- |||||||||| progesterone / Generic mfg.
Review, Journal: Evidence-based practice in canine artificial insemination. (Pubmed Central) - May 11, 2024
Moreover, progesterone assay results can vary widely due to extrinsic factors such as the time of blood sampling, sample storage conditions and the assay employed. Finally, this review investigates evidence surrounding various insemination routes and suggests that well-performed vaginal insemination, even with frozen-thawed semen, may be an acceptable approach for cases where transcervical insemination is impractical.
- |||||||||| progesterone / Generic mfg.
Journal: Microwave Dielectric Response of Bovine Milk as Pregnancy Detection Tool in Dairy Cows. (Pubmed Central) - May 11, 2024
The most reliable methods for pregnancy diagnosis in dairy herds include rectal palpation, ultrasound examination, and evaluation of plasma progesterone concentrations...These findings demonstrate that MDS can be used to detect changes in milk upon pregnancy. The developed machine learning provides a broad classification that could be further enhanced with additional data.
- |||||||||| progesterone / Generic mfg., carboplatin / Generic mfg., cisplatin / Generic mfg.
Review, Journal: Vitamins in Gynecologic Malignancies. (Pubmed Central) - May 11, 2024
Combining cisplatin with calcitriol and progesterone increases VDR expression, potentially enhancing the effectiveness of anticancer therapy in ovarian cancer...A balanced daily intake of vitamins is important, as both deficiency and excess can influence cancer development. It has been observed that there is a U-shaped relationship between group B vitamins and metabolic markers and clinical outcomes.
- |||||||||| Adlumiz (anamorelin) / Helsinn, Ono Pharma
Review, Journal: Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions. (Pubmed Central) - May 11, 2024
In Japan, the clinical practice has changed based on the availability of Anamorelin, a ghrelin receptor agonist that improved lean body mass, weight, and appetite-related quality of life (QoL) compared to a placebo, in phase III trials...In the future, a single therapeutic agent or perhaps multiple medications targeting the various mechanisms of CC may prove to be an effective strategy. Ideally, these medications should be incorporated into a multimodal interdisciplinary approach that includes exercise and nutrition.
- |||||||||| Depo-Estradiol (estradiol cypionate) / Pfizer
Journal: Early induction of luteolysis in a timed AI protocol increases reproductive performance in beef cows. (Pubmed Central) - May 11, 2024
However, in cows with P4 > 2 ng/mL PGF7 cows had higher expression of estrus (89 vs 67.5?%; P = 0.0005) and P/TAI (64.8 vs 48.7?%; P = 0.021) than PGF8. Thus, increasing the proestrous period by inducing luteolysis 24 hours earlier than removing the P4 intravaginal device enhanced fertility in non-suckling cyclic beef cows by increasing expression of estrus and P/TAI.
- |||||||||| progesterone / Generic mfg.
Journal: The uterine secretome initiates growth of gynecologic tissues in ectopic locations. (Pubmed Central) - May 10, 2024
To block implantation factors, progesterone knockout (PKO) tdT mice were created...In conclusion, endometrial derived implantation factors, such as LIF, are necessary to initiate ectopic tissue growth. We have developed an animal model of ectopic growth of gynecologic tissues in a WT mouse which will potentially allow for development of new prevention and treatment modalities.
- |||||||||| progesterone / Generic mfg.
Preclinical, Journal, IO biomarker: The in vitro mechanism of Vaspinregulates the proliferation and steroidogenesis of rat lutein cells. (Pubmed Central) - May 10, 2024
The proliferation, apoptosis, angiogenesis, progesterone (P4) and estradiol (E2) were detected by CCK-8, Anneixn-FITC/PI staining, angiogenesis experiment and ELISA...Also, Vaspin increased the p-MEK1 and p-p38 levels. Vaspin can up-regulate the proliferation and steroidogenesis of rat luteal cells and reduce apoptosis, which may be related to the influence of MEK/MAPK activity.
- |||||||||| progesterone / Generic mfg., paroxetine / Generic mfg.
Preclinical, Journal: Effect of Shenqi Jieyu formula on inflammatory response pathway in hippocampus of postpartum depression rats. (Pubmed Central) - May 10, 2024
SJF, paroxetine hydrochloride and sEH inhibitor (AUDA) were used to treat PPD rats for 3 weeks...SJF reversed the gene expression changes of COX-2, TNF-?, and IL-1?. SJF may have an analogous effect as sEH inhibitor to relieve depressive symptoms by suppressing inflammatory signaling pathways in hippocampi of PPD rats, which involves AA metabolic pathway and NF-?B signal pathway.
- |||||||||| Journal, Metastases: IMPACT OF SYSTEMIC TREATMENTS FOR ADVANCED THYROID CANCER ON THE ADRENAL CORTEX. (Pubmed Central) - May 9, 2024
Our data confirm that systemic treatments for advanced thyroid cancer can lead to an impaired cortisol secretion. A reduction in the other hormones secreted by the adrenal cortex has been firstly reported and should be considered in the more appropriate management of these fragile patients.
- |||||||||| progesterone / Generic mfg.
Review, Journal: Environmental pollutants and male infertility: Effects on CatSper. (Pubmed Central) - May 8, 2024
Environmental pollutants can act as partial agonists or inhibitors of CatSper or exhibit a synergistic effect. In this article, we briefly describe the structure, functions, and regulatory mechanisms of CatSper, and discuss the body of literature covering the effects of environmental pollutants on CatSper.
- |||||||||| progesterone / Generic mfg.
Review, Journal: The hormonal control of parturition. (Pubmed Central) - May 8, 2024
To this end, hormones that affect the function of the gravid uterus, especially progesterone (P4), 17?-estradiol (E2), oxytocin (OT), and prostaglandins (PGs), play pivotal roles...Withdrawal of the P4 block is coordinated with increased E2 actions to enhance uterotonic signals mediated by OT and PGs to promote uterine contractions, cervix softening and membrane rupture i.e., labor. This review examines recent advances in research to understand the hormonal control of parturition, with focus on the roles of P4, E2, PGs, OT, inflammatory cytokines and placental peptide hormones together with evolutionary biology of and implications for clinical management of human parturition.
- |||||||||| progesterone / Generic mfg.
Review, Journal: Royal jelly and its hormonal effects in breast cancer: a literature review. (Pubmed Central) - May 8, 2024
This review examines recent advances in research to understand the hormonal control of parturition, with focus on the roles of P4, E2, PGs, OT, inflammatory cytokines and placental peptide hormones together with evolutionary biology of and implications for clinical management of human parturition. Future clinical studies are essential to confirm the safe dose of royal jelly as an adjuvant therapy in breast cancer.
- |||||||||| progesterone / Generic mfg.
Journal: The interaction between seminal plasma, sperm, and endometrium in inter- and intra-species breeding in equids. (Pubmed Central) - May 7, 2024
Uterine edema, intrauterine fluid accumulation, polymorphonuclear neutrophils on cytology, and concentrations of progesterone, and pro- and anti-inflammatory cytokines (IL1A, IL1B, IL4, IL6, CXCL8, IL10) were assessed pre- and post infusion of semen and seminal plasma (donkey and horse)...In conclusion, breeding horse mares with donkey semen induces a similar post-breeding endometritis to horse semen. Donkey seminal plasma results in a lower post-infusion inflammatory response than other combinations in the immediate post-breeding.
- |||||||||| progesterone / Generic mfg.
Preclinical, Journal: Imaging the dynamics of murine uterine contractions in early pregnancy. (Pubmed Central) - May 7, 2024
We report that the native organ is highly contractile during the progesterone-dominant diestrus stage of the cycle when compared to the estrogen-dominant proestrus and estrus stages...Our method provides a means to understand the wave characteristics of uterine smooth muscle in response to modulators and in genetic mutants. Better understanding uterine contractility in the early pregnancy stages is critical for the advancement of artificial reproductive technologies and a possibility of modulating embryo movement during clinical embryo transfers.
- |||||||||| progesterone / Generic mfg.
Preclinical, Journal: Effect of cryopreservation on Odc1 and RhoA genes expression in diapausing mouse blastocysts. (Pubmed Central) - May 7, 2024
The purpose of this work is to address the possibility of cryopreservation diapausing embryos and to estimate the expression of the Odc1 and RhoA genes in diapausing and non-diapausing embryos before and after freeze-thaw procedures using ovariectomized progesterone treated mice as a model...Although cryopreservation dramatically decreased the expression of the Odc1 and RhoA genes in non-diapausing embryos, no such effects have been observed in diapausing embryos where these genes were already at the low level before freeze-thaw procedures. Future studies may attempt to facilitate the re-activation of diapausing embryos, for example frozen-thawed ones, specifically targeting Odc1 or Rho/ROCK system.
- |||||||||| progesterone / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Relationship between depression and sex steroid hormone among women with epilepsy. (Pubmed Central) - May 7, 2024
There was higher mean depression score, lower prolactin and higher testosterone level among cases compared to control. Furthermore, there was lower prolactin and higher testosterone level in Carbamazepine (CBZ) group compared to Levetiracetam (LEV) groups.
- |||||||||| progesterone / Generic mfg.
Preclinical, Journal: Grid1 regulates the onset of puberty in female rats. (Pubmed Central) - May 6, 2024
The concentration of progesterone (P4) in the serum was significantly decreased compare with control group...The reproductive performance of the rats was not affected by the Grid1 knockdown. Therefore, Grid1 may a?ect the onset of puberty in female rats by regulating the levels of Gnrh, and Rfrp-3 in the hypothalamus, as well as the concentrations of P4, but not reproduction performance.
- |||||||||| progesterone / Generic mfg., megestrol / Generic mfg.
Journal: Correlation between steroid receptor expression and response to progestational therapy in patients with atypical endometrial hyperplasia or cancer. (Pubmed Central) - May 3, 2024
Retrospective cohort study collected data for patients with AEH or EMCA who had an endometrial sample after receiving conservative therapy utilizing either Megestrol acetate or Levonorgestrel Intrauterine device (IUD). Immunohistochemistry (IHC) was performed on pre- and post- treatment biopsy samples to assess androgen receptor (AR), estrogen receptor (ER), and progesterone receptor (PR) expression...Patients who successfully responded to the treatment demonstrated a significantly greater decrease in IHC scores after the treatment compared to those who did not respond (p
- |||||||||| progesterone / Generic mfg.
Review, Journal: Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy. (Pubmed Central) - May 2, 2024
This review summarizes the key findings regarding the role of PGRs and mPRs in ULs, especially highlighting the potential ECM and angiogenesis modulation by P4. An increased understanding of this mechanistic role of nuclear and specifically mPRs in the biology of P4-modulated ECM and angiogenesis in the growth of ULs could turn out to be fundamental for developing effective targeted therapies for ULs.
- |||||||||| progesterone / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: PE-PMA: Reduction of Progesterone Elevation at Trigger in POR After Long Acting COS Compared With Daily COS: a Prospective Randomized Trial (clinicaltrials.gov) - May 1, 2024
P4, N=110, Active, not recruiting,
An increased understanding of this mechanistic role of nuclear and specifically mPRs in the biology of P4-modulated ECM and angiogenesis in the growth of ULs could turn out to be fundamental for developing effective targeted therapies for ULs. Not yet recruiting --> Active, not recruiting | Trial completion date: Feb 2023 --> Apr 2024 | Trial primary completion date: Aug 2022 --> Feb 2024
- |||||||||| progesterone / Generic mfg.
Journal: Comparison of assay methods for quantifying sex hormone concentrations across the menstrual cycle in rhesus macaques. (Pubmed Central) - Apr 30, 2024
We compared AIA and LC-MS/MS for analysis of 17?-estradiol (E2) and progesterone (P4) over the course of several menstrual cycles in 12 rhesus macaques (Macaca mulatta)...Well-characterized AIAs are an excellent tool for daily monitoring of monkey menstrual cycles or providing single data points requiring fast turnaround. In certain situations where AIA may provide inaccurate estimations of E2 and P4 concentrations, LC-MS/MS assays are preferable.
- |||||||||| progesterone / Generic mfg., dydrogesterone / Generic mfg.
Journal: Impact of dydrogesterone use in cycles with low progesterone levels on the day of frozen embryo transfer. (Pubmed Central) - Apr 28, 2024
Despite global evidence supporting vaginal progesterone as the approach with the highest efficacy, only a limited number of facilities have utilized it due to the current drug use regulations in Japan. Live birth rate did not vary significantly in females with low and normal serum P4 levels on the day of FET when DYD was used as rescue therapy.
- |||||||||| progesterone / Generic mfg.
Review, Journal: Endometrial Cancer in Reproductive-Aged Females: Etiology and Pathogenesis. (Pubmed Central) - Apr 27, 2024
Estrogen unopposed by progesterone is considered to be the main driving factor in the pathogenesis of EC...Currently, there are no guidelines established to indicate premenopausal patients who should be screened. This review aims to synthesize current data on the etiology, risk factors, presentation, evaluation, and prognosis of endometrial cancer in this population.
- |||||||||| progesterone / Generic mfg.
Preclinical, Journal, IO biomarker: Adropin may enhance life span and function of corpus luteum by improving antioxidant potential in adult mouse. (Pubmed Central) - Apr 27, 2024
The corpus luteum (CL) is a temporary endocrine gland that synthesizes progesterone...Decreased oxidative stress might inhibit the translocation of NF-?B into the nucleus of luteal cells, resulting into increased survival and decreased apoptosis, as evident by decreased lipid peroxidation, BAX/BCL2 ratio, caspase 3, active caspase 3 expression, and TUNEL-positive cells in adropin treated mice. Our findings suggest that adropin can be a promising candidate that could increase the lifespan of CL and might serve as a potential therapeutic option for treating luteal insufficiency.
- |||||||||| progesterone / Generic mfg.
Journal: Recent insights into egg quality and larval vitality of the European EEL anguilla anguilla. (Pubmed Central) - Apr 27, 2024
17?,20?-dihydroxy-4-pregnen-3-one (DHP) was replaced with upstream precursor progesterone (P) to induce the endogenous production of DHP by the female eel...A deformity determination key for young eel larvae has been developed that provides a framework of reference for larval deformities which will be instrumental with gaining insights on the reasons behind each larval deformity. These improvements of the artificial reproduction protocol and hatchery practices will contribute to the production of robust eel larvae that survive, grow and metamorphose into juveniles that will later be able to reproduce in captivity.
- |||||||||| progesterone / Generic mfg.
Journal, HEOR: Use of menopausal hormone therapy beyond age 65 years and its effects on women's health outcomes by types, routes, and doses. (Pubmed Central) - Apr 26, 2024
Among senior Medicare women, the implications of menopausal hormone therapy use beyond age 65 years vary by types, routes, and strengths. In general, risk reductions appear to be greater with low rather than medium or high doses, vaginal or transdermal rather than oral preparations, and with E2 rather than conjugated estrogen.
- |||||||||| progesterone / Generic mfg.
Journal: Evaluating estrus synchronization and early pregnancy detection in Ossimi sheep: The influence of fluorogestone acetate treatment duration and dosage. (Pubmed Central) - Apr 26, 2024
The study aimed to optimize breeding efficiency by examining the effectiveness of these treatments in synchronizing estrous cycles and by evaluating the use of serum levels of pregnancy-associated glycoprotein 1 (PAG1) and progesterone (P4) as markers for early pregnancy identification...PAG1 also proved to be a reliable marker for early pregnancy detection, offering a promising approach to identifying fetal numbers early in pregnancy. This research suggests optimizing FGA sponge use could be cost-efficient for improving reproductive efficiency and early pregnancy management in sheep.
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