- |||||||||| risperidone / Generic mfg., Egis
Blunted Affect Early Progression in drug-Nave First Episode Schizophrenia patients: 10-Week Follow up (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_858;
Also, we selected only participants in use of risperidone after first assessment in order to reduce bias. A sample of drug naïve FES patients brings opportunities like assessing the course of blunted affect at an early phase of the condition and reducing confounders such as chronicity and exposure to antipsychotics.
- |||||||||| Results of the Hummingbird Study a Multicentre, Pragmatic Trial of a Digital Medicine System (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_833;
P4
Background This was a multicentre, 8-week, single-arm, open-label, pragmatic trial to explore the acceptance and performance of using the Digital Medicine System (DMS) with health care professionals (HCPs) and adult subjects with schizophrenia, schizoaffective disorder (SAD), or first episode psychosis (FEP) on an oral atypical antipsychotic (aripiprazole, olanzapine, quetiapine, or risperidone)...The acceptance and performance of DMS is considered safe and there were no SAEs associated with its use. Funding This study was supported by Otsuka Pharmaceutical Development & Commercialization, Inc.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg., clozapine / Generic mfg.
Association between the Use of an Antipsychotic Drug and Changes in Lipid profile: A Meta-Analysis (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_743;
We expect the findings of this study to be of clinical relevance in the management and monitoring of antipsychotic treatment. The knowledge of whether duration of exposure is associated with different lipid changes could provide interesting results benefiting individualised choices, appropriate prevention and early management.
- |||||||||| Moderators of Weight Gain in Randomized Controlled Trials of Schizophrenia a Meta-Regression Analysis (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_607;
In addition, the scatter plots, presented on the poster, need to be considered to judge the robustness and magnitude of the moderated effects. Additional meta-regressions (planned to present on the poster) should address further potential moderators, such as antipsychotic dose, ethnicity, previous antipsychotic exposure and dropout rates.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg., clozapine / Generic mfg.
Clozapine-Induced hepatotoxicity: Two Case Reports (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_606;
Yet, the early onset of drug injury (1–6w) and the rapid rise in ALT on rechallenge may be a contraindication of a new try or continous use of the drug. Considering guidelines on clozapine induced hepatotoxicity are not clear, we suggest the topic to be revisted and better established.
- |||||||||| risperidone / Generic mfg., Egis, clozapine / Generic mfg.
The structural and functional brain impact of Clozapine in schizophrenic patients: review of the literature. (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_544;
MACHIELSEN et col Discussion These results bring a new light on SZ psychopathological, on CLZ cerebral mechanism and open the debate of actual prescription recommendations. However, we won’t conclude with certainly due heterogeneity of the experimental design, as other studies are necessary to complete knowledge of this subject.
- |||||||||| Disease Prevalence, Comorbid Conditions, and Medication Utilization among Patients with Schizophrenia in the United States (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_531;
Discussion This large-scale database analysis confirmed the burden of medical and psychiatric comorbidities in patients with schizophrenia compared with controls and provided additional insight on treatment approaches in these patients. Understanding the comorbidities affecting this patient population in comparison with the general population highlights the importance of integrated medical and psychiatric care.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg., clozapine / Generic mfg.
Weight Gain and the Pathophysiology of Schizophrenia (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_515;
Open label study of 8 youth (11-18 y.o.) on risperidone (average dose 1.8 mg) for 8 weeks...Betahistine weight gain =0.31 kg, BMI = placebo weight gain = 1.41 , p=n.s) Olanzapine /clozapine subset (n=26) Betahistine weight gain = .03kg, placebo weight gain= 0.54 kg p=.06...Discussion Our findings suggest that sga associated weight gain is not driven by peripheral adipocyte based orexigenic signaling, but that centrally hypothalamic orexigenc mechanisms may be linked to weight gain from medications. Our findings in controls suggest further exploration in to regions that might determine salience in schizophrenia as effecting both eating and social behavior and explaining part of the vulnerability to metabolic illness in schizophrenia.
- |||||||||| risperidone / Generic mfg., Egis, Latuda (lurasidone oral) / Sumitomo Dainippon
Model-Based Analysis of Effects of Lurasidone on Prolactin in Schizophrenia Patients (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_449;
The elevation of PRL in male subjects was significantly lower than in female subjects. Discussion Despite the potential limitation of simulation model, lurasidone might be a valuable option for schizophrenia patients, especially for female patients, to minimize PRL related side effects, which might improve the patients' compliance and quality of life.
- |||||||||| Case Report of Treatment of Neuroleptic Malignant Syndrome in Child Adolescent (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_287;
In cases of NMS in patients who cannot terminate use of neuroleptics due to underlying mental disorders, ECT is an effective method to treat both NMS and mental disorders. Safety and efficacy of ECT have been already proven, and it is highly recommended when needed.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg.
Circadian Patterns of Hallucinatory Experiences in Patients with Schizophrenia: Potentials for Chrono-Pharmacology (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_284;
Since the dopamine D2 receptor blockade by antipsychotics was very stable, the circadian rhythm that we found in this study seemed to be irrelevant to the treatment. These findings will lead to individualized antipsychotic dosing schedule according to the circadian rhythm of the positive symptoms in each individual patient with schizophrenia.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg., clozapine / Generic mfg.
Drug-Nave First-Episode Schizophrenia Spectrum disorders: Pharmacological Treatment Practices in Inpatient Units in Hunan Province, China (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_280;
Different practices were observed between tertiary and non-tertiary hospitals, suggesting possible challenges in delivering mental health care in those facilities where disproportionate distribution of resources might happen. Given the ongoing implementation of the National Mental Health Working Plan, these results provide a useful representation of the current practice in China and could help decision-makers on resource allocation in order to promote the best treatment for first-episode psychosis.
- |||||||||| risperidone / Generic mfg., Egis
Aripiprazole Long-Acting Injectable in schizophrenia during pregnancy: A Case Report (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_277;
She was initially treated with risperidone, suffering from some adverse effects like prolactine elevation and amenorrhea...Discussion Pregnancy and postpartum are periods that carry a high risk of illness onset or recurrence in women with severe mental disorders, such as schizophrenia. Having a good control of the symptoms may prevent from risks to both patient and child, due to the important influence that exists on the development of the baby and the mother-infant relationship.
- |||||||||| risperidone / Generic mfg., Egis, Invega Trinza (paliperidone palmitate extended-release 3-month injection) / J&J
Switching from Risperidone to Paliperidone Palmitate in schizophrenia: changes in cognitive function (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_127;
Some limitations of our study include the lack of randomization (no control group) and the small sample size. The small number of female patients does not allow to explore potential sex differences in the improved cognitive outcome.
- |||||||||| Journal, Adverse events: Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes. (Pubmed Central) - Jan 11, 2020
Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, was manifested as the third most frequently associated drug with hyperglycemia or diabetes (340 cases), following prednisolone (694 cases) and tacrolimus (393 cases), and the reporting odds ratio (ROR 8.56, 95% CI 7.65-9.57) of this drug was higher than that of the two aforementioned drugs (ROR 3.96, 95% CI 3.66-4.28 and ROR 3.51, 95% CI 3.17-3.89). These results suggest that there is a potent association of evelolimus with hyperglycemia in clinical practice in Japan.
- |||||||||| Clinical, Journal: Persistent Genital Arousal Disorder Treated with Duloxetine: A Case Report (Pubmed Central) - Jan 8, 2020
In this case report, we aimed to present the detailed description of a successful treatment procedure with duloxetine in a forty two years old female patient diagnosed with Persistent Genital Arousal Disorder. She had been using various antidepressants, antipsychotics, anxiolytics and mood stabilizers for sixteen years with different psychiatric misdiagnoses like Bipolar Disorder, Obsessive Compulsive Disorder, Anxiety Disorder and Major Depressive Disorder and yet, had not shared her symptoms of genital arousal with any psychiatrist previously.
- |||||||||| Journal: Antipsychotic drugs in epilepsy. (Pubmed Central) - Jan 8, 2020
The incidence of an increased number of seizures is linked to the elevated blood plasma level effect of antipsychotics. To diminish the risk of seizures, it is important to start with a small dose of antipsychotic drug, to titrate slowly, to monitor serum levels of prescribed drugs, and to keep the drug at the minimal effective dose.
- |||||||||| Clinical, Review, Journal: Treatment Options for Acute Agitation in Psychiatric Patients: Theoretical and Empirical Evidence. (Pubmed Central) - Jan 1, 2020
Clinical trials evaluating the efficacy of different treatment options have been conducted but they are extremely heterogenous and most have numerous methodological flaws, leading to a poor overall quality of evidence upon which guidelines for the appropriate treatment could be based. The combination of haloperidol and promethazine, which combines the sedative properties of the antihistamine with the more selective calming action of haloperidol (with a reduced risk of extrapyramidal effects compared to haloperidol alone because of the anticholinergic properties of promethazine) may be the best choice based on empirical evidence.
- |||||||||| Clinical, Journal: Hospitalization Risk in Bipolar Disorder Patients Treated with Lurasidone versus Other Atypical Antipsychotics. (Pubmed Central) - Jan 1, 2020
In this claims database analysis, lurasidone-treated patients with bipolar disorder had a significantly lower risk of psychiatric hospitalization compared to quetiapine, olanzapine, and risperidone, but not aripiprazole or ziprasidone. Lurasidone-treated patients had a significantly lower risk of all-cause hospitalization compared to quetiapine, olanzapine, risperidone, and aripiprazole, but not ziprasidone.
- |||||||||| risperidone / Generic mfg., Egis
Clinical, PK/PD data, Journal: Clinical Pharmacokinetics of a Lipid-Based Formulation of Risperidone, VAL401: Analysis of a Single Dose in an Open-Label Trial of Late-Stage Cancer Patients. (Pubmed Central) - Dec 23, 2019
Further comparisons of the pharmacokinetic parameters of risperidone and 9-hydroxyrisperidone in plasma of patients administered VAL401 and the corresponding parameters obtained from published data for conventionally formulated risperidone provide evidence for altered biological processing of VAL401 as compared to risperidone. The absolute values obtained provide support for future studies of VAL401 as a cancer treatment, as the C demonstrates sufficient exposure to reach the concentrations seen during preclinical anticancer testing, yet the overall exposure to the active moiety supports the use of the safety and tolerability data from conventional risperidone during future clinical trials.
- |||||||||| risperidone / Generic mfg., Egis, paliperidone extended release / Generic mfg.
Journal: Paliperidone extended-release in the short- and long-term treatment of schizophrenia. (Pubmed Central) - Dec 23, 2019
In this critical review of the literature the efficacy and tolerability in the short- and in the long-term have been evaluated in patients with schizophrenia. Taking into account the tolerability and efficacy data, together with the use of innovative sustained-release formulation, with a peculiar pharmacokinetic profile that allows single daily administration, paliperidone can be considered a valid option both for the short and the long-term treatment of schizophrenia.
- |||||||||| aripiprazole / Generic mfg., risperidone / Generic mfg., Egis
Journal: Factors That Affect Continuation of Antipsychotic Long-Acting Injections. (Pubmed Central) - Dec 23, 2019
LAI significantly improved the continuation rate of treatment in the patient group belonging to cluster II. Furthermore, based on other factors and reasons for discontinuation, LAI should be preferably commenced in patients with a more stable condition.
- |||||||||| risperidone / Generic mfg., Egis, lithium / Generic mfg.
[VIRTUAL] TRANSIENT RIGHT BUNDLE BRANCH BLOCK AND ELEVATED TROPONIN IN LITHIUM TOXICITY (eAbstract Virtual Hall) - Dec 22, 2019 - Abstract #ACC2020ACC_7103;
Right bundle branch block can manifest as lithium cardiotoxicity during hemodialysis that is benign and transient. Elevated cardiac Troponins can develop secondary to non-ACS causes during the course of lithium toxicity and hemodialysis.
- |||||||||| risperidone / Generic mfg., Egis
Clinical, Journal: A novel M1 PAM VU0486846 exerts efficacy in cognition models without displaying agonist activity or cholinergic toxicity. (Pubmed Central) - Dec 21, 2019
These findings further strengthen the argument that compounds with modest in vitro M1 PAM activity (EC50s > 100 nM) and pure-PAM activity in native tissues display robust pro-cognitive efficacy without AEs mediated by excessive activation of M1. Overall, the combination of compound assessment with recombinant in vitro assays (mindful of receptor reserve), native tissue systems (PFC), and phenotypic screens (behavioral convulsions) is essential to fully understand and evaluate lead compounds and enhance success in clinical development.
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