risperidone / Generic mfg. 
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  • ||||||||||  risperidone / Generic Mfg., Egis
    Biomarker, Journal:  Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis. (Pubmed Central) -  Aug 28, 2019   
    ...This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve first episode psychosis (AN-FEP) before and after risperidone treatment...The findings indicate that (a) FEP patients are prone to the detrimental effects of M1, Th-1, Th-17 and Th-2 cells, which may contribute to long-lasting abnormalities in brain circuitry; and (b) in FEP, the CIRS may contribute to recovery from the acute phase of illness. Enhancing the CIRS might be a new drug target to treat FEP.
  • ||||||||||  risperidone controlled-release implant (BB-0817) / Braeburn, risperidone / Generic Mfg., Egis
    Preclinical, Journal:  Neurobehavioral effects of chronic low-dose risperidone administration in juvenile male rats. (Pubmed Central) -  Aug 28, 2019   
    Continued research is needed to determine whether early exposure to risperidone may lead to differences in working memory at longer time-points. These results seem to indicate that early low dose risperidone treatment during the peri-adolescent and adolescent period does not severely impair behavior.
  • ||||||||||  risperidone / Generic Mfg., Egis
    Journal:  Hormonal imbalance and pituitary adenoma during antipsychotic treatment in an adolescent with bipolar affective disorder. (Pubmed Central) -  Aug 28, 2019   
    In this paper we present the case of a female teenager patient who was diagnosed with bipolar affective disorder and during psychotropic treatment with risperidone, the prolactin levels ranged between 55 ng/mL and 85 ng/mL at monthly repeated dosing...The patient benefited from brain imaging, which revealed that in sella turcica is distinguished a well-defined and relatively homogeneous formation, measuring approximately 11/8 mm, suggestive of a pituitary adenoma. After changing the antipsychotic treatment, the pituitary formation resolved to a subsequent imaging re-evaluation.
  • ||||||||||  Clinical, Review, Journal:  Efficacy and Tolerability of Atypical Antipsychotics in the Treatment of Delirium: A Systematic Review of the Literature. (Pubmed Central) -  Aug 17, 2019   
    Although the current evidence of the efficacy and tolerability of AAPs in the treatment of delirium is limited and the heterogeneity of the data precluded a meta-analysis, olanzapine and quetiapine seem to be adequate alternatives to haloperidol, especially in patients who are vulnerable for extrapyramidal symptoms, who require sedation or who have a history of haloperidol intolerance. Evidently, larger-scale RCTs are urgently required.
  • ||||||||||  aripiprazole / generics, risperidone / generics
    Journal:  Expert consensus on pharmacotherapy for tic disorders in Japan. (Pubmed Central) -  Aug 17, 2019   
    Evidently, larger-scale RCTs are urgently required. This study will help Japanese physicians choose medications for tic disorders more judiciously and will improve the quality of tic pharmacotherapy in Japan.
  • ||||||||||  risperidone / generics
    Preclinical, Journal:  Delivery of risperidone from gels across porcine skin in vitro and in vivo in rabbits. (Pubmed Central) -  Aug 15, 2019   
    A combination of 6% menthol and 6% PG exhibited highest RIS in vitro penetration rate and showed a high efficiency in vivo, with a relative bioavailability of 131.53% compared with intragastric administration. These findings showed that 1% RIS in 0.5% CBR, containing a combination of 6% menthol and 6% PG, can deliver doses of RIS that are therapeutically relevant for treating patients with schizophrenia.
  • ||||||||||  risperidone / generics
    Biomarker, Preclinical, Journal:  Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia. (Pubmed Central) -  Aug 15, 2019   
    Animals were treated once daily intraperitoneally with morin (100 mg/kg), haloperidol (1 mg/kg), risperidone (0.5 mg/kg), or saline (10 mL/kg) in combination with LPS (0.1 mg/kg) for 14 consecutive days...Moreover, morin reduced regional brain expressions of cyclooxygenase-2, inducible nitric oxide synthase and nuclear factor kappa-B, and also rescued loss of pyramidal neurons in the PFC. Taken together, these findings suggest that morin reduces schizophrenic-like symptoms induced by LPS + KET via mechanisms related to inhibition of the release of pro-inflammatory mediators and suppression of degeneration of cortical pyramidal neurons in mice.
  • ||||||||||  aripiprazole / generics, risperidone / generics
    Clinical, Review, Journal:  Systematic Review of Gender Bias in the Clinical Trials of New Long-Acting Antipsychotic Drugs. (Pubmed Central) -  Aug 10, 2019   
    Women are underrepresented, and the main and secondary variables are not analyzed separately according to gender. This is despite international recommendations establishing these criteria as part of a package of minimum requirements for meeting scientific validity and making results apt to extrapolate to the general population of patients.
  • ||||||||||  risperidone / generics, quetiapine / generics, clozapine / generics
    Journal:  New use for old drugs: the protective effect of atypical antipsychotics on hepatocellular carcinoma. (Pubmed Central) -  Aug 8, 2019   
    In-vitro study results indicated that risperidone, quetiapine and clozapine significantly inhibited cell proliferation, invasion and induced apoptosis in human HCC cell lines. Our results herein suggested that antipsychotic use might reduce the risk of HCC and may provide evidence for new uses of old drugs.
  • ||||||||||  risperidone / generics, clozapine / generics
    Journal:  Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization. (Pubmed Central) -  Aug 7, 2019   
    Other D₂R antagonists, such as clozapine, risperidone, and droperidol did not significantly evoke this dissociation event. Furthermore, molecular modeling reveals that spiperone presents specific Tyr199 and Phe390 conformations, compared to clozapine, which may determine D₂R homodimerization.
  • ||||||||||  aripiprazole / generics, risperidone / generics
    Journal:  CYP2D6 testing to guide risperidone and aripiprazole therapy. (Pubmed Central) -  Aug 7, 2019   
    Furthermore, molecular modeling reveals that spiperone presents specific Tyr199 and Phe390 conformations, compared to clozapine, which may determine D₂R homodimerization. No abstract available
  • ||||||||||  risperidone / generics
    Journal:  Galactorrhea Induced by Risperidone. (Pubmed Central) -  Aug 2, 2019   
    However, there was a 24 h delay between the intracranial injection and tissue harvesting, meaning that brief early drug effects could have been missed. No abstract available
  • ||||||||||  risperidone / generics
    Journal:  Reduction in Use of Risperidone for Dementia in Australia Following Changed Guidelines. (Pubmed Central) -  Jul 25, 2019   
    The TGA labelling changes were associated with a significant reduction in the rate of use of risperidone for BPSD in veterans living in both the aged care and community settings, and in the general older Australian population. The labelling changes were also associated with a reduced duration of risperidone use in aged care residents, although for most people the duration of use still exceeded the recommended 12-week maximum duration.
  • ||||||||||  risperidone / generics
    Journal:  Risperidone for rapid tranquilisation: more evidence required. (Pubmed Central) -  Jul 22, 2019   
    The labelling changes were also associated with a reduced duration of risperidone use in aged care residents, although for most people the duration of use still exceeded the recommended 12-week maximum duration. No abstract available
  • ||||||||||  risperidone / generics, quetiapine / generics
    Clinical, Review, Journal:  Treatment of psychoses in patients with epilepsy: an update. (Pubmed Central) -  Jul 19, 2019   
    Second-generation antipsychotics, especially risperidone, can represent a reasonable first-line option because of the low propensity for drug-drug interactions and the low risk of seizures. Quetiapine is burdened by a clinically significant pharmacokinetic interaction with enzyme-inducing drugs leading to undetectable levels of the antipsychotic, even for dosages up to 700 mg per day.
  • ||||||||||  risperidone / generics
    Journal:  Psychotropic in the environment: risperidone residues affect the behavior of fish larvae. (Pubmed Central) -  Jul 19, 2019   
    Considering the risk of exposure in the early stages of life, we exposed zebrafish embryos to risperidone during the first 5 days of life. Risperidone caused hyperactivity in exposed larvae, which in an environmental context, the animals may be more vulnerable to predation due to greater visibility or less perception of risk areas.
  • ||||||||||  Risperdal Consta (risperidone depot formulation) / J&J
    Trial completion:  High Dose Risperidone Consta for Patients With Schizophrenia With Poor Response to Risperidone (clinicaltrials.gov) -  Jul 19, 2019   
    P4,  N=160, Completed, 
    Risperidone caused hyperactivity in exposed larvae, which in an environmental context, the animals may be more vulnerable to predation due to greater visibility or less perception of risk areas. Recruiting --> Completed
  • ||||||||||  aripiprazole / generics, risperidone / generics, olanzapine / generics
    Journal:  Converting oral to long-acting injectable antipsychotics: a guide for the perplexed. (Pubmed Central) -  Jul 11, 2019   
    The increasing availability of LAI antipsychotic options has raised interest in converting patients from oral medication; however, the successful transition from oral to the comparable LAI antipsychotic requires an understanding of the current extent of antipsychotic exposure, the kinetics of the LAI preparation, and the expected plasma levels achieved by the LAI formulation. The purpose of this article is to provide, in a concise format, the essential information for converting patients to the LAI forms of haloperidol, fluphenazine, risperidone, paliperidone, olanzapine, and aripiprazole from the comparable oral medication, and how the use of plasma antipsychotic levels can be invaluable for this process.
  • ||||||||||  risperidone / generics
    Clinical, Journal:  Treating an Adolescent with Long QT Syndrome for Bipolar Disorder: A Case Presentation. (Pubmed Central) -  Jul 7, 2019   
    This condition should be kept in mind especially in cases where familial risk factors are present and precautions need to be maintained upon required assessments. These cases need to be closely monitored due to risk factors related to both BD and LQTS, in a multidisciplinary fashion, involving both psychiatry and cardiology divisions.
  • ||||||||||  Geodon (ziprasidone) / RaQualia, Meiji Seika, Pfizer
    Journal:  Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes. (Pubmed Central) -  Jul 7, 2019   
    These cases need to be closely monitored due to risk factors related to both BD and LQTS, in a multidisciplinary fashion, involving both psychiatry and cardiology divisions. Compared with women who discontinued use of an atypical antipsychotic medication before the start of pregnancy, women who continued treatment with olanzapine or quetiapine had an increased risk of gestational diabetes that may be explained by the metabolic effects associated with these two drugs.
  • ||||||||||  risperidone / generics
    Clinical, Journal:  Risperidone-induced Tardive Parkinsonism; A Case Report. (Pubmed Central) -  Jul 6, 2019   
    Parkinsonism is a clinical disorder that can occur after initiation of antipsychotic treatment, and is characterized by tremor, akinesia, bradykinesia and muscle rigidity. The development of parkinsonism symptoms are dose dependent and occurs in approximately 20-40% of patients.
  • ||||||||||  risperidone / generics
    Clinical, Journal:  Risperidone-related bilateral cystoid macular edema: a case report. (Pubmed Central) -  Jun 26, 2019   
    We suggest that ABCB1 genetic polymorphisms affect aripiprazole-related ANS dysfunction but do not affect risperidone-, olanzapine-, or quetiapine-related ANS dysfunction. The documentation of a patient who developed cystoid macular edema associated with risperidone usage indicates that it may be beneficial to monitor patients taking risperidone for the development of maculopathy.