Vagifem (estradiol) / Novo Nordisk 
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 9 Diseases   13 Trials   13 Trials   150 News 
20 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Vagifem (estradiol) / Novo Nordisk
2014-000179-18: Local Oestrogen Treatment in Postmenopausal Women Undergoing Pelvic Organ Prolapse Surgery (LOTUS)

Ongoing
4
100
Europe
Vagifem 10 micrograms vaginal tablets, Vaginal tablet, Vagifem 10 micrograms vaginal tablets
University of Birmingham, Birmingham Women's Hospital, NIHR RfPB grant, NIHR RfPB Grant
Pelvic organ prolapse, Prolapse of womb or vagina, Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]
 
 
2005-001975-37: A pilot study to examine the efficacy of vaginally administered oestradiol in the treatment of faecal incontinence in post menopausal women

Ongoing
4
43
Europe
Vagifem
North West London NHS Trust
Faecal Incontinence
 
 
2015-000502-19: Effects of sex hormones on serotonin synthesis and degradation measured with positron emission tomography Effekte von Sexualhormonen auf Serotoninsynthese und -Abbau, gemessen mit der Positronen-Emissions-Tomographie

Ongoing
4
92
Europe
Finasteride, Orgametril, Estradot, Estradiol hemihydrate, Estradiol, 12.352, Injection, Tablet, Transdermal patch, Transdermal gel, Nebido, Finasteride, Orgametril, Androcur, Cerazette, Decapeptyl, Estradot, Estrofem, Estrogel, Testogel
Medical University of Vienna, Department of Psychiatry and Psychotherapy, FWF
Gender Dysphoria (Female-to-male transsexuals and male-to-female transsexuals), A person who has a strong conviction of belonging to the opposite sex and whants to live and be accepted as a member of the opposite sex, Psychiatry and Psychology [F] - Mental Disorders [F03]
 
 
2019-001234-34: The study investigates effects of local estrogen therapy on serum estradiol levels in postmenopausal breast cancer patients taking an aromatase inhibitor therapy. Tutkimuksessa selvitetään veren estradioli (naishormoni) pitoisuuksia rintasyöpäpotilailla, jotka käyttävät paikallista estrogeenihoitoa samanaikaisesti aromataasinestäjän (=suun kautta otettavia hormonaalisia syöpälääkkeitä, joita käytetään vaihdevuosi-iän ohittaneilla naisilla hormoniriippuvaisen rintasyövän hoitona) kanssa.

Not yet recruiting
4
30
Europe
Letrozol ratiopharm, Vagifem, L02BG04, G03CA03, Tablet, Vaginal tablet, Letrozol ratiopharm, Vagifem 10mcg
HUS Syöpäkeskus, HUS Syöpäkeskus
Breast cancer, postmenopausal atrophic vaginitis Rintasyöpä, postmenopausaalinen atrofinen emätintulehdus, Breast cancer, postmenopausal atrophic vaginitis Rintasyöpä, postmenopausaalinen atrofinen emätintulehdus, Diseases [C] - Cancer [C04]
 
 
2019-004934-40: Hormonal, cardiovascular, medical, muscle- and fitness aspects of sex hormone treatment in patients with Turner syndrome - project part B Hormonel, hjertekar, medicinsk, muskel- og konditionsmæssige aspekter ved kønshormonbehandling hos patienter med Turner syndrom - projekt del B

Not yet recruiting
4
50
Europe
Divigel, 9688, Film-coated tablet, Gel, Estrofem, Divigel
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Universityhospital, Aarhus University
Ovarian dysgenesis and related hypogonadism causes by Turner syndrome Ovariedysfunktion og relateret hypogonadisme forårsaget af Turner syndrom, Failure of the ovaries and related decreased production of female sex hormone, estrogen, caused by the congenital Turner syndrome Manglede funktion af æggestokkene og dermed relateret nedsat produktion af kvindelig kønshormon, østrogen, forårsaget af det medfødte Turner syndrom, Diseases [C] - Hormonal diseases [C19]
 
 
2019-001881-14: Hormonal, cardiovascular, medical, muscle- and fitness aspects of sex hormone treatment in patients with Turner syndrome - project part 1 Hormonel, hjertekar, medicinsk, muskel- og konditionsmæssige aspekter ved kønshormonbehandling hos patienter med Turner syndrom - projekt del 1

Not yet recruiting
4
50
Europe
Divigel, 9688, Film-coated tablet, Gel, Estrofem, Divigel
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Universityhospital, Aarhus University
Ovarian dysgenesis and related hypogonadism caused by Turner syndrome Ovariedysfunktion og relateret hypogonadisme forårsaget af Turner syndrom, Failure of the ovaries and related decreased production of female sex hormone, estrogen, caused by the congenital Turner syndrome Manglede funktion af æggestokkene og dermed relateret nedsat produktion af kvindelig kønshormon, østrogen, forårsaget af det medfødte Turner syndrom, Diseases [C] - Hormonal diseases [C19]
 
 
NCT04797338: Gonadotropin Releasing Hormone Agonist (GnRHa) Versus Estrogen and Progesterone for Luteal Support in High Responders

Recruiting
4
100
RoW
Synarel, 0.2 Mg/Inh Nasal Spray, Nafarelin, Estrofem, Progynova, Utrogestan, Endometrin, Hydroxyprogesterone Caproate, Proluton Depot
Assaf-Harofeh Medical Center
Pregnancy Early, Miscarriage, Ovarian Hyperstimulation Syndrome
09/21
09/21
NCT06570460: Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome

Recruiting
4
50
Europe
17-beta estradiol, Estrofem, Divigel
Aarhus University Hospital, University of Aarhus
Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy, Estrogen Deficiency
12/26
12/26
NCT06544473: Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome

Recruiting
4
50
Europe
17-beta estradiol, Estrofem, Divigel
Aarhus University Hospital, University of Aarhus
Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy, Estrogen Deficiency
12/26
12/26
2022-000269-42: Improving diagnostics in cervical dysplasia Bedre diagnostik af celleforandringer på livmoderhalsen

Not yet recruiting
4
150
Europe
Vaginal capsule, Vagifem
Randers Regional Hospital, Department of Gynecology and Obstetrics, Aarhus University
Abnormal cervical cells Celleforandringer på livmoderhalsen, precancerous cervical lesions, Diseases [C] - Cancer [C04]
 
 
NCT04079218: Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial

Completed
4
51
US
Estradiol Vaginal Insert, Vagifem®, Vagifem (estradiol vaginal tablet)
Albert Einstein College of Medicine, National Institute on Aging (NIA), Novo Nordisk A/S
HIV Infection, Vaginal Atrophy, Menopause, Menopause Related Conditions, Aging, Premature Aging, Atrophic Vaginitis, Dysbiosis, Vaginitis
08/23
08/23
NCT06508944: Efficacy of Vaginal 17β-Estradiol on the Urinary Storage Symptoms in Postmenopausal Women

Completed
4
86
RoW
vaginal 17 beta-estradiol, Femiest, ESTRADIOL HEMIHYDRATE, vagifem, Placebo, Agglomerated Lactose, Microcrystalline cellulose PH 102, Magnesium stearate, Behavioral modifications
Mahidol University
Lower Urinary Tract Symptoms, Female Genitourinary Disease, Urinary Stress Incontinence, Urinary Urge Incontinence, Nocturia, Quality of Life, Voiding Disorders, Vagina Atrophy, Urethral Atrophy, Overactive Bladder, Overactive Bladder Syndrome, Bladder, Overactive
10/24
10/24
NCT06353269: Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections

Recruiting
4
111
US
Estring Vaginal Product, Vagifem, Estrace 0.01% Vaginal Cream
University of California, Irvine
Recurrent Urinary Tract Infection, Hypoestrogenism
01/27
10/27
2021-001624-17: Safety of oral micronized progesterone versus norethisterone acetate in continuous combination with oral estrogen as menopausal hormone therapy – a double-blind randomized study- PROBES study (Progesterone Breast Endometrial Safety study) Säkerhet med oralt mikroniserat progesteron jämfört med noretisteronacetat i kontinuerlig kombination med oralt östrogen som menopausal hormonbehandling - en dubbelblind randomiserad studie- PROBES-studien

Ongoing
3
520
Europe
Micronized progesterone, Activelle, Estrofem, Capsule, Utrogestan, Activelle, Estrofem
Karolinska University Hospital, Karolinska University Hospital
Climacteric symptoms, Climacteric symptoms, Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]
 
 
2010-024603-26: The fase II study evaluates the safety and efficacy of treatment with low doses of topical vaginal estrogen in pre- and postmenopausal patients with breast cancer and urogenital symptoms related to adjuvant hormone therapy Studio clinico di fase II che valuta la sicurezza e l’efficacia del trattamento con basse dosi di estrogeno topico in pazienti con una pregressa diagnosi di carcinoma della mammella in pre- e postmenopausa e con sintomi urogenitali correlati alla terapia endocrina adiuvante

Ongoing
2
67
Europe
VAGIFEM*15CPR VAG 25MCG, VAGIFEM*15CPR VAG 25MCG
ISTITUTO EUROPEO DI ONCOLOGIA, Fondazione Istituto Europeo Oncologia, Fondazione Veronesi
Pre- and postmenopausal women who are receiving adjuvant endocrine treatment (LH-RH analogue plus Tamoxifene or Aromatase Inhibitor, Tamoxifene alone, Aromatase Inhibitor alone) for early breast cancer. Pazienti in pre- e postmenopausa in trattamento endocrino per carcinoma della mammella, sintomatiche per disturbi uro-genitali refrattari a trattamento con lubrificanti topici.
 
 
ACTRN12620000955910: OVGUS: A study examining the use oestradiol vaginal tablets (Vagifem Low) to treat genitourinary symptoms in women on adjuvant aromatase inhibitors for breast cancer

Active, not recruiting
2
60
 
University of Sydney, Breast Cancer Trials
Vulvovaginal atrophy, Genitourinary syndrome of menopause, Breast cancer
 
 
NCT03941730: Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer

Active, not recruiting
2
5
US
Biopsy, BIOPSY_TYPE, Bx, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Therapeutic Estradiol, 17 Beta-Estradiol, Aquadiol, Climara, Dimenformon, Diogyn, Diogynets, Estrace, ESTRADIOL, Estraldine, Oestradiol, Ovocylin, Progynon, Vagifem
Mayo Clinic, National Cancer Institute (NCI)
Advanced Triple-Negative Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma, Recurrent Breast Carcinoma
07/26
07/26
NCT06179303: Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer

Recruiting
2
60
US
Abemaciclib, LY-2835219, LY2835219, Verzenio, Anastrozole, Anastrazole, Arimidex, ICI D1033, ICI-D1033, ZD-1033, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, CT, CT Scan, tomography, Diagnostic Imaging, Medical Imaging, Exemestane, Aromasin, FCE-24304, Fludeoxyglucose F-18, 18FDG, FDG, Fludeoxyglucose (18F), fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Fluorine F 18 Fluoro Furanyl Norprogesterone, [18F]FFNP, Fulvestrant, Faslodex, Faslodex(ICI 182,780), ICI 182,780, ICI 182780, ZD9238, Gonadotropin-releasing Hormone Analog, GnRH Agonist, GnRH Analog, Gonadotropin-Releasing Hormone Agonist, Gonadotropin-Releasing Hormone Analogue, LH-RH agonist, LH-RH Analogs, LHRH Agonist, luteinizing hormone-releasing hormone agonist, Luteinizing Hormone-Releasing Hormone Analog, Letrozole, CGS 20267, Femara, Fempro, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Tamoxifen, TMX, Therapeutic Estradiol, 17 Beta-Estradiol, Aquadiol, Climara, Dimenformon, Diogyn, Diogynets, Estrace, ESTRADIOL, Estraldine, Oestradiol, Ovocylin, Progynon, Vagifem
University of Washington, Breast Cancer Research Foundation
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Unresectable HER2-Negative Breast Carcinoma, Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma, Metastatic HER2-Negative Breast Carcinoma, Metastatic Hormone Receptor-Positive Breast Carcinoma
03/25
06/26
NCT00984399: Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen

Completed
N/A
30
US
Vagifem® (vaginal 17β-estradiol) questionnaire & menopause symptom checklist, The bloodwork will take less than one hour to perform and will be drawn +/- 72hrs from the date the, patient is due for bloodwork.Baseline bloodwork will be drawn within 14 days of study enrollment prior to the initiation of vaginal 25μg 17- β estradiol., Patients will be encouraged to come for their research bloodwork 12-24 hours after the insertion of the vaginal 25μg 17- β estradiol tablets., Patients will record in their diary the time of their last vaginal 10μg 17- β estradiol, tablet insertion. Since we do not know the clinical significance of transient, estradiol elevation in these patients, both the patients and the investigators, will be blinded to the results of these assays for the 24 weeks of study, therapy. We will administer the FSFI survey questionnaire and menopause symptom, checklist at baseline, week 12 and week 24.
Memorial Sloan Kettering Cancer Center
Atrophic Vaginitis, Breast Cancer
05/24
05/24
IDEAL, NCT05283421: Improving Diagnostics in Cervical Dysplasia

Recruiting
N/A
150
Europe
Estrogen, Vagifem, Placebo
University of Aarhus
Cervical Cancer
06/25
07/25

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