mononitrate tablets | The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine; The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine, State administration of traditional Chinese medicine | the chronic heart failure | | | | |
NCT05125224: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide |
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| Active, not recruiting | N/A | 163720 | US | Dihydropyridine calcium channel blocker, Hydrochlorothiazide | Brigham and Women's Hospital, National Institute on Aging (NIA), Rutgers University, Johns Hopkins University | Hypertension | 07/23 | 12/23 | | |
ChiCTR2000038715: Comparison of different combination therapies in Lowering blood pressure and target organ protection in Fujian Province: COOPERATION STUDY 2x4 Factorial randomized open label multicenter trial |
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| Not yet recruiting | N/A | 1236 | | amlodipine + valsartan ;amlodipine + betaloc sustained-release tablets ;amlodipine + hydrochlorothiazide ;valsartan+hydrochlorothiazide ;amlodipine + valsartan +hydrochlorothiazide ;amlodipine+ valsartan+betaloc sustained-release tablets | The First Clinical Medical College, Fujian Medical University; The First Clinical Medical College, Fujian Medical University, Fujian Science and Technology Innovation Joint Fund Project | Hypertation | | | | |
NCT05413057: An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ |
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| Recruiting | N/A | 20000 | RoW | | Boryung Pharmaceutical Co., Ltd | Hypertension,Essential | 06/26 | 06/26 | | |
FASTR-EU, NCT06362668: EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System |
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| Recruiting | N/A | 30 | Europe | Reprieve Decongestion Management System, Diuretic (furosemide, bumetanide, torsemide, hydrochlorothiazide, and/or acetazolamide) | Reprieve Cardiovascular, Inc | Acute Decompensated Heart Failure | 10/24 | 12/24 | | |
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants |
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| Recruiting | N/A | 1600 | Canada, US | Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | 09/24 | 09/24 | | |
ChiCTR2200055240: A multicenter randomized controlled study of hydrochlorothiazide on the morbidity of hypertension in prehypertensive population with high salt threshold |
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| Recruiting | N/A | 2550 | | Hydrochlorothiazide ;Placebo | Daping Hospital of Third Military Medical University; Army Medical Center of PLA, Training program of clinical scientific research talents of Army Medical University (No:40142-3028) | Prehypertension | | | | |
NCT03476551: Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide |
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| Recruiting | N/A | 12 | Europe | Hydrochlorothiazide, Dichlothiazide, Esidrix, Hypothiazide | Norwegian University of Science and Technology, St. Olavs Hospital, Volvat Medisinsk Senter Stokkan, Namsos Hospital, Alesund Hospital | Obesity, Morbid | 10/26 | 10/26 | | |
ACTRN12607000477426: Effects of aspirin and a blood pressure medicine on the blood concentrations of allopurinol, a common treatment for gout |
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| Active, not recruiting | N/A | 8 | | | Professor Richard Day, St Vincent?s Clinical Trials Account and Professor Richard Day General Purpose Fund, St Vincent's Hospital Sydney Ltd | Potential drug interaction(s) between low-dose aspirin, hydrochlorothiazide (HCT) and allopurinol | | | | |
| Active, not recruiting | N/A | 6000 | | | Cardiovascular Institute, Chinese Academy of Medical Sciences, the Ministry of Science and Technology of China | Hypertension | | | | |
