- |||||||||| Z160 / Sun Pharma
PK/PD data, Preclinical, Journal: Comparative pharmacokinetics of four major compounds after oral administration of Mori Cortex total flavonoid extract in normal and diabetic rats. (Pubmed Central) - Mar 21, 2023
The transitions of m/z 300.9?107.1, m/z 419.3?297.1, m/z 160.9?77.0, m/z 567.1?243.2 and m/z 283.1?268.2 were selected for morin, morusin, umbelliferone, mulberroside A and internal standard, respectively...For umbelliferone and mulberroside A, the AUC and C also increased significantly in diabetic rats (p < 0.05). The validated method was successfully applied to the pharmacokinetic study in normal and diabetic rats.
- |||||||||| Z160 / Sun Pharma
Journal: Development of Flow Injection Analysis Method for the Second-Tier Estimation of Succinylacetone in Dried Blood Spot of Newborn Screening. (Pubmed Central) - Feb 8, 2022
Detection and quantification was performed by the mass spectrometer using multiple reaction monitoring mode at m/z 155.1 → 109.1 for SUAC and m/z 160.1 → 114.1 for the SUAC IS...The accuracy also ranged between 101.2 and 103.87%.This method provided the necessary sensitivity, precision, accuracy, recovery and linearity and hence, has the potential to reduce the false positive, false negative results which significantly minimise the cost involved in the screening and follow up of TYR1 patients. The online version of this article (10.1007/s12291-020-00944-z) contains supplementary material, which is available to authorized users.
- |||||||||| Z160 / Sun Pharma
Journal: The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum. (Pubmed Central) - Mar 13, 2020
solanacearum F1C1 cells fed with [C]glucose (99% [1-C]glucose or 99% [1,2-C]glucose or 40% [C]glucose) followed by gas chromatography-mass spectrometry (GC-MS)-based labeling analysis of fragments from amino acids, glycerol, and ribose provided clear evidence that rather than glycolysis and the OxPPP, the ED pathway and non-OxPPP are the main routes sustaining metabolism in R. solanacearum The C incorporation in the mass ions of alanine (m/z 260 and m/z 232), valine (m/z 288 and m/z 260), glycine (m/z 218), serine (m/z 390 and m/z 362), histidine (m/z 440 and m/z 412), tyrosine (m/z 466 and m/z 438), phenylalanine (m/z 336 and m/z 308), glycerol (m/z 377), and ribose (m/z 160) mapped the pathways supporting the observations...The outcomes help better define the central carbon metabolic network of R. solanacearum that can be integrated with C metabolic flux analysis as well as flux balance analysis studies for defining the metabolic phenotypes. The study highlights the need to critically examine phytopathogens whose metabolism is poorly understood.
- |||||||||| Z160 / Sun Pharma
Journal: Real-Time Quantitative Analysis of Valproic Acid in Exhaled Breath by Low Temperature Plasma Ionization Mass Spectrometry. (Pubmed Central) - May 18, 2019
...In particular, the effect of working conditions and geometry of the LTP source on the ions of interest, protonated molecular ion at m/z 143 and ammonium adduct ion at m/z 160, were systematically characterized...Our results show that LTP-MS is a powerful analytical platform with high sensitivity for quantitative analysis of volatile organic compounds in human breath, and can have potential applications in pharmacokinetics or for patient monitoring and treatment. Graphical Abstract ᅟ.
|
