allopurinol / Generic mfg. 
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 0 Diseases   61 Trials   61 Trials   3860 News 


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  • ||||||||||  Urece (dotinurad) / Fuji Yakuhin, Mochida, Fortress, Eisai
    Trial completion, Phase classification, Trial completion date, Trial primary completion date:  Open Label PK, PD and DDI of Dotinurad and Allopurinol in Gout Patients with Hyperuricemia (clinicaltrials.gov) -  Jan 28, 2025   
    P1/2,  N=20, Completed, 
    Recruiting --> Completed | Phase classification: P1b --> P1/2 | Trial completion date: Nov 2023 --> Jul 2024 | Trial primary completion date: Nov 2023 --> Jun 2024
  • ||||||||||  allopurinol / Generic mfg.
    Review, Journal:  Lesch-Nyhan Syndrome and Oral Self-injury: A Systematic Review of Case Reports. (Pubmed Central) -  Jan 27, 2025   
    Multiple teeth extractions, mouth splints and guards, allopurinol, and botulinum toxin-A were reported as common treatment modalities...Lesch-Nyhan Syndrome and Oral Self-injury: A Systematic Review of Case Reports. Int J Clin Pediatr Dent 2024;17(12):1431-1438.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Dementia Care Research and Psychosocial Factors. (Pubmed Central) -  Jan 12, 2025   
    Considering this data belonging to a recent transmission area, treatment strategy suggests effective in controlling canine visceral leishmaniasis. The results suggest that the neuroprotective effects of allopurinol in STZ-induced Alzheimer's-type dementia might be attributed to anticholinesterase, antioxidative, and anti-inflammatory effects.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Therapeutic Effects of Tea Polyphenols on Renal Damage Induced by High Uric Acid. (Pubmed Central) -  Jan 12, 2025   
    Tea polyphenols could effectively alleviate renal damage in rats with nephrectomy combined with hyperuricemia. They demonstrate high cost-effectiveness and minimal side effects, positioning them as a promising new therapeutic option for hyperuricemia- induced renal damage.
  • ||||||||||  Elitek (rasburicase) / Sanofi, allopurinol / Generic mfg.
    Review, Journal:  Acute kidney injury following CAR-T cell therapy: a nephrologist's perspective. (Pubmed Central) -  Jan 12, 2025   
    Future prospective studies with larger patient populations are needed to gain insights into the pathophysiology of CAR-T-related AKI and, more importantly, to be able to prevent as well as to develop novel and more efficient treatment modalities. In this narrative review, we discuss the underlying pathophysiology, risk factors, potential interventions and future directions related to AKI following CAR-T cell therapy.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  DRESSed for distress: a case of allopurinol-induced DRESS syndrome. (Pubmed Central) -  Jan 12, 2025   
    The condition progressed to renal impairment but showed significant improvement upon cessation of the drug and administration of high-dose corticosteroids. This case aims to shed light on one of the most underrecognized types of systemic drug reactions, hoping to raise awareness about this rare yet serious complication of one of the most widely prescribed drugs.
  • ||||||||||  5-fluorouracil / Generic mfg., methotrexate / Generic mfg., allopurinol / Generic mfg.
    Journal:  Studies of the FBT family transporters in Leishmania infantum by gene deletion and protein localization. (Pubmed Central) -  Jan 6, 2025   
    The protein was also located at the plasma membrane and its gene was dispensable for growth and not associated to any of the drug tested. Our work has indicated that large diploid deletion is achievable in Leishmania and the cell lines produced here will serve to better understand the function and putative substrates of these FBT proteins yet to be characterized.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Journal:  Synthesis and (Pubmed Central) -  Jan 3, 2025   
    The most potent compounds exhibited a mix-type inhibition mechanism and were predicted to interact with the same amino acid residues as allopurinol. These novel purine analogues are promising hits for further new lead development among purine-like drug XO inhibitors with therapeutic potential in the treatment of hyperuricemia and associated diseases.
  • ||||||||||  Review, Journal:  An update on the pharmacotherapy of gout. (Pubmed Central) -  Jan 3, 2025   
    There are also emerging therapies in development. However, there is increasing personalization of treatment, adjusting pharmacotherapy depending on comorbidities, such as chronic kidney disease and ischemic heart disease, as well as patient preference.
  • ||||||||||  febuxostat / Generic mfg., allopurinol / Generic mfg.
    Retrospective data, Review, Journal:  Cardiovascular Outcomes of Uric Acid Lowering Medications: A Meta-Analysis. (Pubmed Central) -  Dec 24, 2024   
    XOI was not associated with reduced cardiovascular events compared to placebo. When comparing XOI agents, Febuxostat might reduce the risk of HF, but future studies are required to confirm the findings from the current study.
  • ||||||||||  allopurinol / Generic mfg.
    Journal, Immunomodulating:  New immunomodulatory treatment protocol for canine leishmaniosis reduces parasitemia and proteinuria. (Pubmed Central) -  Dec 19, 2024   
    The current standard treatment for canine leishmaniosis (CanL), N-methylglucamine antimoniate (MGA) given with allopurinol, is not fully effective and may cause adverse effects and drug resistance...The daily intake of the supplement over two years proved safe and well tolerated. Our study confirms the efficacy of the recommended standard treatment for CanL, but also reveals that by adding Impromune additional benefits are obtained, especially reduced parasitemia and improved renal function.
  • ||||||||||  allopurinol / Generic mfg.
    Retrospective data, Review, Journal:  Effect of urate-lowering therapy on all-cause and CVD-specific mortality in gout and hyperuricemia: a (Pubmed Central) -  Dec 18, 2024   
    This meta-analysis indicates that ULT substantially reduces all-cause mortality in patients with gout or hyperuricemia, although allopurinol does not significantly affect CVD-specific mortality. These results underscore the potential of ULT for enhancing survival rates in special patient populations.
  • ||||||||||  allopurinol / Generic mfg.
    Clinical data, Journal:  Relative Forgiveness of Different Allopurinol Implementation Patterns in People with Gout and their Impact on Clinical Outcomes: a Simulation Study. (Pubmed Central) -  Dec 18, 2024   
    Our study provides evidence that missing one or two doses of allopurinol, even repeatedly over a year, does not significantly impact serum urate target achievement or clinical outcomes. However, people who take repeated drug holidays of more than 3 days in a row (followed by less than 15 consecutive days of dosing) are less than 0.3 times as likely (at least 70% less likely) to achieve adequate urate control than those with perfect implementation and may see an increase in the frequency of gout flares.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  Protective effect of xylosma congesta extract on renal injury in hyperuricemic rats. (Pubmed Central) -  Dec 11, 2024   
    And then the rats were treated with allopurinol and different doses of oak extract...Additionally, the xylosma congesta groups showed a significant rise in CD206 and a considerable decrease in CD68. The extract from xylosma congesta has the ability to lower serum uric acid and creatinine levels while also providing protection against kidney damage caused by hyperuricemia.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie
    Outpatient Administration of First Cycle Azacitidine-Venetoclax in Acute Myeloid Leukemia Patients Compared to Inpatient Care: Preliminary Results of a Single-Center Retro-Prospective Study () -  Dec 7, 2024 - Abstract #ASH2024ASH_8117;    
    No differences were seen in leukocytes, neutrophils and platelet count between infected and not infected patients.Regarding secondary endpoints, between the two cohorts there was no significant difference in OS at 12 months (inpts : 51.6%, CI 21.6-74.5; outpts : 40.5%, CI 15.2-64.8; p=0.75) or PFS (median PFS : inpts not reached; outpts 21.14 months; p=0.59).Conclusions : Our preliminary results, based on a retro-prospective analysis, suggest that outpatient administration of C1 AZA-Ven could be a viable alternative to inpatient care, potentially improving patient quality of life and reducing healthcare costs. Further studies with larger sample sizes are warranted to confirm these findings and to identify patients suitable for therapy initiation in an outpatient setting and to determine what baseline characteristics, if any, can aid in risk stratification for TLS or early hospitalization.
  • ||||||||||  allopurinol / Generic mfg.
    Journal:  Genome-Wide Profiling of H3K27ac Identifies TDO2 as a Pivotal Therapeutic Target in Metabolic Associated Steatohepatitis Liver Disease. (Pubmed Central) -  Dec 4, 2024   
    A bovine serum albumin nanoparticle is fabricated to provide sustained release of Allopurinol (NPs-Allo) for TDO2 inhibition, possessing excellent biocompatibility and desired targeting capacity...This study reveals the pivotal role of TDO2 and its underlying mechanisms in pathogenesis of MASLD epigenetically and genetically. Targeting H3K27ac-TDO2-NF-?B axis may provide new insights into the pathogenesis of abnormal lipid accumulation and pave the way for developing novel strategies for MASLD prevention and treatment.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia. (Pubmed Central) -  Nov 27, 2024   
    In terms of safety, engineered macrophages did not cause liver or kidney dysfunction in mice, nor did they induce systemic immune response. Using macrophages as a chassis to deliver uricase might be a new, safe and effective strategy for the treatment and control of hyperuricemia.
  • ||||||||||  allopurinol / Generic mfg.
    Biomarker, Journal:  Short Term Treatment Monitoring of Renal and Inflammatory Biomarkers with Naturally Occurring Leishmaniosis: A Cohort Study of 30 Dogs. (Pubmed Central) -  Nov 26, 2024   
    In addition to Leishmania real-time PCR in the bone marrow, blood and urine, previously studied biomarkers, and several inflammatory and renal markers never investigated in canine leishmaniosis, such as fibrinogen, antithrombin, urinary fractional excretion of sodium, and urinary amylase-to-creatinine ratio were measured pre- and post-treatment (meglumine antimoniate or miltefosine + allopurinol)...Urinary amylase-to-creatinine ratio, total iron-binding capacity, and antithrombin were the variables most strongly associated with disease severity (p < 0.005, respectively). Urinary amylase-to-creatinine ratio can be a useful marker to monitor treatment response and to classify the degree of disease severity.
  • ||||||||||  allopurinol / Generic mfg.
    Preclinical, Journal:  Oral gavage of Lactococcus lactis expressing urate oxidase regulates serum uric acid level in mice (Pubmed Central) -  Nov 25, 2024   
    Furthermore, compared with allopurinol, the first-line agent for HUA treatment, mice fed with NZ9000-aUox exhibited comparable liver safety but better kidney safety than allopurinol, indicating that the use of engineered NZ9000 strains not only alleviated kidney injury caused by HUA, but could also avoided the risk of kidney injury elicited by using allopurinol. Collectively, our study offers an effective and safe therapeutic approach for HUA long-term treatment and controlling.
  • ||||||||||  nifedipine immediate release / Generic mfg., allopurinol / Generic mfg.
    Journal:  Successful Surgical Management of Grade 4 Gynecomastia in a Renal Transplant Recipient. (Pubmed Central) -  Nov 22, 2024   
    The patient underwent bilateral breast tissue excision with free nipple grafting under general anesthesia. Postoperative management included overnight admission, and follow-up showed successful graft take and satisfactory wound healing.