zidovudine / Generic mfg. 
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 94 Diseases   6 Trials   6 Trials   1432 News 


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  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Synthesis of ?-lactam-zidovudine pronucleosides as potential selective narrow-spectrum antibacterial agents. (Pubmed Central) -  Jan 3, 2025   
    Enzymatic and microbiological evaluations were performed to evaluate the synthesized pronucleosides, yielding new insights into molecular recognition of ?-lactamase enzymes. This approach would potentially allow a targeted and selective eradication of antibiotic-resistant ?-lactamase-producing (opportunistic) pathogens, as the inactive prodrug is unable to harm the commensal microbial flora.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie
    Venetoclax Alone or in Combination Shows Promising Activity in Preclinical Models and Clinical Cases of Relapsed/Refractory North American Adult T-Cell Leukemia Lymphoma (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_5210;    
    Venetoclax has shown activity in other T-cell malignancies, alone or in combination with hypomethylating agents (HMA), AZT (Zidovudine) with Interferon-alpha has been the backbone of acute ATLL treatment for the past three decades...Results : Preclinical : We observed that both the J-ATLL and NA-ATLL cells are sensitive to BCL-2 inhibitors (Venetoclax & Sonrotoclax) with IC50s in the 1-10uM range...To determine synergy between drugs we tested the combination of Decitabine (hypomethylating agent)-Venetoclax as well as between Biktarvy-Venetoclax...TP53 mutated patients had poorer responses. Given the encouraging preclinical and clinical activity of this agent, a prospective clinical trial is being developed using these agents.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Factors associated with skeletal muscle mass in middle-aged men living with HIV. (Pubmed Central) -  Oct 2, 2024   
    These factors, along with BMI, could be used conveniently to predict low muscle mass. Furthermore, the association between the oedema index and muscle mass suggests that observing signs of oedema may indicate a risk of low muscle mass in PLWH.
  • ||||||||||  Journal:  Screening miRNAs to Hinder the Tumorigenesis of Renal Clear Cell Carcinoma Associated with KDR Expression. (Pubmed Central) -  Sep 20, 2024   
    However, further in vitro studies are imperative to validate these findings and gain a comprehensive understanding of the intricate regulatory interplay involving hsa-miR-200c-3p, KDR, 5-fluorouracil, and other FDA-approved drugs for the treat-ment of KIRC. This will facilitate the identification of KIRC stage progression and its underlying pre-ventative mechanisms.
  • ||||||||||  dolutegravir/emtricitabine/tenofovir alafenamide (DTG/FTC/TAF) / Viatris
    Clinical, Journal:  Characterizing HIV drug resistance in cases of vertical transmission in the VESTED randomized antiretroviral treatment trial. (Pubmed Central) -  Aug 23, 2024   
    P3
    VESTED (NCT03048422) compared the safety and efficacy of three antiretroviral treatment (ART) regimens in pregnant and postpartum women: dolutegravir+emtricitabine/tenofovir alafenamide fumarate; dolutegravir+emtricitabine/tenofovir disoproxil fumarate (TDF); efavirenz/emtricitabine/TDF...Their infants received postnatal nevirapine+/-zidovudine prophylaxis and were breastfed...VT was rare. New-onset NNRTI HIVDR in Case mothers was likely from efavirenz-ART prescribed prior to study dolutegravir-ART, and in one case appeared transmitted to the infant despite nevirapine prophylaxis.
  • ||||||||||  stavudine / Generic mfg., zidovudine / Generic mfg.
    Journal:  Metabolic engineering of Escherichia coli for thymidine production (Pubmed Central) -  Aug 23, 2024   
    Thymidine, as a crucial precursor of anti-AIDS drugs (e.g., zidovudine and stavudine), has wide application potential in the pharmaceutical industry. The engineered THY6-2 strain produced 11.10 g/L thymidine in a 5 L bioreactor with a yield of 0.04 g/g glucose and productivity of 0.23 g/(L
  • ||||||||||  favipiravir / Generic mfg.
    Journal:  Convenient screening of the reproductive toxicity of favipiravir and antiviral drugs in Caenorhabditis elegans. (Pubmed Central) -  Aug 21, 2024   
    The concordance between the results of the screening system for reproductive toxicity of antivirals in C. elegans and those in experimental animals based on the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use, reproductive toxicology confirms its appropriateness as a screening system for reproductive toxicity. Favipiravir and zidovudine were the least toxic to C. e legans among the antiviral drugs examined.
  • ||||||||||  Beleodaq (belinostat) / Aurobindo, Assertio
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma (clinicaltrials.gov) -  Aug 18, 2024   
    P2,  N=15, Active, not recruiting, 
    Favipiravir and zidovudine were the least toxic to C. e legans among the antiviral drugs examined. Recruiting --> Active, not recruiting | N=10 --> 15 | Trial completion date: Dec 2025 --> Jul 2025 | Trial primary completion date: Dec 2024 --> Jul 2024
  • ||||||||||  zidovudine / Generic mfg.
    Framing stigma: a systematic review of cinema's HIV narrative between 2015 and 2023 (Poster Exhibition) -  Aug 9, 2024 - Abstract #HIVR4P2024HIVR4P_905;    
    Cinema often portrays HIV dramatically, overlooking chances to normalize it. The rarity of PEP, PrEP and U=U underscores the need for further discussion on cinema's potential role in raising awareness and fighting HIV stigma.
  • ||||||||||  zidovudine / Generic mfg.
    A RARE DEFECT OF STEROL BIOSYNTHESIS IN AN INFANT WITH CATARACT, MICROCEPHALY AND LIVER ANOMALIES (Poster Room | Level 0) -  Jul 30, 2024 - Abstract #SSIEM2024SSIEM_777;    
    This case highlights the importance of considering diagnoses other than the ones extensively described in literature when abnormal metabolites are observed but are clinically unlikely. The biochemical and clinical combination led to quick analysis of the correct gene (CYP51A1), which led to the diagnosis of lanosterol 14?- demethylase deficiency.
  • ||||||||||  zidovudine / Generic mfg., rifampicin / Generic mfg.
    Journal:  Lowering Mortality Risk in CR-HvKP Infection in Intestinal Immunohistological and Microbiota Restoration. (Pubmed Central) -  Jul 22, 2024   
    Gut inflammation and disrupted microbiota are key disease features of CR-HvKP infection but can be reversed by the RIF and ZDV drug combination. The finding that these drugs can restore host immunity through multiple mechanisms is novel and deserves further investigation of their clinical application potential.
  • ||||||||||  zidovudine / Generic mfg.
    Journal, Metastases:  In Situ Forming, Enzyme-Responsive Peptoid-Peptide Hydrogels: An Advanced Long-Acting Injectable Drug Delivery System. (Pubmed Central) -  Jun 26, 2024   
    Drug release proceeds via hydrolysis of an ester linkage under physiological conditions, releasing the drug in an unmodified form and further reducing the initial drug burst. Subcutaneous administration of (NPhe)4GGGGk(AZT)y(p)-OH to Sprague-Dawley rats resulted in zidovudine blood plasma concentrations within the 90% maximal inhibitory concentration (IC90) range (30-130 ng mL-1) for 35 days.
  • ||||||||||  Vemlidy (tenofovir alafenamide) / Gilead
    Journal:  HIV and adipose tissue: A long history linked to therapeutic classes of antiretrovirals. (Pubmed Central) -  Jun 19, 2024   
    However, among the NRTIs, the thymidine analogues stavudine and zidovudine led to lipoatrophy, either generalized or associated with visceral fat hypertrophy and buffalo hump...More recently, the NRTI tenofovir disoproxyfumarate (TDF) and the NNRTI efavirenz have been associated with inhibition of fat gain but not with clear lipoatrophy...Also, in the NRTI class, TDF has often been replaced by tenofovir alafenamide (TAF) due to bone and renal toxicities, and TAF has been associated with global fat gain...In the global obesogenic worldwide context, PWH are gaining weight as well in relation to poor health life conditions. Taking in charge obesity uses the same strategies as those used in the general population.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Evaluating Hepatotoxicity: A Comparative Analysis of New Generation versus Historical Antiretroviral Agents. (Pubmed Central) -  May 28, 2024   
    (1) Background: Since the advent of zidovudine in 1987, antiretroviral therapy has undergone significant evolution, marked by the introduction of 34 antiretroviral drugs and 24 fixed-dose combinations...(4) The findings suggest that the latest-generation antiretroviral medications may offer a safer profile in terms of hepatotoxicity compared to older therapies, with potential benefits for long-term liver health. This study underscores the importance of continuous monitoring and further research to optimize ART strategies, ensuring improved patient outcomes and quality of life for individuals living with HIV.
  • ||||||||||  Review, Journal:  Drug-Induced Myopathies: A Comprehensive Review and Update. (Pubmed Central) -  May 25, 2024   
    The article considers the clinical course of the different types of myopathies, their pathogenesis, histopathological features, and treatment methods of these disorders. The aim of this paper is to gather from the latest available literature up-to-date information on the course, pathophysiology, and therapeutic options of drug-induced myopathies, to systematize the knowledge of drug-induced myopathies and to draw the attention of internists to the fact that these clinical issues are an important therapeutic problem.
  • ||||||||||  Tivicay (dolutegravir) / ViiV Healthcare
    Journal:  Clinical Trials That Have Changed Clinical Practice and Care of Pregnant People With HIV. (Pubmed Central) -  Apr 30, 2024   
    Collectively, these trials not only advanced obstetric practice but also advanced scientific understanding of the timing, mechanisms, and determinants of perinatal HIV transmission. For each trial, we will describe key aspects of the study protocol and outcomes, insights gleaned about the dynamics of perinatal transmission, how each study changed clinical practice, and relevant updates to current practice since the trial's publication.
  • ||||||||||  zidovudine / Generic mfg.
    Journal:  Pregnancy Management in HIV Viral Controllers: Twenty Years of Experience. (Pubmed Central) -  Apr 26, 2024   
    (2) A multi-centre, retrospective case series (1999-2021) comparing pre- and post-2012 when guidelines departed from zidovudine-monotherapy (ZDVm) as a first-line option...No transmissions were reported. (4) UK practice has been influenced by the change in guidelines, but this has had little impact on CS rates.
  • ||||||||||  Vistide (cidofovir) / Gilead, TPOXX (tecovirimat) / SIGA Technologies
    Journal:  Proteome-Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease. (Pubmed Central) -  Apr 24, 2024   
    MPX treatment mainly includes Cidofovir and Tecovirimat but they have several side effects and solely depending on these drugs may promote the emergence of drug-resistant variants...DrugBank screening revealed drugs such as Brinzolamide, Dorzolamide, Methazolamide, Zidovudine, Gemcitabine, Hydroxyurea, Fludarabine, and Tecovirimat as controls...Molecular Dynamics (MD) simulations suggest all of these compounds can change the C-alpha backbone, residue mobility, compactness, and solvent accessible surface area of L2R and I4L. Our results strongly suggest that these drug repurposing small molecules are worth exploring in vivo and in vitro for clinical applications.
  • ||||||||||  stavudine / Generic mfg., zidovudine / Generic mfg.
    Journal:  Determinants of Metabolic Syndrome Among Patients Receiving Anti-Retro-Viral Treatment in A Tertiary Hospital, Central Ethiopia: Unmatched Case-Control Study. (Pubmed Central) -  Mar 25, 2024   
    Similarly, higher odds were observed among patients who frequently consumed animal source foods than among those who consumed cereals or vegetables (AOR, 1.94; 95% CI, 1.03-3.63), those who had HIV lipodystrophy (AOR 1.73; 95% CI: 1.05-2.86), those who were treated with stavudine (AOR 3.08; 95% CI: 1.89-5.04), and those who were treated with zidovudine (AOR 1.71, 95% CI: 1.02-2.88) compared to their counterparts. Older age, diet from animal sources, exposure to zidovudine or stavudine, and the presence of lipodystrophy were independent determinants of MetS.
  • ||||||||||  efavirenz / Generic mfg., zidovudine / Generic mfg., enoxaparin sodium / Generic mfg.
    Could This Be Cell-Associated Perinatal HIV Transmission? (Poster hall) -  Mar 5, 2024 - Abstract #CROI2024CROI_353;    
    HIV exposed children Mother A had 6 weeks of enoxaparin from 11 weeks GA; mother B an iron infusion at 33 weeks GA...Both infants had negative HIV VL at birth, had standard of care zidovudine PEP for 2
  • ||||||||||  Invirase (saquinavir) / Roche, Viracept (nelfinavir) / ViiV Healthcare, Roche
    Enrollment change, Trial completion date, Trial primary completion date:  A Prospective Cohort of Children With HIV Infection (clinicaltrials.gov) -  Feb 28, 2024   
    P=N/A,  N=500, Active, not recruiting, 
    WHO staging, and CD4 count were the primary risk factors for anaemia, which a change of treatment regimen and supportive measures can reverse. N=1000 --> 500 | Trial completion date: Dec 2030 --> Jun 2024 | Trial primary completion date: Dec 2030 --> Jun 2024
  • ||||||||||  Journal:  Potential mechanisms and drug prediction of Rheumatoid Arthritis and primary Sj (Pubmed Central) -  Feb 19, 2024   
    In conclusion, we identified commom targets as potential biomarkers in RA and pSS from publicly available databases and predicted potential drugs based on the targets. A new understanding of the molecular mechanisms associated with RA and pSS is provided according to the miRNA-gene network.