- |||||||||| terbinafine HCL / Generic mfg.
Clinical, Journal: Laboratory monitoring during antifungal treatment of pediatric tinea capitis. (Pubmed Central) - Jul 28, 2021
Mild elevation in hepatic transaminases is relatively common among pediatric patients treated with systemic antifungal treatment for TC. However, significant laboratory abnormalities are extremely rare and may be diagnosed and addressed early through periodic laboratory tests monitoring.
- |||||||||| terbinafine HCL / Generic mfg.
Preclinical, Journal: In vitro activities of antifungal drugs against a large collection of Trichophyton tonsurans isolated from wrestlers. (Pubmed Central) - Jul 14, 2021
Therefore, our results strongly suggest six peptides with high potential to be employed alone as new drugs or as adjuvants to enhance the activity and decrease the toxicity of griseofulvin. Evaluation of antifungal susceptibility of dermatophytes showed that tolnaftate and itraconazole were the most effective drugs against T tonsurans and fluconazole had the least effect.
- |||||||||| terbinafine HCL / Generic mfg.
Journal: Tinea capitis: advances and a needed paradigm shift. (Pubmed Central) - Jul 14, 2021
We recommend all clinical providers ascertain the causative organism in fungal infection, either through fungal culture or newer methods which may become more readily available and cost-effective in the future, such as polymerase chain reaction assay. We also recommend terbinafine as first-line treatment of tinea capitis, with adjustment as necessary after species identification.
- |||||||||| griseofulvin / Generic mfg.
Journal: Exploring Tablet Design Options for Tailoring Drug Release and Dose via Fused Deposition Modeling (FDM) 3D Printing. (Pubmed Central) - Jun 22, 2021
The drug, griseofulvin (GF), the polymer, hydroxypropyl cellulose (HPC), and processing temperatures were selected to avoid confounding effects arising from drug-polymer interactions...For duo-tablets, long lag times proportional to placebo shell-thickness were observed. These results suggest that design options other than varying the tablet size would be needed to achieve desired drug release from FDM-based 3D printed personalized dosages.
- |||||||||| griseofulvin / Generic mfg.
Journal: Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation. (Pubmed Central) - Jun 22, 2021
The ability of the resultant aggregates in aqueous solution to encapsulate and liberate model drugs (e.g., propofol, griseofulvin and prednisolone) was then determined...Similarly, propofol showed 70% liberation from the polymer aggregate after 24 h, compared with only 30% liberation pre-PEGylation. These studies give an insight into the potential of the HMPA based amphiphiles as thermally responsive cargo carrier/release systems which could be exploited in the delivery of poorly soluble drugs.
- |||||||||| griseofulvin / Generic mfg.
Journal: Preparation and Characterization of Griseofulvin Solid Dispersions. (Pubmed Central) - Jun 8, 2021
Slight peak shifts were observed in IR and Raman; however, these shifts were inconclusive of molecular interactions between GSV and hydrophilic polymers. GSV's high crystallization tendency coupled with a lack of hydrogen bond acceptors/donors hinders the formation of stable SD, and thus, a higher polymer concentration is a prerequisite for their long-term stability.
- |||||||||| griseofulvin / Generic mfg.
Journal: Polyelectrolyte Multi-Layered Griseofulvin Nanoparticles: Conventional versus Continuous In-Situ Layer-by-Layer Fabrication. (Pubmed Central) - May 14, 2021
In comparison to the continuous in situ method, the conventional method yielded nanoparticles of smaller size (282 ±9 nm vs. 497 ±34 nm) and higher stability by maintaining its size for 6 months. In conclusion, the parent griseofulvin nanosuspension proved to be a suitable candidate for the polyelectrolyte multilayer fabrication providing an avenue for a bespoke formulation with versatile and potentially enhanced drug delivery properties.
- |||||||||| griseofulvin / Generic mfg.
Journal: A general method for cultivating single crystals from melt microdroplets. (Pubmed Central) - Apr 17, 2021
Here, we report a general strategy for rapidly cultivating single crystals from melt microdroplets within tens of minutes at the microgram scale. This strategy was successfully applied to the important polymorphic system griseofulvin to provide missing structural information of Form III, for which single crystals could not be cultivated from solution, as well as to twenty clinical drugs to verify its generality.
- |||||||||| griseofulvin / Generic mfg.
Journal: Natural product fragment combination to performance-diverse pseudo-natural products. (Pubmed Central) - Apr 10, 2021
We describe the synthetic combination of the fragment-sized natural products quinine, quinidine, sinomenine, and griseofulvin with chromanone or indole-containing fragments to provide a 244-member pseudo-natural product collection...Identification of phenotypic fragment dominance enables design of compound classes with correctly predicted bioactivity. The results demonstrate that fusion of natural product fragments in different combinations and arrangements can provide chemically and biologically diverse pseudo-natural product classes for wider exploration of biologically relevant chemical space.
- |||||||||| terbinafine HCL / Generic mfg., voriconazole / Generic mfg.
Journal: Virulence and Antifungal Susceptibility of Microsporum canis Strains from Animals and Humans. (Pubmed Central) - Apr 7, 2021
Voriconazole, terbinafine, and posaconazole were the most active drugs followed by ketoconazole, griseofulvin, itraconazole, and fluconazole in decreasing activity order. The significant positive correlation between azole susceptibility profile of M. canis and virulence factors (i.e., hemolysin and catalase) suggest that both enzyme patterns and antifungal susceptibility play a role in the appearance of skin lesions in animals and humans.
- |||||||||| griseofulvin / Generic mfg.
Journal: Synergistic and Antagonistic Effects of Various Amphiphilic Polymer Combinations in Enhancing Griseofulvin Release from Ternary Amorphous Solid Dispersions. (Pubmed Central) - Mar 23, 2021
A strong synergistic effect emerged for the ASD with 5:1 Sol:VA64: ∼220% supersaturation within 30 min was generated and maintained over three hours, whereas an antagonistic effect was observed for 1:5 Sol:VA64 with 70% supersaturation. The combination of an amphiphilic polymer that provides effective drug wettability enhancement (VA64) as a minor component along with an amphiphilic crystallization inhibiting polymer as a major component (Sol), which also provides micellar solubilization of the drug, in a ternary ASD exhibited synergistic rapid drug release with prolonged supersaturation.
- |||||||||| griseofulvin / Generic mfg.
Journal: Ferrochelatase regulates retinal neovascularization. (Pubmed Central) - Mar 17, 2021
Griseofulvin is an antifungal drug that inhibits FECH as an off-target effect...In sum, mutation and chemical inhibition of Fech reduces retinal neovascularization and promotes physiological angiogenesis, suggesting a dual effect on vascular repair upon FECH inhibition, without ocular toxicity. These findings suggest that FECH inhibitors could be repurposed to treat retinal neovascularization.
- |||||||||| disulfiram / Generic mfg.
Journal: Increased Brain Serotonin Rather Than Increased Blood Acetaldehyde as a Common Denominator Behind Alleged Disulfiram-Like Reactions. (Pubmed Central) - Mar 13, 2021
On the other hand, all tested agents share the common property to enhance brain serotonin, whereas a respective effect of ethanol is well established. Hence, the ethanol intolerance produced by these agents, whether blood acetaldehyde concentration is elevated or not, could be the result of a "toxic serotonin syndrome," as in the case of the concomitant use of serotonin-active medications that provoke clinical manifestations similar to those of a disulfiram reaction.
- |||||||||| Journal: Synthesis and Bioactivity of a Cyclopolypeptide from Caribbean Marine Sponge. (Pubmed Central) - Mar 9, 2021
Cyclopeptide 8 possessed promising activity against pathogenic fungi Candida albicans (ZOI: 24 mm, MIC: 6 μg/mL) and Gram-negative bacteria Pseudomonas aeruginosa (ZOI: 27 mm, MIC: 6 μg/mL) and Klebsiella pneumoniae (ZOI: 23 mm, MIC: 12.5 μg/mL), in comparison to reference drugs - griseofulvin (ZOI: 20 mm, MIC: 6 μg/mL) and ciprofloxacin (ZOI: 25 mm, MIC: 6 μg/mL/ZOI: 20 mm, MIC: 12.5 μg/mL). Also, newly synthesized heptacyclopeptide exhibited potent anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses, and Eudrilus species (MPT/MDT ratio - 8.22-16.02/10.06-17.59 min), in comparison to standard drugs - mebendazole (MPT/MDT ratio - 10.52-18.02/12.57-19.49 min) and piperazine citrate (MPT/MDT ratio - 12.38-19.17/13.44-22.17 min).
- |||||||||| levofloxacin / Generic mfg., griseofulvin / Generic mfg.
Journal: Occurrence of pharmaceutical and personal care products in Cau River, Vietnam. (Pubmed Central) - Mar 5, 2021
The water-sediment partition coefficient (K) was estimated to explore the fate of PPCP in the river, and the observed K mean values for lincomycin, sulfamethoxazole, and griseofulvin were 223.0, 7.6, and 997.0 kg/L, respectively. Risk assessment was initially conducted by applying a semi-quantitative assessment risk quotient (RQ); the potential ecological risk to the aquatic organism of PPCPs posed a moderate risk.
- |||||||||| Clinical, Journal: Clinical aspects of previously treated chromoblastomycosis: a case series from Madagascar. (Pubmed Central) - Mar 2, 2021
Risk assessment was initially conducted by applying a semi-quantitative assessment risk quotient (RQ); the potential ecological risk to the aquatic organism of PPCPs posed a moderate risk. Our study is the first to show that cicatricial lesions are a clinical aspect presented by CBM patients who received antifungals before presentation.
- |||||||||| griseofulvin / Generic mfg.
Journal: Impact of media material and process parameters on breakage kinetics-energy consumption during wet media milling of drugs. (Pubmed Central) - Feb 10, 2021
The aim of this study is to investigate the impact of stirrer speed (2000-4000 rpm) and CPS bead loading (~20-60%) on the breakage kinetics-energy consumption during milling of griseofulvin, a model poorly soluble drug, and compare the performance of CPS vs. YSZ at the highest bead loading...While YSZ generally required higher specific energy consumption than CPS, it achieved the same product fineness faster than CPS. The microhydrodynamic model rationalized the favorable use of YSZ over CPS beads within the experimental domain studied.
- |||||||||| griseofulvin / Generic mfg., terbinafine HCL / Generic mfg., itraconazole / Generic mfg.
Preclinical, Journal: In vitro and ex vivo biofilms of dermatophytes: a new panorama for the study of antifungal drugs. (Pubmed Central) - Feb 2, 2021
SEM analysis demonstrated a retraction in the biofilm matrix, but fungal structures and water channels were preserved. These results show that ex vivo biofilms are more tolerant to antifungal drugs than in vitro biofilms, suggesting that environmental and nutritional conditions created by this ex vivo model favor biofilm growth and robustness, and hence drug tolerance.
- |||||||||| griseofulvin / Generic mfg.
Journal: Determination of Inherent Dissolution Performance of Drug Substances. (Pubmed Central) - Jan 28, 2021
Three different drugs-benzocaine, theophylline and griseofulvin-were used to investigate the mass flux during dissolution due to surface reaction, diffusion and convection kinetics. This new technique shows potential to be a valuable tool for the identification of formulation strategies.
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi
Journal: Solubility of Pharmaceutical Ingredients in Natural Edible Oils. (Pubmed Central) - Jan 14, 2021
In this work, solubilities of indomethacin (IND), ibuprofen (IBU), and fenofibrate (FFB) in soybean oil and in coconut oil were measured via differential scanning calorimetry, high-performance liquid chromatography, and Raman spectroscopy...Furthermore, the solubilities of five more APIs (IND, cinnarizine, naproxen, griseofulvin, and felodipine) were modeled in soybean oil...The influence of different NEO kinds on API solubility was examined by comparing FFB and IBU solubilities in soybean oil and refined coconut oil. PC-SAFT was thus found to allow assessing the batch-to-batch consistency of NEO batches in silico.
- |||||||||| Flagyl (metronidazole) / SLA
Review, Journal: Fact vs. Fiction: The Evidence Behind Alcohol and Antibiotic Interactions, a Review. (Pubmed Central) - Dec 23, 2020
Available data support that oral penicillins, cefdinir, cefpodoxime, fluoroquinolones, azithromycin, tetracycline, nitrofurantoin, secnidazole, tinidazole, and fluconazole can be safely used with concomitant alcohol consumption...Erythromycin may have reduced efficacy with alcohol consumption, and doxycycline may have reduced efficacy in chronic alcoholism...The disulfiram-like reaction, though classically associated with metronidazole, occurs with uncertain frequency and with varied severity...Alcohol and antimicrobial interactions are often lacking evidence. This review questions common beliefs due to poor, often conflicting data and identifies important knowledge gaps.
- |||||||||| Spherazole (itraconazole) / RA Chem, JW Pharma, Spherics
Review, Journal: Tinea Capitis: An Updated Review. (Pubmed Central) - Dec 18, 2020
Topical antifungal therapy, however, can be used to reduce transmission of spores and can be used as adjuvant therapy to systemic antifungals. Combined therapy with topical and oral antifungals may increase the cure rate.
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