- |||||||||| carbamazepine / Generic mfg.
Preclinical, Journal: The Effect of Carbamazepine on Performance, Carcass Value, Hematological and Biochemical Blood Parameters, and Detection of Carbamazepine and Its Metabolites in Tissues, Internal Organs, and Body Fluids in Growing Rabbits. (Pubmed Central) - Jun 28, 2023
Mainly, the CBZ doses affected the count of leukocytes and other blood traits, meaning the higher the dose, the higher the reduction. Moreover, there were only low amounts of CBZ in rabbits' meat or tissues when they were exposed to the treatment.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Xcopri (cenobamate) / SK Bio, Angelini Group, Endo, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Review, Journal: Antiseizure Medication-Induced Alopecia: A Literature Review. (Pubmed Central) - Jun 27, 2023
Alopecia should be considered one important adverse effect of ASMs. Patients reporting hair loss with ASM therapy should be further investigated, and specialist consultation is recommended.
- |||||||||| carbamazepine / Generic mfg.
Journal: Ictal nystagmus: acquired nystagmus of infrequent cause in pediatrics (Pubmed Central) - Jun 26, 2023
When faced with a case of acquired nystagmus, epileptic etiology should be included in the differential diagnosis, especially if the frequency of episodes is high, of short duration, and associated with consciousness impairment. The diagnosis is based on a video-electroencephalogram with electro-clinical correlations and a good response to treatment with antiepileptic drugs is expected.
- |||||||||| carbamazepine / Generic mfg.
Journal: Graphitic carbon nitride metal-free photocatalyst for the simultaneous removal of emerging pharmaceutical pollutants in wastewater. (Pubmed Central) - Jun 19, 2023
In this study, graphitic carbon nitride (g-CN), a metal-free photocatalyst, was synthesized by the polymerization of melamine and assessed as a potential candidate for the photodegradation of acetaminophen (AP) and carbamazepine (CZ) in wastewater...Finally, the photodegradation mechanism and environmental impacts were discussed. This study presents a promising approach for treating and mitigating pharmaceutical contaminants in wastewater.
- |||||||||| carbamazepine / Generic mfg.
Journal: Priority screening of contaminants of emerging concern in drinking water sources of eastern China: Assessing risks based on exposure-activity ratios (EARs). (Pubmed Central) - Jun 16, 2023
Based on EARs and occurrence, priority chemicals were identified as difenoconazole (priority level 1), dimethomorph (priority level 2), acetochlor, caffeine, carbamazepine, carbendazim, paclobutrazol and pyrimethanil (priority level 3)...Furthermore, the difference between the maximum EAR for a given chemical in a sample (EAR) and the toxicity quotient (TQ) in priority screening of CECs was compared. The results show that screening priority CECs based on the EAR method is acceptable and more sensitive, suggesting the difference between in vitro and in vivo toxic effects and the necessity of incorporating the harm degree of biological effects into the EAR method to screen priority chemicals in the future.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Association between the mood stabilizing treatment of bipolar disorder and risk of suicide attempts: A self-controlled case series study. (Pubmed Central) - Jun 16, 2023
This study aimed to examine the association between mood stabilizing agents (lithium, valproate, lamotrigine, carbamazepine or antipsychotics) and risk of suicide attempts in patients with BPD using self-controlled case series study design...Indeed, there are potential protective effects of lithium and antiepileptics against suicide attempts. Assiduous monitoring of symptoms relapse and warning signs of suicide should be part of the management plan and discussed between clinicians, caregivers and patients.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Valproate (VPA) Decreases the Expression of Glucose Transporters as a Potential Mechanism of Inositol Depletion and Therapeutic Mechanism (Regency Ballroom A-C) - Jun 15, 2023 - Abstract #ISBD2023ISBD_348;
VPA and structurally dissimilar mood stabilizers lithium and carbamazepine, which inhibit inositol monophosphatase and inositol transporter SMIT1, respectively, have been shown to cause inositol depletion, supporting this biochemical outcome as a potential therapeutic mechanism... Overall, our results show that VPA decreases glucose transporters and that could be the mechanism of inositol reduction, and the therapeutic mechanism of VPA
- |||||||||| carbamazepine / Generic mfg.
Journal: Water Vapor Condensation on Iron Minerals Spontaneously Produces Hydroxyl Radical. (Pubmed Central) - Jun 14, 2023
Our findings largely broaden the natural source of OH. Given the ubiquitous existence of iron minerals on Earth's surface, those newly discovered OH could play a role in the transformation of pollutants and organic carbon associated with iron mineral surfaces.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. (Pubmed Central) - Jun 14, 2023
Findings from this explorative study strengthen the evidence for the warning against the use of valproate in pregnancy and raise concern of risks of specific psychiatric disorders associated with topiramate and levetiracetam. This study provides reassuring evidence that lamotrigine, carbamazepine, and oxcarbazepine are not associated with long-term behavioral or developmental disorders but cannot rule out risks with higher doses.
- |||||||||| vixotrigine (BIIB074) / Biogen, GSK
Journal: Structural mapping of Na1.7 antagonists. (Pubmed Central) - Jun 8, 2023
We show that vinpocetine, a synthetic derivative of a vinca alkaloid, and hardwickiic acid, a natural product with antinociceptive effect, bind to the III-IV fenestration, while vixotrigine, an analgesic candidate, penetrates the IV-I fenestration of the pore domain. Our results permit building a 3D structural map for known drug-binding sites on Na channels summarized from the present and previous structures.
- |||||||||| flucloxacillin sodium / Generic mfg., carbamazepine / Generic mfg., abacavir / Generic mfg.
Preclinical, Journal, PD(L)-1 Biomarker, IO biomarker: Transgenic murine models for the study of drug hypersensitivity reactions linked to HLA-I molecules. (Pubmed Central) - Jun 7, 2023
HLA-I transgenic mouse models are now available to study ABC, FLX and carbamazepine-induced adverse reactions. In vivo studies range from characterizing drug-antigen presentation, T cell activation, immune-regulatory molecules and cell-cell interaction pathways that are specifically involved in causing or controlling unwanted DHRs.
- |||||||||| Journal: Amino acid metabolism characteristics of Banxia Baizhu Tianma Decoction in realizing drug withdrawal based on transcriptomic analysis (Pubmed Central) - Jun 7, 2023
This study aimed to demonstrate the effect of Banxia Baizhu Tianma Decoction(BBTD) on realizing withdrawal of anti-epileptic drugs and explore the relationship between BBTD and the amino acid metabolism by transcriptomic analysis in the rat model of epilepsy induced by lithium chloride-pilocarpine...The BADIG was given BBTD extract and carbamazepine solution by gavage for 12 weeks...Finally, the circRNA-miRNA-mRNA ternary transcription network of 17 circRNA, 5 miRNA, and 2 mRNA, and a lncRNA-miRNA-mRNA ternary network of 10 lncRNA, 5 miRNA, and 2 mRNA were constructed in ADWG vs BADIG. In conclusion, BBTD can effectively achieve the withdrawal of antiepileptic drugs, which may be related to the transcriptomic regulation of amino acid metabolism.
- |||||||||| Epilepsy and Multiple Sclerosis - a Clinical Conundrum (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_892;
It is now known that epilepsy and MS can accumulate lesions in both the gray and white matter, and in the context of MS seizures can exacerbate demyelination; our records show an aggressive burden of disease, onset < 12 years notwithstanding. Hence, MS lesions can become epileptogenic and require treatment.
- |||||||||| Treatment of chorea in NXK2-1-related disorders: A Systematic Review (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_626;
The percentage of patients treated with methylphenidate who experience improvement in chorea is greater than that of patients treated with other medications. However, due to poor methodological quality, additional treatment studies may be required to recommend therapeutic options.
- |||||||||| flunarizine / Generic mfg.
Flunarizine - responsive episodic ataxia type 2. (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_615;
Our report adds important therapeutic considerations. Further studies are needed to prove the efficacy of flunarizine and possible long-term adverse effects.
- |||||||||| inosine pranobex / Generic mfg., carbamazepine / Generic mfg.
A Never Ending Story: Two Cases of SSPE presented with Focal Dystonia (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_529;
While patients could be diagnosed earlier with typical clinical presentations such as myoclonic jerks, cognitive impairment, and seizures, diagnosis is difficult in patients presenting with focal isolated findings such as focal dystonia. Since, this situation causes delay in diagnosis and treatment of patients, we wanted to emphasis focal findings of SSPE in this article.
- |||||||||| carbamazepine / Generic mfg.
GENOTYPE - PHENOTYPE CORRELATIONS AND IMPLICATION FOR TREATMENT IN A CASE SERIES OF SODIUM CHANNELOPATHIES (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_499;
We present 4 patients with mutations in the SCN2A gene, of which 2 siblings with focal seizures in the neonatal period, respectively in infancy, with a good response to Carbamazepine, the 2 other patients with intellectual disability with or without disorder of autistic spectrum and focal seizures started in childhood... The functional effect of a mutation (GoF, LoF) in the genes coding for the voltage-dependent sodium channel is decisive in choosing the appropriate anti-seizure medication, personalized for each patient.
- |||||||||| Diacomit (stiripentol) / Biocodex, Meiji Seika
Efficacy of stiripentol in the management of status epilepticus (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_494;
STP is an effective and well-tolerated therapy that should be introduced as early as possible in DS patients in order to suppress SE. In addition, STP is useful to treat SE in patients with drug-resistant SLC13A5-related epilepsy and SRSE.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
The Effects of Antiepileptic Drugs on heart rate, QT interval, TpE interval and Tpe-QTc ratio in children with epilepsy (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_470;
Although many studies are conducted on the ECG changes and underlying cardiac electrophysiological changes observed in pediatric epilepsy, their clinical significance is still not fully known. Our study will be important in terms of clinical use of these markers in the evaluation of arrhytmia tendency in childhood, and also in terms of raising awareness about cardiovascular system (CVS) comorbidities in the follow-up of pediatric patients with epilepsy.
- |||||||||| carbamazepine / Generic mfg.
Clinical spectrum associated with PRRT2 gene mutations in neuropediatric patients (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_430;
8 of them had favorable response to carbamazepine... These data add to the current understanding of the PRRT2 related synaptopathies and provide additional tools for early diagnosis while also underlining the importance of genetic testing in being able to orientate targeted treatment options for our patients.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Clinical description of patients with PCDH19 mutation. A multicentre retrospective study (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_429;
52/100.000 ); 2/ higher proportion of positive familial epileptic history; 3/high proportion of status epilepticus, 4/ higher proportion of brain anomalies on MRI. Molecular genetic testing for PCDH 19 mutation is necessary especially in girls with early onset childhood epilepsies.
- |||||||||| In utero seizures - prediction of genetic epilepsy (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_415;
Seizures stopped and the girl was put on carbamazepine (25 mg/kg per day) She is seizure free since then and acquires her milestones with some delay, occasionally she has dystonic movements Genetic test results came in 2 weeks after introduction of carbamazepine ( sequence analysis and deletion/duplication testing of the 1769 genes - multi-panel testing)...Conclusion. In utero seizures are reported rarely and should be suspicious for KCNQ2 -related seizures
- |||||||||| carbamazepine / Generic mfg.
A SCN2A loss-of-function variant causing early infantile onset encephalopathy (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_98;
SCN2A loss-of-function mutations may cause a severe phenotype like GOF mutation but with no response to sodium channel blockers. Functional characterization may direct clinical interventions and expand funotype-phenotype correlations.
|
