Radiesse (calcium hydroxylapatite) / Merz Pharma 
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 2 Diseases   1 Trial   1 Trial   564 News 


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  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Journal:  Hyperdiluted Calcium Hydroxylapatite for the Treatment of Skin Laxity of the Neck. (Pubmed Central) -  Nov 4, 2021   
    This study supports the efficacy (according to the NSL scale) and safety of hy-CaHA (1:2) for NSL. Our results also highlight the utility of the newly developed NSL scale, being a useful tool to evaluate the level of NSL before treatment and to measure the outcome.
  • ||||||||||  Phase classification:  RADIESSE Injection in Perioral and Marionette Lines (clinicaltrials.gov) -  Aug 23, 2021   
    P=N/A,  N=10, Completed, 
    A kind of injected material (CaHA or HA), age, perceptual, objective and subjective voice assessment do not seem to impact the likelihood of reoperation in patients with UVFP. Phase classification: P3 --> P=N/A
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Review, Journal:  Non-Hyaluronic Acid Fillers for Midface Augmentation: A Systematic Review. (Pubmed Central) -  Jul 24, 2021   
    Medical Subject Headings terms used were "cheek" OR "midface" OR "malar" and "filler" OR "poly-L-lactic acid" OR "calcium hydroxyapatite," "autologous fat" OR "polymethylmethacrylate" OR "Artefill" OR "Bellafill" OR "Radiesse" OR "Sculptra." The initial search identified 271 articles...Autologous fat is a good option in many patients with the major drawback of unpredictable longevity, which may require a secondary procedure. Future studies should examine the longevity and long-term side effects of these fillers.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Preclinical, Journal:  Comparison of Polycaprolactone and Calcium Hydroxylapatite Dermal Fillers in A Rat Model. (Pubmed Central) -  May 25, 2021   
    We found that PCL and CaHA fillers are effective in increasing dermal collagen density, type 1 and type 3 collagen amount, and preventing dermis atrophy and showed that they have no advantage over each other in this respect. We have shown that PCL filler provides more fibroblast increase compared to CaHA filler and the effect of stimulating fibroblast proliferation takes longer.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Journal:  Managing intravascular complications following treatment with calcium hydroxylapatite: An expert consensus. (Pubmed Central) -  May 15, 2021   
    All physicians should be prepared for the eventuality of intra-arterial injection of a dermal filler, despite its rarity. These consensus recommendations combine advice from aesthetic experts with the latest reports from the published literature to provide an up-to-date office-based protocol for the prevention and treatment of complications arising from intra-arterial CaHA injection.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Review, Journal:  Management of periorbital hyperpigmentation- An overview of nature based agents and alternative approaches. (Pubmed Central) -  May 15, 2021   
    An exhaustive literature search revealed that other techniques such as blepharoplasty, carboxytherapy, calcium hydroxylapatite fillers, tear trough implant, Q-switched ruby laser, medicated tattoo, fat transfer, micro-needling, chemical peels, nitrogen plasma skin regeneration, intense pulsed light, and radiofrequency have been evaluated and reported to be beneficial in the treatment of POH...This review aims to provide a comprehensive perspective on the role of several topical actives in the modulation of melanin and tyrosinase biosynthesis pathway involved in the complex pathophysiology of periorbital hyperpigmentation. It also presents the advantages of combination products and other alternative therapies used in the management of POH.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Journal:  Generation of Filler Emboli as a Mechanism for Filler-Related Blindness. (Pubmed Central) -  Apr 27, 2021   
    Hyaluronic acid and hydroxylapatite fillers break up into small particles immediately after injection into a flowing system, generating emboli rather than a column of filler. The results of this study lead us to hypothesize another potential mechanism leading to filler-related blindness.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Preclinical, Journal:  Intraarterial Degradation of Calcium Hydroxylapatite Using Sodium Thiosulfate - An In Vitro and Cadaveric Study. (Pubmed Central) -  Apr 20, 2021   
    The results of this study indicate that STS is limited in its potential to dissolve intraarterial CaHA of cadaveric human facial arteries, despite the fact that it appears effective when in direct contact with the CaHA. Adverse events caused by intraarterial administration of CaHA-based fillers still lack a suitable antidote.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Clinical, Journal:  Treating Striae Distensae Albae in Asians: Efficacy and Safety of Combined MFU-V and CaHA. (Pubmed Central) -  Mar 9, 2021   
    This study evaluated the efficacy and safety of a single treatment combining microfocused ultrasound with visualization (MFU-V) and subdermal diluted calcium hydroxylapatite with lidocaine (CaHA+) for Striae Distensae Albae (SDA)...No adverse events occurred. A single combination treatment of MFU-V and diluted CaHA+ improves SDA without side effects and may be considered for patients seeking to minimize SDA.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Clinical, Journal:  Minimally Invasive Facial Cosmetic Procedures for the Millennial Aesthetic Patient. (Pubmed Central) -  Jan 26, 2021   
    The three most popular minimally invasive facial procedures in this demographic include botulinum toxin, dermal fillers (eg, hyaluronic acid, calcium hydroxylapatite, facial fat-fillers), and microdermabrasion...While some research studies have elicited the opinions of millennials on social issues, education, and technology, there is a paucity of literature on millennials' impressions, opinions, and perceptions of aesthetic procedures. As a generation that has been reshaping the culture of healthcare delivery and encouraging the innovation of products and procedures with their unique values and perspectives, accounting for their beliefs and fostering a better understanding of their experiences will promote an elevation in the quality of their care.
  • ||||||||||  Radiesse (calcium hydroxylapatite) / Merz Pharma
    Clinical, Journal:  Efficacy and Safety of 2 Injection Techniques for Hand Biostimulatory Treatment With Diluted Calcium Hydroxylapatite. (Pubmed Central) -  Jan 23, 2021   
    As a generation that has been reshaping the culture of healthcare delivery and encouraging the innovation of products and procedures with their unique values and perspectives, accounting for their beliefs and fostering a better understanding of their experiences will promote an elevation in the quality of their care. Diluted CaHA improves the skin quality of aging hands with a safe profile, without substantial differences between the techniques.