- |||||||||| leuprolide acetate for depot suspension / Generic mfg.
Preclinical, Journal: Leuprolide acetate improves ovarian indices but does not restore uterine morphometry in obese Zucker rats. (Pubmed Central) - Nov 7, 2026 At the uterine level, LA reduced uterine diameter in obese rats but did not modify endometrial thickness. These findings indicate that LA produces markedly different reproductive responses according to the metabolic and reproductive context, improving several follicular and luteal histomorphometric indices in obese Zucker rats without a parallel restoration of uterine morphometry.
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Clinical, Retrospective data, Review, Journal: Gonadotropin-releasing hormone antagonists versus agonists for endometriosis: a systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Nov 6, 2026 We performed a systematic review and meta-analysis of randomized controlled trials comparing GnRH-ant with leuprolide-based GnRH-a for the treatment of endometriosis, assessing symptom relief, pelvic signs, bone mineral density (BMD), quality of life, and hormonal outcomes...Long-term head-to-head trials are warranted. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261289010, identifier CRD420261289010.
- |||||||||| Leukostasis in Setting of Acute Leukemia: A Rare Cause of Right Ventricular Failure & Group 5 Pulmonary Hypertension (Clinical Science Zone 1' Science and Technology Hall' South Hall' Leve; In-Person; Board no. 1136) - Nov 3, 2026 - Abstract #AHA2026AHA_12193;
This prompted initiation of emergent induction chemotherapy with leuprolide, daunorubicin, and cytarabine...Early recognition of RV failure and prompt initiation of supportive therapy, including diuresis and inhaled pulmonary vasodilation, were key strengths, along with treatment of the underlying leukemia. While rare, leukostasis?associated PH can be reversible with rapid cytoreduction, consistent with the partial improvement observed in this case, underscoring the need of coordinated multidisciplinary care.
- |||||||||| Journal: A Systematic Review of Elagolix for the Management of Endometriosis-associated Pain. (Pubmed Central) - Nov 1, 2026
Elagolix represents an effective, patient centered therapeutic option for moderate to severe endometriosis associated pain, with a well characterized safety profile. Future research should address long term safety beyond 48 months, direct comparisons with first line hormonal therapies, and cost effectiveness in non US healthcare settings.
- |||||||||| leuprolide acetate for depot suspension / Generic mfg., cyproterone acetate / Generic mfg.
Enrollment change: PCNET: Comparison of Two Pharmacological Treatments of Pedophilia (clinicaltrials.gov) - Oct 28, 2026 P3, N=6, Terminated, Readers should interpret these findings as hypothesis-generating and not proof of universal toripalimab activity. N=48 --> 6
- |||||||||| Erleada (apalutamide) / J&J, Firmagon (degarelix) / Astellas, Ferring, Orgovyx (relugolix) / Takeda, Sumitomo Pharma, Pfizer
Enrollment closed: VA STARPORT: Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer (clinicaltrials.gov) - Oct 19, 2026 P2/3, N=378, Active, not recruiting, These findings support that JCPyV-derived virus-like particles constitute a promising therapeutic approach for metastatic CRPC, enabling systemic delivery of suicide gene therapy with selective inhibition of tumor growth and translational relevance. Recruiting --> Active, not recruiting
- |||||||||| Herceptin (trastuzumab) / Roche, Perjeta (pertuzumab) / Roche
Trial completion date, Trial primary completion date: ADEPT: A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer (clinicaltrials.gov) - Oct 6, 2026 P2, N=393, Active, not recruiting, Not yet recruiting --> Completed Trial completion date: Sep 2030 --> Sep 2032 | Trial primary completion date: Mar 2026 --> Mar 2029
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A Rare Case of Kidney Failure Due to Deeply Infiltrating Endometriosis and Nonsteroidal Anti-Inflammatory Drug Use (Exhibit Hall A, Convention Center) - Oct 2, 2026 - Abstract #KIDNEYWEEK2026KIDNEY_WEEK_4830; She completed leuprolide therapy of endometriosis two months prior and had worsened abdominal pain afterwards, prompting NSAID use exceeding 3 g daily...Patients with CKD related to endometriosis have increased risks for deterioration of kidney function from both structural changes and NSAID use. Interdisciplinary management with a multimodal approach, preventive counseling and safe pain management are vital for staving off kidney failure and prolonging survival.
- |||||||||| enzalutamide / Generic mfg., leuprolide acetate for depot suspension / Generic mfg.
NELL-1-Associated Membranous Nephropathy in a Patient with Prostate (and Later Pancreatic) Cancer () - Oct 2, 2026 - Abstract #KIDNEYWEEK2026KIDNEY_WEEK_4296; Further investigation need determine the mechanism linking antibody production and development of related MN. Our patient illustrates not only these principles, but also the potential for occult malignancy, present even as MN remission has been achieved.
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Puberty Blockade Via Leuprolide Acetate Disrupts Bone Accrual in Adolescent Rats (Meeting Room 302) - Sep 20, 2026 - Abstract #ASBMR2026ASBMR_1893; Ultimately, temporary suppression of puberty produced a transient, sex, and compartment-specific disruption of bone acquisition in rats. Whether longitudinal structural recovery fully restores peak bone mass, material quality, or strength remains a future direction.
- |||||||||| giredestrant (RG6171) / Roche
Enrollment closed, Trial primary completion date: CO44657: A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer) (clinicaltrials.gov) - Sep 14, 2026 P3, N=1050, Active, not recruiting, Whether longitudinal structural recovery fully restores peak bone mass, material quality, or strength remains a future direction. Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2027 --> Apr 2028
- |||||||||| Kisqali (ribociclib) / Novartis
Severe Delayed Ribociclib-Induced Liver Injury Despite Prolonged Drug Interruption (Exhibit Halls A - D (Level 3)) - Aug 29, 2026 - Abstract #ACG2026ACG_7072; Although hepatotoxicity from CDK4/6 inhibitors is recognized, progression after prolonged drug interruption is uncommon and warrants vigilant monitoring. Figure: Trend of Liver Function Tests and Bilirubin during Hospitalization Figure: Laboratory values during the admission
- |||||||||| leuprorelin acetate (DKF-MA102) / Dongkook Pharma
Trial completion, Trial completion date, Trial primary completion date: Efficacy and Safety of DKF-MA102 in Patients With Prostate Cancer (clinicaltrials.gov) - Aug 14, 2026 P3, N=161, Completed, The observed increase in stroke risk suggests a potential vascular effect of estrogen suppression, warranting further investigation and long-term cardiovascular surveillance in this population. Recruiting --> Completed | Trial completion date: May 2025 --> Mar 2026 | Trial primary completion date: May 2025 --> Jan 2026
- |||||||||| Prolia (denosumab) / Amgen, Firmagon (degarelix) / Astellas, Ferring
Do diagnostic and therapeutic patterns influence the outcomes in patients with metastatic castration sensitive prostate cancer? Real-world data from 2 independent tertiary centers in Slovakia () - Jul 17, 2026 - Abstract #ESMO2026ESMO_5069; Docetaxel and denosumab were more frequent in CO (87% vs 13% and 64% vs 36%, respectively)...No significant differences were observed in treatment outcomes (PSA?0.2: 63% vs 60%; PSA90: 98% vs 95%; progression: 34% vs 34%; mortality: 25% vs 25%; all p=NS). Similarly, Kaplan-Meier analysis showed no significant differences in PFS and OS (Log Rank test, p=NS).Conclusions Even though RWD confirmed differences in how oncologists and urologists manage mCSPC in Slovakia, both adhere to EAU/NCCN guidelines, resulting in comparable clinical outcomes such as PSA response, PFS, and OS.
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Puberty Blockade Via Leuprolide Acetate Disrupts Bone Accrual in Adolescent Rats (Discovery Hall - Exhibit Hall C & D) - Jul 11, 2026 - Abstract #ASBMR2026ASBMR_80; Ultimately, temporary suppression of puberty produced a transient, sex, and compartment-specific disruption of bone acquisition in rats. Whether longitudinal structural recovery fully restores peak bone mass, material quality, or strength remains a future direction.
- |||||||||| Lynparza (olaparib) / Merck (MSD), AstraZeneca
Enrollment closed, Trial primary completion date: NePtune: Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations (clinicaltrials.gov) - Jul 10, 2026 P2, N=32, Active, not recruiting, Whether longitudinal structural recovery fully restores peak bone mass, material quality, or strength remains a future direction. Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2026 --> Aug 2026
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