- |||||||||| carbamazepine / Generic mfg.
Journal: Multiple sclerosis relapse presenting as trigeminal neuralgia. (Pubmed Central) - Jul 1, 2024
She was started on carbamazepine 300 mg 4 times a day. This case highlights the need for early diagnosis by MRI with gadolinium enhancement and prompt initiation of treatment helped her pain to subside and was able to return a week later to the MS clinic to be restarted on her prior DMT to prevent further MS relapses.
- |||||||||| carbamazepine / Generic mfg.
Journal: Carbamazepine in osteoarthritis treatment: A novel approach targeting Nav1.7 channels. (Pubmed Central) - Jul 1, 2024
Carbamazepine's repurposing holds promise for OA management, potentially revolutionizing treatment paradigms. Further research is essential to bridge the gap between preclinical evidence and clinical application, offering hope for improved OA management and enhanced patient quality of life.
- |||||||||| Journal: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports. (Pubmed Central) - Jun 27, 2024
The top 10 involved drugs are as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin and amoxicillin with beta-lactam inhibitors (8.8%), paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid (4.1%), omeprazole (3.5%), and levetiracetam (3.5%). (4) Our study was the first study in Russia aimed at the assessment of the structure of the drugs involved in SJS and TEN on the national level.
- |||||||||| carbamazepine / Generic mfg.
PN407. Unlocking the Mysteries of Vasoplegia: Navigating Risks, Diagnosis, and Future Treatment Options (102AB) - Jun 25, 2024 - Abstract #ASA2024ASA_3278;
His regular medications include aspirin, atorvastatin, metoprolol, and carbamazepine (prescribed for headaches)...During the procedure, while on cardiopulmonary bypass (CPB), the perfusionist administered two bags of phenylephrine, while the anesthesiologist initiated a norepinephrine infusion at a rate of 0.05 mcg/kg/min. The heart-lung machine is currently operating with a flow index of 2.5 LPM/m?.
- |||||||||| carbamazepine / Generic mfg.
Journal: Sydenham's chorea in a 16-year-old female from Bhutan: A case report. (Pubmed Central) - Jun 24, 2024
She was managed as Acute Rheumatic Fever with oral Phenoxymethyl penicillin and Carbamazepine...Sydenham's chorea is a rare presentation of acute rheumatic fever. The absence of clinical carditis does not rule out carditis.
- |||||||||| Journal: Graphene-coated sand for enhanced water reuse: Impact on water quality and chemicals of emerging concern. (Pubmed Central) - Jun 22, 2024
The study also highlights the material's capacity to remove challenging CECs like Sulfamethoxazole (up to 80?% removal) and Diphenhydramine (up to 90?% removal), showcasing its potential as a sustainable solution for water reuse applications. This research contributes to the field by providing a comprehensive evaluation of GCS in water treatment, suggesting its potential for removing CECs from treated municipal wastewater.
- |||||||||| Exxua (gepirone ER) - Fabre / Kramer
Journal: Gepirone (Exxua) for depression. (Pubmed Central) - Jun 21, 2024
This research contributes to the field by providing a comprehensive evaluation of GCS in water treatment, suggesting its potential for removing CECs from treated municipal wastewater. No abstract available
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg., L-ornithine-L-aspartate / Generic mfg.
Journal: From seizures to cognitive dysfunction: A case report of Fahr syndrome in an Afghan patient. (Pubmed Central) - Jun 21, 2024
No abstract available This case underscores the importance of raising awareness among physicians, especially in areas with limited medical resources, about the significance of prompt diagnosis and appropriate symptomatic treatment in enhancing patient prognosis and quality of life.
- |||||||||| carbamazepine / Generic mfg.
Journal: New Perspectives on the Interactions between Adsorption and Degradation of Organic Micropollutants in Granular Activated Carbon Filters. (Pubmed Central) - Jun 18, 2024
These findings suggest that the retention of micropollutants in GAC filters, by prolonging the micropollutant residence time through adsorption, can enable longer time periods for degradations than what the hydraulic retention time would allow for. For the biologically recalcitrant compound carbamazepine, differences in breakthrough between the 14C-labeled and nonradiolabeled compounds revealed a substantial retention via successive adsorption-desorption, which could pose a potential challenge in the interpretation of GAC filter performance.
- |||||||||| sertraline / Generic mfg., fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Journal: The Tissue-Specific Eco-Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions. (Pubmed Central) - Jun 18, 2024
Caffeine and sucralose, two common effluent tracers, were quantitated at low micrograms per liter levels in surface water, while an anticonvulsant, carbamazepine, was observed at levels up to 37?ng/L. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and primary metabolites were detected in at least one tissue of all three species at low micrograms per kilogram concentrations..
- |||||||||| indomethacin / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
An ocular disease presenting as a mimicker of paroxysmal hemicrania () - Jun 18, 2024 - Abstract #AHS2024AHS_194;
When evaluating a patient, it is important to prioritize ruling out secondary causes of headache before diagnosing a primary headache disorder. Unfortunately, there is limited literature regarding whether primary headache disorders can overlap with primary ocular disorders.
- |||||||||| A case of bilateral paraneoplastic trigeminal neuralgia associated with renal cell carcinoma () - Jun 18, 2024 - Abstract #AHS2024AHS_187;
Of these three patients, two had detectable anti-Hu antibodies (one with lung cancer and one with intestinal-type mucinous ovarian carcinoma), whereas the remaining patient with serous-type ovarian carcinoma did not have any paraneoplastic antibodies detected. Our patient represents one of only a small subset of reported cases of paraneoplastic trigeminal neuralgia and the first documented case of paraneoplastic trigeminal neuralgia associated with renal cell carcinoma.
- |||||||||| Zavzpret (zavegepant nasal spray) / Pfizer, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Review, Journal: An update on pharmacotherapy for trigeminal neuralgia. (Pubmed Central) - Jun 13, 2024
Third-generation anticonvulsants, new calcitonin gene-related peptide blockers for migraine, and older drugs such as ketamine and cannabinoids may be promising adjuvants or monotherapeutic options...Combination therapy might allow for lower doses of carbamazepine or oxcarbazepine, thus reducing the number and severity of potential adverse events but the potential for pharmacokinetic drug-drug interactions must be considered. Drug therapy for trigeminal neuralgia involves acute or abortive treatments, often administered in hospital versus long-term preventive therapy, usually involving oral agents.
- |||||||||| carbamazepine / Generic mfg.
Journal: A Bulk Oxygen Vacancy Dominating WO3-x Photocatalyst for Carbamazepine Degradation. (Pubmed Central) - Jun 13, 2024
In summary, the influence of oxygen vacancy on photocatalytic degradation performance depends on both the proportion and location distribution and could lie in the optimization of the photodegradation mechanism. The results of this study could potentially broaden our understanding of the role of oxygen vacancies and provide optimal directions and methods for oxygen vacancy regulation for photocatalysts.
- |||||||||| carbamazepine / Generic mfg.
Journal: Identification of a Safe and Tolerable Carbamazepine Dosing Paradigm that Facilitates Effective Evaluation of CYP3A4 Induction. (Pubmed Central) - Jun 12, 2024
P1
Carbamazepine (CBZ) is the recommended alternative to rifampicin as a CYP3A4 inducer in drug-drug interaction studies...This study tested a shorter CBZ dosing regimen using the CYP3A4-sensitive index substrate midazolam (MDZ)...The data are consistent with predictions of physiologically-based pharmacokinetic models in Simcyp. The 9-day dosing regimen for CBZ induction was well-tolerated by healthy participants, supporting the use of a shorter CBZ regimen for CYP3A4 induction studies.
- |||||||||| carbamazepine / Generic mfg.
Journal: Response to Carbamazepine in a Case of Kleine-Levin Syndrome. (Pubmed Central) - Jun 11, 2024
A notable application of the LED-IoT system at an operating sewage treatment plant showed nearly 80% efficiency in carbamazepine removal from sewage in the secondary settling tank after 6 No abstract available
- |||||||||| carbamazepine / Generic mfg.
Biomarker, Review, Journal: Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 Polymorphisms. (Pubmed Central) - Jun 11, 2024
No abstract available Although these findings highlight the impact of genetic variations in the CYP3A4 and CYP3A5 genes on CBZ pharmacokinetics and pharmacodynamics, further studies across diverse populations are essential to enhance personalized epilepsy therapy in clinical settings.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Diacomit (stiripentol) / Biocodex, Meiji Seika, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Journal, Adverse events: An analysis of suicidal and self-injurious behavior reports with antiseizure medications in the FDA adverse event database. (Pubmed Central) - Jun 6, 2024
These drugs included diazepam, brivaracetam, gabapenetin, and pregabalin. Although several limitations are present with the FAERS database, it is imperative to closely monitor patient comorbidities for increased risk of suicidality with the use of several ASMs.
- |||||||||| cephalexin / Generic mfg., carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: Environmental risk assessment of pharmaceutical pollutants in the Oro River Sub-basin (Colombia). (Pubmed Central) - Jun 4, 2024
This wastewater treatment plant receives hospital discharges from the city, including internationally recognized clinics accepting patients from different parts of the country. The environmental risk assessment showed that ibuprofen and Cephalexin have a higher impact on aquatic organisms.
- |||||||||| Journal: Triazole antifungal drug interactions-practical considerations for excellent prescribing. (Pubmed Central) - Jun 2, 2024
We highlight interactions with drugs used in children and new agents introduced for the treatment of haematological malignancies or graft versus host disease (midostaurin, ibrutinib, ruxolitinib and venetoclax). We also summarize the multiple interactions between oral and inhaled corticosteroids and triazole antifungals, and the strategies needed to optimize the therapeutic benefits of triazole antifungal therapy while minimizing potential harm to patients.
- |||||||||| pentylenetetrazole (BTD-001) / Balance Therap
Preclinical, Journal: Synthesis, In vivo, and In silico Evaluation of New Pyrazoline- Benzothiazole Conjugates as Orally Administered Antiepileptic Agents. (Pubmed Central) - Jun 1, 2024
The study concluded that compounds 9c, 9d, 9f, 9i, 9n, and 9o possessed good antiepileptic potential when compared with standard drugs like carbamazepine and phenytoin...In-silico studies have been performed to determine the eligibility of synthesized compounds as orally administered molecules and interactions with the target proteins. The result of in-silico studies reinforced results obtained by in vivo study of the synthesized compounds along with their possible mechanism of antiepileptic action i.e. via inhibiting voltage-gated sodium channels (VGSCs) and gamma-aminobutyric acid-A receptor.
- |||||||||| olanzapine / Generic mfg., carbamazepine / Generic mfg., quetiapine / Generic mfg.
Journal: XOB: A novel phenylalkylamine antagonist of 5-HT2A receptors and voltage-gated sodium channels. (Pubmed Central) - Jun 1, 2024
Significance Statement We synthesized a novel small molecule (XOB) that simultaneously antagonizes two key therapeutic targets of bipolar disorder, 5-HT2A receptors and voltage-gated sodium channels (VGSCs), in heterologous cells, and inhibits the intrinsic excitability of mouse prefrontal cortex layer V pyramidal neurons in brain slices. XOB represents a valuable new proof-of-principle tool for future preclinical investigations and provides a novel molecular approach to the pharmacological treatment of complex neuropsychiatric disease, which often requires a combination of therapeutics for sufficient patient benefit.
- |||||||||| carbamazepine / Generic mfg.
Journal: Neurotoxic effects of carbamazepine on the mosquitofish Gambusia affinis. (Pubmed Central) - May 28, 2024
Furthermore, the neurotoxic effects of carbamazepine were clearly demonstrated through alterations in various neurological parameters, including acetylcholinesterase, dopamine, gamma-aminobutyric acid, serotonin, monoamine oxidase, 5-hydroxyindole acetic acid, adrenaline, and nor-adrenaline. These findings raise concerns about the survival of fish populations in their natural environment.
- |||||||||| carbamazepine / Generic mfg.
Journal: Protecting against micropollutants in water storage tanks using in-situ TiO2 coated quartz optical fibers. (Pubmed Central) - May 27, 2024
This study overcomes this limitation and reveals strategies to improve the light dissipation uniformity along P-OFs, and demonstrates the performance of P-OFs on degrading a model micropollutant, carbamazepine (CBZ)...Moreover, these optimizations led to a remarkable three-fold improvement in CBZ degradation rates and a 65% reduction in energy consumption. Such improvement substantially reduces the capital and operational cost and enhances practicality of energy-efficient photocatalysis without additional chemical oxidants for micropollutant degradation in water storage tanks.
- |||||||||| CoAprovel (irbesartan hydrochlorothiazide) / Sanofi, Prezista (darunavir) / J&J
Journal: Comparing the adsorption of micropollutants on activated carbon from anaerobically stored, organics-depleted, and nitrified urine. (Pubmed Central) - May 27, 2024
In addition, we showed that the relative pharmaceutical removal in all solutions was independent of the initial pharmaceutical concentration unless the background organics matrix changed considerably. We conclude that removal of micropollutants in GAC columns from organics-depleted urine can be performed without clogging, but with the drawback of a higher carbon usage compared to removal from nitrified urine.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-effectiveness analysis of HLA-B*15:02 screening before treatment of epilepsy in Indonesia. (Pubmed Central) - May 26, 2024
This suggests that therapy revision could be expedited. Calculation of the cost-effectiveness of lifetime epilepsy therapy in this study found that the initial screening strategy with the HLA-B*15:02 test was the most cost-effective.
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