- |||||||||| soluble interleukin-17 receptor C therapeutics / EMD Serono, actoxumab/bezlotoxumab (MK-3415A) / Merck (MSD)
Monoclonal anti-toxin therapy supports the protective innate immune response following Clostridioides difficile infection (P423) (Exhibit Hall; Poster Board No. P423) - Apr 11, 2023 - Abstract #IMMUNOLOGY2023IMMUNOLOGY_862;
Monoclonal antibodies (mAbs) that neutralize Toxin A and Toxin B, actoxumab and bezlotoxumab, respectively, significantly reduce disease severity in a murine model of C. difficile infection, however the impact of toxin neutralization on the induction of the innate immune response following infection is unknown...Further, no difference in neutrophil infiltration or production of IFNg or IL-17 from innate lymphoid cells (ILCs) was observed within the intestinal lamina propria following infection...Both IL-22+ ILCs and eosinophils promote protective host response following C. difficile infection. These findings indicate that activation of natural host protective mechanisms remain intact in the context of treatment that neutralizes toxin but does not alter C. difficile burden in the intestine.
- |||||||||| soluble interleukin-17 receptor C therapeutics / EMD Serono
IL-23 maintains tissue resident memory Th17 cells in murine and psoriatic skin () - Nov 11, 2021 - Abstract #ISDS2021ISDS_43;
Analysis of psoriasis skin from patients’ pre- and post-anti-IL-23 therapy revealed reduced numbers of IL-17-producing resident memory Th17 cells (TRM17) in skin post treatment...Thus, locally produced IL-23 promotes in situ proliferation of TRM17 and is required for their long-term retention in skin. Together with analysis of psoriasis patients, these results suggest that locally administered therapies targeting IL-23 may induce durable remission in psoriasis and other tissue-specific autoimmune diseases by depleting TRM17.
- |||||||||| soluble interleukin-17 receptor C therapeutics / EMD Serono
[VIRTUAL] Inhibition of protein disulfide isomerase has neuroprotective effects in a mouse model of experimental autoimmune encephalomyelitis () - Aug 16, 2020 - Abstract #MSDC2020MSDC_972;
The obtained lysates were used to measure IL-1β, IL-6, IL-17, IL-23, IFN-γ, and Bcl2 by commercially available ELISA kits...The significant differences between the two groups were calculated by the Student′s t-test or Mann-Whitney U test where appropriateResults Our observations suggested that CCF642 administration attenuates EAE clinical symptoms and the expression of ER stress-related proteins. Further, it suppressed the inflammatory infiltration of CD4 + T cells and the activation of hippocampus-resident microglia and Th17 cells.Conclusions We reported here that the inhibition of PDI protected EAE mice against neuronal apoptosis induced by prolonged ER stress and resulted in neuroprotection.
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