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- | Cordran (flurandrenolide) / Almirall, AbbVie
Biomarker, Journal: Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers. (Pubmed Central) - Oct 25, 2024
Further investigation of these drugs is essential to improve the treatment of cardiovascular disease. Additionally, supporting the clinical use of miRNAs as biomarkers for diagnosing and predicting CVD is crucial.
- | sirolimus / Generic mfg.
Journal: A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease. (Pubmed Central) - Mar 8, 2022
In short, gallamine triethiotide, diflorasone, fenoterol, and pralidoxime ameliorate steatosis similarly to resveratrol/sirolimus. The implementation holds great potential in reducing screening time in the early drug discovery stages and in delivering promising compounds for in vivo testing.
- | Psorcon (diflorasone diacetate) / Bausch Health
Journal: Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6- epi-Garcimultiflorone A. (Pubmed Central) - Sep 25, 2020
Using this strategy, we achieved the enantioselective total syntheses of the type A PPAPs (-)-nemorosone and (-)-6- epi-garcimultiflorone A. Diverse photocyclization substrates have been investigated leading to divergent photocyclization processes as a function of tether length. Photophysical studies were performed, and photocyclization mechanisms were proposed based on investigation of various substrates as well as deuterium-labeling experiments.
- | Psorcon (diflorasone diacetate) / Bausch Health
Journal: Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells. (Pubmed Central) - Mar 3, 2020
Conclusion Our data demonstrate the anti-angiogneic effects of garcimultiflorone K in both in vitro and in vivo models. Garcimultiflorone K appears to have potential in the treatment of angiogenesis-related diseases.