- |||||||||| Lung Involvement in VEXAS Syndrome (Northern Liberties Stage) - Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_2114;
The pulmonary manifestations of VEXAS are nonspecific and characterized predominantly by inflammatory parenchymal involvement.Response to glucocorticoids documented with chest HRCT. Follow-up chest HRCT was available for 8 patients (36%): GGO resolved (5), new or increased GGO (3) (during flares), increased interlobular septal thickening (1)
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly, Xeljanz (tofacitinib) / Pfizer, Rinvoq (upadacitinib) / AbbVie
Real-world Utilisation and Switching Between Janus Kinase Inhibitors in Patients with Rheumatoid Arthritis in the Australian OPAL Dataset (Virtual Poster Hall) - Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_1547;
There has been rapid uptake of the 3 approved JAKi: tofacitinib (TOF; available since October 2015), baricitinib (BARI, Sept 2018) and upadacitinib (UPA; May 2020). In Australian real-world clinical practice, median persistence was similar across treatment groups and JAKi to JAKi switching was frequently observed.NR, not reached.a Includes patients who are currently still on JAKi, did not start a subsequent b/tsDMARD or are lost to follow-up.b Denominator is total patients who switched from that JAKi.c Defined as JAKi with at least one csDMARD (methotrexate, leflunomide, hydroxychloroquine, sulfasalazine, cyclosporine) at switch, regardless of corticosteroids.d Denominator is total patients that initiated that JAKi
- |||||||||| Cimzia (certolizumab pegol) / Astellas, UCB
National Multicenter Study of 80 Patients with Refractory Uveitis Due to Immune-Mediated Inflammatory Diseases Treated with Certolizumab Pegol (Virtual Poster Hall) - Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_1418;
Anterior was the most frequent uveitis pattern (n=61).In 20 patients, besides the presence of refractory uveitis, desire of pregnancy was the reason for CZP initiation.Prior to CZP, patients had received: methotrexate (n=38), sulfasalazine (28), azathioprine (14), cyclosporine (10), leflunomide (3), mycophenolate mofetil (4), and cyclophosphamide (1)...The most used biologic was adalimumab (n=48), followed by infliximab (32), golimumab (15), tocilizumab (5), etanercept (7), rituximab (1), anakinra (1) and secukinumab (1)... CZP seems to be effective and safe in the control of uveitis associated to different IMIDs.Main ocular parameters analyzed in 80 patients with uveitis due to IMID and treated with CZP
- |||||||||| leflunomide / Generic mfg.
Journal: Photomediated reductive coupling of nitroarenes with aldehydes for amide synthesis. (Pubmed Central) - Sep 14, 2022
Our method provides an orthogonal strategy to conventional amide couplings, tolerating nucleophilic substituents such as free alcohols and sensitive functional groups to amines such as carbonyl or formyl groups. The synthetic utilization of this reductive amidation is demonstrated by the late-stage modification of complex biologically active molecules and direct access of drug molecules leflunomide and lidocaine.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen
MEDIASTINAL LYMPH NODES AND PULMONARY SARCOIDOSIS IN A PATIENT TREATED WITH ETANERCEPT: A CASE REPORT (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4084;
Due to previous intolerance to methotrexate and the unefficacy of leflunomide, low doses of methylprednisolone (8-4 mg/day), sulfasalazine 2 g/day were prescribed, and etanercept 50 mg/week was added to therapy about 1 year ago. With an increase in mediastinal lymph nodes and the appearance of pulmonary pathology in patients treated with TNF-a inhibitors, it is necessary to include in the diagnostic search not only tuberculosis, oncological diseases, but also sarcoidosis.
- |||||||||| methotrexate / Generic mfg., leflunomide / Generic mfg.
Review, Journal: Immune hallmarks of rheumatoid arthritis management: A brief review. (Pubmed Central) - Sep 10, 2022
The most recent strategies modulate the immune response of the individual RA patient using tsDMARDs such as JAK inhibitors and bDMARDs such as ig-CTLA-4, anti- IL6R, anti-TNF-α and anti-CD20. To better understand current immunopharmacological interventions, we also looked at documented mechanisms of RA-mediated immunomodulation, highlighting perspectives potentially boosting RA treatment.
- |||||||||| leflunomide / Generic mfg.
Drug-Induced Colitis Secondary to Leflunomide (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3556;
This case highlights both the importance of keeping leflunomide-induced colitis in the differential and the potential adverse effects of delay in diagnosis. Figure: Figure 1 (a) erythema and congestion, (b) ulceration, (c) erosions with exudates
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / Eisai, AbbVie
Hepatic Lymphoproliferative Lesions in the Setting of Chronic, Multi-Drug Immunosuppression (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_1841;
Long-term use of adalimumab is thought to have caused this patient’s lesions while the prednisone simultaneously treated them, explaining the inconclusive biopsies and fluctuating CT findings...Further studies are needed to elucidate the influence of these medications on hepatic lymphoproliferative disease processes. Figure: (A) Liver CT from 2021 depicting an enlarging, hypodense lesion (B) Liver biopsy H&E stain, 4x (C) Liver biopsy H&E stain, 20x
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Rinvoq (upadacitinib) / AbbVie
Disseminated Histoplasmosis Causing Peritoneal Implants in Patient Receiving Tumor Necrosis Factor-Alpha Inhibitor (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_1380;
Case Description/ A 43-year-old female with known history of rheumatoid arthritis (RA) on leflunomide, infliximab, and recent steroid course presented to the ED for abdominal pain and shortness of breath...Initial broad antibiotic therapy for sepsis of unknown origin was transitioned to itraconazole and she was eventually discharged...Her RA treatment was switched to upadacitinib, with some control of her symptoms...Figure: Figure 1: Diffuse nodularity to the mesentery most prevalent along anterior abdominal wall right paracolic gutter regions concerning for metastatic disease to the mesentery (Arrow). Mild bowel wall thickening seen involving descending colon.
- |||||||||| methotrexate / Generic mfg.
Retrospective data, Review, Monotherapy: Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. (Pubmed Central) - Aug 24, 2022
4) Compared with MTX + hydroxychloroquine (HCQ), IGU + MTX was superior in improving DAS28-ESR (MD -2.16, 95% CI -2.53 to -1.79, p < 0.00001)...Furthermore, IGU + MTX does not increase the risk of leukopenia, but it can decrease the risk of liver function tests (LFTs), regardless of the age or the stage of RA. Clinical Trial Registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42022295217.
- |||||||||| leflunomide / Generic mfg.
Retrospective data, Journal: Efficacy of leflunomide in the treatment of palindromic rheumatism. (Pubmed Central) - Aug 24, 2022
Clinical Trial Registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42022295217. Our results indicate that leflunomide controls PR attacks and it might be a new option for patients with PR.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
INADEQUATE IMMUNE RESPONSE TO COVID-19 VACCINES IN THE PRESENCE OF DISEASE-MODIFYING ANTIRHEUMATIC DRUGS (DMARDS) (Convention Center Exhibit Hall: Poster Area) - Aug 16, 2022 - Abstract #CHEST2022CHEST_2704;
He was on treatment for RA with leflunomide, rituximab and prednisone...He was treated with remdesivir and dexamethasone... This case highlights patients on immunosuppressant therapy failing to mount an adequate immune response to the COVID-19 vaccine, warranting more booster doses in patients on DMARDs.
- |||||||||| Bredinin (mizoribine) / Asahi Kasei, Leukeran (chlorambucil) / GSK, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Retrospective data, Review: Efficacy and safety of 12 immunosuppressive agents for idiopathic membranous nephropathy in adults: A pairwise and network meta-analysis. (Pubmed Central) - Aug 13, 2022
On the contrary, there seems to be little advantage on STE alone, LEF, AZA, and MZB in treating patients with IMN compared with CON. Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42021287013].
- |||||||||| Cimzia (certolizumab pegol) / Astellas, UCB
Uveitis Due To Immune-Mediated Inflammatory Diseases Treated With Certolizumab Pegol. Spanish Multicenter Study Of 80 Patients. (Screen # 1) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_338;
Previous biologic therapy was administered in 52 patients (63%): 48 adalimumab, 32 infliximab, 15 golimumab, 5 tocilizumab, 7 etanercept, 1 rituximab, 1 anakinra and 1 secukinumab...297.1±45. 286.5±39.8 277.6±43.3 271.5±38.6 269.0±38.8 1 5 * * * * Choroiditis, affected eyes, n (%) 3 (2.4) 3 (2.4) 2 (1.6) 2 (1.6) 1 (0.8) 1 (0.8) Retinal vasculitis, affected eyes, n (%) 3 (2.4) 2 (1.6) 1 (0.8) 0 (0) 0 (0) 0 (0) *p<0.01 Conclusion CZP seems to be effective and safe in the control of uveitis associated to IMIDs.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Sars-Cov2 Infection In Patients With Rheumatoid Arthritis (Screen # 2) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_269;
As for comorbidities, 58.6% of them had some: 34.48% had arterial hypertension; 13.79% obesity; 10.34% dyslipidemia, 6.8% diabetes. Image 1 Image 2 Conclusion 22.3% of RA patients had SARS-COV2 infection; they were mostly female, symptomatic; a low percentage of patients had moderate-severe disease, no patient died.
- |||||||||| Xeljanz (tofacitinib) / Pfizer
Endothelial Inflammation In Rheumatoid Arthritis Patients Treated With Tofacitinib (Screen # 1) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_246;
No significant difference achieved after 12 weeks of tofacitinib Conclusion Despite a significant improvement in joint activity and function, there was no modification in EI measured by FDG-PET during tofacitinib treatment along 12 weeks. It is noteworthy that all patients initially presented high inflammatory endothelial uptake values, which reinforces the hypothesis of vascular compromise associated with active joint disease
- |||||||||| Cancer Risk In A Cohort Of Patients With Rheumatoid Arthritis In Colombia (Screen # 4) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_232;
Conclusion RA patients presented an increased risk of cancer, especially lymphoma, thyroid, prostate, breast, and cervix cancer. It is necessary to implement routine clinical strategies for early cancer detection in the population with RA with the development of public policies that must be included in care programs.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / Eisai, AbbVie, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
A Rheumatoid Arthritis Cohort Study Caracterization In Colombia (Screen # 4) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_228;
17.58% (n=937) received biologic DMARD, and in this group, the most prevalent was etanercept at 40.2% (n=377), rituximab in 25.5% (n=239) and adalimumab at 22.5% (n=211)...Only 17.6% of patients needed biologic treatment. During the followup most of the patients were in remission.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / Eisai, AbbVie, Cimzia (certolizumab pegol) / Astellas, UCB
An Old Method For Current Challenges: Skin Test Conversion Of Purified Protein Derivative (Ppd) In Rheumatological Patients Treated With Anti-Tnf-Alfa (Screen # 1) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_192;
Concomitant use of immunomodulators (52 methotrexate, 23 leflunomide, 10 hidroxicloroquine, 3 sulfasalazine, 2 azathioprine and 1 mycophenolate mofetil) and glucocorticoids (33/62) was observed...PPD is a well known, cheap, sensitive and widely available method, suitable for LTBI diagnosis. Although sensitivity could be increased using, in addition, other LTBI detection methods such as IGRAs (interferon gamma release assays), they are usually unavailable in developing countries (1-2).
- |||||||||| Descriptive And Retrospective Study Of Sars-Cov2 Infection In Patients With Systemic Autoimmune Diseases (Screen # 1) - Aug 7, 2022 - Abstract #PANLAR2022PANLAR_132;
Of the patients with steroid treatment, 7 were admitted to hospital, all with Prednisone at doses higher than 5mg...Table Table 1 Treatments in the total sample (n=101) N=102 Previous Biological DMARDs 54 patients Abatacept 11 Certolizumab 3 Adalimumab 10 Infliximab 9 Ixekizumab 1 Rituximab 11 Sarilimumab 1 Secukinumab 1 Golimumab 1 Tocilizumab 5 Previous Conventional DMARDs 44 patients Metotrexate 24 Azatioprine 3 Dolquine 4 Leflunomide 11 Mycophenolate mofetil 2 Image 1 Conclusion In our cohort, 18 patients required hospital admission of whom 16.7% required ICU...Two patients died of SARS-CoV2, one of whom had rheumatoid arthritis and the other spondyloarthritis. The most affected groups were Rheumatoid Arthritis and Spondyloarthritis in both SARS-CoV2 infection and admissions.
- |||||||||| leflunomide / Generic mfg.
Trial initiation date, Metastases: Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies (clinicaltrials.gov) - Jul 12, 2022
P1a/1b, N=24, Not yet recruiting,
• Arterial hypertension, cardiovascular disease or obesity were associated with severe COVID-19. Initiation date: May 2022 --> Aug 2022
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