- |||||||||| topiramate / Generic mfg., carbamazepine / Generic mfg.
Journal: Chemicals of emerging concern in coastal aquifers: Assessment along the land-ocean interface. (Pubmed Central) - Feb 5, 2023
Among them, the perfluoroalkyl and polyfluoroalkyl substances (PFAS), along with the pharmaceuticals carbamazepine and topiramate, were revealed to be good markers for tracing anthropogenic contamination in ground- and seawater, in concrete situations (e.g., highly contaminated sites). Additionally, non-target analysis expanded the number of potential tracers, making it a promising tool for identifying both the source and the fate of pollutants.
- |||||||||| golidocitinib (DZD4205) / Dizal Pharma
Trial completion, Trial completion date: Drug-drug Interactions Between AZD4205 and Itraconazole/Carbamazepine (clinicaltrials.gov) - Feb 1, 2023
P1, N=32, Completed,
Drug lists for preventing future episodes in the same patients are also a must. Recruiting --> Completed | Trial completion date: Apr 2023 --> Oct 2022
- |||||||||| carbamazepine / Generic mfg.
Journal: Adsorption of Carbamazepine in All-Silica Zeolites Studied with Density Functional Theory Calculations. (Pubmed Central) - Jan 31, 2023
Further calculations addressed the role of temperature, performing DFT-based molecular dynamics simulations for selected systems, and of guest-guest interactions between coadsorbed CBZ molecules. In addition to predicting zeolite frameworks of particular interest as materials for selective CBZ removal, the calculations presented here also contribute to the atomic-level understanding of the interaction of functional organic molecules with all-silica zeolites.
- |||||||||| lumacaftor (VX-809) / Vertex
Review, Journal: The impact of N-nitrosamine impurities on clinical drug development. (Pubmed Central) - Jan 29, 2023
Consequent interruption or discontinuation of the manufacturing and distribution of several marketed drugs has culminated into shortages of marketed drugs, including the antidiabetic drug metformin and the potentially life-saving drug rifampin for the treatment of tuberculosis...In particular, rifampin is a key clinical index drug employed in drug-drug interaction (DDI) studies, and as a result of nitrosamine impurities regulatory bodies no longer accept the administration of rifampin in DDI studies involving healthy subjects. Drug developers are now forced to look at alternative approaches for commonly employed perpetrators, which will be discussed in this review.
- |||||||||| sodium valproate / Generic mfg., carbamazepine / Generic mfg.
Journal: For the love of all that is holy, stop prescribing sodium valproate and carbamazepine together. (Pubmed Central) - Jan 26, 2023
This write up attempts to give an overview of the mechanism of this drug interaction, and informs readers why this combination is a bad choice. The author hopes that this will help in raising awareness among the physicians regarding the dangers of this prescription, and in putting a full stop to this practice.
- |||||||||| LY294002 / Eli Lilly, ABT-737 / AbbVie
Preclinical, Journal: Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro. (Pubmed Central) - Jan 22, 2023
Amongst these compounds, carbamazepine, ABT-737, LY294002, oridonin, and paroxetine could restore LC3 puncta in the MPAN fibroblasts, identifying them as novel potential therapeutic compounds to treat MPAN. In summary, our study confirms a role for C19orf12 in autophagy, proposes LC3 puncta as a functionally robust and consistent readout for testing compounds, and pinpoints potential therapeutic compounds for MPAN.
- |||||||||| sunvozertinib (DZD9008) / Dizal Pharma
Enrollment closed: Drug-drug Interactions Between DZD9008 and Itraconazole/Carbamazepine (clinicaltrials.gov) - Jan 20, 2023
P1, N=40, Active, not recruiting,
In summary, our study confirms a role for C19orf12 in autophagy, proposes LC3 puncta as a functionally robust and consistent readout for testing compounds, and pinpoints potential therapeutic compounds for MPAN. Recruiting --> Active, not recruiting
- |||||||||| phenytoin / Generic mfg., carbamazepine / Generic mfg.
Journal, Gene Signature: A pilot study on identifying gene signatures as markers for predicting patient response to antiseizure medications. (Pubmed Central) - Jan 20, 2023
Moreover, based on the gene expression profiles of the patients with the treatment of valproate, carbamazepine, and phenytoin, we proposed a strategy for predicting the response to the ASMs by using the Connectivity Map scoring method. Our findings could be helpful for better understanding the mechanisms of drug resistance of ASMs and improving the clinical treatment of epilepsy.
- |||||||||| Vocabria (cabotegravir oral) / ViiV Healthcare, Edurant (rilpivirine) / J&J, Rekambys (rilpivirine LA) / J&J
Clinical, Journal: Cabotegravir: a novel HIV integrase inhibitor combined with rilpivirine as the first long-acting injectable program for the treatment of HIV infection. (Pubmed Central) - Jan 19, 2023
Cabotegravir, a novel HIV integrase inhibitor, shares structural similarity with dolutegravir and bictegravir...Drug interactions are minimal, although oral doses require spacing from polyvalent cations, and potent uridine glucuronosyltransferase induction (e.g., rifampin, carbamazepine) requires avoidance due to anticipated subtherapeutic cabotegravir exposure through extended intervals...A key component of the first U.S. Food and Drug Administration (FDA)-approved injectable maintenance treatment program for HIV, injectable cabotegravir heralds a new era in HIV treatment innovation. Here we provide a detailed review of the clinical pharmacology, administration and available formulations of the novel HIV integrase inhibitor cabotegravir with in-depth analysis of the clinical trial data, safety, satisfaction and viral resistance development when combined with rilpivirine as the first long-acting injectable program for the treatment of HIV infection.
- |||||||||| topiramate / Generic mfg.
Journal: A Comprehensive Analysis of Topiramate and Drug Reaction With Eosinophilia and Systemic Symptoms. (Pubmed Central) - Jan 17, 2023
When accounting for co-administered drugs, ERAM was statistically significant for carbamazepine (4.53), lamotrigine (ERAM=6.54), phenytoin (ERAM=2.91), and zonisamide (ERAM=2.25) exceeding disproportionality thresholds, but the score of topiramate was no longer significant (0.25). Conclusion A comprehensive review of all available evidence does not support a causal association between topiramate and DRESS.
- |||||||||| carbamazepine / Generic mfg.
Journal: Individual and combined effect of ions species and organic matter on the removal of microcontaminants by Fe-EDDS/solar-light activated persulfate. (Pubmed Central) - Jan 16, 2023
This work is focused on improving the understanding of the complex water matrix interactions occurring during the removal of a microcontaminants mixture (acetamiprid, carbamazepine and caffeine) by solar/Fe-EDDS/persulfate process...It was concluded that there is neither any influence of this variable on Fe-EDDS concentration and PS consumption profiles. In contrast, there was a general negative effect on MC removal efficiency, which strongly depended on both the concentration and composition of the dissolved organic matter.
- |||||||||| phenytoin / Generic mfg., carbamazepine / Generic mfg.
Journal: Development of a useful single-reference HPLC method for therapeutic drug monitoring of phenytoin and carbamazepine in human plasma. (Pubmed Central) - Jan 14, 2023
A preliminary application was performed using chemiluminescent immunoassay and SR-HPLC method, in which the detectable values of the correlation coefficient and the slope of the intercept were PHT: 0.964 and 0.992647, and CBZ: 0.969 and 1.072089, respectively. Based on these results, we propose that the SR-HPLC method with RMS would be offered to the useful and accurate TDM of various medicines in plasma/serum samples.
- |||||||||| sulphadiazine / Generic mfg., carbamazepine / Generic mfg.
Journal: g-CN/polyvinyl alcohol-sodium alginate aerogel for removal of typical heterocyclic drugs from water. (Pubmed Central) - Jan 13, 2023
The photodegradation of SDZ, SMX and CBZ was confirmed to be driven by ⋅O and h through scavenger-quenching experiments. The new low carbon and recyclable g-CN/PVA-SA aerogel reported in this study indicated a good potential for efficient removal of HCDs from water, which provides an alternative strategy for advanced purification and safe reuse of wastewater.
- |||||||||| Journal: Preparation of entrapment-based microcolumns for analysis of drug-humic acid interactions by high-performance affinity chromatography. (Pubmed Central) - Jan 12, 2023
The binding constants measured by HPAC for the given drugs with entrapped Aldrich humic acid gave good agreement with values reported in the literature under similar pH and temperature conditions for this and other forms of humic acid. Besides providing valuable data on the binding strength of various drugs with humic acid, this work illustrates how HPAC may be used as an analytical tool for screening and characterizing the interactions of drugs and man-made contaminants with humic acid or related binding agents in water and the environment.
- |||||||||| Journal: Features of the choice and the use of antiepileptic drugs as analgesics in elderly. (Pubmed Central) - Jan 9, 2023
Variety of antiepileptics used as analgesics have variable efficacy and safety profile in elderly. «Old» antiepileptics (phenobarbital, clonazepam, ethosuximide, carbamazepine, phenytoin, valproate, etc.) and «new» (gabapentin, pregabalin, oxcarbazepine, lamotrigine, levetiracetam, topiramate, zonisamide, tiagabine) are considered in this review with insights on pharmacokinetic features of these drugs in elderly, profile of side effects, parameters of analgesic efficacy.
- |||||||||| tramadol hydrochloride / Generic mfg., carbamazepine / Generic mfg.
Journal: Lignin nanoparticle-decorated nanocellulose cryogels as adsorbents for pharmaceutical pollutants. (Pubmed Central) - Jan 8, 2023
The resistance of the cryogels towards disintegration with exposure to water also improved with crosslinking, which eventually enabled the cryogels, especially the TCNF-based one, to be regenerated and reused for five cycles of adsorption-desorption experiment for the model pharmaceutical MPL. Thus, this study opened new opportunities to utilize LNPs in providing nanocellulose-based adsorbents with additional functional groups, which were otherwise often achieved by rigorous chemical modifications, at the same time, crosslinking the nanocellulose network.
- |||||||||| diazepam / Generic mfg., carbamazepine / Generic mfg.
Review, Journal: Effects of common antiepileptic drugs on teleost fishes. (Pubmed Central) - Jan 8, 2023
Thereby, AED exposure severely compromises individual fitness across teleost fish species, which may lead to population and ecosystem impairment. We also showcase promising avenues for future research by highlighting where we lack data when it comes to effects of certain AEDs, AED concentrations and behavioral endpoints.
- |||||||||| carbamazepine / Generic mfg.
Journal: Photocatalysis of carbamazepine via activating bisulfite by ultraviolet: Performance, transformation mechanism, and residual toxicity assessment of intermediates products. (Pubmed Central) - Jan 8, 2023
CBZ intermediates interfered in several key metabolic pathways, including pentose phosphate, amino acids, lysine degradation, glycerophospholipid, glutathione, nucleotides and carbohydrate, which was alleviated after UV/bisulfite treatment. This work provided a meaningful support to potential risk of CBZ intermediates products, which shed light on the future application in eliminating drugs using UV /bisulfite.
- |||||||||| topiramate / Generic mfg., carbamazepine / Generic mfg.
Journal: Diagnosis and treatment strategies of 56 cases of middle ear myoclonus (Pubmed Central) - Jan 6, 2023
Middle ear myoclonus tinnitus and the inducing factors manifestate diversity. Oral carbamazepine and other sedative drugs are effective for some patients, and surgical treatment is feasible for those who are ineffective for medication.
- |||||||||| Tysabri (natalizumab) / Biogen, Royalty
Journal, Adverse events, BRCA Biomarker: Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies. (Pubmed Central) - Jan 3, 2023
Measures of clinical validity and utility compare favorably to other genetic risk tests, such as BRCA1 and BRCA2 screening for breast cancer risk and HLA-B15:02 pharmacogenetic screening for pharmacovigilance of carbamazepine to prevent Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. For the first time, a PML genetic risk test can be implemented for screening patients taking or considering treatment with a PML-linked drug in order to decrease the incidence of PML and enable safer use of highly effective therapies used to treat their underlying disease.
- |||||||||| carbamazepine / Generic mfg.
Journal: Architecture of 3D graphene oxide sky-parking toward highly-efficient water purification. (Pubmed Central) - Jan 2, 2023
The assembled 3D SP-GOs exhibit superior adsorption capacity and short removal time for various aromatic organic compounds in water, achieving record-breaking maximum adsorption capacity of 535.79 mg/g toward the most common water-pollutant bisphenol A (BPA) at ambient conditions as well as significantly improved removal of other organic pollutants including sulfapyridine, carbamazepine, ketoprofen and 2-naphthol. The construction of SP-GO provides a simple approach for evolving the GO material from 2D to 3D and a new avenue for the decontamination of pollutants in environmental remediation.
- |||||||||| Review, Journal: Overview of therapeutic options for epilepsy. (Pubmed Central) - Jan 1, 2023
(1) As first-line treatment, vigabatrin is unanimously recommended for infantile spasms and focal seizures before 2 years and is also widely used for seizures over 2 years, as are levetiracetam and carbamazepine. (2) If seizures persist (about 40% of children and adolescents), cannabidiol and everolimus, an inhibitor of the mTOR pathway, have recently been approved as adjunctive therapy to the arsenal of antiseizure medications authorized for this age group and to the ketogenic diet..
- |||||||||| carbamazepine / Generic mfg.
Journal: Removal of pharmaceutically active compounds (PhACs) by zero-valent iron: quantification of removal mechanisms consisting of degradation, adsorption and co-precipitation. (Pubmed Central) - Jan 1, 2023
The removal mechanisms of carbamazepine (CBZ), which is one of pharmaceutically active compounds, using zero-valent iron (ZVI) were quantified by defining three fractions, namely "degradation", "adsorption", and "co-precipitation"...A novel kinetic model for removal of CBZ by ZVI was developed to simulate the dynamic concentration profiles of CBZ, TOC, total Fe ions, and dissolved oxygen linked closely with each other and the contributions of degradation, adsorption, and co-precipitation in TOC removal of CBZ. Reasonable agreement between experimental data and model predictions suggests the applicability of the proposed kinetic model to quantitatively analyze the mechanisms of CBZ removal by ZVI.
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