- |||||||||| brequinar (DUP 785) / BMS, Clear Creek Bio
Journal: An insilico workflow that yields experimentally comparable inhibitors for human DiHydroOrotate DeHydrogenase. (Pubmed Central) - Apr 7, 2021
This study aims to review the pharmacological and safety profile of LF with a focus on the LF-induced hepatic injury from the perspective of pathophysiology and possible protective agents. This suggests the use of the 2D fingerprint similarity search in various databases, followed by multiple docking algorithms and dynamics as a workflow that will lead to finding novel compounds that a structurally and functionally similar to LEF and BREQ.
- |||||||||| leflunomide / Generic mfg.
Journal: Leflunomide Sustained Skin Delivery Based on Sulfobetaine-Modified Chitosan Nanoparticles Embedded in Biodegradable Polyesters Films. (Pubmed Central) - Apr 7, 2021
Results showed the formation of polymeric thin-films with no agglomeration (or trapped air) and uniform structure in all cases, while the LFD-loaded NPs were successfully embedded in the polymeric matrix. Analysis of the obtained in vitro dissolution profiles revealed a sustained release profile of the drug for up to approximately twelve days, while between the two proposed systems, the use of CS-SDAEM NPs (independently of the polyester type) was the most promising formulation approach.
- |||||||||| Orencia (abatacept) / BMS, Actemra IV (tocilizumab) / Roche, JW Pharma
[VIRTUAL] REAL-WORLD RETENTION OF JAK INHIBITORS IS LONGER THAN BDMARDS IN RHEUMATOID ARTHRITIS (Room 2) - Apr 6, 2021 - Abstract #EULAR2021EULAR_1208;
However, this study demonstrates that JAKi has a greater durability than biologics regardless of gender, age, disease duration, and line of therapy. Therefore, JAKi may be considered as a preferable method of treatment post csDMARD failure in active RA.
- |||||||||| leflunomide / Generic mfg.
Preclinical, Journal: Anti-inflammatory and anti-rheumatic activities in vitro of alkaloids separated from Aconitum soongoricum Stapf. (Pubmed Central) - Apr 2, 2021
Compared with the lipopolysaccharide (LPS) group, the contents of IL-6, IL-1β, TNF-α and PGE-2 in the culture supernatant were significantly declined in the leflunomide + LPS and intervention+LPS groups, as well as the mRNA expression levels of HIF-1α, VEGFA and TLR4...Songorine, benzoylaconine and aconitine from Aconitum soongoricum Stapf. have anti-rheumatic activities in vitro, which may inhibit the proliferation of HFLS-RA cells, and the underlying mechanisms may be associated with inhibiting the inflammatory cytokine production and downregulating the expression levels of HIF-1α, VEGF and TLR4.
- |||||||||| hydroxychloroquine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] LEFLUNOMIDE-INDUCED COLITIS IN IMMUNOSUPPRESSED PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND RHEUMATOID ARTHRITIS () - Mar 25, 2021 - Abstract #CDDW2021CDDW_291;
Challenges related to the diagnosis of leflunomide-induced colitis exist, including the rarity of the diagnosis, a not completely understood mechanism for acute leflunomide-induced diarrhea, as well as variable endoscopic and histologic findings associated with the diagnosis. This report illustrates a case of leflunomide-induced colitis which should be considered in patients on leflunomide, who present with symptoms of abdominal pain and diarrhea, even years after medication initiation.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / Eisai, AbbVie
Clinical, Journal, Real-world evidence, Adverse drug reaction: Frequency of real-world reported adverse drug reactions in rheumatoid arthritis patients. (Pubmed Central) - Mar 18, 2021
Also, its potential compounds might offer guidelines for developing a novel treatment strategy of ccRCC. Although ADR data in the DREAM-RA registry were partly comparable with data in the SmPCs, RWD from this patient registry provided an added value to the currently available information on the incidences of ADRs associated with DMARDs in RA patients as described in SmPCs.
- |||||||||| cyclosporin A microemulsion / Generic mfg., mycophenolate mofetil / Generic mfg., leflunomide / Generic mfg.
Retrospective data, Journal: Efficacy and safety of immunosuppressive therapies in the treatment of high-risk IgA nephropathy: A network meta-analysis. (Pubmed Central) - Mar 17, 2021
Although ADR data in the DREAM-RA registry were partly comparable with data in the SmPCs, RWD from this patient registry provided an added value to the currently available information on the incidences of ADRs associated with DMARDs in RA patients as described in SmPCs. MMF+CS and LEF+CS appear to serve as the best choice for treating high-risk IgAN than other immunosuppressive therapies.
- |||||||||| ceftriaxone / Generic mfg., amoxicillin / Generic mfg.
[VIRTUAL] Pulmonary Actinomycosis in an Immunocompromised Rheumatoid Arthritis Patient () - Mar 14, 2021 - Abstract #ATS2021ATS_2260;
Thus, diagnosing pulmonary actinomycosis will require tissue sampling with histopathological examination along with gram stain and cultures. The standard of care treatment involves high dose IV penicillin or ceftriaxone for 2 to 6 weeks followed by oral amoxicillin for 6 to 12 months.
- |||||||||| clarithromycin / Generic mfg.
[VIRTUAL] Invasive Pulmonary Aspergillosis Masquerading as Progression of Cavitary Nontuberculous Mycobacterial (NTM) Infection () - Mar 14, 2021 - Abstract #ATS2021ATS_1400;
Medications included prednisone 2.5mg daily, leflunomide, and methotrexate...Methotrexate and leflunomide were stopped and she was placed back on her regimen of clarithromycin, ethambutol, and rifabutin...CT scan after 6 weeks of IV amikacin revealed further increase of cavity to 3.9 x 4.2 cm...Invasive pulmonary aspergillosis should remain on the differential for progressive disease in immunocompromised patients with negative cultures if the disease is not responding to other pharmacologic therapy. Cavitary disease and steroid usage have been shown to be independent risk factors for invasive aspergillosis.
- |||||||||| methotrexate / Generic mfg.
Journal: Disease-modifying antirheumatic drugs and organising pneumonia. (Pubmed Central) - Feb 23, 2021
She responded within 6 months of corticosteroid therapy with clinical and radiological resolution. This case series highlights that OP may developed with low-dose MTX (as early as 3 weeks) and leflunomide and the diagnosis requires a high index of suspicion.
- |||||||||| leflunomide / Generic mfg.
Clinical, Review, Journal: Management of BK virus-associated haemorrhagic cystitis in allogeneic stem cell transplant recipients. (Pubmed Central) - Feb 23, 2021
These include antiviral drugs, fluoroquinolones, leflunomide, growth factors, clotting factors, estrogens, and prostaglandins...Despite the availability of various treatment options, the management of BKV-related HC in day-to-day practice continues to be a challenge. The aim of this article is to put forward an up-to-date review of the preventive and therapeutic strategies for BKV-related HC.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] Airway Compromise from Cricoarytenoid Joint Swelling Secondary to Rheumatoid Arthritis () - Feb 21, 2021 - Abstract #CRAAHPA2021CRA-AHPA_323;
He was initially managed with hydroxychloroquine and methotrexate (MTX) SC...Adalimumab was added with no improvement in his symptoms after 8 months...His hospital stay was complicated by MSSA pneumonia with paratracheal cellulitis treated with a course of cefazolin. Airway obstruction secondary to cervical spine RA is uncommon but can occur in the setting of severe, chronic, and poorly controlled disease.
- |||||||||| [VIRTUAL] Long-Term Treatment in a Patient With Cryptococcal Meningitis and Rheumatoid Arthritis () - Feb 21, 2021 - Abstract #CRAAHPA2021CRA-AHPA_261;
The cryptococcal infection was managed as an outpatient with 6 weeks of induction therapy of 5-Flucytosine, followed by 6 months of Fluconazole 200 mg daily...To the best of our knowledge, we are the first to report ongoing management with concurrent immunosuppressive and chronic antifungal therapies. Our report also highlights the potentially serious complications of iatrogenic immunosuppression, and the difficulty of managing infections while preventing autoimmune disease flares.
- |||||||||| Xeljanz (tofacitinib) / Pfizer, Marche Polytechnic University, Enbrel (etanercept) / Pfizer, Amgen
[VIRTUAL] Seronegative Rheumatoid Arthritis and Persistently High C-Reactive Protein: A Seven Year Misdiagnosis () - Feb 21, 2021 - Abstract #CRAAHPA2021CRA-AHPA_45;
In summary, we are presenting a case of Whipple’s disease, masquerading as symmetrical polyarthritis for 7 years, until development of classic symptoms. Treatment of this rare disease was further complicated by a rare manifestation of IRIS post antibiotic therapy and recurrence of his Whipple’s in his muscles despite being on antibiotic therapies.
- |||||||||| leflunomide / Generic mfg.
Trial completion date, Trial primary completion date: Leflunomide in Treating Patients With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) - Feb 17, 2021
P1/2, N=39, Active, not recruiting,
Greatest risk was seen in patients with older age, health plan type, and previous ER visits/hospitalization. Trial completion date: May 2022 --> Sep 2021 | Trial primary completion date: Sep 2018 --> Sep 2021
- |||||||||| cyclosporine / Generic mfg.
Retrospective data, Journal, Monotherapy: Efficacy and Safety of Immunosuppressive Monotherapy Agents for IgA Nephropathy: A Network Meta-Analysis. (Pubmed Central) - Feb 9, 2021
Corticosteroids might induce remission and increase renal survival in IgAN; however, adverse reactions should be taken into consideration. MMF, TAC, and HCQ might improve the remission of proteinuria when treating IgAN, but showed no superiority compared to steroids, and the long-term effects require further study.
- |||||||||| methotrexate / Generic mfg.
Retrospective data, Journal: A retrospective study on the predictive implications of clinical characteristics and therapeutic management in patients with rheumatoid arthritis-associated interstitial lung disease. (Pubmed Central) - Feb 2, 2021
No correlation was found between traditional DMARDs and ILD progression. Advanced age and extensive lung involvement on HRCT independently predict mortality; cyclophosphamide treatment helps to improve the prognosis of RA-ILD.Key Points• We designed this study to investigate the predictive and prognostic factors for RA-ILD and to explore the potential role of DMARDs in the evolution of RA-ILD from the development to progression and death.• Patients without ILD at RA diagnosis were enrolled and followed up retrospectively.• Our results showed that no correlation was found between traditional DMARDs and the development and progression of ILD, and regular treatment may improve the development of RA-ILD.• Our results revealed that clinical variables appeared predictive implications for the diagnosis of ILD and physiological and radiological variables appeared predictive implications for the prognosis of ILD, which can provide reference to rheumatologists and help to improve poor prognosis of RA-ILD.
- |||||||||| leflunomide / Generic mfg.
Trial completion date, Trial primary completion date: Anti-rheumatic Drug Use and Risk of COVID-19 Infection in Rheumatoid Arthritis Patients (clinicaltrials.gov) - Feb 1, 2021
P=N/A, N=600, Enrolling by invitation,
Advanced age and extensive lung involvement on HRCT independently predict mortality; cyclophosphamide treatment helps to improve the prognosis of RA-ILD.Key Points• We designed this study to investigate the predictive and prognostic factors for RA-ILD and to explore the potential role of DMARDs in the evolution of RA-ILD from the development to progression and death.• Patients without ILD at RA diagnosis were enrolled and followed up retrospectively.• Our results showed that no correlation was found between traditional DMARDs and the development and progression of ILD, and regular treatment may improve the development of RA-ILD.• Our results revealed that clinical variables appeared predictive implications for the diagnosis of ILD and physiological and radiological variables appeared predictive implications for the prognosis of ILD, which can provide reference to rheumatologists and help to improve poor prognosis of RA-ILD. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- |||||||||| Vistide (cidofovir) / Gilead
[VIRTUAL] Hemorrhagic Cystitis : 8 Year Experience from a North Indian Tertiary Care Teaching Hospital () - Jan 27, 2021 - Abstract #TCTASTCTCIBMTR2021TCT_ASTCT_CIBMTR_3065;
Pharmacological management included- reduction in immunosuppression where possible, antibiotics as per urine culture sensitivity (n=3), Cidofovir (n=2), Ribavirin(n=2), Levofloxacin (n=6), Leflunomide(n=1). Incidence of HC in study was 11.3% and was more common in non-MSD, ABO incompatible HSCT ,in patients with grade 3-4 aGVHD , suggesting the role of stringent monitoring for HC in patients with these risk factors for early detection and treatment for better outcome
- |||||||||| Vistide (cidofovir) / Gilead
[VIRTUAL] Hemorrhagic Cystitis : 8 Year Experience from a North Indian Tertiary Care Teaching Hospital () - Jan 27, 2021 - Abstract #TCTASTCTCIBMTR2021TCT_ASTCT_CIBMTR_3064;
Pharmacological management included- reduction in immunosuppression where possible, antibiotics as per urine culture sensitivity (n=3), Cidofovir (n=2), Ribavirin(n=2), Levofloxacin (n=6), Leflunomide(n=1). Incidence of HC in study was 11.3% and was more common in non-MSD, ABO incompatible HSCT ,in patients with grade 3-4 aGVHD , suggesting the role of stringent monitoring for HC in patients with these risk factors for early detection and treatment for better outcome
- |||||||||| Vistide (cidofovir) / Gilead
[VIRTUAL] Hemorrhagic Cystitis : 8 Year Experience from a North Indian Tertiary Care Teaching Hospital () - Jan 27, 2021 - Abstract #TCTASTCTCIBMTR2021TCT_ASTCT_CIBMTR_3063;
Pharmacological management included- reduction in immunosuppression where possible, antibiotics as per urine culture sensitivity (n=3), Cidofovir (n=2), Ribavirin(n=2), Levofloxacin (n=6), Leflunomide(n=1). Incidence of HC in study was 11.3% and was more common in non-MSD, ABO incompatible HSCT ,in patients with grade 3-4 aGVHD , suggesting the role of stringent monitoring for HC in patients with these risk factors for early detection and treatment for better outcome
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