- |||||||||| Elitek (rasburicase) / Sanofi
3, 2, 1, BLAST-OFF: A RARE CAUSE OF APPENDICITIS () - Jan 25, 2023 - Abstract #SCCM2023SCCM_1240;
AML involving the appendix has been described uncommonly, and there is very limited data on the best therapeutic approach, such as the role and timing of surgery in these immunosuppressed patients. There are case reports with good results following urgent surgery, though in our case delayed intervention may have contributed to the poor outcome.
- |||||||||| trimetazidine / Generic mfg., allopurinol / Generic mfg.
Enrollment open: Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients (clinicaltrials.gov) - Jan 19, 2023
P4, N=124, Recruiting,
The results of our review may assist in highlighting the efficacy and testing the effectiveness of low-cost, safe preventative measures for oral mucositis in cancer patients. Not yet recruiting --> Recruiting
- |||||||||| allopurinol / Generic mfg.
Journal: Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents. (Pubmed Central) - Jan 12, 2023
The top hits Spartinin C10 & C22 suggested high inhibition percentages (78.54 and 93.74) at 10 μM dosage, which were higher than the positive control Allopurinol...The preliminary pharmacokinetics evaluation indicated that the rapid absorption, metabolism and elimination of Spartinin C10 should be further improved. The discovery of pharmaceutical molecules from coastal marine source here might inspire the inter-disciplinary investigations on public health.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie, allopurinol / Generic mfg.
Cool NEJM Case of Spinal Gout in 82-yr-old woman with 3-wk hx of severe LBP, rigors, anorexia, incomplete urination. Hx of PsA, CKD, CHF treated w/ Humira, HCQ, diuretics. Imaging tophi in spine, responded to steroids and allopurinol. https://t.co/Ny50BLk7H3 (Twitter) - Dec 27, 2022
- |||||||||| acetylcysteine solution / Generic mfg., allopurinol / Generic mfg.
Journal: Growth Factors Upregulated by Uric Acid Affect Guanine Deaminase-Induced Melanogenesis. (Pubmed Central) - Dec 23, 2022
However, HO or NAC did not upregulate or downregulate bFGF or SCF, respectively. Overall, uric acid could be involved in melanogenesis induced by GDA overexpression in keratinocytes via bFGF and SCF upregulation not via ROS generation.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Jaypirca (pirtobrutinib) / Eli Lilly, Gazyva (obinutuzumab) / Roche, Biogen
Enrollment open: NCI-2022-07625: Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-na (clinicaltrials.gov) - Dec 23, 2022
P2, N=60, Recruiting,
This study suggests the need for prescriber education and supports expansion of pharmacist-led gout management to primary care settings. Not yet recruiting --> Recruiting
- |||||||||| allopurinol / Generic mfg.
Journal: Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction. (Pubmed Central) - Dec 18, 2022
Nine derivatives (9a-e, 10b,c, and 15a,b) exhibited apparent XO inhibitory activity in vitro (IC values varied from 0.121 to 7.086 μM), 15b presented the most potent inhibitory activity (IC = 0.121 µM), which was 27.47-fold higher than that of allopurinol (IC = 3.324 µM)...Briefly, compound 15b emerges as an interesting XO inhibitor for the treatment of hyperuricemia and gout with beneficial effects on serum uric acid levels regulating. Meanwhile, the XO inhibitors with chalcone skeleton will deserve further attention and discussion.
- |||||||||| allopurinol / Generic mfg.
Update on DILI in Asia-Pacific Region (4F VIP Room) - Dec 18, 2022 - Abstract #APASL2023APASL_300;
Allopurinol is the leading incriminated drug...Among them, slow NAT2 acetylation status has been most studied and confirmed in different ethnic populations. Application of this pharmacogenomic or pharmacogenetic assay may help mitigate the crucial ATDILI or other DILI.
- |||||||||| famotidine / Generic mfg., allopurinol / Generic mfg.
Retrospective data, Journal: In-Hospital Prescription Checking System for Hospitalized Patients with Decreased Glomerular Filtration Rate. (Pubmed Central) - Dec 16, 2022
We demonstrated that a prescription audit by hospital pharmacists using the PCS reduced the rate of dosage errors in the target renally excreted drugs in hospitalized patients. Although further studies are needed to confirm whether our results can be generalized to other health facilities, our findings highlight the need for a PCS to prevent the overdose of renally excreted drugs.
- |||||||||| allopurinol / Generic mfg.
Journal: Canine leishmaniosis: an update regarding diagnostics, therapeutic approaches, and monitoring (Pubmed Central) - Dec 16, 2022
For dose adjustments of allopurinol, the "step plan" should be taken in consideration...Next to vectorial transmission mating, transplacental infections, bite wounds, and blood transfusions were described in canine leishmaniosis. Additionally, L. infantum is a zoonotic vector-borne infectious pathogen, which is important regarding the "One-health"-aspect.
- |||||||||| verinurad (RDEA3170) / AstraZeneca
Journal: Verinurad does not prolong QTc interval: A thorough QT study using concentration-QTc modelling. (Pubmed Central) - Dec 13, 2022
P1
Additionally, L. infantum is a zoonotic vector-borne infectious pathogen, which is important regarding the "One-health"-aspect. As the effect on ΔΔQTcF was below the threshold for regulatory concern (10 msec) at the supratherapeutic exposure, it can be concluded that verinurad and allopurinol treatment does not induce QTcF prolongation at the highest clinically relevant exposures.
- |||||||||| febuxostat / Generic mfg., allopurinol / Generic mfg.
Review, Journal: Research Progress of Natural Active Substances with Uric-Acid-Reducing Activity. (Pubmed Central) - Dec 10, 2022
In addition, the mechanisms by which these bioactive compounds exhibit hypouricemic effects can be divided into four classes: inhibition of key enzyme activities, promotion of uric acid excretion and inhibition of reabsorption in the kidney, promotion of decomposing uric acid precursors, and promotion of decomposing uric acid. Overall, this current and comprehensive review examines the role of natural active substances in the treatment of hyperuricemia.
- |||||||||| allopurinol / Generic mfg.
Preclinical, Journal: Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats. (Pubmed Central) - Dec 9, 2022
AO's impact on allopurinol metabolism is meaningful enough that individual differences in AO may explain allopurinol toxicity events. Considering the inter-individual differences in AO activity, these findings can aid to dose adjustment of allopurinol to avoid potential adverse effects.
- |||||||||| Elitek (rasburicase) / Sanofi
A Rare Case of Spontaneous Tumor Lysis Syndrome As a Consequence of Forgone Treatment in Multiple Myeloma () - Nov 29, 2022 - Abstract #ASH2022ASH_7706;
Chemotherapy was initiated while inpatient and he received two rounds of bortezomib/cyclophosphamide therapy prior to discharge...The actual incidence of developing spontaneous TLS, in general, is difficult to predict and in multiple myeloma other than a few case reports, it has not been widely documented. The goal of sharing this case is to contribute to the information already known about this condition and hopefully encourage others to share similar cases to improve recognition for earlier treatment and lower morbidity and mortality associated with spontaneous TLS in the future.
- |||||||||| Acute Myeloid Leukemia in Western Kenya: Exploring Outcome Disparities through Cases () - Nov 29, 2022 - Abstract #ASH2022ASH_7206;
Prior to referral he received hydroxyurea, allopurinol, and 6 units of blood...The next major barrier was induction of chemotherapy, including the practice of low-dose chemotherapy (low-dose cytarabine or etoposide alone) without intent to cure, due to concerns of managing the complications of induction chemotherapy...Barriers identified from examining cases included access to bone marrow aspiration and flow cytometry, availability of blood products, choice of chemotherapy approach (low-dose versus standard induction), supportive care environment, and availability of treatment options including bone marrow transplant. More research is needed to identify the causes of death for patients in this local population, and create a system that can reduce the international disparities and move towards equitable goals of remission and cure.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Repurposing of Empagliflozin as Treatment for Neutropenia in Glycogen Storage Disease Type Ib: A Case Report (Poster Gallery) - Nov 29, 2022 - Abstract #IDF2022IDF_976;
The CDAI decreased to 52 and stool calprotectin levels decreased from 141 to 35 μg/g (>50 representing a marker of intestinal inflammation). Her serum 1,5AG level decreased from 140.07 to 33.87 μM after 10 months of treatmentConclusionEmpagliflozin is a new alternative for neutropenia and can also ameliorate IBD symptoms in GSD-1b patients
- |||||||||| verinurad (RDEA3170) / AstraZeneca
Journal: Considerations for Choosing First-Line Urate-Lowering Treatment in Older Patients with Comorbid Conditions. (Pubmed Central) - Nov 28, 2022
The combination therapy of a novel uricosuric, verinurad, plus febuxostat reduced albuminuria in hyperuricemic patients with type 2 diabetes and CKD in a phase 2a trial, and further RCTs are awaited. Finally, the sodium-glucose cotransporter-2 inhibitor class of oral hypoglycemic agents, known to exert beneficial CV and renal effects independent of glycemic control, have shown a uricosuric effect and could be used as adjunctive therapy in older patients with cardiorenal comorbidities.
- |||||||||| allopurinol / Generic mfg.
Journal: Insights into the Inhibitory Mechanism of Viniferifuran on Xanthine Oxidase by Multiple Spectroscopic Techniques and Molecular Docking. (Pubmed Central) - Nov 27, 2022
An enzyme kinetics analysis showed that viniferifuran possessed a strong inhibition on XO in a typical anti-competitive manner with an IC value of 12.32 μM (IC for the first-line clinical drug allopurinol: 29.72 μM)...A molecular docking analysis revealed that viniferifuran bound to the amino acid residues located within the activity cavity of XO by a strong hydrophobic interaction (for Ser1214, Val1011, Phe914, Phe1009, Leu1014, and Phe649) and hydrogen bonding (for Asn768, Ser876, and Tyr735). These findings suggested that viniferifuran might be a promising XO inhibitor with a favorable mechanism of action.
- |||||||||| allopurinol / Generic mfg.
Journal: Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia. (Pubmed Central) - Nov 25, 2022
Hyperuricemia response affects the expression of PDZK1; PDZK1 affects the proliferation, migration, and apoptosis through the STAT3/C-myc pathway in hepatocellular carcinoma. It is suggested that PDZK1 maybe closely related to the occurrence, development, and prognosis of HCC and allopurinol maybe have potential anticancer effects.
- |||||||||| allopurinol / Generic mfg.
Biomarker, Journal: Identification of Leishmania infantum Epidemiology, Drug Resistance and Pathogenicity Biomarkers with Nanopore Sequencing. (Pubmed Central) - Nov 25, 2022
Twenty-two genes were studied to generate a genetic pharmacoresistance profile against miltefosine, allopurinol, trivalent antimonials, amphotericin, and paromomycin...All four samples displayed a genetic profile for resistance against trivalent antimonials. Overall, this proof-of-concept revealed the potential of nanopore sequencing and LeishGenApp for the determination of epidemiological, drug resistance, and pathogenicity biomarkers in L. infantum.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen
Journal: Is the treatment of inflammatory arthritis different in sickle cell disease? (Pubmed Central) - Nov 25, 2022
The use of drugs such as steroids, methotrexate, or anti-TNF in sickle cell patients with rheumatic disease is the same as in patients without sickle cell disease. However, treatment should be individualized in patients with complications such as infection.
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