mupirocin / Generic mfg. 
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  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Subinhibitory Concentrations of Antibiotics Alter the Response of Klebsiella pneumoniae to Components of Innate Host Defense. (Pubmed Central) -  Oct 21, 2022   
    For example, a subinhibitory concentration of mupirocin increased survival for 7 of 10 clinical isolates evaluated and there was increased cell-associated CPS for 3 of these isolates compared with untreated controls...We found that exposure of ST258 to antibiotics at low concentrations differentially altered gene expression, capsule production, serum complement deposition, and bacterial survival. The findings were isolate and antibiotic dependent but provide insight into a potential confounding issue associated with ST258 infections.
  • ||||||||||  Journal:  Effect of the Presence of Antibiotic Residues on the Microbiological Quality and Antimicrobial Resistance in Fresh Goat Meat. (Pubmed Central) -  Oct 15, 2022   
    Nine samples were free of antibiotic residues, while in the other two samples the presence of sulfadiazine and doxycycline was detected...epidermidis isolated from one sample containing doxycycline residues showed resistance to mupirocin...Neither extended-spectrum β-lactamase -producing E. coli nor vancomycin-resistant enterococci were detected in any sample...The presence of multidrug-resistant bacteria in goat meat could be considered a potential threat and should be monitored. Special measures should be taken at the farm level and during slaughter to reduce antimicrobial resistance.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Genomic characterization of two community-acquired methicillin-resistant Staphylococcus aureus with novel sequence types in Kenya. (Pubmed Central) -  Oct 14, 2022   
    Linezolid and mupirocin resistance was observed, yet mupirocin is not commonly used in the country...The genomic research highlights resistance to anti-staphylococcal broad-spectrum antimicrobials not used frequently in the country, jeopardizing successful MRSA treatment since most health facilities do not perform genotypic resistance tests for routine patient management. Preliminary insights into unidentified STs of CA-MRSA in Kenya show the need for molecular epidemiological surveillance studies to further understand the diversity of S. aureus in Africa.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin. (Pubmed Central) -  Oct 14, 2022   
    These investigations reveal a complex interplay between a novel iterative or 'stuttering' KS-AT didomain (MmpF), the multi-domain module MmpB and multiple ACPs. This work has important implications for understanding the late-stage biosynthetic steps of mupirocin and will be important for future engineering of related trans-AT biosynthetic pathways (eg thiomarinol).
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Genomic and Epidemiological Features of Two Dominant Methicillin-Susceptible Staphylococcus aureus Clones from a Neonatal Intensive Care Unit Surveillance Effort. (Pubmed Central) -  Oct 12, 2022   
    Almost all ST1898 isolates harbored plasmids encoding mupirocin resistance (mupA), suggesting an association between the proliferation of this clone and decolonization efforts with mupirocin...Using genomic surveillance and phylogenetic analysis, coupled with epidemiological investigation, we found that these two sequence types had distinct modes of spread, namely the suggested exchange with community reservoirs for ST398 and the contribution of antibiotic resistance to dissemination of ST1898 in the health care setting. This study highlights the additional benefits of whole-genome surveillance for colonizing pathogens, beyond routine species identification and genotyping, to inform targeted infection prevention strategies.
  • ||||||||||  mupirocin / Generic mfg.
    Review, Journal:  Role of antiseptics in the prevention and treatment of infections in nursing homes. (Pubmed Central) -  Oct 11, 2022   
    As no reports of bacterial resistance or cross-resistance following exposure to povidone-iodine exist, it may be preferable for MRSA decolonization compared with mupirocin and chlorhexidine, which can cause resistant MRSA strains...Importantly, povidone-iodine activity is not adversely affected by organic material, such as that found in chronic wounds and the oral cavity. Povidone-iodine is a promising antiseptic agent for the management of infections in the nursing home setting, including MRSA decolonization procedures, chronic wound management, and oral care.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    Mycosis Fungoides (MF): The Master Of Mimicry (Exhibit Hall (Upper Concourse); Monitor 05) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_1037;    
    Treatment for an initial diagnosis of fungal dermatitis with mupirocin, clotrimazole, and lotrisone was started with regular debridement of the feet...Dupixent for AD was discussed but not started...This case highlights important points for the allergist. 1) Erythema in skin of color is hard to appreciate 2) MF can often look like AD and 3) Palmoplantar Keratoderma may be associated with MF.
  • ||||||||||  Humira (adalimumab) / Eisai, AbbVie
    An uncommon cause of lip swelling (Exhibit Hall (Upper Concourse); Monitor 04) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_903;    
    Discussion While allergic and immunologic pathology are common causes of angioedema, this case encourages consideration of other etiologies of lip swelling, such as inflammatory bowel disease. Other diagnoses to consider include sarcoidosis, infections, miescher's cheilitis, and autoimmune conditions.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., rifampicin / Generic mfg., mupirocin / Generic mfg.
    Methicillin-resistant Staphylococcus aureus eradication rate increased after the initiation of a standardized regimen in children with cystic fibrosis (Exhibition Hall) -  Oct 8, 2022 - Abstract #NACFC2022NACFC_1090;    
    Other diagnoses to consider include sarcoidosis, infections, miescher's cheilitis, and autoimmune conditions. Eradication is defined as negative MRSA respiratory cultures(at least three samples) during the 12 months after eradication treatment.First-line antibiotic regimen for eradication of MRSA was peroraltrimethoprim-sulfamethoxazole and rifampicin or sodium fusidate andrifampicin for 3 weeks (intravenous antibiotics if the patient is unwell).Body cleaning, environmental decontamination, and nasal mupirocin wereused as adjuvant therapy...Oral trimethoprim-sulfamethoxazole and rifampi-cin were used in 54.1% (n = 13) of the patients and oral sodium fusidate andtrimethoprim-sulfamethoxazole in 23.8% (n = 5)...A standardized MRSA eradication protocol was appliedsuccessfully, and the eradication rate was high.
  • ||||||||||  mupirocin / Generic mfg.
    Review, Journal:  Nasal vestibular furunculosis: Summarised case series. (Pubmed Central) -  Sep 29, 2022   
    The most frequent, successful management of NVF frequently included intranasal topical mupirocin and in some cases oral sodium fusidate...Although a very common condition, much research is required to allude to the pathophysiology and management of NVF. Future studies should explore the reasons as to the resistance of topical antibiotics in some patients, the differing strains of staphylococcus aureus and their resulting complications, the reasons behind the familiar connection and the most effective management plan for NVF.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Pre-surgical Nasal Decolonization of Staphylococcus aureus: A Health Technology Assessment. (Pubmed Central) -  Sep 29, 2022   
    Targeted nasal decolonization with mupirocin combined with chlorhexidine body wash may also reduce S. aureus-related surgical site infections but increase the overall cost of treatment for the health care system. We estimate that publicly funding universal nasal decolonization using mupirocin combined with chlorhexidine body wash would result in a total cost savings of $45.08 million over the next 5 years, whereas publicly funding targeted nasal decolonization using mupirocin combined with chlorhexidine body wash would incur an additional cost of $1.17 million over the next 5 years.People undergoing surgery value treatments aimed at preventing surgical site infections.
  • ||||||||||  chlorhexidine gluconate / Generic mfg., mupirocin / Generic mfg.
    Journal:  Implementation of a surgical site infection prevention bundle: Patient adherence and experience. (Pubmed Central) -  Sep 29, 2022   
    We evaluated barriers and facilitators to patient adherence with a bundled intervention including chlorhexidine gluconate (CHG) bathing and decolonizing Staphylococcus aureus nasal carriers in a real-world setting. Survey data identified 85.5% adherence with home use of CHG as directed and 52.9% adherence with home use of mupirocin as directed.
  • ||||||||||  chlorhexidine gluconate / Generic mfg., mupirocin / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, HEOR:  Bacterial Decolonization to Prevent Radiation Dermatitis (clinicaltrials.gov) -  Sep 14, 2022   
    P2/3,  N=80, Completed, 
    Based on the results obtained, the present study concluded that the formulated stable network might be an ideal network for the delivery of mupirocin in skin infections. Recruiting --> Completed | Trial completion date: Dec 2022 --> Dec 2021 | Trial primary completion date: Oct 2022 --> Dec 2021
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Skin Infections Due to Panton-Valentine Leukocidin-Producing S. Aureus. (Pubmed Central) -  Sep 14, 2022   
    Recruiting --> Completed | Trial completion date: Dec 2022 --> Dec 2021 | Trial primary completion date: Oct 2022 --> Dec 2021 PVL-SA skin infections are easily distinguished from other skin diseases with targeted history-taking and diagnostic evaluation.
  • ||||||||||  chlorhexidine gluconate / Generic mfg., mupirocin / Generic mfg.
    Journal:  A preoperative protocol to reduce SSI rates in elective neurosurgical procedures. (Pubmed Central) -  Aug 12, 2022   
    This retrospective review of a presurgical protocol with measuring of HbA1c and nasal swabs revealed a significant decrease in the infection rate of patients undergoing elective neurosurgical procedures. Additional investigations are necessary; however, we recommend its use.
  • ||||||||||  mupirocin / Generic mfg.
    Preclinical, Journal:  Optimization, Characterization and In Vivo Evaluation of Mupirocin Nanocrystals for Topical Administration. (Pubmed Central) -  Aug 5, 2022   
    In vivo studies, using a rat excision burn wound model, demonstrated rapid and complete healing of infected burn wounds in rats treated with MP-NC cream in comparison to marketed Avoban ointment. Our results suggest that nanocrystallization of MP may provide an avenue through which higher levels of a topically applied MP can be permeated into the skin to reach relevant infectious areas and exert potential local antibacterial effects.
  • ||||||||||  mupirocin / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Infection Prevention Bundle in Brain Tumor Surgery (clinicaltrials.gov) -  Aug 4, 2022   
    P=N/A,  N=300, Suspended, 
    It is important to quickly diagnose and treat this type of infection, especially when it presents as a localized pustule, boil, tear, peeling, or crust before it becomes systemic. Trial completion date: Jun 2022 --> Dec 2022 | Trial primary completion date: Feb 2022 --> Oct 2022
  • ||||||||||  mupirocin / Generic mfg.
    Bacterial Decolonization to Prevent Acute Radiation Dermatitis: A Randomized Controlled Trial (Henry B. Gonzalez Convention Center, Room 007 A/B) -  Aug 1, 2022 - Abstract #ASTRO2022ASTRO_491;    
    Our study included mainly breast cancer patients; thus BD efficacy needs to be tested in other solid tumors receiving RT. This is the first study demonstrating efficacy of bacterial decolonization to reduce RD for cancer patients.
  • ||||||||||  Cubicin (daptomycin) / Merck (MSD), Zeftera (ceftobiprole) / Basilea
    Review, Journal:  Molecular Mechanisms of Drug Resistance in Staphylococcus aureus. (Pubmed Central) -  Jul 30, 2022   
    (9) Mupirocin...(11) Daptomycin. (12) Resistance to other antibiotics and chemioterapeutics (e.g., streptogramins A, quinupristin/dalfopristin, chloramphenicol, rifampicin, fosfomycin, trimethoprim) (13) Molecular epidemiology of MRSA.
  • ||||||||||  vancomycin / Generic mfg., mupirocin / Generic mfg.
    Journal:  Formulation of Chrysomycin A Cream for the Treatment of Skin Infections. (Pubmed Central) -  Jul 29, 2022   
    The particle size of the product met Chinese Pharmacopoeia specifications and the entire cream showed long-term stability in destructive tests. The in vitro and in vivo studies indicated that CA cream had a similar anti-MRSA activity to commercially available mupirocin, showing its potential as an efficacious topical delivery system for skin infections treatment.