- |||||||||| lorazepam / Generic mfg., alprazolam / Generic mfg.
Journal: Endoscopic management of carefully selected asymptomatic body stuffers. (Pubmed Central) - Jan 12, 2025
These cases prompt reconsideration of current guidelines, particularly in light of emerging literature advocating for early UGI endoscopy as a viable intervention. However, proficiency in UGI endoscopy, often necessitating additional experience beyond standard training, remains imperative for successful outcomes in such cases.
- |||||||||| Journal: PBPK modeling: What is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first-pass metabolism? (Pubmed Central) - Jan 8, 2025
However, proficiency in UGI endoscopy, often necessitating additional experience beyond standard training, remains imperative for successful outcomes in such cases. The resulting CYP3A4 expression profile and two previously published profiles were applied to PBPK models of seven CYP3A4 substrates (alfentanil, alprazolam, felodipine, midazolam, sildenafil, triazolam, and verapamil) built-in PK-Sim
- |||||||||| oxycodone/acetaminophen / Generic mfg., alprazolam / Generic mfg.
New P1/2 trial: Opioid Drug Interaction Study (clinicaltrials.gov) - Jan 3, 2025
P1/2, N=25, Not yet recruiting,
- |||||||||| ritonavir / Generic mfg.
PK/PD data, Journal: Development of a physiologically-based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady-state conditions. (Pubmed Central) - Dec 23, 2024
The resulting CYP3A4 expression profile and two previously published profiles were applied to PBPK models of seven CYP3A4 substrates (alfentanil, alprazolam, felodipine, midazolam, sildenafil, triazolam, and verapamil) built-in PK-Sim A total of 13 clinical PK studies of RTV covering a wide dose range (100 to 600?mg including both single and multiple dosing), and eight clinical DDI studies with RTV on CYP3A and P-gp substrates, including alprazolam, midazolam, rivaroxaban, clarithromycin, fluconazole, sildenafil, and digoxin
- |||||||||| morphine sulphate / Generic mfg., alprazolam / Generic mfg.
Journal: Weighted Blankets for Pain and Anxiety Relief in Acutely Injured Trauma Patients. (Pubmed Central) - Dec 2, 2024
The majority of patients who took a post-intervention questionnaire reported less pain and less anxiety with blanket use compared to those without blanket use (78% and 56% of patients, respectively). To summarize, trauma patients in acute pain had less opioid use and reported less pain and anxiety when using a weighted blanket for five consecutive days compared to a control group who did not use a blanket.
- |||||||||| Fintepla (low-dose fenfluramine) / UCB, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
A Systematic Literature Review of Substance Use Disorders Involving Antiseizure Medications (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_1459;
Carbamazepine was the remote second-most cited ASM involving SUDs. These results may be informative to prescribers and policymakers on the potential for misuse, dependence, and abuse among the ASMs.
- |||||||||| zolpidem ER / Generic mfg., clonazepam / Generic mfg., alprazolam / Generic mfg.
Retrospective data, Journal: Dispensing of zolpidem and benzodiazepines in Brazilian private pharmacies: a retrospective cohort study from 2014 to 2021. (Pubmed Central) - Nov 26, 2024
Alprazolam followed in second place with 20.6% of sales, while zolpidem came in third with 14.4%...In contrast, the extended-release form of zolpidem remained stable over the years...The epidemic of sleeping pills arises in a scenario of expectancy of short-term amelioration of symptoms, with no correspondence in best clinical practice. Education and counseling for both healthcare professionals and the general population are essential to address this growing health concern and ensure the safe and appropriate use of medications for sleep disorders.
- |||||||||| fentanyl citrate / Generic mfg., alprazolam / Generic mfg., methamphetamine / Generic mfg.
Journal: Four-year evaluation of drug-impaired driving drug concentrations. (Pubmed Central) - Nov 16, 2024
Other findings included increases in the maximum reported concentrations between 2017 and 2020 for amphetamine (1400 to 2700?ng/mL), methamphetamine (5550 to 13?000?ng/mL), and fentanyl (56 to 310?ng/mL). Statistically significant concentration decreases were noted for several central nervous system depressants, notably prescription benzodiazepines, and several prescription narcotic analgesics.
- |||||||||| Journal: Association between psychopharmacotherapy and postpartum hemorrhage. (Pubmed Central) - Nov 15, 2024
Prenatal PPT exposure is associated with increased odds of clinically significant PPH+pRBC after adjusting for other hemorrhage risk factors. Combination PPT was associated with greater odds of PPH+pRBC than monotherapy.
- |||||||||| lorazepam / Generic mfg., alprazolam / Generic mfg.
Journal: Benzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends. (Pubmed Central) - Oct 28, 2024
Rates were highest in the southeast (5.1% [95% CI, 4.8%-5.3%]) and lowest in the midwest (4.0% [95% CI, 3.8%-4.3%]), with a modest nationwide initiation decline from 2013 to 2021 (cumulative incidence difference, 1.6%). Despite a gradual decline in benzodiazepine initiation from 2013 to 2021, we noted excessive supplies in prescriptions post-acute ischemic stroke discharge, underscoring the need for improved policies.
- |||||||||| Journal: The Emergence of Bromazolam in Jefferson County AL. A Case Series. (Pubmed Central) - Oct 28, 2024
While all manners of death were ruled as accidental, bromazolam was included in the cause of death statements in nine of the ten cases. Capturing important emerging drug trends on the death certificate is critical to help inform public health and medical colleagues for preventive measures and treatment in the continued drug epidemic.
- |||||||||| KRM-81 / RespireRx, BAER-101 / AstraZeneca, Fortress, darigabat (CVL-865) / AbbVie
Review, Journal: Nonsedating anxiolytics. (Pubmed Central) - Oct 27, 2024
This has rekindled the interest in the GABAA-receptor (GABAAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and alprazolam...Advances in molecular biology gave birth to a host of subtype selective GABAAR-PAMs which suffered from signs of sedation and motor impairment and only three compounds progressed to proof-of-concept studies (TPA-023, AZD7325 and PF-06372865)...In preclinical studies KRM-II-81 produced anxiolytic-like effects but with minimal sedation, respiratory depression, and abuse liability. Thus, KRM-II-81 is a newly discovered, non- BZD anxiolytic compound, which targets a selective population of GABAAR for improved therapeutic gain and reduced side effects.
- |||||||||| methylphenidate tablet / Generic mfg., alprazolam / Generic mfg., amphetamine / Generic mfg.
Journal: Detection of drugs and hepatitis C virus in used syringes from a needle exchange in Gothenburg, Sweden. (Pubmed Central) - Oct 16, 2024
Less common findings were testosterone (2.7%), methylphenidate (2.0%), MDMA (0.7%), trenbolone (0.7%) and zopiclone (0.7%)...HCV RNA was detected in 13% of the syringes, and one in 10 contained enough to potentially transmit an infection. This study underlines the importance of access to NEPs for PWID to reduce the risks associated with drug injection.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Agitated Depression Associated With Flurazepam Discontinuation. (Pubmed Central) - Sep 30, 2024
She finally had a complete resolution of these symptoms with a combination of alprazolam, zopiclone, and olanzapine. This case provides insight into this unique variant of depression and the role of GABA agonists in its pathology and management.
- |||||||||| clonazepam / Generic mfg., lorazepam / Generic mfg., alprazolam / Generic mfg.
Journal: Benzodiazepine receipt in adults with psychogenic non-epileptic seizures in the USA. (Pubmed Central) - Sep 24, 2024
Baseline BZD receipt and anxiety disorders, but not baseline ES diagnoses, were strong independent predictors of post-PNES BZD receipt. While new BZD initiation is rare after PNES, most individuals with BZD scripts 1?month before PNES continue scripts after diagnosis.
- |||||||||| fentanyl citrate / Generic mfg., alprazolam / Generic mfg., methamphetamine / Generic mfg.
Journal: The Rise of Bromazolam in Postmortem Cases from Travis County, Texas and Surrounding Areas: 2021-2023. (Pubmed Central) - Sep 14, 2024
In light of the significant increase in fentanyl-related deaths in Travis County, the increasing prevalence of bromazolam accompanying fentanyl was particularly alarming due to the heightened risk of toxicity when used in combination. Identifying and evaluating bromazolam-related deaths clarifies the impact of bromazolam on this population, promotes awareness, and aids in identifying meaningful harm reduction strategies to decrease bromazolam-related morbidity and mortality.
- |||||||||| alprazolam / Generic mfg.
CRISIS IN THE LUNGS: EVALI UNVEILED IN A YOUNG MALE PATIENT (Convention Center Exhibit Hall: Poster Area 5) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6651;
EVALI represents a significant public health concern, and proactive measures are needed to address its growing impact. Through collaborative efforts involving healthcare professionals, policymakers, and the public, we can work towards mitigating the risks associated with vaping and protecting the health and well-being of individuals, particularly young people.
- |||||||||| alprazolam / Generic mfg.
Observational data, Retrospective data, Journal: Effects of integrative therapy with Du Meridian moxibustion, ear acupuncture, and alprazolam on cardiac function and neurotransmitter levels in patients with coronary heart disease and insomnia: An observational study. (Pubmed Central) - Aug 26, 2024
The serum traditional Chinese medicine syndrome score and Pittsburgh sleep quality index score of the 2 groups decreased after treatment, and the experimental group was lower than the conventional group (P?<?.05). The combination of Du Meridian acupuncture with ear acupuncture in the treatment of insomnia in coronary heart disease can regulate the expression of serum melatonin, leptin, and neurotransmitters, alleviate symptoms, and improve therapeutic efficacy.
- |||||||||| rifampicin / Generic mfg., midazolam hydrochloride / Generic mfg., alprazolam / Generic mfg.
Journal: Utilization of a Human Liver Tissue Chip for Drug-Metabolizing Enzyme Induction Studies of Perpetrator and Victim Drugs. (Pubmed Central) - Aug 2, 2024
We also investigated the induction effects of different dosing regimens of the perpetrator drug (rifampicin) on CYP activity levels, showing minimal variation in the intrinsic clearance of the victim drug (midazolam). This study demonstrates the utility of the LTC for in vitro liver-specific DDI induction studies, providing a translational experimental system to predict clinical clearance values of both perpetrator and victim drugs.
- |||||||||| BATTLING THE BLOCKADE: A CASE OF MULTIFACTORIAL SHOCK IN POLYSUBSTANCE OVERDOSE (Convention Center Exhibit Hall: Rapid Fire Area 2D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_4820;
Early recognition of shock etiology can facilitate in choosing appropriate management and possibly reduce mortality. In the setting of CCB and BB overdose, ILE may improve patient outcomes by acting as a reservoir for these lipophilic medications and stabilize cardiac function.
- |||||||||| alprazolam / Generic mfg., tadalafil / Generic mfg.
UNUSUAL CASE OF PULMONARY ARTERIAL HYPERTENSION: VITAMIN C DEFICIENCY LINKED TO CARNIVOROUS DIET (Convention Center Exhibit Hall: Poster Area 4) - Jul 31, 2024 - Abstract #CHEST2024CHEST_3047;
CASE PRESENTATION: A 35-year-old male with anxiety and Celiac disease presented with persistent tachycardia and exertional dyspnea despite metoprolol and alprazolam treatment...He was diagnosed with precapillary PH and started on tadalafil 20mg daily... Severe vitamin C deficiency is a rare cause of PAH, and supplementation treatment may resolve the condition.
- |||||||||| alprazolam / Generic mfg., dexmedetomidine / Generic mfg., apixaban / Generic mfg.
BEYOND BREATHLESSNESS: MANAGING ANXIETY-ASSOCIATED RESPIRATORY FAILURE WITH MECHANICAL VENTILATION (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1648;
We want to emphasize the importance of recognizing and addressing the multifaceted interplay between psychological stressors and respiratory pathology in clinical practice. Further research is warranted to better understand the underlying mechanisms and optimal management strategies for patients presenting with anxiety-induced respiratory distress.
- |||||||||| clonazepam / Generic mfg., diazepam / Generic mfg., alprazolam / Generic mfg.
Retrospective data, Journal: Benzodiazepine Discharge Prescriptions from Emergency Departments across the United States between 2012 and 2019: A National Analysis. (Pubmed Central) - Jul 31, 2024
Concerningly, alprazolam, a benzodiazepine with high misuse potential, was frequently prescribed despite limited ED indications, and there was a large percentage of visits where benzodiazepines were prescribed to older adults despite warnings for adverse effects in this population. Future studies should assess rational prescribing and the role of targeted interventions to curb inappropriate use.
- |||||||||| alprazolam / Generic mfg.
Journal: Increased sexual function after intake of clomethiazole. (Pubmed Central) - Jul 23, 2024
Considering the chronology of the events, increased sexual function was likely a manifestation of the introduction of clomethiazole. However, because alprazolam was interrupted when clomethiazole was introduced, we cannot exclude an association between increased sexual function and alprazolam interruption.
- |||||||||| sertraline / Generic mfg., alprazolam / Generic mfg.
Journal: Predicting the potential risks posed by antidepressants as emerging contaminants in fish based on network pharmacological analysis. (Pubmed Central) - Jul 21, 2024
After filtering each antidepressant-target interaction node using the predicted drug concentrations in the blood of fish under realistic exposure scenarios in China, an environmental risk-based network was refined and showed that 11 targets, including muscarinic acetylcholine receptor M1, alpha-2B adrenergic receptor, serotonin 2?A receptor, etc. might be modulated by antidepressants at concentrations equal to or below the environmental exposure levels and their mixtures in fish. Environmentally relevant concentrations of antidepressants in water samples from China might perturb the behavior, stress response, phototaxis, and development in exposed fish.
- |||||||||| morphine sulphate / Generic mfg., alprazolam / Generic mfg., methadone / Generic mfg.
Journal: "Tranq-dope": The first fatal intoxication due to xylazine-adulterated heroin in Italy. (Pubmed Central) - Jul 13, 2024
The combination of central nervous system depressants, i.e., opioids, benzodiazepines, and xylazine, was the principal cause of death by cardiorespiratory failure. The case was promptly reported to the UE Early Warning System on drugs.
- |||||||||| gabapentin / Generic mfg., alprazolam / Generic mfg.
Journal: Use of Gabapentin or Alprazolam in Cats during Postoperative, Short-Term Hospitalization. (Pubmed Central) - Jul 13, 2024
In the context of postoperative hospitalization, pharmacological intervention with anxiolytics could be effective in reducing stress levels. Despite potential side effects, gabapentin and alprazolam may contribute to an improved quality of short-term hospitalization for cats.
- |||||||||| Journal: Identification of Benzodiazepine Use Based on Dried Blood Stains Analysis. (Pubmed Central) - Jun 27, 2024
We splashed blood stains on cotton fabric with different concentrations of the following benzodiazepines: alprazolam, bromazepam, clonazepam, diazepam and lorazepam, which were dried for 96 h and subsequently quantified by high-performance liquid chromatography coupled mass spectrometry (HPLC-MS). Our results show that it is possible to identify several benzodiazepines contained in a cotton fabric blood stain; consequently, this method may add another sample option to the toxicological analysis of biological vestiges found at a crime scene.
- |||||||||| Journal: Trends in commonly used and potentially inappropriate medications in older Korean patients with polypharmacy. (Pubmed Central) - Jun 22, 2024
Additionally, it highlighted that the utilisation of commonly prescribed potentially inappropriate medications, such as benzodiazepines and tricyclic antidepressants, has remained persistent, particularly among patients aged???85 years who practiced polypharmacy. These findings provide evidence-based guidance for the development of robust polypharmacy management strategies to ensure medication safety among older adults.
- |||||||||| alprazolam / Generic mfg., clotiazepam / Generic mfg.
Journal: Clinical practice for unspecified anxiety disorder in primary care. (Pubmed Central) - Jun 13, 2024
It can avoid adverse reactions caused by long-term use of drugs, so It is a safe and reliable method, worthy of recommendation for clinical use. While several benzodiazepine anxiolytics were familiar to primary care physicians, the frequencies of prescribing them, including alprazolam (4.6?
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