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- lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
[VIRTUAL] Lycium barbarum extracts preserve retinal function by rescuing synaptic loss in 3xTg mouse model of Alzheimer's disease () - Aug 2, 2020 - Abstract #AAIC2020AAIC_530;
Our results indicated that at early- and mid-stage of AD, presynaptic changes in IPL contributed to b-wave decline and LBE gavage could rescue the retinal functional deterioration in 3xTg AD mice by preventing the synapse loss in IPL through inhibiting oxidative stress and lowering Ca2+ in retinas.
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Journal: Lycium barbarum (Wolfberry) Increases Retinal Ganglion Cell Survival and Affects both Microglia/Macrophage Polarization and Autophagy after Rat Partial Optic Nerve Transection. (Pubmed Central) - Jul 16, 2020
We find that LBP can delay secondary degeneration of RGCs after temporal injury of optic nerves, promote the M2 polarization of microglia/macrophages, and down-regulate the level of autophagy after PONT. In conclusion, we find that the polarization of microglia/macrophages and the autophagy level change after PONT; LBP treatment delays secondary degeneration of RGCs; and the polarization of microglia/macrophages and the level of autophagy are also altered after LBP treatment.
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Journal: Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier. (Pubmed Central) - Jul 1, 2020
This study was approved by the Committee for the Use of Live Animals in Teaching and Research (approval No. CULTRA-#1664-08).
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Preclinical, Journal: Posttreatment Intervention With Lycium Barbarum Polysaccharides is Neuroprotective in a Rat Model of Chronic Ocular Hypertension. (Pubmed Central) - Feb 1, 2020
However, both LBP treatments preserved the retinal ganglion cells (RGC) and retinal functions up to week 15, which were significantly reduced in vehicle control. LBP posttreatment arrested the subsequent neuronal degeneration after treatment commencement and preserved RGC density and retinal functions in a chronic OHT model, which was comparable with pretreatment outcomes.
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Journal: Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury. (Pubmed Central) - Jan 31, 2020
The results of flow cytometric analysis showed LBP could effectively reduce the CoCl-induced retinal ganglion cell apoptosis, inhibited the generation of reactive oxygen species and the reduction of mitochondrial membrane potential. These findings suggested that LBP could protect retinal ganglion cells from CoCl-induced apoptosis by reducing mitochondrial membrane potential and reactive oxygen species.
- | fasudil / Generic Mfg., lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Preclinical, Journal: Protective effects of lycium barbarum polysaccharides on blood-retinal barrier via ROCK1 pathway in diabetic rats. (Pubmed Central) - Nov 20, 2019
LBP has the protective effects on blood-retinal barrier by regulating the Rho/ROCK signaling pathway in diabetic rats. LBP may be served as a Rho/ROCK inhibitor for the treatment of DR.
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Preclinical, Journal: Lycium Barbarum Polysaccharides Rescue Neurodegeneration in an Acute Ocular Hypertension Rat Model Under Pre- and Posttreatment Conditions. (Pubmed Central) - Oct 11, 2019
GCL density was reduced in vehicle control (P = 0.0001), but did not differ between sham and pre- and posttreated AOH groups. The rescue effect of LBP posttreatment was observed later, which arrested the secondary degeneration and improved the retinal function.
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Preclinical, Journal: The protective effects of lycium barbarum polysaccharides on retinal neurons in diabetic rats and its mechanism (Pubmed Central) - Sep 7, 2019
The rescue effect of LBP posttreatment was observed later, which arrested the secondary degeneration and improved the retinal function. LBP can improve retinal oxidative stress and exert beneficial neuroprotective effects in diabetic rats, and its mechanism may be associated with the activation of the Nrf2/HO-1 antioxidant pathway.
- | lycium anti-angiogenic proteoglycan (LAP) / RetinaPharma Technologies
Journal: Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement. (Pubmed Central) - Aug 21, 2019
P=N/A
LBP can improve retinal oxidative stress and exert beneficial neuroprotective effects in diabetic rats, and its mechanism may be associated with the activation of the Nrf2/HO-1 antioxidant pathway. LB supplement provides a neuroprotective effect for the retina and could help delay or minimize cone degeneration in RP.