alprazolam / Generic mfg. 
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  • ||||||||||  Journal:  Large scale consumption monitoring of benzodiazepines and z-drugs by hair analysis. (Pubmed Central) -  Dec 17, 2020   
    Therefore, we strongly recommend to reconsider whether the use of an equal BDZ/z-drug cut-off is reasonable and whether minimum requirements for LODs should be lowered. The statistical evaluation of BDZ/Z-drug hair concentrations by box-plots can help in the development of analytical methods for hair samples and in the interpretation of BDZ/z-drug hair levels.
  • ||||||||||  alprazolam / Generic mfg.
    Journal:  Nonlinear relationship between early life stress exposure and subsequent resilience in monkeys. (Pubmed Central) -  Nov 7, 2020   
    Juvenile squirrel monkeys underwent one of five treatment conditions between 17-27 weeks of age: Stress inoculation (SI) with continuous access to mother (SI + Mom; one stress element), SI without continuous access to mother (SI; two stress elements), SI without continuous access to mother and with alprazolam injection pretreatments (SI + Alz; three stress elements), SI without continuous access to mother and with vehicle injection pretreatments (SI + Veh; three stress elements), or standard housing (No SI; zero stress elements)...Subjects exposed to three early life stressors did not differ on most measures from one another or from No SI subjects. These findings provide empirical support for a nonlinear J-shaped relationship between early life stress exposure and subsequent resilience.
  • ||||||||||  alprazolam / Generic mfg., dextromethorphan / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Licorice Botanical Dietary Supplements - Metabolism and Safety in Women (clinicaltrials.gov) -  Nov 6, 2020   
    P1,  N=19, Active, not recruiting, 
    Certain benzodiazepines may provide a reduced risk of development of SRBs, suggesting careful consideration when prescribing benzodiazepines to the PTSD population. Recruiting --> Active, not recruiting | Trial completion date: Jun 2020 --> Dec 2020 | Trial primary completion date: Jun 2020 --> Dec 2020
  • ||||||||||  lorazepam / Generic mfg., alprazolam / Generic mfg.
    Journal:  Benzodiazepines use in Morocco: A nation wide consumption database study between 2004 and 2017. (Pubmed Central) -  Oct 30, 2020   
    To our knowledge, this is the first study that describes the consumption of BZDs and their agonists (Zolpidem, Zopiclone) in Morocco. This data may help the analytical toxicology laboratory and health organizations operating in the field of analytical biochemistry to develop specific BZDs quantification and detection methods needed for the Moroccan population.
  • ||||||||||  lorazepam / Generic mfg., alprazolam / Generic mfg.
    Journal:  Benzodiazepines for cancer dyspnoea: a nationwide survey of palliative care physicians. (Pubmed Central) -  Oct 24, 2020   
    This data may help the analytical toxicology laboratory and health organizations operating in the field of analytical biochemistry to develop specific BZDs quantification and detection methods needed for the Moroccan population. Patients with anxiety or receiving a high baseline opioid dose could be potential candidates for future studies investigating the effectiveness of benzodiazepines against cancer dyspnoea.
  • ||||||||||  Review, Journal:  Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding (Pubmed Central) -  Oct 21, 2020   
    Our findings indicated that carrier systems were involved in the uptake of gabapentin (GBP) and lamotrigine (LTG) in placental trophoblast cell lines...LTG was transported by a carrier that was sensitive to chloroquine, imipramine, quinidine, and verapamil...Furthermore, VPA administration changed the expression levels of various transporters in rat placenta, suggesting that sensitivity to VPA differed across gestational stages. Lastly, we developed a method for quantifying eight BZDs in human breast milk and plasma using LC/MS/MS, and successfully applied it to quantify alprazolam in breast milk and plasma donated by a lactating woman.
  • ||||||||||  carisoprodol / Generic mfg., amphetamine/dextroamphetamine immediate release tablet / Generic mfg.
    [VIRTUAL] Carisoprodol Overdose Clinical Implications And Review Of The Literature () -  Oct 17, 2020 - Abstract #ASA2020ASA_805;    
    We present a 38-year-old woman who was admitted to the intensive care unit after taking approximately fifty 350-milligram tablets of carisoprodol (Somadril), an unknown amount of amphetamine/dextrampheatmine (Adderall), and alprazolam (Xanax). Carisoprodol overdose is characterized by excessive sedation, unresponsiveness to stimuli, severe ataxia, amnesia, agitation, myoclonus, CNS depression, respiratory failure, seizures, and coma.
  • ||||||||||  alprazolam / Generic mfg.
    Journal:  Inhibition in the somatosensory system: An integrative neuropharmacological and neuroimaging approach. (Pubmed Central) -  Sep 30, 2020   
    Three different GABA agonists (GABA: alprazolam, ethanol; GABA: baclofen) were investigated in a double blind cross-over design in 16 male participants, accomplishing a tactile perception task...By comparing measured and predicted data, we propose a model in which the initial activation of SI is modulated through GABA receptors and subsequently propagated to SII, without any significant further inhibition. In addition, initial GABA effects in SI appear to be strongly potentiated with time, selectively in SI but not in SII.
  • ||||||||||  JNJ-61393215 / J&J
    [VIRTUAL] Translational Evaluation of Novel Selective Orexin-1 Receptor Antagonist JNJ-61393215 in an Experimental Model for Panic in Rodents and Humans () -  Sep 30, 2020 - Abstract #ACNP2020ACNP_777;    
    Conclusions These results support the safety, tolerability, and anxiolytic effects of JNJ-61393215, and validate CO2 exposure as a translational cross-species experimental model to evaluate the therapeutic potential of novel anxiolytic drugs. Statistics To investigate the anxiolytic effects of JNJ-61393215 in the CO2 challenge model in humans the following statistical analyses were performed: Within each arm, the active treatment was compared to matched placebo on PSL-IV total score by using a linear mixed effects model, controlling for treatment, period and sequence as a fixed effect, participant as a random effect and baseline score as a covariate.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
    [VIRTUAL] Anxiolytic-Like Activity of Cariprazine, a Dopamine D3 Receptor-Preferring Antipsychotic, in Rat Models () -  Sep 30, 2020 - Abstract #ACNP2020ACNP_369;    
    Cariprazine showed anxiolytic-like activity in rats within the dose range of its antipsychotic- and antidepressant-like activity. These findings suggest that cariprazine may have potential efficacy to treat common comorbidities, such as anxiety and depression/anhedonia, associated with schizophrenia or bipolar I disorder.
  • ||||||||||  alprazolam / Generic mfg.
    Clinical, Journal:  Transient hyperprolactinemia secondary to benzodiazepines: a case report. (Pubmed Central) -  Sep 27, 2020   
    After eliminating all known causes of hyperprolactinemia, alprazolam intake is finally assumed...However, benzodiazepines are not known as hyperprolactinemia-inducing drugs by the endocrinologists and do not appear in the list of drugs established by a consensus of experts from the French Society of Endocrinology. This article aims to increase awareness of prescribing physicians and biologists of the possible occurrence of hyperprolactinemia in patients treated by benzodiazepines, especially since the intake of this molecule is particularly common in France, whether it is a medical prescription or self-medication.
  • ||||||||||  Journal:  LC-MS/MS METHOD FOR THE DETERMINATION OF ANTIDEPRESSANTS AND BENZODIAZEPINES IN MECONIUM. (Pubmed Central) -  Sep 25, 2020   
    The authentic meconium samples tested positive for alprazolam, α-hydroxyalprazolam, clonazepam, diazepam, nordiazepam, fluoxetine, norfluoxetine, clomipramine and norclomipramine. Therefore, the present LC-MS/MS method allows a high throughput determination of the most common benzodiazepines and antidepressants in meconium, which could be useful in clinical and forensic settings.
  • ||||||||||  alprazolam / Generic mfg.
    And xanax for all (Twitter) -  Sep 22, 2020