leflunomide / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 88 Diseases   68 Trials   68 Trials   2888 News 


12345678910111213...3536»
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  Long-term impacts of oil spill pollution on the insectivorous bat community in the hyper-arid Evrona Nature Reserve, Israel. (Pubmed Central) -  Mar 10, 2025   
    In both 1974 and 2014, large-scale oil spills contaminated the hyper-arid Evrona Nature Reserve in the southern Arava Valley, Israel...The increase in feeding activity and species richness over the years reflects a decrease in the negative effects on the bats from the oil spill, possibly due to increase in resource availability and reduction in the contamination's direct effects. This trend enabled the recovery of the foraging behavior of different assemblages of bat species in Evrona Nature Reserve and may indicate how these top nocturnal insect predators react over time to terrestrial oil spill events in other desert ecosystems.
  • ||||||||||  Orencia (abatacept) / BMS
    Trial completion date, Trial primary completion date:  SEQUENS-RA: Efficacy of a Sequential Treatment Strategy in Rheumatoid Arthritis (clinicaltrials.gov) -  Mar 6, 2025   
    P3,  N=220, Recruiting, 
    Exposure to IL-13 is important for periostin production from nasal epithelial cells. Trial completion date: Nov 2025 --> Nov 2027 | Trial primary completion date: Nov 2024 --> Nov 2026
  • ||||||||||  methotrexate / Generic mfg., leflunomide / Generic mfg.
    Journal:  Clinical features of inflammatory arthritis in daily practice-China's perspective. (Pubmed Central) -  Feb 26, 2025   
    Patients with different types of inflammatory arthritis exhibited varying predisposing factors, joint inflammation, concomitant diseases, and medication choices, highlighting the importance of individualized approaches in the clinic. Key Points
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  Kimura's disease: a mysterious orbital mass. (Pubmed Central) -  Feb 14, 2025   
    The swelling started to decrease within 2?weeks of treatment. At 2 months follow-up, the swelling and mass resolved completely and the patient was asymptomatic.
  • ||||||||||  teriflunomide / Generic mfg., leflunomide / Generic mfg.
    Preclinical, Journal:  Correcting mitochondrial loss mitigates NOTCH1-related aortopathy in mice. (Pubmed Central) -  Feb 13, 2025   
    Prophylactic or therapeutic approaches aimed at increasing mitochondrial DNA copy number, either through AAV-mediated overexpression of Mfn1/2 or oral treatment with mitofusion activators teriflunomide or leflunomide, help mitigate or slow the progression of aortopathy in SMC-Notch1-/- mice. Our findings provide a molecular framework for exploring pharmacological interventions to restore mitochondrial function in NOTCH1-related aortopathy.
  • ||||||||||  leflunomide / Generic mfg.
    Trial completion date, Trial primary completion date:  Leflunomide Treatment for MEN1 Patients - the LUMEN1 Trial (clinicaltrials.gov) -  Jan 29, 2025   
    P=N/A,  N=15, Recruiting, 
    2025; 23(1): 25-35. Trial completion date: Jan 2025 --> Jan 2026 | Trial primary completion date: Jan 2025 --> Jan 2026
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  GRP78 mediates mitochondrial fusion and fission in cigarette smoke-induced inflammatory responses in airway epithelial cells. (Pubmed Central) -  Dec 13, 2024   
    Additionally, we proved that GRP78 played an important regulatory role as an essential endoplasmic reticulum protein, regulating the mitochondrial fusion/fission process and subsequently activating the NF-?B pathway to regulate airway inflammation. Taken together, these results suggested that the GRP78-mediated mitochondrial fusion and fission process played a vital role in cigarette smoke-induced airway inflammation and might be a potential therapeutic target in this regard.
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  The foraging behavior of gerbils reveals the ecological significance of crude oil pollution. (Pubmed Central) -  Dec 11, 2024   
    The oil spill disasters occurred in 1975 and 2014 and the spill sites are located within a few hundred meters of each other, in the 'Avrona Nature Reserve in the Arava hyper-arid region in Israel...Chronic oil exposure did not lead to mortality or weight loss, but female gerbils exhibited heightened cortisol. We conclude that terrestrial oil pollution may have significant sublethal impacts on animal behavior, even when there is no obvious short-term physiological cost to the exposure.
  • ||||||||||  leflunomide / Generic mfg., celecoxib oral / Generic mfg.
    Journal:  Defluorinative thio-functionalization: direct synthesis of methyl-dithioesters from trifluoromethylarenes. (Pubmed Central) -  Dec 2, 2024   
    In addition, it does not rely on highly odorous thiol sources, and utilizes the commercially available reagent BF3SMe2 complex as a multifunctional Lewis acid/sulfur source/defluorination and demethylation agent. Finally, this approach is suitable for late-stage functionalizations, as shown by the transformation of pharmaceuticals leflunomide, flufenamic acid and celecoxib into novel methyl-dithioester derivatives.
  • ||||||||||  methotrexate / Generic mfg., leflunomide / Generic mfg.
    Journal:  Effects of Biologics on Temporomandibular Joint Inflammation in Juvenile Idiopathic Arthritis. (Pubmed Central) -  Dec 2, 2024   
    Finally, this approach is suitable for late-stage functionalizations, as shown by the transformation of pharmaceuticals leflunomide, flufenamic acid and celecoxib into novel methyl-dithioester derivatives. This is the first prospective observational study with evidence to support that the orofacial signs, symptoms and MRI-derived inflammation score in TMJ arthritis can be reduced by treatment with TNFi.
  • ||||||||||  leflunomide / Generic mfg.
    Review, Journal:  Leflunomide nanocarriers: a new prospect of therapeutic applications. (Pubmed Central) -  Nov 28, 2024   
    Despite the aforementioned pharmacological effects exploring these effects in nanomedicine applications has been focused mainly on RA and cancer treatment. This review summarises the main pharmacological, and pharmacokinetic effects of LEF along with highlighting the applications of nanoencapsulation of LEF and its metabolite in different diseases.
  • ||||||||||  leflunomide / Generic mfg.
    Clinical, Retrospective data, Review, Journal:  Risk factors for incidence of interstitial lung disease in patients with rheumatoid arthritis: a systematic review and meta-analysis. (Pubmed Central) -  Nov 18, 2024   
    This cost minimization study, the first to the best of our knowledge in the field of chronic musculoskeletal ailments, indicates the usefulness of JA drugs in reducing the patient's financial costs for most drugs. Physicians should be aware that patients with RA with the above risk factors are likely to develop RA-ILD, and perform close ILD screening during follow-ups so that the patients can be early diagnosed and treated, and achieve improved prognosis.
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  Acneiform lesions in a 57-year-old woman. (Pubmed Central) -  Nov 16, 2024   
    These dermatologic manifestations, laboratory evaluation, and punch biopsy led to a final diagnosis of acneiform or comedonal discoid lupus erythematosus (ACDLE). For patients with acneiform or comedonal lesions, ACDLE should be considered if the lesions do not improve with conventional treatment for acne vulgaris.
  • ||||||||||  Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie, Rituxan (rituximab) / Roche
    Journal:  Sarcoidosis Treatment Patterns in the United States: 2016-2022. (Pubmed Central) -  Nov 16, 2024   
    Non-steroidal immunosuppressives were used in 40% of treated patients. While factors associated with treatment initiation aligned with guideline recommendations, practice patterns of treatment were variable, particularly in choice and sequence of non-steroidal immunosuppressive therapy, underscoring the need for future trials and comparative effectiveness studies.
  • ||||||||||  cholestyramine (A3384) / Ipsen, Humira (adalimumab) / AbbVie, Rituxan (rituximab) / Roche
    DMARD preconception counselling and reinforcement should be a norm in all rheumatology clinics () -  Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_66;    
    Introduction: Leflunomide is known to be teratogenic in animal studies, particularly in rats, with increased risk of malformations and reduced foetal viability...She was diagnosed with seropositive RA in 2016 and was managed on methotrexate for the first two years but was stopped due to hair loss. She was started on hydroxychloroquine and sulfasalazine with partial response...She had to come off adalimumab in 2021 after brief use due to weight gain...She was started on rituximab infusion in June 2022 in view of high DAS-28 score of 6.57 and subsequent received IM depomedrone injection in August 2022.She was reviewed in a routine rheumatology clinic in November 2022 when she informed us that she was 15 weeks pregnant...Although the manufacturer recommends an 11-day washout using colestyramine or activated charcoal, this was not recommended by UKTIS in this case, as the patient was 14+ weeks gestation...This should be treated as never-events and easily avoidable.
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  Mitochondrial elongation impairs breast cancer metastasis. (Pubmed Central) -  Nov 6, 2024   
    To study the impact of mitochondrial dynamics on metastasis, we promoted mitochondrial elongation in metastatic breast cancer cells by individual genetic deletion of three key regulators of mitochondrial fission (Drp1, Fis1, Mff) or by pharmacological intervention with leflunomide...Furthermore, the transcriptomic signature associated with elongated mitochondria correlated with improved clinical outcome in patients with breast cancer. Overall, our findings highlight mitochondrial dynamics as a potential therapeutic target in breast cancer.
  • ||||||||||  decitabine / Generic mfg.
    Decitabine Activity Against TP53-Mutated Myeloid Neoplasms Is Enhanced By Combination with a Non-Cytotoxic p53/BAX-Independent Inhibitor of Pyrimidine Synthesis (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_5246;    
    DNA methyltransferase 1 (DNMT1)-degraders decitabine (Dec) or 5-azacytidine (Aza) (hypomethylating agents, HMA) with or without the BCL2-inhibitor venetoclax (Ven), are standard-of-care for TP53-mutated (m) acute myeloid leukemias (AML)...(iv) We thus considered p53/BAX-independent methods to reduce pyrimidine nucleotides : teriflunomide (Teri), approved to treat multiple sclerosis, directly inhibits de novo pyrimidine synthesis at dihydroorotate dehydrogenase (DHODH)...Conclusion. Mechanism and in vivo proof-of-principle thus support metronomic, timed-combination Teri/HMA, or Teri pro-drug leflunomide/HMA, as candidate solutions for Ven/HMA-resistance, including to treat TP53-mutated disease.
  • ||||||||||  hydroxychloroquine / Generic mfg., mycophenolate mofetil / Generic mfg., leflunomide / Generic mfg.
    Trial completion date, Trial primary completion date:  NECESSITY: New Clinical End-points in Patients With Primary Sj (clinicaltrials.gov) -  Nov 1, 2024   
    P2,  N=300, Recruiting, 
    cDMARDS are safe to use in patients with RA with comorbid T2DM. Trial completion date: Apr 2025 --> Oct 2025 | Trial primary completion date: Feb 2024 --> Apr 2025
  • ||||||||||  methotrexate / Generic mfg., leflunomide / Generic mfg.
    Journal:  Synthesis, XRD structural analysis and theoretical studies of a potential inhibitor against rheumatoid arthritis (RA). (Pubmed Central) -  Oct 25, 2024   
    The interaction energies of molecular pairs around NTFC are highest for those interactions linked by N-H hydrogen bonds. The properties of the NTFC ligand as a potential inhibitor of the DHODH (dihydroorotate dehydrogenase) enzyme were evaluated by molecular docking, showing coupling energies very close to those obtained with the control drug for rheumatoid arthritis, i.e. leflunomide.
  • ||||||||||  methotrexate / Generic mfg., leflunomide / Generic mfg.
    Journal, Combination therapy:  Efficacy of formic acid in combination with cDMARDs in rheumatoid arthritis. (Pubmed Central) -  Oct 22, 2024   
    Leflunomide use was associated with a higher risk of reinfection. Overall, the incorporation of all-trans retinoic acid alongside conventional treatments for children with RA appears to enhance their efficacy.
  • ||||||||||  leflunomide / Generic mfg.
    Journal:  Cavitary pulmonary rheumatoid nodules in a patient on leflunomide: A case report. (Pubmed Central) -  Oct 21, 2024   
    The diagnosis of excavated pulmonary nodules in rheumatoid arthritis was made after aspiration of one of the nodules, which ruled out infectious and cancerous causes. These nodules regressed 6 months after leflunomide was stopped.