- |||||||||| methotrexate / Generic mfg.
Fatal Case of Methotrexate Toxicity Presenting With Severe Myelosuppression and Punctate Cutaneous Eruption of the Skin Flexures (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6620;
Her medical regimen included furosemide, hydrochlorothiazide, levothyroxine, methotrexate, metoprolol succinate, and atorvastatin...Patient was treated with Leucovorin, intravenous fluids, Intravenous antibiotics, Filgrastim and wound care...This case illustrates why reviewing home medications and catching subtle cues can lead to faster diagnostic tests, treatment, and better outcomes. Her sepsis was addressed and treated immediately with broad spectrum antibiotics, however it was not enough to prevent further decompensation due to her ongoing myelosuppression and active infection.
- |||||||||| metformin / Generic mfg.
An Ophtha-MALA-gic Anomaly: Metformin Associated Lactic Acidosis Causing Transient Blindness (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6600;
Home medications included metformin, lisinopril, hydrochlorothiazide, amlodipine, and as-needed ibuprofen and naproxen for pain...He then developed profound shock necessitating initiation of norepinephrine, vasopressin, and stress-dosed hydrocortisone...Return of vision after bicarbonate administration but before hemodialysis in our case would seemingly point towards acidemia playing a key role in precipitating the blindness. Our case highlights the importance of prompt recognition of this clinical syndrome in allowing for correction of acidemia, improvement in hemodynamics and resolution of visual symptoms.
- |||||||||| hydralazine hydrochloride / Generic mfg.
Hydralazine-induced ANCA Associated Vasculitis Presenting With Hemoptysis (Walter E. Washington Convention Center, Area E, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6245;
She was transferred to a tertiary care center, and then discharged home eleven days later on a prednisone taper and rituximab...Treatment is usually to stop the offending agent and occasionally with immunosuppression. Overall mortality is approximately 20%, but increases in those with DAH.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Pulmonary Renal Syndrome: A Rare Life-threatening Disease (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4573;
Home medications include lisinopril, hydrochlorothiazide and ezetimibe...She was discharged with long term steroids and rituximab...Treatment consists of a combination of steroids and immunosuppressive agents. The addition of plasmapheresis might bring benefits in severe cases.
- |||||||||| hydrochlorothiazide / Generic mfg., Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Journal: News in cardiology. (Pubmed Central) - Mar 24, 2023
In patients with increased cardiovascular risk, highly sensitive troponin should be measured before non-cardiac surgery as well as 24 and 48 hours after surgery to detect perioperative myocardial infarction. Different blood pressure and oxygenation targets in patients after resuscitation for out-of-hospital cardiac arrest do not affect the outcomes of their treatment.
- |||||||||| hydrochlorothiazide / Generic mfg., doxycycline / Generic mfg.
Syndrome of Inappropriate Antidiuretic Hormone Secretion - A Rare Initial Presentation of Lyme Neuroborreliosis (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3274;
It was thought to be multifactorial due to SIADH and the use of hydrochlorothiazide...Ultimately, he was treated with doxycycline and discharged home...The mechanism of this phenomenon remains unclear; likely related to the inflammation cascade induced by CNS infection. Prompt recognition is critical for timely diagnosis and treatment.
- |||||||||| hydrochlorothiazide / Generic mfg., betahistine / Generic mfg., amiloride hydrochloride / Generic mfg.
Review, Journal: Systemic pharmacological interventions for M (Pubmed Central) - Feb 24, 2023
Assessment of methods' sustainability and greenness was performed using different greenness assessment tools. The evidence for systemic pharmacological interventions for M
- |||||||||| hydrochlorothiazide / Generic mfg.
Colormetric analysis of HTZ and other diuretics by long path absorbance spectrophotometry (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_4599;
A spectrophotometric technique was developed to detect the diuretic hydrochlorothiazide (HTZ) in urine...The method has the potential to be a rapid, less expensive technique for the determination of PEDs used by athletes. Optimized reaction conditions for the colorimetry reaction, linear dynamic range, and detection limits will be presented.
- |||||||||| hydrochlorothiazide / Generic mfg.
Review, Journal: Single-Pill Combination with Three Antihypertensive Agents to Improve Blood Pressure Control in Hypertension: Focus on Olmesartan-Based Combinations. (Pubmed Central) - Jan 26, 2023
Among the various angiotensin receptor blockers, olmesartan (OM) is available as a monotherapy and in dual and triple single-pill combinations (SPCs) with amlodipine (AML) and/or hydrochlorothiazide (HCTZ)...Furthermore, triple OM-based SPC has been shown to improve therapeutic adherence in hypertensive patients compared to free combinations. The availability of OM combined with HCTZ, AML or both at different dosages makes it a valuable option to customize therapy based on the levels of BP and the clinical characteristics of hypertensive patients.
- |||||||||| hydrochlorothiazide / Generic mfg., cyclobenzaprine / Generic mfg.
BLUE, INSIDE AND OUT: METHYLENE BLUE AS THE RESCUE THERAPY FOR REFRACTORY DISTRIBUTIVE SHOCK () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1578;
MB inhibits nitric oxide synthase and guanylate cyclase which decreases the amount of vasodilating nitric oxide and cyclic guanosine monophosphate. No recommendations regarding the use of MB are in the 2017 Experts Consensus Recommendations for the Management of CCB Poisoning in Adults, however, there is growing evidence that MB should be in the algorithm of rescue therapies in CCB overdose.
- |||||||||| chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
Trial completion, Trial completion date: DCP: Diuretic Comparison Project (clinicaltrials.gov) - Jan 19, 2023
P3, N=13523, Completed,
No recommendations regarding the use of MB are in the 2017 Experts Consensus Recommendations for the Management of CCB Poisoning in Adults, however, there is growing evidence that MB should be in the algorithm of rescue therapies in CCB overdose. Active, not recruiting --> Completed | Trial completion date: Apr 2023 --> Dec 2022
- |||||||||| hydrochlorothiazide / Generic mfg.
Review, Journal: Altered dietary salt intake for preventing diabetic kidney disease and its progression. (Pubmed Central) - Jan 17, 2023
Although no potent GsaCAβ-selective inhibitors were detected so far, this preliminary investigation may be helpful for better understanding the inhibition profile of this parasite enzyme and for the potential development of more effective and eventually parasite-selective inhibitors. This systematic review shows an important reduction in SBP and DBP in people with diabetes with normal GFR during short periods of salt restriction, similar to that obtained with single drug therapy for hypertension. These data support the international recommendations that people with diabetes with or without hypertension or evidence of kidney disease should reduce salt intake to less than 5 g/day (2 g sodium).
- |||||||||| Parmodia (pemafibrate) / Kowa
Review, Journal: Highlights of Cardiovascular Disease Prevention Studies Presented at the 2022 American Heart Association Scientific Sessions. (Pubmed Central) - Jan 6, 2023
The PROMINENT trial compared pemafibrate to a placebo in patients with type 2 diabetes mellitus (DM) and mild-to-moderate hypertriglyceridemia and high-density lipoprotein cholesterol (HDL-C)<40 mg/dL who were already on guideline-directed statin therapy...The DCP trial compared hydrochlorothiazide and chlorthalidone for blood pressure control and CV outcomes in hypertension...The QUARTET USA trial compared the effectiveness and safety of 4 antihypertensive medications in ultra-low doses with angiotensin-receptor blocker monotherapy. The late-breaking science presented at the 2022 scientific session of the AHA paves the way for future pragmatic trials and provides meaningful information to guide management strategies in cardiovascular disease prevention.
- |||||||||| hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
Review, Journal: Diuretics in pediatrics. (Pubmed Central) - Jan 4, 2023
Discharging patient without any complications This educational review offers a didactical overview of diuretics in Pediatrics.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
Clinical, Journal: Clinical observation of sacubitril valsartan sodium in the treatment of resistant hypertension: A randomized clinical trial. (Pubmed Central) - Jan 3, 2023
In the research group the 24 h average BP, daytime average BP, and nighttime average BP were 144.84/79.82, 147.10/82.06, and 138.67/76.31 mmHg at baseline, and reduced to 128.96/73.32, 131.50/74.94, and 122.11/69.27 mmHg at week 8, which were significantly decreased (P < 0.05 or P < 0.01), and the left ventricular ejection fraction was significantly increased (P < 0.05), compared with the control group. Sacubitril valsartan sodium can effectively reduce BP and improve cardiac function in RH.
- |||||||||| Tekturna (aliskiren) / PDL
Journal: Mathematical modeling of antihypertensive therapy. (Pubmed Central) - Jan 3, 2023
The extended model paves the way for the next step in personalized medicine that is adapting the model parameters to a real patient and predicting his response to antihypertensive therapy. The model is implemented in the BioUML software and is available at https://gitlab.sirius-web.org/virtual-patient/antihypertensive-treatment-modeling.
- |||||||||| candesartan cilexetil / Generic mfg., hydrochlorothiazide / Generic mfg., rosuvastatin / Generic mfg.
Journal: Role of polypills in cardiovascular risk reduction in primary prevention (Pubmed Central) - Dec 27, 2022
Additionally, we review the clinical messages of the HOPE-3 trial, which aim to control two of the most prevalent conditions, such as high blood pressure and high cholesterol, through a combination of candesartan, hydrochlorothiazide and rosuvastatin. Finally, we propose its potential indication in a heterogeneous health system such as that of our country, both at the population level based on intermediate or low risk, determined intuitively or using a risk calculator, as well as in the personalized care that is practiced in many health scenarios.
- |||||||||| hydrochlorothiazide / Generic mfg., irbesartan / Generic mfg., carbamazepine / Generic mfg.
Journal: The removal of micropollutants from treated effluent by batch-operated pilot-scale constructed wetlands. (Pubmed Central) - Dec 27, 2022
Besides, the presence of bark-biochar also enhanced the removal of total nitrogen during 10 months of operation, but no improvement was observed on the total organic carbon and total phosphorus removal. Considering the application in a batch-operated CW, MP removal can be greatly enhanced by replacing sand with bark-biochar that will act as MP adsorbing matrix.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, omecamtiv mecarbil (AMG 423) / Amgen, Servier, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Review, Journal: Heart failure: an update from the last years and a look at the near future. (Pubmed Central) - Dec 23, 2022
Ferric derisomaltose had an effect on the primary outcome of CV mortality or HF rehospitalizations in IRONMAN (rate ratio 0.82; 95% confidence interval 0.66-1.02; P = 0.070). Further options for the treatment of HF, including device therapies, cardiac contractility modulation, and percutaneous treatment of valvulopathies, are summarized in this article.
- |||||||||| chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
Journal: Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. (Pubmed Central) - Dec 16, 2022
P3
In this large pragmatic trial of thiazide diuretics at doses commonly used in clinical practice, patients who received chlorthalidone did not have a lower occurrence of major cardiovascular outcome events or non-cancer-related deaths than patients who received hydrochlorothiazide. (Funded by the Veterans Affairs Cooperative Studies Program; ClinicalTrials.gov number, NCT02185417.).
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