Dyloject (diclofenac) / Pfizer 
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 11 Diseases   1 Trial   1 Trial   285 News 


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  • ||||||||||  Dyloject (diclofenac) / Pfizer
    Journal:  Antinociceptive Potential of Zinnia grandiflora. (Pubmed Central) -  Sep 2, 2020   
    The structure of compound 2 was established unequivocally by an X-ray crystallographic analysis. This compound exerted a significant antinociceptive effect in the formalin assay, better than that of diclofenac used as a positive control.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    Preclinical, Journal:  Delivery and biodistribution of traceable polymeric micellar diclofenac in the rat. (Pubmed Central) -  Aug 19, 2020   
    This compound exerted a significant antinociceptive effect in the formalin assay, better than that of diclofenac used as a positive control. Developed nano-formulations of diclofenac prolonged diclofenac circulation and reduced its presence in heart and kidney; strongly suggesting a cardiac-safe delivery vehicle for diclofenac.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    Journal:  Pain relief of arthroscopic rotator cuff repair by nerve block. (Pubmed Central) -  Aug 18, 2020   
    Interscalene nerve blocks yielded good pain relief for ARCR. Although continuous interscalene nerve block produced continuous pain relief, complications are a concern.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    [VIRTUAL] Participation COX and NOS in effect of IL-1ß on lung ventilation and hypoxic chemoreception (Pre-congress content) -  Jul 15, 2020 - Abstract #ERS2020ERS_1961;    
    Pretreatment with both inhibitors diclofenac and L-NAME significantly reduced respiratory effects of IL-1β.We suggested that the effect of pro-inflammatory cytokines on the respiratory system is due to the interaction of СОХ and NOS mechanisms. The study was supported by Program for Basic Research of the RAS Presidium№19
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    Journal:  Kounis syndrome, the allergic acute coronary syndrome (Pubmed Central) -  May 23, 2020   
    In patients with Kounis syndrome therapy should focus on both the allergy and the acute coronary syndrome. Early recognition and intervention have a great effect on prognosis.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Dyloject (diclofenac) / Pfizer
    [VIRTUAL] DICLOFENAC IN THE MANAGEMENT OF CYTOKINE RELEASE SYNDROME AFTER CAR-T INFUSION IN B-ALL PEDIATRIC PATIENTS () -  May 16, 2020 - Abstract #EHA2020EHA_1194;    
    Aims The aim of this study is to describe the possible role of diclofenac in the management of CRS after tisagenlecleucel infusion in pediatric B-ALL patients in terms of fever control and improvement of vital parameters and hemodynamic functions...Despite CRS might evolve regardless of diclofenac, the control of fever and the absence of its detrimental effect on vital parameters, make patients more stable and decrease their discomfort.. Stable clinical conditions might lead to a reduced need or a delayed timing of tocilizumab administration, which ultimately might turn up into patients being spared tocilizumab and, mainly, subsequent steroid, possibly impairing CAR-T cell efficacy.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    PRECUT WITH THE STANDARD PULL-TYPE SPHINCTEROTOME FOR DIFFICULT BILIARY CANNULATION IN ERCP () -  May 4, 2020 - Abstract #DDW2020DDW_6974;    
    Stable clinical conditions might lead to a reduced need or a delayed timing of tocilizumab administration, which ultimately might turn up into patients being spared tocilizumab and, mainly, subsequent steroid, possibly impairing CAR-T cell efficacy. Precutting the Papilla of Vater for biliary access using a standard pull-type sphincterotome appears to be an effective and safe procedure when the GW neither entered the CBD nor the MPD and the sphincterotome tip was inside the papillary orifice.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    Journal:  Diclofenac Versus Ketorolac for Pain Control After Primary Total Joint Arthroplasty: A Comparative Analysis. (Pubmed Central) -  Apr 23, 2020   
    Conclusion This study demonstrated that both TKA and THA patients treated with IV diclofenac had no difference in postoperative pain intensity while THA patients had no difference in opioid consumption relative to those treated with IV ketorolac. Further comparison of IV NSAIDs with other IV pain medications may provide broader insight into the ideal management for postoperative pain for this widening patient population.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    Fatal Intercerebral Hemorrhage Secondary To Alemtuzumab (Exhibit Hall A, Convention Center - Board no. P084) -  Feb 21, 2020 - Abstract #ACTRIMSForum2020ACTRIMS_FORUM_228;    
    2019;18(4):329-331), 4 in basal ganglia, 1 in frontal lobe. All patients recovered; post-infusion transient elevations in blood pressure were postulated.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    PK/PD data, Journal:  Pharmacokinetics of diclofenac sodium injection in swine. (Pubmed Central) -  Dec 19, 2019   
    After the single i.m. administration, the pharmacokinetic parameters were as follows: peak time (Tmax) was 1.19±0.26 h; and peak concentration (Cmax) was 11.61±5.99 μg mL-1. The diclofenac sodium has the following pharmacokinetic characteristics in swine: rapid absorption and elimination; high peak concentration; and bioavailability.
  • ||||||||||  pregabalin / generics
    Clinical, Journal:  Pre-emptive multimodal analgesic regimen reduces post-operative epidural demand boluses in traumatic shaft of femur fracture - A randomised controlled trial. (Pubmed Central) -  Nov 29, 2019   
    Patients received either (Preemptive multimodal group) intravenous acetaminophen 1 gm, diclofenac 75 mg, morphine 3 mg, 75 mg Pregabalin (per oral) or a placebo 30 minutes pre-operatively...Post-operatively, patients received patient-controlled epidural analgesia (PCEA) programmed to deliver a bolus of 5 ml of 0.2% Ropivacaine with 2 μg/ml of Fentanyl with lockout interval time of 15 min...Time to first rescue epidural bolus was significantly greater in preemptive multimodal group than placebo group. The use of preemptive MMA regimen reduced the requirement of demand epidural bolus doses.
  • ||||||||||  ciprofloxacin / Generic Mfg., Dyloject (diclofenac) / Pfizer
    Clinical, Journal:  Drug-induced acute interstitial nephritis: Prospective randomized trial comparing oral steroids and high-dose intravenous pulse steroid therapy in guiding the treatment of this condition. (Pubmed Central) -  Oct 24, 2019   
    Patients were randomized to oral prednisolone (Group A) 1 mg/kg for two weeks or pulse methylprednisolone (Group B) 30 mg/kg for three days (maximum 1 g) followed by oral prednisolone 1 mg/kg for two weeks, tapered over two weeks...Drugs implicated in the causation of AIN included pantoprazole, diclofenac, rifampicin, naproxen, aspirin, imipenem, piroxicam, cefixime, lornoxicam, Chinese herbs, etoricoxib, ciprofloxacin, and phenytoin...Pulses of high doses of corticosteroids have a significant but transient anti-inflammatory effect. Both oral and IV suprapharmacological doses of corticosteroids are equally effective in the treatment of drug-induced AIN, if used early.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    An Ethical and Management Dilemma. Acute Gastrointestinal Bleeding in Jehovah’s Witness. () -  Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1272;    
    There is a need for a dedicated Multidisciplinary team knowledge of techniques of blood conservation which is crucial for successful outcomes. Educational and clinical relevance of this case is blood conservation and resuscitation without red cells and medico legal aspects to be aware of as an ED today.
  • ||||||||||  ceftriaxone / Generic Mfg.
    Al Wakra Type II MI, a case study in Our Emergency Department. () -  Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1268;    
    2- Overcrowded ED needs more facilities, man power, and quality improvement to avoid any complication from the waiting time or missed case. 3- The Triage is a dynamic process and all ED areas need regular re triage.
  • ||||||||||  pregabalin / generics
    Different approaches in pain management of acute low back pain in Emergency Department. () -  Sep 10, 2019 - Abstract #EUSEM2019EUSEM_985;    
    2nd line treatment, designed for patients that didnt benefit from the 1st line, consists from a Lidocaine 1%(3mg/kg) + Ketamine(0.25mg/kg) mixed infusion over two hours...Conclusion There is not yet a defined therapeutic care process for the patient with LBP with clear criteria for an ED visit. Most of the time, different approaches in multimodal pain management may be useful, in complicated chronic sciatic pain the role of pain interventionist is clear.
  • ||||||||||  Dyloject (diclofenac) / Pfizer
    QUALITY IN ERCP - APPLICATION OF QUALITY INDICATORS TO EVALUATE TECHNICAL OUTCOMES AND ADVERSE EVENTS (Poster Exhibition - Hall 7) -  Aug 18, 2019 - Abstract #UEGW2019UEGW_3236;    
    The only independent predictor of PEP were ≥2 cannulations of the pancreatic duct. The awareness and use of a prospective database allowed a detailed analysis of the performance indicators in ERCP as recommended by ASGE and ESGE and may have contributed to the good technical outcomes and low incidence of adverse outcomes.