- |||||||||| Journal: Consensus on the pharmacological treatment of acute stress disorder in Chinese pilots: a Delphi study. (Pubmed Central) - Sep 13, 2023
We demonstrate that LOR stimulates fibrosis and inflammatory signaling, promotes desmoplasia and ischemic necrosis, and is associated with decreased pancreatic cancer patient survival. This study formed a consensus on rapid and effective pharmacological treatment for different symptoms of acute stress disorder pilots, which provides a reference for clinical treatment.
- |||||||||| tamsulosin / Generic mfg., alprazolam / Generic mfg.
Reimbursement, Retrospective data, Review, US reimbursement, Journal: Analysis of the prescription trends of potentially inappropriate medications in Korean older outpatients by sex: A retrospective study using data from the health insurance review and assessment service. (Pubmed Central) - Sep 1, 2023
Moreover, during this period, the prescription trend of benzodiazepine-type drugs and zolpidem increased in both male and female patients. Therefore, management policies regarding PIMs and drug ingredients, such as benzodiazepines and zolpidem, are required.
- |||||||||| Nuplazid (pimavanserin) / Acadia Pharma
Rapid cognitive decline and new-onset psychosis after GPi DBS in a severe GBA mutation carrier: a case demonstrating the importance of genetic screening pre-DBS () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1982;
She was treated with Sertraline, Alprazolam prn, and Temazepam...Over the next 9 months, she required titration of Rivastigmine, Quetiapine, Pimavanserin, Gabapentin, and Clozapine but symptoms worsened and she had progressive visual and auditory hallucinations, delusional jealousy, Capgras syndrome, and paranoia... This case report contributes to the growing body of evidence of impact of DBS in mutation carriers and highlights the importance of genetic testing, counseling and comprehensive neuropsychological assessment in pre-surgical decision-making.
- |||||||||| lorazepam / Generic mfg., alprazolam / Generic mfg.
Early-onset spastic ataxia in a patient with prion (PRNP) p.Val180Ile mutation () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_277;
Current medications included flurazepam, alprazolam, and lorazepam, but there were no other medications that could cause neurological symptoms. Our case implies that mutation might be manifested as early onset insidious ataxia without obvious cognitive impairment, thus broadens the phenomenology of mutation related diseases.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Lamotrigine-induced atypical DRESS syndrome with erythema multiforme-like eruption (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2396;
As in our patient, Dress syndrome can manifest as target or targetoid lesions and pustules can also be seen. This case highlights these atypical manifestations of a severe systemic drug reaction to insure early diagnosis and the dermatologist
- |||||||||| Viibryd (vilazodone) / AbbVie
Journal: Drugs for anxiety disorders. (Pubmed Central) - Aug 3, 2023
Although short-acting benzodiazepines and gamma-aminobutyric acid medications may have transient anxiolytic effects, a single oral dose of 5 mg of diazepam can provide a sustained anxiolytic effect in Mohs surgery, with excellent patient safety. No abstract available
- |||||||||| alprazolam / Generic mfg.
Adventures In Mri: Headaches, Mental Health And Pediatric Assent (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1358;
The patient begins to have a panic attack as no one has discussed this with her.8.How do you handle the panic attack in the MRI holding area?Mom has alprazolam with her (which is prescribed for the patient in the event of panic attacks)...Why or Why not? 10.How would explain to mom that you still cannot sedate the patient now that she is agreeable to the exam?
- |||||||||| alprazolam / Generic mfg.
Adventures In Mri: Headaches, Mental Health And Pediatric Assent (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_967;
The patient begins to have a panic attack as no one has discussed this with her.8.How do you handle the panic attack in the MRI holding area?Mom has alprazolam with her (which is prescribed for the patient in the event of panic attacks)...Why or Why not? 10.How would explain to mom that you still cannot sedate the patient now that she is agreeable to the exam?
- |||||||||| alprazolam / Generic mfg.
Journal: GABAergic Effects of Etifoxine and Alprazolam Assessed by Double Pulse TMS. (Pubmed Central) - Jul 14, 2023
Moreover, it revealed differential GABA-related effects on neuromuscular function by means of TMS. The side effects and TMS profile of etifoxine are compatible with the involvement of neurosteroidogenesis and a predominant ?3 subunit modulation compared to alprazolam.
- |||||||||| morphine sulphate / Generic mfg., alprazolam / Generic mfg.
Trial completion date, Trial primary completion date: MAP: Opioid/Benzodiazepine Polydrug Abuse: Aim 3 (clinicaltrials.gov) - Jul 6, 2023
P2, N=24, Recruiting,
Due to Mexico's limited opioid overdose surveillance infrastructure, the current death rate from these substances remains unknown. Trial completion date: Dec 2024 --> Oct 2025 | Trial primary completion date: Aug 2024 --> Aug 2025
- |||||||||| Journal: Rilmazafone: A designer benzodiazepine pro-drug involved in fatal intoxications. (Pubmed Central) - Jun 22, 2023
Rilmazafone metabolizes into active compounds by a ring closure resulting in a triazolo benzodiazepine structure similar to alprazolam...Additional toxicological findings included the medications haloperidol, alimemazine, fluoxetine, olanzapine, and acetaminophen...Additional toxicological findings included loperamide, alimemazine, and pregabalin. The intake of rilmazafone was determined as the cause of death in Case 1 and contributed in the Case 2.
- |||||||||| Review, Journal: Recent advances in the detection of drugs of abuse by Dried Blood Spots. (Pubmed Central) - Jun 21, 2023
The most recent, innovative and fully validated methods for the qualitative and/or quantitative detection of common drugs of abuse are reported, including alprazolam, clonazepam, diazepam, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methyl- enedioxyethylamphetamine (MDEA), amphetamine, methamphetamine, cocaine, tetrahydrocannabinol (THC), 6-monoacetylmorphine, morphine, codeine, hydromorphone, hydrocodone, oxycodone, noroxycodone, tramadol, methadone, buprenorphine, fentanyl, ketamine and their respective metabolites and ?-hydroxybutyric acid (GHB). DBS proved to be extremely promising for routine analysis of forensic cases, although large-scale experiments on real samples need to be performed to confirm the emerging advantages of the technique and remove the potential limitations still affecting its widespread application.
- |||||||||| alprazolam / Generic mfg.
Journal: COVID-19-Related Shifts in Polysubstance Use. (Pubmed Central) - Jun 16, 2023
The swap from leisure (e.g. MDMA) to anti-anxiety (e.g. Xanax) drugs is not surprising. Yet, the rise in novel benzodiazepines (Laing et al., 2021) is a point of concern that suggests drug checking and educational efforts can best reduce potential risks.
- |||||||||| Retrospective data, Journal: Drug prescriptions preceding opioid-related deaths-a register study in forensic autopsy patients. (Pubmed Central) - Jun 4, 2023
Yet, the rise in novel benzodiazepines (Laing et al., 2021) is a point of concern that suggests drug checking and educational efforts can best reduce potential risks. Prescription of certain drugs, especially alprazolam and diazepam, should be made with great caution to patients with a history of illicit substance use or concurrent use of opioids.
- |||||||||| Journal: Characterization of Potential Intoxications with Medicines in a Regional Setting. (Pubmed Central) - Jun 1, 2023
Although there has been a decrease in calls to report possible drug intoxication in the Algarve region, the profile of calls was very similar. Paracetamol was the drug with the highest number of reported cases and the group of psychotropic drugs showed the largest increase between 2019 and 2020.
- |||||||||| valsartan / Generic mfg., alprazolam / Generic mfg., lignocaine / Generic mfg.
Journal: Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis. (Pubmed Central) - May 31, 2023
The DrugMatrix database was used to predict alprazolam, valsartan, biotin A, lignocaine, and curcumin as potential drugs to delay lesion progression by antagonizing PLAUR, and AutoDock was used to verify the binding ability of drugs and PLAUR. Overall, this study provides the first systematic identification of the diagnostic and therapeutic value of PLAUR in AS and offers multiple treatment options with potential applications.
- |||||||||| fentanyl citrate / Generic mfg.
Retrospective data, Review, Journal: Emergence of fentanyl-related deaths in Travis County, Texas and surrounding areas: A retrospective review of postmortem fentanyl-related drug toxicities from 2020 to 2022. (Pubmed Central) - May 17, 2023
Illicit oxycodone (44%, n?=?67) and illicit "Xanax" (38%, n?=?59) pills were frequently reported on scene; however, toxicology only identified oxycodone and alprazolam in 2 and 24 of these cases, respectively. The results of this study provide a better understanding of the fentanyl epidemic in this region creating an opportunity to promote increased awareness, shift focus to harm reduction, and aid in minimizing public health risks.
- |||||||||| duloxetine / Generic mfg.
A Case of Duloxetine-Induced Psychosis in an Older Adult (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_965;
While useful in treating several mental health disorders and pain, duloxetine must be managed carefully by physicians caring for geriatric populations. Vigilance for potential side effects, including psychosis must be maintained, especially in older adults, as they may be hard to detect and challenging to treat.
- |||||||||| alprazolam / Generic mfg.
Risk of Psychosis With High Potency Thc Cannabis: A Case Report (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_545;
Patient is prescribed Xanax of 0.5mg/day p.o for anxiety...The AKT1 gene codes for an enzyme that affects dopamine signalling in the striatum [3]. Although more research needs to be done, this shows promise in identifying individuals that are susceptible to developing psychosis with the use of cannabis.
- |||||||||| alprazolam / Generic mfg., dextromethorphan / Generic mfg.
Trial completion: Licorice Botanical Dietary Supplements - Metabolism and Safety in Women (clinicaltrials.gov) - May 6, 2023
P1, N=19, Completed,
Identifying the presence of elevated HAMA can prevent misdiagnosis and inappropriate patient management. Active, not recruiting --> Completed
- |||||||||| nifedipine immediate release / Generic mfg., midazolam hydrochloride / Generic mfg., alprazolam / Generic mfg.
Journal: Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs. (Pubmed Central) - May 5, 2023
Individual differences in drug oxidation activities were investigated, including correlations with immunoreactive CYP3A protein intensities and CYP3A mRNA expression levels in liver microsomes.Pooled and individual dog liver microsomes showed activities toward nifedipine, midazolam, alprazolam, and estradiol, but the levels of catalytic activities varied approximately twofold among the individual dogs. One dog harbored a CYP1A2 variant causing protein deletion, but showed higher activities than the other dogs toward nifedipine oxidation, midazolam 1'-hydroxylation, alprazolam 4-hydroxylation, estradiol 16?-hydroxylation activities, and caffeine C-hydroxylation; the latter is used as a reference reaction for CYP1A.In individual dog liver microsomes, the intensities of the immunochemical bands with anti-human CYP3A4 and anti-rat CYP3A2 antibodies along with CYP3A12 and CYP3A26 mRNA expression levels showed good correlations (p?<?0.05) with nifedipine oxidation, midazolam 1'- and 4-hydroxylation, alprazolam 1'- and 4-hydroxylation, and estradiol 16?-hydroxylation activities.These results suggest that the oxidation activities of dog liver microsomes toward nifedipine and other typical CYP3A-catalyzed drugs exhibit approximately twofold individual differences and were predominantly mediated by liver-specific CYP3A12 in the dogs.
- |||||||||| Quantifying Benzodiazepine Effects Using Actigraphy: First Evidence from a Psychiatric Inpatient Cohort (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_312;
We found significant differences in activity at 2.6 -4.1h post-administration for Diazepam, 0.8 - 6.8h post-administration for Lorazepam (N=189/39) and 1.8 -7.5h post-administration for Clonazepam (N=121/9)...Detectable duration of BZD action is close to previous estimates. Sleep duration is not affected in an inpatient setting, while sleep fragmentation is reduced after Clonazepam administration.
- |||||||||| Nitredon (nitrazepam) / Remedica
Preclinical, Journal: LC-Q-TOF/MS-based Fragmentation Behavior Study and In vitro Metabolites Identification of Nine Benzodiazepines. (Pubmed Central) - Apr 28, 2023
Sleep duration is not affected in an inpatient setting, while sleep fragmentation is reduced after Clonazepam administration. These experimental data add to our knowledge of the nine benzodiazepine drugs and their metabolism study, which could provide useful information and evidence of their in vivo metabolic profile prediction and help promote their monitoring in both clinical use and social/illegal abuse.
- |||||||||| alprazolam / Generic mfg.
Preclinical, Journal: Prolonged Alprazolam Treatment Alters Components of Glutamatergic Neurotransmission in the Hippocampus of Male Wistar Rats-The Neuroadaptive Changes following Long-Term Benzodiazepine (Mis)Use. (Pubmed Central) - Mar 30, 2023
Specifically, an increase in NMDAR subunits (NR1, NR2A, NR2B), a decrease in vesicular glutamate transporter 1 (vGlut1), and differential modulation of excitatory amino acid transporters 1 and 2 (EAAT1/2, in vivo and in vitro) were observed, alongside a decrease in ?1-containing GABAR following the treatment. By describing the development of compensatory actions in the glutamatergic system, the present study provides valuable information on neuroadaptive mechanisms following prolonged ALP intake.
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