- |||||||||| Dipentum (olsalazine sodium) / Viatris, UCB
Journal: A Rapid and Reliable Absorbance Assay to Identify Drug-Drug Interactions with Thiopurine Drugs. (Pubmed Central) - Dec 27, 2024
With purified TPMT on hand and the absorbance activity assay, we confirmed several compounds that inhibit TPMT, and the results were comparable to a mass spectral assay that measured 6-MP methylation. Understanding the impact of co-administered drugs on TPMT activity will improve the safety and efficacy of thiopurine-based treatment regimens.
- |||||||||| amoxycillin/clavulanate / Generic mfg.
Drug-Induced Liver Injury: A Case of Amoxicillin-Clavulanate-Induced Liver Injury (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1931;
Management includes immediate cessation of the offending agent with supportive care with n-acetylcysteine (NAC) and ursodiol, although there is little evidence to support their use...Case Description/ A 59-year-old male with ulcerative colitis on balsalazide presented with nausea, vomiting, fatigue, jaundice, scleral icterus, and pruritis...Figure: Cholestatic hepatitis with canalicular cholestasis, associated with hepatocellular degeneration and mild portal inflammatory infiltrates, consistent with drug-induced bile metabolism. Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
- |||||||||| Remicade (infliximab) / J&J, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Cytomegalovirus Colitis Mimicking Steroid-Refractory Ulcerative Colitis in an Immunocompetent Elderly Patient (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1516;
After being diagnosed with ulcerative colitis a few weeks prior, she was discharged on a short course of prednisone...She was started on methylprednisolone and infliximab, and endoscopy was scheduled...She was started on IV ganciclovir and transitioned to oral valganciclovir for 3 additional weeks...She is currently being treated with balsalazide with plans to follow up with repeat colonoscopy in 6 months...The patient's inability to afford mesalamine also emphasizes the role of socioeconomic factors in managing her IBD, potentially impacting treatment outcomes. Figure: Eosinophilic inclusions, large atypical cells with intranuclear inclusion bodies or "owl-eye appearance"
- |||||||||| Salmonella Colitis Masquerading as Ulcerative Colitis Flare (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_761;
She was diagnosed with UC 15 years prior and was controlled well on azathioprine and balsalazide without missed doses...Ceftriaxone was switched to ciprofloxacin with resolution of symptoms and discharge...Antibiotic therapy use is reserved for severe disease or those at risk of invasive disease, such as patients with UC. Figure: Coronal View Computed Tomography of Acute Long Segment Descending Colon Colitis
- |||||||||| Dipentum (olsalazine sodium) / Viatris, UCB
5-AMINOSALICYLATES FOR PATIENTS WITH ACTIVE OR QUIESCENT CROHN (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1584;
However, evidence does not support the role of 5-ASA for maintaining medically induced remission. Updating SRs with new evidence is imperative to provide guidance on patient subsets who may benefit from 5-ASA use and these results will be updated with the STATIC trial 1.
- |||||||||| RATES OF ESCALATION TO ADVANCED THERAPY IN PATIENTS WITH ULCERATIVE PROCTITIS AT SIX MONTHS, ONE YEAR, AND TWO YEARS POST DIAGNOSIS (Hall A, Poster Hall - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_5339;
We excluded those on prior advanced therapy (azathioprine, methotrexate, mercaptopurine, infliximab, golimumab, adalimumab, vedolizumab, tofacitinib, upadacitinib, ustekinumab, ozanimod)...Anti-TNFs were the most used medication class, with infliximab or adalimumab being the most frequently used agents. Our data suggests a mostly benign disease course in patients with UP with a low percentage requiring advanced therapies.
- |||||||||| Jakafi (ruxolitinib) / Novartis, Incyte
Journal: CD45 inhibition in myeloid leukaemia cells sensitizes cellular responsiveness to chemotherapy. (Pubmed Central) - Jan 3, 2024
Bioinformatics analysis identified genes whose expression was correlated with CD45 expression such as JAK2, ACTR2, THAP3 Serglycin, and PBX-1 genes, as well as licensed drugs (alendronate, allopurinol, and balsalazide), which could be repurposed as CD45 inhibitors which effectively increases sensitivity to cytarabine and ruxolitinib at low doses. Therefore, CD45 inhibition could be explored as a potential therapeutic partner for treatment of myeloid malignancies in combination with chemotherapy such as cytarabine especially for elderly patients and those showing chemotherapy resistance.
- |||||||||| Dipentum (olsalazine sodium) / Viatris, UCB
VISUALIZING HETEROGENEOUS TRAJECTORIES OF SUBJECTS WITH SURGICAL RELAPSE IN INFLAMMATORY BOWEL DISEASE FROM UK BIOBANK GENERAL PRACTICE DATA (Bellagio Ballroom - Bellagio Las Vegas) - Dec 24, 2023 - Abstract #CCCongress2024CCCongress_323;
Therefore, CD45 inhibition could be explored as a potential therapeutic partner for treatment of myeloid malignancies in combination with chemotherapy such as cytarabine especially for elderly patients and those showing chemotherapy resistance. Additionally, data for the 9 most used IBD prescription medications: budesonide, sulfasalazine, methotrexate, hydrocortisone, balsalazide, olsalazine, prednisolone, azathioprine, and mesalamine was analyzed as well...The majority of patients fell within the states labeled
- |||||||||| balsalazide / Generic mfg., mesalamine rectal enema / Generic mfg.
Liver Masses Presenting as Stage IV Neuroendocrine Tumor in BRCA1 Mutation (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4351;
Our case represents the first instance in the literature describing the connection between BRCA1 mutations and primary pancreaticobiliary neuroendocrine tumors, proving they should remain on the differential in patients with vague presenting symptoms, specifically those with genetic mutations that might place them at higher risk for cancer incidence. Figure: Multifocal hepatic masses in the setting of BRCA1 Mutation
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / AbbVie
A Functional Medicine Program for Patients With Inflammatory Bowel Disease and Improvement in Fecal Calprotectin Levels (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4121;
She achieved symptomatic improvement on tofacitinib, but serial colonoscopies showed persistent inflammation in the rectum and ascending colon...Previous therapy included mesalamine enemas...These cases show improvement in fecal calprotectin. A larger, prospective design with other measures of inflammation is needed to further investigate this effect.
- |||||||||| Lactobacillus Sepsis, Endocarditis, and Septic Emboli in a Patient with Ulcerative Colitis Taking Probiotics (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3784;
His medical history included bioprosthetic aortic valve replacement 2-years prior and ulcerative colitis taking daily balsalazide and lactobacillus-containing probiotics...The patient was subsequently treated with IV gentamycin and ampicillin, with transition to indefinite oral amoxicillin suppressive therapy...(A-B) Demonstrates supratentorial ring-enhancing lesions involving the left parietal and left occipital regions (green arrows). (C) Susceptibility weighted imaging (SWI) shows evidence of hemorrhage (red arrow) within lesions, with greatest hemorrhage involving the left middle frontal gyrus.
- |||||||||| balsalazide / Generic mfg.
Polyp That Wears a Cap: A Case of Inflammatory Cap Polyposis Mimicking Neoplasm (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_2490;
He received Miralax for constipation and Balsalazide for UC from 2013 to 2020 but continued to have polyps...More research needs to be done to evaluate preventive and curative therapy for this benign pathology. Figure: Ulcerated, friable pedunculated polyps with mucus caps in the rectosigmoid region.
- |||||||||| balsalazide / Generic mfg., mesalazine / Generic mfg.
Mesalamine Hypersensitivity Induced Hemorrhagic Shock (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_2201;
He began oral mesalamine and mesalamine suppository therapy...He began intravenous steroids and his mesalamine therapy was changed to balsalazide...Although mesalamine hypersensitivity is not common, it is important to include it in the differential diagnoses of patients with pertinent inflammatory bowel disorders who present with worsening clinical symptoms after introduction to mesalamine or similar 5-aminosalicylic acid compounds. Figure: Figure A: CT A/P w/o IV contrast demonstrating edematous rectum with perirectal fat stranding suggesting proctitis FIgure B: diffuse area of severely hemorrhagic and ulcerated mucosa in the rectum
- |||||||||| Factors Associated With Delayed Corticosteroid Treatment for Patients With Acute Flares in Inflammatory Bowel Disease and Hospital Outcomes (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_1660;
One hundred fifty-eight patients (61.5%) received steroids within 24h, 51 (19.8%) 24-48h, 26 (10.1%) 48-72h, and 22 (8.6%) >72h. Fever, diarrhea, and elevated ESR and CRP were more prevalent in patients who received steroids within 48-72h (p= 0.0208, 0.0367, 0.0117, and 0.0163, respectively) compared to those who received steroids within 24h, but not any other time frame .
- |||||||||| balsalazide / Generic mfg.
Journal: Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition. (Pubmed Central) - Aug 18, 2022
An immobilised balsalazide-analogue specifically pulled down Sirt5 from whole cell lysates and competition experiments identified glutaryl-CoA dehydrogenase (GCDH) and nucleotide diphosphate kinase (NME4) as potential off-targets, once again confirming the selectivity of the novel balsalazide-derived Sirt5 inhibitors. In summary, a combination of targeted chemical synthesis, biological work, and computational studies led to a new generation of tailored Sirt5 inhibitors, which represent valuable chemical tools for the investigation of the physiological role of Sirt5, but could also serve as advanced lead structures for drug candidates for systemic use.
- |||||||||| Dipentum (olsalazine sodium) / Viatris, UCB
Clinical, Journal: Trends of 5-Aminosalicylate Medication Use in Patients With Crohn Disease. (Pubmed Central) - Feb 8, 2022
About 1 in 3 privately insured patients with CD received 5-ASA prescriptions despite their questionable effectiveness; however, in an encouraging trend, prescription rates significantly decreased from 2009 to 2014. This high prescription rate may reflect a gap in providers' knowledge regarding the available evidence-an opportunity for cost savings with improved health care delivery.
- |||||||||| balsalazide / Generic mfg., sulfasalazine / Generic mfg.
Review, Journal: Cardiovascular Manifestations in Inflammatory Bowel Disease: A Systematic Review of the Pathogenesis and Management of Pericarditis. (Pubmed Central) - Apr 23, 2021
The majority of studies suggest that pericarditis arises as a complication of drug therapy by 5-aminosalicylic acid derivatives such as sulfasalazine, mesalamine, and balsalazide, and it occurs due to IgE-mediated allergic reactions, direct cardiac toxicity, cell-mediated hypersensitivity reactions, and humoral antibody response to therapy. Drug cessation or the initiation of a corticosteroid regimen seems to be the most effective means of managing pericarditis in IBD due to drug therapy or an extraintestinal manifestation.
- |||||||||| balsalazide / Generic mfg.
Journal: Mirror Instabilities in the Inner Magnetosphere and Their Potential for Localized ULF Wave Generation. (Pubmed Central) - Mar 9, 2021
Our results indicate a strong preference for the premidnight sector of the night-side magnetosphere, with events ranging in time scales from half a minute (roughly 200 km in scale size) to several hours (multiple Earth radii). The statistical distribution of these plasma regions explicitly identifies the source region of "storm time Pc5 ULF waves" and suggests an alternative mechanism for their generation in the night-side inner magnetosphere.
- |||||||||| balsalazide / Generic mfg.
Journal: Statistical Properties of Electron Curtain Precipitation Estimated With AeroCube-6. (Pubmed Central) - Feb 2, 2021
We found that curtains are observed in the late-morning and premidnight magnetic local times, with a higher occurrence rate at premidnight, and curtains are observed more often during times of enhanced Auroral Electrojet...Such observations suggest that continuous curtain precipitation may be a significant loss of >35-keV electrons from the magnetosphere into the atmosphere. We hypothesize that the curtains observed in the bounce loss cone were accelerated by parallel electric fields, and we show that this mechanism is consistent with the observations.
- |||||||||| allopurinol / Generic mfg.
[VIRTUAL] Could CD45 have a role in the development of myeloid malignancies? () - Jan 5, 2021 - Abstract #BSHI2020BSH-I_145;
The combination of these drugs with Cytarabine has indicated some degree of synergy. In conclusion, CD45 is highly expressed in AML cell lines and the inhibition of the gene, by siRNA or novel repurposed agents targeting CD45, have given an insight into the molecular pathways and potential therapeutic options associated with this gene.
- |||||||||| Clinical, Review, Journal: Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. (Pubmed Central) - Oct 10, 2020
There is probably little or no difference between 5-ASA and placebo, and 5-ASA and SASP in commonly reported AEs such as flatulence, abdominal pain, nausea, diarrhea, headache, and dyspepsia. Oral 5-ASA administered once daily has a similar benefit and harm profile as conventional dosing for maintenance of remission in quiescent UC.
- |||||||||| Entyvio (vedolizumab) / Takeda
[VIRTUAL] COVID-19 and Ulcerative Colitis in Pregnancy () - Sep 15, 2020 - Abstract #ACG2020ACG_2350;
She was diagnosed in 2015 and established care with us in 2018 while on balsalazide...She was started on budesonide 9mg daily, however due to persistent symptoms 2 weeks later, was switched to prednisone 40mg daily with clinical response within 72 hours...With collaboration with her obstetrics team, the decision was made to proceed with vedolizumab after delivery...Cautious treatment of maternal IBD is necessary. A multidisciplinary approach between IBD gastroenterology and Obstetrics is critical in safely managing these patients.
- |||||||||| Journal: Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1's hypothesized function? (Pubmed Central) - Aug 5, 2020
Some compounds previously reported to be OATP2B1 substrates in the literature, aliskiren, erlotinib, montelukast, fexofenadine, and taurocholate could not be confirmed as substrates.Literature describing in vivo outcomes for OATP2B1 substrates, coproporphyrin III, ARBs, balsalazide, olsalzine, and gavestinel highlight the absence of a substantial impact of OATP2B1 on the oral absorption and/or brain penetration of OATP2B1 substrates. Suggestions of including OATP2B1 assessment as part of the drug approval process are likely premature and further mechanistic work with more robust OATP2B1 substrates, which may include some of those described here, is desirable.
- |||||||||| balsalazide / Generic mfg., Asacol foam (mesalazine rectal foam) / Nogra Pharma, sulfasalazine / Generic mfg.
Thanks, Marisa, this was yrs ago, pre-biologic era, & before jpouch, but I was amazed by my profound response to Colazal, after being on Asacol for yrs. Both ⬆️ pill burden, maybe no longer relevant w qd dosed 5ASAs! (I’m so old that I was first on sulfasalazine) #MondayNightIBD (Twitter) - Jul 29, 2020
|
