Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine 
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 12 Diseases   8 Trials   8 Trials   107 News 


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  • ||||||||||  An unusual genotypic case of very early onset inflammatory bowel disease () -  Mar 27, 2023 - Abstract #BSPGHAN2023BSPGHAN_112;    
    Further research is required to improve post-partum care in women following repair of OASIs. She was treated for 6 months with Movicol and sodium picosulfate with partial resolution...She was started on infliximab infusions, azathioprine, and topical tacrolimus (for rectal lesions)...She is currently on 4 weekly vedolizumab treatment, with steroids, following poor response to high dose infliximab and is being considered for colostomy and colectomy if current treatment fails...As highlighted above, our patient is currently on vedolizumab therapy, some authors suggest
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Enrollment status:  CACODI: Colon Capsule Endoscopy in Patients With Colonic Diverticulitis (clinicaltrials.gov) -  Mar 2, 2023   
    P=N/A,  N=120, Enrolling by invitation, 
    She was treated for 6 months with Movicol and sodium picosulfate with partial resolution...She was started on infliximab infusions, azathioprine, and topical tacrolimus (for rectal lesions)...She is currently on 4 weekly vedolizumab treatment, with steroids, following poor response to high dose infliximab and is being considered for colostomy and colectomy if current treatment fails...As highlighted above, our patient is currently on vedolizumab therapy, some authors suggest Recruiting --> Enrolling by invitation
  • ||||||||||  Terrosa (teriparatide biosimilar) / Mochida, Gedeon Richter, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap, Movicol (AJG555) / Mochida, Eisai
    Resolution of severe constipation following a switch from calcium carbonate to recombinant human PTH therapy: A case report (Rome, Italy) -  Nov 13, 2022 - Abstract #ESPE2022ESPE_1314;    
    She developed constipation at 4-years-old when she was commenced on Movicol...Unfortunately, the patient developed soiling and management was escalated to Picolax and then Botox and manual extraction...She was admitted at 12 years of age for rhPTH (Terrosa) therapy subcutaneously...Recombinant human PTH therapy can be used successfully to wean calcium supplements and reduce severe complications secondary to the oral medication. It also improves compliance and overall bone biochemistry.
  • ||||||||||  Movicol (AJG555) / Mochida, Eisai
    What about movicol? (Twitter) -  Mar 4, 2022   
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Antibiotic Combination Therapy Improves Symptoms of Parkinson’s Disease in Individuals With Chronic Constipation (Shoreline Exhibit Hall) -  Sep 8, 2021 - Abstract #ACG2021ACG_204;    
    ACT successfully treated constipation and improved neurological symptoms of PD in two cases. Our findings suggest that treatments modulating the gut microbiota may play a role in reducing the severity and progression of PD as well as ameliorating non-motor symptoms such as constipation.
  • ||||||||||  Emla-cream / Akorn, AstraZeneca, Movicol (AJG555) / Mochida, Eisai
    [VIRTUAL] Getting to the root of it: contact anaphylaxis from polyethylene glycol in a dental lubricant () -  Jul 5, 2021 - Abstract #BAD2021BAD_195;    
    We report this case to raise awareness of severe immediate hypersensitivity to these apparently innocuous ingredients and a novel source of exposure. A low index of suspicion, lack of standardized nomenclature and commercial reagents for testing are current barriers to diagnosis.
  • ||||||||||  Linzess (linaclotide) / Astellas, Ironwood Pharma, AbbVie
    Journal:  Bioactivity of oral linaclotide in human colorectum for cancer chemoprevention. (Pubmed Central) -  Mar 21, 2018   
    These data show that the current FDA-approved formulation of oral linaclotide developed for small bowel delivery to treat chronic idiopathic constipation is inadequate for reliably regulating GUCY2C in the colorectum to prevent tumorigenesis. The study results highlight the importance of developing a novel GUCY2C agonist formulated for release and activity targeted to the large intestine for colorectal cancer prevention.
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Trial completion:  General Clinical Study of AJG555 in Pediatric Patients With Chronic Constipation (clinicaltrials.gov) -  Oct 24, 2017   
    P3,  N=39, Completed, 
    The study results highlight the importance of developing a novel GUCY2C agonist formulated for release and activity targeted to the large intestine for colorectal cancer prevention. Active, not recruiting --> Completed
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Enrollment closed:  General Clinical Study of AJG555 in Pediatric Patients With Chronic Constipation (clinicaltrials.gov) -  Mar 28, 2017   
    P3,  N=39, Active, not recruiting, 
    Active, not recruiting --> Completed Recruiting --> Active, not recruiting
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Trial completion:  Maintenance Treatment for Children With Constipation (clinicaltrials.gov) -  Sep 25, 2015   
    P=N/A,  N=115, Completed, 
    Phase classification: P3 --> P2 Active, not recruiting --> Completed
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Enrollment closed, Trial primary completion date:  Maintenance Treatment for Children With Constipation (clinicaltrials.gov) -  May 26, 2015   
    P=N/A,  N=125, Active, not recruiting, 
    Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Apr 2015
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Trial primary completion date:  Maintenance Treatment for Children With Constipation (clinicaltrials.gov) -  Dec 6, 2014   
    P=N/A,  N=125, Recruiting, 
    Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2015 --> Apr 2015 Trial primary completion date: Sep 2014 --> Aug 2015
  • ||||||||||  Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine
    Enrollment open:  Maintenance Treatment for Children With Constipation (clinicaltrials.gov) -  Mar 18, 2014   
    P=N/A,  N=125, Recruiting, 
    Trial primary completion date: Sep 2014 --> Aug 2015 Not yet recruiting --> Recruiting