- |||||||||| Orencia (abatacept) / BMS, Simponi (golimumab) / Merck (MSD), Mitsubishi Tanabe, J&J, Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal, Combination therapy: Biologics in the treatment of juvenile idiopathic arthritis : A comparison of mono- and combination therapy with synthetic DMARDs (Pubmed Central) - Oct 8, 2019 With regard to tolerability, apart from the classic side effects of MTX, there are no other significant differences concerning the combination of MTX and biologics. In case of MTX intolerance, leflunomide may be considered as an (unapproved) alternative.
- |||||||||| hydroxychloroquine / Generic Mfg., Azulfidine (sulfasalazine) / Generic Mfg., hydroxychloroquine / VG Lifesciences
Improving Lactation Knowledge Among Providers Caring for Rheumatology Patients (Hall B5) - Oct 7, 2019 - Abstract #ACRARHP2019ACR_3448; Creating a simple structured information card helped to address these deficiencies. The sustainability of this intervention will be measured.
- |||||||||| Effectiveness and Safety of Off-label Use of Tocilizumab in Refractory Autoimmune Diseases: A Multicenter Study (Hall B5) - Oct 7, 2019 - Abstract #ACRARHP2019ACR_2181;
Previous therapies included corticosteroids (83%) , methotrexate (66%), TNF inhibitor drug (44%), azathioprine (20.8%), mycophenolate (12%), cyclophosphamide (8%), rituximab (10%), hydroxychloroquine (6%), anakinra in 2 patients and interferon, dapsone, etoposide, leflunomide, abatacept, salazopyrin or intra-venous immunoglobulin in 1 patient each. In conclusion, TCZ is used off-label in daily practice to treat various refractory autoimmune diseases with a good short-term efficacy and tolerance.
- |||||||||| cyclophosphamide intravenous / Generic Mfg.
Treatment Efficacy Evaluation of Leflunomide by Regulating Macrophages in Takayasu Arteritis (Hall B5) - Oct 7, 2019 - Abstract #ACRARHP2019ACR_1769; Treatment with LEF in TA can achieve clinical remission in a short period of time, and maintain long-term stability of the disease, especially for refractory patients. LEF presents safety for women of childbearing age, and can be used for long-term treatment of patients with TA.
- |||||||||| leflunomide / generics
Journal: Tree growth and water-use in hyper-arid Acacia occurs during the hottest and driest season. (Pubmed Central) - Sep 26, 2019 Stem diameter dynamics, leaf phenology, and sap flow were monitored during 3 consecutive years in five Acacia raddiana trees and five Acacia tortilis trees in the Arid Arava Valley, southern Israel (annual precipitation 20-70 mm, restricted to October-May)...These findings point to the possibility that summer cambial growth in Acacia under hyper-arid conditions relies on concurrent leaf gas exchange, which is in turn permitted by access to deep soil water. Soil water can support low-density tree populations despite heat and drought, as long as recharge is kept above a minimum threshold.
- |||||||||| Xeljanz (tofacitinib) / Pfizer
Clinical, Journal: Tofacitinib in the treatment of active rheumatoid arthritis - single-centre experience. (Pubmed Central) - Sep 25, 2019 Despite the observed adverse effects, in the light of the available data tofacitinib demonstrates a favourable safety profile. JAK kinase inhibitors - a new class of drugs - will enable a wider population of patients to achieve remission or low disease activity.
- |||||||||| prednisone / generics, leflunomide / generics
NECROBIOTIC LUNG NODULE: AN UNUSUAL PRESENTATION OF RHEUMATOID ARTHRITIS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 3) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3756; There are many etiologies of pulmonary nodules, and therefore, it is imperative to keep a wide differential diagnosis. In patients with RA and subcutaneous nodules, the possibility of necrobiotic lung nodule should be included in the differential diagnosis.
- |||||||||| methotrexate / generics, leflunomide / generics
RARE PRESENTATION OF LUNG DISEASE IN RHEUMATOID ARTHRITIS (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2821; There is a need to formulate new studies to gather data on newly diagnosed disease with rapidly progressing lung cavitations. The high frequency of Leflunomide therapy in patients with RA with cavitary pulmonary nodules should also be emphasized.
- |||||||||| hydroxychloroquine / Generic Mfg., Desoxyn (methamphetamine) / Lundbeck, hydroxychloroquine / VG Lifesciences
CHYLOPYOPNEUMOTHORAX IN A PATIENT WITH RHEUMATOID LUNG DISEASE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_1574; They should be considered in the differential when an immunocompromised individual with chronic lung disease presents with acute worsening. We describe a rare association of rheumatoid lung disease with M. fortuitum pulmonary infection which lead to acute presentation with chylopyopneumothorax.
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