- |||||||||| carbamazepine / Generic mfg.
A Case of Paraneoplastic Trigeminal Neuropathy in the Setting of Renal Cell Carcinoma (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_4127;
Despite treatment with carbamazepine, the pain worsened and became bilateral prompting an ED visit...To our knowledge, this represents the first reported case of trigeminal neuropathy associated with RCC, featuring pain phenotypically consistent with burning mouth syndrome and bilateral trigeminal nerve enhancement on imaging. The patient's clinical and radiographic improvement post-tumor resection emphasizes the significance of considering paraneoplastic neuropathy in cases of trigeminal neuropathic pain and conducting thorough secondary work-up.
- |||||||||| A Case of Satoyoshi Syndrome with Predominantly Neurological Symptoms (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3762;
Neurologists should maintain a comprehensive perspective and not overlook non-neurological symptoms in patients. Distinguishing involuntary movements can be particularly challenging for neurologists.
- |||||||||| TBC1D24 Mutation Presenting as Post-partum New Onset Refractory Status Epilepticus (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3654;
This variant has been reported in one other non-related heterozygous carrier who presented in infanthood with prolonged tonic-clonic seizures during febrile episodes. While this individual showed a dramatic improvement in seizure control associated with less frequent febrile episodes, no prior response to immunomodulatory therapies have been previously described in TBC1D24 variants.
- |||||||||| Zavzpret (zavegepant nasal spray) / Pfizer
Physiologically-based Pharmacokinetic Modeling for Assessment of the Drug-drug Interaction Potential of Zavegepant (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3210;
Models predicted DDI of intranasal zavegepant with single-dose (SD) or MD rifampin, cyclosporine A (OATP1B3, NTCP, and P-gp inhibitor), and moderate (efavirenz) or strong (carbamazepine) CYP3A4 and/or P-gp inducers...PBPK modeling and observed clinical pharmacokinetic data support zavegepant labeling recommendations that CYP3A4 inhibitors/inducers or P-gp inhibitors do not have clinically relevant effects on zavegepant exposure. OATP1B3/NTCP inhibitors may significantly increase zavegepant exposure and co-administration should be avoided.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
A Case of a Rare Seizure Mimic: Acute Intermittent Porphyria Attack (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3044;
The diagnosis of porphyria was complex due to the patient's inability to verbalize his symptoms, difficulty differentiating seizure from porphyria attacks, and complex video EEG and laboratory evaluation. This case illustrates a rare seizure mimic, important clinical consideration, and testing in improving patient outcome and reducing morbidity.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, VS-5095 / Verastem
Sex Steroid Hormone Serum Concentrations in Pregnant Women with Epilepsy in MONEAD (Colorado Convention Center | 708/710/712) - Mar 8, 2024 - Abstract #AAN2024AAN_2940;
However, estrone concentrations were lower in the second and third trimesters. Future studies will include investigation of potential implications for maternal and child outcomes.
- |||||||||| Journal: Lettre to editor: Case report of an ictal asystole as debut in new onset epilepsy. (Pubmed Central) - Mar 6, 2024
Anti-seizures drugs must be initiated in all patients, and there is a recommendation to avoid those with negative inotropic and arrhythmogenic effects (such as phenytoin, carbamazepine, and lacosamide). There is a discussion about pacemaker indication, however, it is highly recommended in non-controlled epilepsy and in ictal asystoles that last for more than 6
- |||||||||| carbamazepine / Generic mfg.
Journal: The Effects of the Fraction Isolated from Iranian Buthotus shach Scorpion Venom on Synaptic Plasticity, Learning, Memory, and Seizure Susceptibility. (Pubmed Central) - Mar 6, 2024
At first, ventricular cannulation was performed in rats, and then the active fraction (i.e., F3), carbamazepine, and the vehicle were microinjected into the brain before seizure induction by the subcutaneous (SC) injection of pentylenetetrazol (PTZ)...Our results support the antiepileptic effects of the F3 fraction of BS venom, evidenced by behavioral and electrophysiological studies. However, the effects of this fraction on memory and learning were not in the same direction, suggesting the involvement of two different pathways.
- |||||||||| carbamazepine / Generic mfg.
Journal: Frequencies of HLA-B alleles in Indonesian Malay Ethnic. (Pubmed Central) - Mar 5, 2024
The Indonesian population, represented by Malay, Javanese, and Sundanese ethnicities, was similar to South East Asian, Han Chinese, and Taiwanese populations based on HLA-B*15:02 frequency as the most common allele found in Malay ethnics. We provided valuable information on the frequency of drug hypersensitivity-associated HLA-B alleles in Indonesian Malay ethnic population, which can improve treatment safety.
- |||||||||| carbamazepine / Generic mfg.
Journal: Sustainable bioelectric activation of periodate for highly efficient micropollutant abatement. (Pubmed Central) - Mar 3, 2024
We provided valuable information on the frequency of drug hypersensitivity-associated HLA-B alleles in Indonesian Malay ethnic population, which can improve treatment safety. In this work, novel bioelectric activation of PI using the electrons generated by electroactive bacteria was developed and investigated for rapid removal of carbamazepine (CBZ), achieving 100 %, 100 %, and 76 % removal efficiency for 4.22
- |||||||||| pregabalin / Generic mfg., carbamazepine / Generic mfg.
Retrospective data, Journal: Collateral-Pricking and Bloodletting Cupping Combined with Electroacupuncture for Postherpetic Neuralgia: A Meta-Analysis. (Pubmed Central) - Mar 2, 2024
Existing evidence suggests that the combination of collateral-pricking and bloodletting cupping and electroacupuncture demonstrates efficacy in pain relief, improvement of sleep quality, and enhanced therapeutic outcomes for patients with postherpetic neuralgia. However, further validation through large-scale multicenter randomized controlled trials is warranted due to the limited quantity and quality of the included literature in this study.
- |||||||||| Reimbursement, US reimbursement, Journal, Claims database: Comparing the efficacy of anti-seizure medications using matched cohorts on a large insurance claims database. (Pubmed Central) - Feb 28, 2024
However, we note that our data set for this study only used insurance claims events, which does not comprise actual seizure frequencies, nor a clear picture of side effects. Our results do not advocate for any change in practice but demonstrate that conclusions from large databases may differ from and supplement those of randomized trials and clinical practice and therefore may guide further investigation.
- |||||||||| carbamazepine / Generic mfg.
Preclinical, Journal: Sex differences in carbamazepine effects in a rat model of trigeminal neuropathic pain. (Pubmed Central) - Feb 26, 2024
In conclusion, male and female CCI-ION rats presented differences in the expression of the affective-motivational pain component and CBZ was more effective in females than males. Further studies using both sexes in trigeminal neuropathic pain models are warranted for a better understanding of potential differences in the pathophysiological mechanisms and efficacy of pharmacological treatments.
- |||||||||| oxcarbazepine / Generic mfg.
Biomarker, Journal: Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond HLA-B*15:02. (Pubmed Central) - Feb 24, 2024
While preemptive genetic testing for HLA-B*15:02 in individuals of Asian ancestry is recommended to prevent severe hypersensitivity reactions to oxcarbazepine, oxcarbazepine concentrations and AKR1C variation may contribute to the risk of severe adverse reactions. We provide recommendations for future study to elucidate whether these individual factors are important for reducing the risk of severe adverse events.
- |||||||||| carbamazepine / Generic mfg.
Journal, Surgery: Long-term outcomes of Gamma Knife radiosurgery in treating glossopharyngeal neuralgia. (Pubmed Central) - Feb 22, 2024
Initial treatment involves medications like carbamazepine, but if these are ineffective or cause side effects, interventional pain management techniques or surgery may be considered...The patient who underwent radiofrequency rhizotomy continued to experience inadequately controlled pain despite medication (Grade IV). Gamma Knife radiosurgery is a non-invasive, efficacious treatment option for idiopathic GPN, offering short- and long-term relief without permanent complications.
- |||||||||| Retevmo (selpercatinib) / Eli Lilly
Hemoptysis and Thrombocytopenia in a Patient With Metastatic Lung Adenocarcinoma on Selpercatinib: A Diagnostic and Therapeutic Challenge (San Diego Convention Center, Area J (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6919;
Oncology's directive to discontinue Selpercatinib and Pulmonology's decision to defer invasive interventions resulted in symptom resolution and a safe discharge plan. The experience prompts consideration for heightened vigilance in monitoring potential side effects of targeted therapies, especially when co-administered with anticoagulants, in a vulnerable patient population with multiple comorbidities.
- |||||||||| Paxlovid (nirmatrelvir/ritonavir) / Pfizer
Covid Confusion: A Case of Paxlovid Induced Carbamazepine Toxicity (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6031;
Other important measures include endotracheal intubation in patients who require airway stabilization and intravenous hydration. Our case highlights both the effects of carbamazepine toxicity and importance of considering drug interactions when prescribing Paxlovid for treatment of COVID-19.
- |||||||||| Ocrevus (ocrelizumab) / Roche
Ocrelizumab Induced Organizing Pneumonia: A Case Report (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3792;
While there is limited data on ocrelizumab's impact on the lungs, cases of OP linked to the anti-CD-20 agent rituximab have been documented...Azathioprine and mycophenolate have shown promise in case studies, while cyclophosphamide and cyclosporine are considered secondary options for patients not responding to steroids...As ocrelizumab use increases in MS patients, there is a potential for more cases to arise. Therefore, healthcare providers should consider OP when patients on ocrelizumab show pulmonary symptoms.
- |||||||||| levetiracetam / Generic mfg.
A Case of Keppra-Induced Torsades de Pointes in a Patient With Congenital Long QT Syndrome (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3585;
Clinicians should be aware that malignant arrhythmias such as TdP can lead to arrhythmic syncope with generalized seizure activity. If this seizure activity is misdiagnosed as a primary seizure disorder in a patient with LQTS, clinicians should be aware that Keppra does have an increased risk of QT prolongation in the LQTS population and initiation could have fatal outcomes.
- |||||||||| fluconazole oral / Generic mfg.
Fluconazole Associated DRESS Syndrome in Patient With Coccidioidomycosis Pneumonia (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_976;
Regarding fluconazole as an offending agent, there has been limited literature that demonstrates systemic adverse effects with eosinophilia. In the context of the timing, symptoms, and lesion biopsy, fluconazole likely led to the exhibited immune response of the patient.
- |||||||||| lithium carbonate ER / Generic mfg.
Trial termination, HEOR: Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies (clinicaltrials.gov) - Feb 15, 2024
P=N/A, N=1037352, Terminated,
The relative standard deviation of retention time and areas of chromatographic peaks of carbamazepine did not exceed 0.5%. Completed --> Terminated; Per PI, this study is not a clinical trial and was inadvertently entered in the system
- |||||||||| Review, Journal: Pharmacological management of gambling disorder: an update of the literature. (Pubmed Central) - Feb 15, 2024
The review highlights current gaps/limitations, including small sample sizes, limited diversity in participant demographics, the need for exploring different gambling subtypes and treatment responses, high placebo response rates, lack of longer-term longitudinal information, limited investigation of neurobiological correlates and co-occurring disorders, and the importance of implementation research. Further research is needed to address these gaps and explore additional medications, as well as interventions like neuromodulation.
- |||||||||| carbamazepine / Generic mfg.
Journal: Natural Silicates Encapsulated Enzymes as Green Biocatalysts for Degradation of Pharmaceuticals. (Pubmed Central) - Feb 15, 2024
With the natural silicate as a core and silica layer as a shell, it was possible to encapsulate two different enzymes: horseradish peroxidase (HRP) and laccase, for removal and degradation of three pharmaceuticals: diclofenac (DFC), carbamazepine (CBZ), and paracetamol (PC)...The immobilization method played a significant role in this process by providing stability and protection for the enzymes over 3 weeks. Furthermore, the enzymes acted differently in the three chosen supports due to their complex chemical composition, which could have an effect on the overall enzyme activity.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Interactions between antiseizure medications and foods and drinks: A systematic review. (Pubmed Central) - Feb 12, 2024
Drugs-foods (-drinks) interactions may change the drug exposure or plasma levels of drugs (e.g., grapefruit juice increases carbamazepine concentrations and the bioavailability of cannabidiol is increased 4-5 folds with concomitant intake of fat-rich food); this may require dosage adjustments...PLAIN LANGUAGE SUMMARY: Interactions between antiseizure medications and foods and drinks may be important. This should be taken into consideration in patients with epilepsy.
- |||||||||| Journal: The teratogenesis risk associated with antiseizure medication duotherapy in women with epilepsy. (Pubmed Central) - Feb 11, 2024
Leaving aside issues in relation to seizure control, our data suggest that it would be best to avoid using established teratogenic antiseizure medications (carbamazepine, valproate and topiramate) in combination with each other due to the increased FM risks. When combining an established teratogenic medication with a less teratogenic one, i.e. lamotrigine, levetiracetam or clonazepam, lamotrigine appears to be the safer option.
- |||||||||| carbamazepine / Generic mfg.
Journal: Reinvestigation on High-Valent Cobalt for the Degradation of Micropollutants in the Co(II)/Peroxymonosulfate System: Roles of Co(III). (Pubmed Central) - Feb 9, 2024
Additionally, the degradation pathway of CBZ by Co(III) and the Co(II)/PMS system was comparatively explored, confirming that Co(III) participated in the hydroxylation, carbonylation, deacetylation, and ring reduction of CBZ by the Co(II)/PMS system. Our work addresses the controversy regarding the reactive Co species involved in the Co(II)/PMS system with evidence of Co(III) as the chief one, which highlights the significance of re-evaluating the relative contribution of Co(III) in relevant environmental decontamination processes.
- |||||||||| carbamazepine / Generic mfg.
Journal: Synthesis technique and electron beam damage study of nanometer-thin single-crystalline thymine. (Pubmed Central) - Feb 2, 2024
This raises interesting questions about the role of the fast relaxation processes of electron scattering-induced excited states, extending the concept of radiation hardening beyond photoexcited states. The high stability of thymine in particular opens the door for further studies of these ultrafast relaxation processes giving rise to the high stability of DNA to UV radiation.
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