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9 Diseases |  |
13 Trials |
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13 Trials |  |
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- | Verzenio (abemaciclib) / Eli Lilly
Enrollment open: Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer (clinicaltrials.gov) - Jan 16, 2025
P2, N=60, Recruiting, Sponsor: University of Washington
Suspended --> Recruiting
- | Vagifem (estradiol) / Novo Nordisk, Estrofem (estradiol oral) / Novo Nordisk, alendronate / Generic mfg.
Journal: Bilateral Ovarian Agenesis and Bone Modeling Disease in Pre-puberty Girl With Primary Amenorrhea. (Pubmed Central) - Jan 12, 2025
This is the first reported case of bilateral ovarian agenesis with chromosome X translocation presenting with phenotypic amenorrhea and bone deformities, demonstrating the value of tailored therapeutic approaches. Ongoing monitoring remains essential to ensure continued progress and mitigate long-term risks.
- | Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
Reimbursement, US reimbursement, Journal, Medicare: Vaginal Estrogen Prescribing and Cost Trends Among Medicare Part D Beneficiaries. (Pubmed Central) - Dec 18, 2024
However, spending per beneficiary and VE claims have increased. Our data suggest that utilization and accessibility of vaginal estrogen may be influenced, in part, by cost.
- | Vivelle (estradiol transdermal system) / Sanofi, Hisamitsu, Novartis, Vagifem (estradiol) / Novo Nordisk
Trial completion: Efficacy of Vaginal 17?-Estradiol on the Urinary Storage Symptoms in Postmenopausal Women (clinicaltrials.gov) - Nov 7, 2024
P4, N=86, Completed, Sponsor: Mahidol University
Our data suggest that utilization and accessibility of vaginal estrogen may be influenced, in part, by cost. Active, not recruiting --> Completed
- | Verzenio (abemaciclib) / Eli Lilly
Trial suspension: Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer (clinicaltrials.gov) - Sep 20, 2024
P2, N=60, Suspended, Sponsor: University of Washington
Active, not recruiting --> Completed Recruiting --> Suspended
- | Climara (estradiol) / Bausch Health, Bayer, Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
Enrollment closed, Enrollment change, Metastases: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov) - Aug 18, 2024
P2, N=5, Active, not recruiting, Sponsor: Mayo Clinic
Recruiting --> Suspended Enrolling by invitation --> Active, not recruiting | N=38 --> 5
- | Vagifem (estradiol) / Novo Nordisk, Estrofem (estradiol oral) / Novo Nordisk, Divigel (estradiol) / Sawai Pharma
New P4 trial: Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome (clinicaltrials.gov) - Aug 8, 2024
P4, N=50, Recruiting, Sponsor: Aarhus University Hospital
- | Vivelle (estradiol transdermal system) / Sanofi, Hisamitsu, Novartis, Vagifem (estradiol) / Novo Nordisk
New P4 trial: Efficacy of Vaginal 17?-Estradiol on the Urinary Storage Symptoms in Postmenopausal Women (clinicaltrials.gov) - Jul 17, 2024
P4, N=86, Active, not recruiting, Sponsor: Mahidol University
- | Verzenio (abemaciclib) / Eli Lilly
Enrollment open: Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer (clinicaltrials.gov) - Jul 11, 2024
P2, N=60, Recruiting, Sponsor: University of Washington
Enrolling by invitation --> Active, not recruiting | N=38 --> 5 Not yet recruiting --> Recruiting
- | Climara (estradiol) / Bausch Health, Bayer, Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
Trial completion date, Trial primary completion date, Metastases: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov) - Jun 3, 2024
P2, N=38, Enrolling by invitation, Sponsor: Mayo Clinic
Not yet recruiting --> Recruiting Trial completion date: Apr 2024 --> Jul 2026 | Trial primary completion date: Apr 2024 --> Jul 2026
- | Vagifem (estradiol) / Novo Nordisk
Trial completion, Trial completion date, Trial primary completion date: Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen (clinicaltrials.gov) - May 14, 2024
P=N/A, N=30, Completed, Sponsor: Memorial Sloan Kettering Cancer Center
Trial completion date: Apr 2024 --> Jul 2026 | Trial primary completion date: Apr 2024 --> Jul 2026 Active, not recruiting --> Completed | Trial completion date: Sep 2024 --> May 2024 | Trial primary completion date: Sep 2024 --> May 2024
- | Estring (estradiol) / Pfizer, Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
New P4 trial: Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections (clinicaltrials.gov) - Apr 8, 2024
P4, N=111, Recruiting, Sponsor: University of California, Irvine
- | Verzenio (abemaciclib) / Eli Lilly
Trial completion date: Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer (clinicaltrials.gov) - Mar 18, 2024
P2, N=60, Not yet recruiting, Sponsor: University of Washington
Active, not recruiting --> Completed | Trial completion date: Sep 2024 --> May 2024 | Trial primary completion date: Sep 2024 --> May 2024 Trial completion date: Mar 2025 --> Jun 2026
- | Climara (estradiol) / Bausch Health, Bayer, Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
Enrollment status, Metastases: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov) - Mar 14, 2024
P2, N=38, Enrolling by invitation, Sponsor: Mayo Clinic
Trial completion date: Mar 2025 --> Jun 2026 Recruiting --> Enrolling by invitation
- | Journal: Drugs for menopausal symptoms. (Pubmed Central) - Mar 2, 2024
Recruiting --> Enrolling by invitation No abstract available
- ||| Vagifem (estradiol) / Novo Nordisk
Trial completion, Trial completion date: Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial (clinicaltrials.gov) - Feb 2, 2024
P4, N=51, Completed, Sponsor: Albert Einstein College of Medicine
No abstract available Active, not recruiting --> Completed | Trial completion date: Dec 2023 --> Aug 2023
- | Verzenio (abemaciclib) / Eli Lilly
New P2 trial: Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer (clinicaltrials.gov) - Dec 20, 2023
P2, N=60, Not yet recruiting, Sponsor: University of Washington
- | Vagifem (estradiol) / Novo Nordisk
Trial completion date, Trial primary completion date: Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen (clinicaltrials.gov) - Oct 19, 2023
P=N/A, N=30, Active, not recruiting, Sponsor: Memorial Sloan Kettering Cancer Center
Active, not recruiting --> Completed | Trial completion date: Dec 2023 --> Aug 2023 Trial completion date: Sep 2023 --> Sep 2024 | Trial primary completion date: Sep 2023 --> Sep 2024
- || Vagifem (estradiol) / Novo Nordisk
Enrollment closed: Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial (clinicaltrials.gov) - Sep 11, 2023
P4, N=51, Active, not recruiting, Sponsor: Albert Einstein College of Medicine
Trial completion date: Sep 2023 --> Sep 2024 | Trial primary completion date: Sep 2023 --> Sep 2024 Recruiting --> Active, not recruiting
- | Climara (estradiol) / Bausch Health, Bayer, Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
Trial primary completion date, Metastases: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov) - Jul 28, 2023
P2, N=38, Recruiting, Sponsor: Mayo Clinic
Recruiting --> Active, not recruiting Trial primary completion date: Apr 2023 --> Apr 2024
- || Milprosa (progesterone vaginal ring) / Ferring
P1 data, PK/PD data, Journal: Evaluation of 28-day estradiol and progesterone vaginal rings in a phase 1 clinical pharmacokinetic study. (Pubmed Central) - Mar 28, 2023
The 80/4 IVR and 160/8 IVR gave similar steady-state concentrations of E2 as seen with drug products approved by the US Food and Drug Administration for treatment of VMS and genitourinary symptoms of menopause. The E2 concentrations of this study support the potential of DARE-HRT1, a promising new option for hormone therapy for treatment of VMS and vaginal symptoms associated with menopause.
- || Vagifem (estradiol) / Novo Nordisk
Estradiol Cream: Mark Cuban's Cost Plus Drugs. Affordable. Better precise topical application than Vagifem! (Twitter) - Mar 4, 2023
- ||| Vagifem (estradiol) / Novo Nordisk
Clinical: Thanks. Unfortunately some of my patients swear that they only get symptom relief with brand Vagifem. Still amazed at how many women inappropriately treated with antibiotics for “UTI” 🤦🏻♂️ (Twitter) - Mar 4, 2023
- ||| Vagifem (estradiol) / Novo Nordisk
FDA event, Reimbursement, US reimbursement: Great pic 👸👸! Q for the queens - why is #Vagifem so 💰💰💰 and not covered by many insurance plans? @novonordiskus received FDA approval 24 yrs ago! (Twitter) - Mar 4, 2023
- || Vagifem (estradiol) / Novo Nordisk
Trial initiation date: Vaginal Estradiol Tablets (Vagifem (clinicaltrials.gov) - Dec 23, 2022
P=N/A, N=500000, Completed, Sponsor: Novo Nordisk A/S
The E2 concentrations of this study support the potential of DARE-HRT1, a promising new option for hormone therapy for treatment of VMS and vaginal symptoms associated with menopause. Initiation date: May 2022 --> Jan 2022
- Vagifem (estradiol) / Novo Nordisk
Trial completion date, Trial primary completion date: Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial (clinicaltrials.gov) - Nov 4, 2022
P4, N=50, Recruiting, Sponsor: Albert Einstein College of Medicine
Initiation date: May 2022 --> Jan 2022 Trial completion date: Aug 2023 --> Dec 2023 | Trial primary completion date: Aug 2022 --> Aug 2023
- || Vagifem (estradiol) / Novo Nordisk
Ontario ODB program covers Vagifem for persons 65 years and up. (Twitter) - Jul 21, 2022
- ||| Vagifem (estradiol) / Novo Nordisk
Trial completion: Vaginal Estradiol Tablets (Vagifem (clinicaltrials.gov) - Jul 6, 2022
P=N/A, N=500000, Completed, Sponsor: Novo Nordisk A/S
Trial completion date: Aug 2023 --> Dec 2023 | Trial primary completion date: Aug 2022 --> Aug 2023 Not yet recruiting --> Completed
- | Vagifem (estradiol) / Novo Nordisk
I use 10mcg Vagifem daily. It has transformed my life (Twitter) - Jun 15, 2022
- | Vagifem (estradiol) / Novo Nordisk
So what dose of vagifem would you like to use then? (Twitter) - Jun 14, 2022
- | Vagifem (estradiol) / Novo Nordisk
Also is dose recommendation (850mcg) not dependent on type and preparation of oestrogen? Vagifem works well at only 20mcg per week and generally lowest dose of oestrogen is best! (Twitter) - Jun 11, 2022
- | Climara (estradiol) / Bausch Health, Bayer, Vagifem (estradiol) / Novo Nordisk, Estrace (estradiol) / AbbVie
Trial completion date, Trial primary completion date, Metastases: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov) - Jun 1, 2022
P2, N=38, Recruiting, Sponsor: Mayo Clinic
Not yet recruiting --> Completed Trial completion date: Apr 2022 --> Apr 2024 | Trial primary completion date: Apr 2022 --> Apr 2023
- || Vagifem (estradiol) / Novo Nordisk
If only there were TV ads for vaginal estrogen similar to those for Cialis (broadcast during MLB games) - and @novonordiskus stopped price gauging for #Vagifem (Twitter) - May 15, 2022
- || Vagifem (estradiol) / Novo Nordisk, Estrofem (estradiol oral) / Novo Nordisk
Hiçbir eczanede bulunmayan, depolarda olmayan ilacı var sayamazsınız. Lütfen artık ilaçları verin. @novonordisk #estrofem #novonordiks (Twitter) - Apr 9, 2022
- | Vagifem (estradiol) / Novo Nordisk, Estrofem (estradiol oral) / Novo Nordisk
We can't find Estrofem in Turkey @novonordisk #NovoNordisk (Twitter) - Apr 7, 2022
- | Vagifem (estradiol) / Novo Nordisk
New trial: IDEAL: Improving Diagnostics in Cervical Dysplasia (clinicaltrials.gov) - Mar 16, 2022
P=N/A, N=150, Not yet recruiting, Sponsor: University of Aarhus
- | progesterone / Generic mfg.
Journal: Progesterone and estrogen levels are associated with live birth rates following artificial cycle frozen embryo transfers. (Pubmed Central) - Mar 3, 2022
Trial completion date: Apr 2022 --> Apr 2024 | Trial primary completion date: Apr 2022 --> Apr 2023 Serum progesterone and estradiol levels impact live birth rate in AC-FET.
- ||| Vagifem (estradiol) / Novo Nordisk
Reimbursement: Repeat question - what can be done to address the exorbitant price of #Vagifem ? Price gouging by @novonordisk and health insurance companies @RosenthalHealth @KHNews (Twitter) - Feb 25, 2022
- || Vagifem (estradiol) / Novo Nordisk
Maybe by then @novonordisk @novonordiskus won’t be charging exorbitant 💵💵 for #Vagifem (Twitter) - Feb 17, 2022
- |||||| Vagifem (estradiol) / Novo Nordisk
New trial: Vaginal Estradiol Tablets (Vagifem (clinicaltrials.gov) - Feb 17, 2022
P=N/A, N=500000, Not yet recruiting, Sponsor: Novo Nordisk A/S
- |||| Vagifem (estradiol) / Novo Nordisk, equine conjugated estrogens / Generic mfg.
Clinical: Interesting note from pharmacist today regarding Rx for Vagifem. Patient tells pharmacist she has “urinary incontinence”, pharmacist looks up product monograph, may cause “bladder spasm”, asks me to switch to Premarin. Thoughts? @drrachelrubin @AshleyGWinter @RRGonzalezMD?? (Twitter) - Feb 16, 2022
- ||| Vagifem (estradiol) / Novo Nordisk
Reimbursement: 45$ in Israel without insurance. 5.5$ with insurance. Vagifem . (Twitter) - Jan 23, 2022
- ||| Vagifem (estradiol) / Novo Nordisk
Pricing: Amen 🙏 Why does Vagifem from @novonordisk @novonordiskus cost over $160 a month with @UHC and a drug approved by @US_FDA over 15 year ago?? And generics are not equivalent. (Twitter) - Jan 23, 2022
- ||| Vagifem (estradiol) / Novo Nordisk
Reimbursement: #vagifem is $45CAD/month in Canada, $21CAD/month after insurance (Twitter) - Jan 23, 2022
- || Vagifem (estradiol) / Novo Nordisk, tamoxifen / Generic mfg.
That’s interesting. I was advised sager with tamoxifen than aromatase but risk minuscule with both. Also that ovestin much more effective than vagifem. (Twitter) - Oct 22, 2021
- || Vagifem (estradiol) / Novo Nordisk
Vagifem comes as a pessary but you can get gels (Twitter) - Oct 22, 2021
- || Vagifem (estradiol) / Novo Nordisk
Vagifem is safe and you should be able to get it prescribed (Twitter) - Oct 22, 2021
- || Vagifem (estradiol) / Novo Nordisk
Vagifem is fine (Twitter) - Oct 22, 2021
- ||| Vagifem (estradiol) / Novo Nordisk
These are the latest guidelines about Managing Genitourinary Syndrome of Menopause in Breast Cancer Survivors Receiving Endocrine Therapy - Vagifem is safe. (Thanks again to @CliffordHudis) https://t.co/V8uQhVowo2 (Twitter) - Oct 22, 2021
- |||| Vagifem (estradiol) / Novo Nordisk
This is the link to the paper showing that low dose Vagifem does NOT increase estradiol levels in Postmenopausal Women with Breast Cancer on Aromatase Inhibitors | Cancer Research (thanks to @CliffordHudis) https://t.co/GmIWxC3zE7 (Twitter) - Oct 22, 2021