zidovudine / Generic mfg. 
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 94 Diseases   6 Trials   6 Trials   1432 News 


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  • ||||||||||  zidovudine / Generic mfg., lorazepam / Generic mfg.
    Review, Journal:  PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates. (Pubmed Central) -  Sep 29, 2021   
    Drug-drug interactions (DDIs) of UGT1A1 substrates dolutegravir and raltegravir with UGT1A1 inhibitor atazanavir have been simulated, and the role of intestinal metabolism in these clinical DDIs examined...Improved in vitro tools to study metabolism for UGT compounds, such as coculture models for low clearance compounds and better understanding of optimal conditions for in vitro studies, may provide an opportunity for improved in vitro-in vivo extrapolation (IVIVE) and prospective predictions. PBPK modeling shows promise as a useful tool for predicting intestinal metabolism for UGT substrates.
  • ||||||||||  zidovudine / Generic mfg.
    Review, Journal, IO biomarker:  Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets. (Pubmed Central) -  Sep 23, 2021   
    In this context, abacavir and ritonavir-boosted lopinavir and darunavir have all been linked to an increased risk of CVD. This narrative review is therefore focused primarily on the role of neutrophils and platelets in HIV transmission and disease, as well as on the effect of HIV and the most common ARVs on the numbers and functions of these cells, including neutrophil-platelet-endothelial interactions.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Cardiovascular toxicity of contemporary antiretroviral therapy. (Pubmed Central) -  Sep 22, 2021   
    CVD risk should be monitored carefully in PLWH who were exposed to first generation ART, efavirenz or to PIs. Registries should capture ART use and CVD events to stay informed on actual clinical risk in the current era of rapid initiation on integrase inhibitor-based ART.
  • ||||||||||  zidovudine / Generic mfg.
    Biomarker, Journal:  ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma. (Pubmed Central) -  Sep 14, 2021   
    Finally, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression levels of ESPL1 in glioma cell lines. This study plays an important role in revealing the etiology of glioma by revealing the function of ESPL1, providing a potential molecular marker for the diagnosis and treatment of glioma, especially low-grade glioma.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Nucleoside Reverse Transcriptase Inhibitor (NRTI) Interaction with Human Equilibrative Nucleoside Transporters 1 and 2. (Pubmed Central) -  Sep 10, 2021   
    This provides a method to assess the influence of nucleoside reverse transcriptase inhibitors (NRTIs) on natively expressed transporter function. Determining substrate selectivity of the ENTs in HeLa cells can be effectively translated into the activity of these transporters in Sertoli cells that comprise the blood-testis barrier, thereby assisting targeted drug development of compounds capable of circumventing the blood-testis barrier.
  • ||||||||||  zidovudine / Generic mfg.
    Review, Journal:  An Overview of Human Immunodeficiency Virus-1 Antiretroviral Drugs: General Principles and Current Status. (Pubmed Central) -  Aug 20, 2021   
    Since the approval of zidovudine in 1987, over thirty antiretroviral drugs have been categorized into the following six distinct classes based on their biological function and resistance profiles: (1) nucleoside analog reverse-transcriptase inhibitors; (2) non-nucleoside reverse transcriptase inhibitors; (3) integrase strand transferase inhibitors; (4) protease inhibitors; (5) fusion inhibitors; and (6) co-receptor antagonists...Although plenty of antiretroviral drugs are beneficially used to treat patients with HIV-1, the ongoing efforts to develop antiretroviral drugs have overcome the drug resistances, adverse effects, and limited adherence of drugs observed in previous drugs to some extent. Furthermore, studies focused on agents targeting latent HIV-1 reservoirs should be strengthened, as that may lead to eradication of HIV-1.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  In utero exposure to zidovudine-containing antiretroviral therapy and clonal hematopoiesis in HIV-exposed uninfected newborns. (Pubmed Central) -  Aug 8, 2021   
    Other individual risk factors were independently associated with LD, and its subtypes, suggesting that the pathogenesis itself is differently manifested for each type of LD. Our results suggest that CH at levels detectable in our study is not strongly influenced by in utero ZDV exposure; however, additional follow-up studies are needed to further evaluate the safety and potential long-term impacts of in utero ZDV exposure in HEU children as well as better investigate genomic aberrations occurring late in pregnancy.
  • ||||||||||  zidovudine / Generic mfg.
    Clinical, Journal, Real-world evidence:  Real-World Data on Adult T-Cell Leukemia/Lymphoma in Latin America: A Study From the Grupo de Estudio Latinoamericano de Linfoproliferativos. (Pubmed Central) -  Aug 8, 2021   
    This study confirms Latin American ATLL presents at a younger age and has a high incidence of lymphomatous type, low incidence of indolent subtypes, and worse survival rates as compared with Japanese patients. In aggressive ATLL, chemotherapy remains the preferred choice for lymphomatous favoring etoposide-based regimen (etoposide, cyclophosphamide, vincristine, doxorubicin, and prednisone), whereas AZT-IFN remains a good first-line option for acute subtype.
  • ||||||||||  Revlimid (lenalidomide) / BMS
    Journal:  Development of future treatment for ATL (Pubmed Central) -  Aug 6, 2021   
    Moreover, an EZH1/2 inhibitor has completed the enrollment of a phase 2 trial in Japan. The standard of care for elderly patients should be established because the median age of those with newly diagnosed ATL reaches up to 70 years old.
  • ||||||||||  zidovudine / Generic mfg.
    [VIRTUAL] Lung and HIV () -  Jul 29, 2021 - Abstract #ERS2021ERS_2816;    
    Six patients died from acute respiratory failure. The therapeutic management is complex.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Karplus relationships of the J and J couplings in organic azides. (Pubmed Central) -  Jul 21, 2021   
    Karplus equations were derived from the DFT computations on the isopropylazide model system. In light of these stablished relationships natural abundance H- N couplings obtained for the azide group of the zidovudine antiviral helped to probe its conformation around the C-N bond as being of the synclinal type.
  • ||||||||||  zidovudine / Generic mfg.
    Clinical, Journal:  Evaluation of infants with HIV-infected mothers and perinatal transmission in Turkey: A single-center experience. (Pubmed Central) -  Jul 6, 2021   
    In light of these stablished relationships natural abundance H- N couplings obtained for the azide group of the zidovudine antiviral helped to probe its conformation around the C-N bond as being of the synclinal type. Our findings highlight the importance of initiating ART for all HIV-infected pregnant women and the importance of protection modalities during pregnancy, delivery, and the postnatal period for the prevention of perinatal transmission of HIV.
  • ||||||||||  zidovudine / Generic mfg.
    [VIRTUAL] Longitudinal melanonychia with spontaneous resolution () -  Jul 5, 2021 - Abstract #BAD2021BAD_292;    
    Regression of longitudinal melanonychia is exceptional but has been reported in children and in the context of nail biting and exposure to antiretroviral drugs, including zidovudine...Definitive diagnosis requires nail matrix biopsy, which could leave a permanent nail defect, with aesthetic and functional consequences. Therefore, in the absence of other features suggestive of malignancy a conservative, observational approach may be adopted in the first instance in paediatric cases.
  • ||||||||||  zidovudine / Generic mfg., lamivudine HBV / Generic mfg.
    Journal:  Structural dynamics and susceptibility of anti-HIV drugs against HBV reverse transcriptase. (Pubmed Central) -  Jul 4, 2021   
    In the present study, we aimed to investigate the structural dynamics and susceptibility of the known anti-HIV drugs (stavudine [d4T], didanosine [DDI], and zidovudine [ZDV]) against HBV-RT enzyme in comparison to the anti-HBV drug lamivudine (3TC) and deoxythymidine triphosphate (dTTP) substrate using several computational approaches...The predicted binding free energy results based on QM/MM-GBSA and MM/GB(PB)SA methods suggested that the susceptibility towards HBV-RT of d4T and ZDV is higher than that of 3TC and dTTP. Altogether, this work sheds light on the potentiality of d4T and ZDV as a promising drug for HBV-infected patients harboring 3TC resistance.Communicated by Ramaswamy H. Sarma.
  • ||||||||||  zidovudine / Generic mfg.
    Review, Journal:  Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1. (Pubmed Central) -  Jul 2, 2021   
    Currently, the derivatives of natural products available as anti-HIV-1 agents include zidovudine, an arabinonucleoside derivative of the Caribbean marine sponge (Tectitethya crypta), which inhibits the reverse transcriptase of the virus...Additionally, bevirimat (isolated from Syzygium claviflorum) and calanolide A (isolated from Calophyllum sp.) are inhibitors of viral maturation and reverse transcription process, respectively. In the present review, we aimed to describe the wide repertoire of natural compounds exhibiting anti-HIV-1 activity that can be considered for designing new therapeutic strategies to curb the HIV pandemic.
  • ||||||||||  zidovudine / Generic mfg., rifampicin / Generic mfg.
    Preclinical, Journal:  Role of the SOS Response in the Generation of Antibiotic Resistance In Vivo. (Pubmed Central) -  Jun 30, 2021   
    Zinc was able to inhibit SOS-induced emergence of antibiotic resistance in vivo, as previously observed in vitro. Our findings may have relevance in reducing emergence of resistance to new antimicrobial drugs.
  • ||||||||||  zidovudine / Generic mfg.
    Clinical, Journal:  Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil. (Pubmed Central) -  Jun 24, 2021   
    Additionally, artificial neural network-based immunoinformatic predictions suggest that K65R could enhance viral recognition by HLA-B27 that has relatively low prevalence in the Brazilian population. Overall, the results suggest that tenofovir-based regimens need to be carefully monitored particularly in settings with subtype C and specific HLA profiles.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Laser facilitates week-long sustained transdermal drug delivery at high doses. (Pubmed Central) -  Jun 22, 2021   
    Using sulforhodamine b, zidovudine, and bovine serum albumin as model hydrophilic drugs, we found tapped coating could coat 10-20 mg drug per 0.5 cm reservoir patch to elicit 3-day sustained delivery, while compression coating could coat ~35-70 mg drug per 0.5 cm reservoir patch to elicit week-long sustained delivery...Enlarging reservoir patch size to 10 cm can conveniently expands the delivery capacity to gram scale. To our knowledge, this is the first time that high-dose week-long sustained transdermal delivery of hydrophilic drugs was achieved via a simple laser-based powder delivery platform.