mupirocin / Generic mfg. 
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  • ||||||||||  mupirocin / Generic mfg.
    Journal, Surgery:  Mupirocin Ointment Effect on Polyposis Recurrence After Sinus Surgery. (Pubmed Central) -  Sep 26, 2024   
    However, there was no significant difference in the radiological and endoscopic score improvements between the study and control groups (P-value > 0.56, 0.74). Nasal mupirocin administration following endoscopic sinus surgery cannot significantly prevent symptom recurrence in chronic rhinosinusitis with nasal polyps.
  • ||||||||||  mupirocin / Generic mfg.
    Review, Journal:  Mupirocin for Skin Infection: Clinical Experience from China. (Pubmed Central) -  Sep 20, 2024   
    According to the experience of Chinese doctors in the past few years, mupirocin presented low drug resistance rates, and could be used as a treatment option for various primary infections and secondary infections, with antibacterial effects in a broad application. In this review, we summarized the experience of mupirocin used in the Chinese population and discussed its clinical value to provide novel insights and inspiration for physicians.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., mupirocin / Generic mfg.
    Trial initiation date, Trial primary completion date:  Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients (clinicaltrials.gov) -  Sep 19, 2024   
    P4,  N=100, Not yet recruiting, 
    In this review, we summarized the experience of mupirocin used in the Chinese population and discussed its clinical value to provide novel insights and inspiration for physicians. Initiation date: Sep 2024 --> Dec 2024 | Trial primary completion date: Sep 2028 --> Dec 2028
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Fabrication of Mupirocin-Loaded PEGylated Chitosan Nanoparticulate Films for Enhanced Wound Healing. (Pubmed Central) -  Sep 14, 2024   
    The film has higher water absorption (?1700%) and moderate water retention ability within 6 h. Furthermore, histological findings showed significant development, with re-epithelialization and granulation of tissues after 19 days, indicating the healing efficiency of CNBF. These results suggest that drug-loaded films could be an effective carrier and delivery agent for Mup-like anti-inflammatory drugs.
  • ||||||||||  mupirocin / Generic mfg., gentamicin sulfate / Generic mfg.
    Journal:  Reduction of peritoneal dialysis associated infections using a novel exit-site care practice. (Pubmed Central) -  Sep 1, 2024   
    For this to occur, clinicians must maintain high clinical suspicion for M abscessus infection in any chronic, nonhealing wound failing to respond to initial treatment. An exit site care protocol that includes water avoidance and local Mupirocin use reduced substantially both CRI and peritonitis rate in patients treated with PD.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., mupirocin / Generic mfg.
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients (clinicaltrials.gov) -  Aug 9, 2024   
    P4,  N=0, Withdrawn, 
    The antibacterial activity of selected phytochemicals (berberine, curcumin, farnesol, gallic acid, and quercetin; 6.25-1000 N=50 --> 0 | Trial completion date: Jul 2028 --> Dec 2028 | Not yet recruiting --> Withdrawn | Trial primary completion date: May 2028 --> Sep 2028
  • ||||||||||  Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
    Inhibition of epidermal isoleucyl-tRNA synthetase ameliorates psoriasis-like skin lesions via JAK2/STAT3/CXCL16 signaling pathway (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_4824;    
    Our previous study revealed that mupirocin blocked imiquimod (IMQ) -induced psoriasis-like skin lesions by inhibiting epidermal IARS, but the mechanisms by which IARS affects psoriatic local inflammation have remained unclear. This study identifies inhibition of epidermal isoleucyl-tRNA synthetase that can ameliorate psoriasis-like skin lesions via the JAK2/STAT3/CXCL16 signaling pathway and proposes IARS as a novel potential therapeutic intervention for psoriasis.
  • ||||||||||  cephalexin / Generic mfg., mupirocin / Generic mfg., acyclovir / Generic mfg.
    The importance of thorough medical history in diagnosis of vesicular lesions in children (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_4594;    
    HSV infection usually starts with prodromal symptoms and commonly appears unilaterally, for example, on the lip in the vermilion area, while the disseminated form is present in children with immunodeficiency or underlying dermatosis. In our case, there were no prodromal symptoms, and the lesions appeared on different parts of the face over several days.
  • ||||||||||  Maxidex (dexamethasone eye drops, suspension) / Novartis
    Reactive infectious mucocutaneous eruption secondary to Chlamydia pneumoniae infection. (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_4039;    
    In our case, there were no prodromal symptoms, and the lesions appeared on different parts of the face over several days. Additionally, the mother reported that the child had previously suffered from a cold, which was treated with carbocisteine and paracetamol...Serologies and PCR of mucosal swabs were performed, and due to the patient
  • ||||||||||  Uninvited Guests: A Clinical Encounter with Cutaneous Myiasis (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_3888;    
    Skin lesions form when the eggs hatch on human skin and/or when the maggots themselves penetrate the skin. Upon larval penetration, an erythematous papule develops, eventually becoming a nodule resembling a furuncle.
  • ||||||||||  aspirin / Generic mfg., mupirocin / Generic mfg.
    Necrosis of nasal septum due to filler-induced columellar artery occlusion (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2810;    
    The case underscores the crucial role of technique, the choice of instruments, and the necessity for prompt recognition and treatment of complications. Although rare, the potential severity of such outcomes necessitates heightened awareness among practitioners and patients considering or performing nasal filler injections.
  • ||||||||||  Antimicrobial Resistance Trends in Hidradenitis Suppurativa Lesions (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_1654;    
    A targeted antibiotic therapy guided by microbiological assessments, including prolonged culture periods, is preferable over empirical, nonspecific methods. Revised therapeutic guidelines for HS should incorporate the latest insights into bacterial antibiotic resistance.
  • ||||||||||  mupirocin / Generic mfg.
    Review, Journal:  New Insights into Pseudomonas spp.-Produced Antibiotics: Genetic Regulation of Biosynthesis and Implementation in Biotechnology. (Pubmed Central) -  Jul 27, 2024   
    Pseudomonas bacteria are renowned for their remarkable capacity to synthesize antibiotics, namely mupirocin, gluconic acid, pyrrolnitrin, and 2,4-diacetylphloroglucinol (DAPG)...Thus, the present review comprehensively studies the genetic organization and regulation of the biosynthesis of these antibiotics and provides a comprehensive summary of the genetic organization of antibiotic biosynthesis pathways in pseudomonas strains, appealing to both molecular biologists and biotechnologists. In addition, attention is also paid to the application of antibiotics in plant protection.
  • ||||||||||  vancomycin / Generic mfg., clindamycin phosphate / Generic mfg., mupirocin / Generic mfg.
    Journal:  Prevalence and genetic characteristics of (Pubmed Central) -  Jul 2, 2024   
    Overall, 7.8% of the isolates displayed an inducible clindamycin resistance phenotype, while 26.7% showed resistance to mupirocin...The most prevalent type was CC8-MRSA III/t030 (18.7%), followed by CC8-MRSA III/t037 (12.5%), CC/ST22-MSSA/t790 (10.9%), CC1-MRSA IV-t114 (9.4%), CC1-MRSA IV-t127 (7.8%), CC8-MRSA V/t064 (7.8%), CC/ST15-MSSA-t360 (7.8%), CC30-MSSA/t021(6.3%), MRSA V-t355 (6.3%), CC8-MRSA III/t421 (4.7%), CC1-MRSA V-t267 (4.7%), and CC/ST15-MSSA-t084 (3.1%). The genetic diversity and prevalent multidrug resistance indicate that the resistance situation of S. aureus recovered from mobile phones in Tehran is severe, posing a potential threat to patients, the community, and healthcare settings.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Exploring mechanisms of mupirocin resistance and hyper-resistance. (Pubmed Central) -  Jun 17, 2024   
    Low-level resistance arises by mutations of the housekeeping IleRS1, while high-level resistance develops by the acquisition of the resistant IleRS2 on a plasmid. There is no evidence that hyper-resistant variants have been found in clinical isolates.
  • ||||||||||  trimethoprim/sulfamethoxazole / Generic mfg., mupirocin / Generic mfg.
    Trial initiation date:  Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients (clinicaltrials.gov) -  Jun 10, 2024   
    P4,  N=50, Not yet recruiting, 
    A topical formulation combining mupirocin and ?-Pi may aid in the development of innovative agents for treating MRSA infections. Initiation date: May 2024 --> Sep 2024
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Antiseptics in otorhinolaryngology-a (Pubmed Central) -  May 23, 2024   
    For decolonization of the nares, polyhexanide and octenidine are available as nasal gels, but these are inferior to mupirocin for MRSA decolonization...With an intact eardrum, acetic acid-containing eardrops can be used to prevent and treat external otitis and myringitis. When the eardrum is perforated, only alcohol-free PVP-iodine and HOCL may be used.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Genomic Characterization and Safety Assessment of Bifidobacterium breve BS2- PB3 as Functional Food. (Pubmed Central) -  Apr 26, 2024   
    breve BS2-PB3 only exhibited selected resistance phenotypes, i.e., to mupirocin (minimum inhibitory concentration/MIC >1,024 ?g/ml), sulfamethoxazole (MIC >1,024 ?g/ml), and oxacillin (MIC >3 ?g/ml)...While no virulence factor was detected, four insertion sequences were identified within the genome but were located away from the identified antibiotic resistance genes. In conclusion, B. breve BS2-PB3 demonstrated a sufficient safety profile, making it a promising candidate for further development as a potential functional food.
  • ||||||||||  mupirocin / Generic mfg.
    Staphylococcus aureus drives type I interferon-mediated monocyte recruitment and skin barrier disruption in cutaneous lupus erythematosus lesions (Exhibit Hall F1; Poster Board Number: B524) -  Mar 29, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_1513;    
    Mupirocin treatment decreased the abundance of Staphylococcus associated with CLE lesions without altering the diversity of the skin microbiota relative to vehicle, and this correlated with decreased IFN pathway signaling and inflammatory gene expression in lesional skin. This study suggests that a topical antibiotic could be employed decrease lupus skin inflammation and cutaneous type I IFN responses by reducing Staphylococcus colonization.
  • ||||||||||  mupirocin / Generic mfg.
    Journal:  Structure and Function of the ?-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase. (Pubmed Central) -  Mar 22, 2024   
    Furthermore, using purified enzyme, it is shown that the MmpA KS0 shows relaxed substrate specificity, suggesting precise spatiotemporal control of in trans MupA recruitment in the context of the PKS. Finally, the detection of multiple intermodular MupA/ACP interactions suggests these bimodules may integrate MupA into their assembly.